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Associations between physical activity levels and ATPase inhibitory factor 1 concentrations in older adults

Journal of Sport and Health Science 2024年第3期13卷 409-418页

作者： Jérémy Raffin Yves Rolland Annelise Genoux Guillaume Combes mikael Croyal Bertrand Perret Sophie Guyonnet Bruno Vellas Laurent O.Martinez Philipe de Souto Barreto For the MAPT/DSA Group Institut du Vieillissement Gérontopôle de ToulouseCentre Hospitalo-Universitaire de ToulouseToulouse 31000France Centre d'Epidémiologie et de Recherche en Santédes Populations UnitéMixte de Recherche 1295Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse-III-Paul-SabatierToulouse 31000France LimitAging Team Institut des Maladies Métaboliques et CardiovasculairesUnitéMixte de Recherche 1297Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse III-Paul SabatierToulouse 31432France Service de Biochimie Pôle de biologieHôpital de PurpanCentre Hospitalo-Universitaire de ToulouseToulouse 31300France L'Institut du Thorax Institut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France BioCore US16Structure Fédérative de Recherche BonamyInstitut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France Plate-forme de spectrométrie de masse Centre de Recherche en Nutrition HumaineOuestNantes 44000France 不详

Background:Adenosine triphosphatase inhibitory factor 1(IF1)is a key protein involved in energy ***1 has been linked to various agerelated diseases,although its relationship with physical activity(PA)remains ***,the apolipoprotein A-I(apoA-I),a PA-modulated lipoprotein,could play a role in this relationship because it shares a binding site with IF1 on the cell-surface ATP *** examined here the associations between chronic PA and plasma IF1 concentrations among older adults,and we investigated whether apoA-I mediated these ***:In the present work,1096 healthy adults(63.8%females)aged 70 years and over who were involved in the Multidomain Alzheimer Prevention Trial study were ***1 plasma concentrations(square root of ng/mL)were measured at the 1-year visit of the Multidomain Alzheimer Prevention Trial,while PA levels(square root of metabolic equivalent task min/week)were assessed using questionnaires administered each year from baseline to the 3-year *** linear regressions were performed to investigate the associations between the first-year mean PA levels and IF1 *** analyses were conducted to examine whether apoA-I mediated these *** linear regressions were carried out to investigate whether the 1-year visit IF1 concentrations predicted subsequent changes in ***:Multiple linear regressions indicated that first-year mean PA levels were positively associated with IF1 concentrations(B=0.021;SE=0.010;p=0.043).Mediation analyses revealed that about 37.7%of this relationship was mediated by apoA-I(B_(ab)=0.008;SE=0.004;p=0.023).Longitudinal investigations demonstrated that higher concentrations of IF1 at the 1-year visit predicted a faster decline in PA levels over the subsequent 2 years(time×IF1:B=0.148;SE=0.066;p=0.025).Conclusion:This study demonstrates that regular PA is associated with plasma IF1 concentrations,and it suggests that apoA-I partly med

关键词： Aging Apolipoprotein Bioenergetics Exerkine Mitochondria

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瑞典国家技术博物馆Wisdome Stockholm扩建项目

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现代装饰 2024年第3期 108-113页

作者：无 mikael Olsson(摄影) 范嘉苑(编译) Elding Oscarson设计团队不详

在探讨公共文化建筑时,如何处理形式与功能的关系,无疑是设计时最值得思考的要点之一。一方面,公共建筑需要建立其公共效能;另一方面,公共建筑也需体现其美学价值。从更新、扩建到新建,每一座公共建筑都拥有不同的建设背景和语境,如何... 详细信息

在探讨公共文化建筑时,如何处理形式与功能的关系,无疑是设计时最值得思考的要点之一。一方面,公共建筑需要建立其公共效能;另一方面,公共建筑也需体现其美学价值。从更新、扩建到新建,每一座公共建筑都拥有不同的建设背景和语境,如何寻找合适自身的设计方式,以更好地融入所在的场域环境和人们的日常生活,是关键突破点。本期的建筑栏目,试图从不同的角度发散,寻找构筑公共建筑空间的可能性。

关键词：公共建筑形式与功能扩建项目博物馆美学价值日常生活突破点

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基于“心脑一体观”探讨针灸调节褪黑素的作用机理

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中国医药科学 2024年第6期14卷 21-24页

作者： Walker Joel mikael 王建明于冬冬王文哲韩乐河南中医药大学河南郑州450046

现代医学认为,脑主导机体的一切生命过程和精神活动,且与周围环境的平衡和调节存在关系。而中医认为“心者,君主之官,神明出焉”,心有主宰身体和神志的功能。褪黑素(MT)是脑室内松果体分泌的一种激素,其在人体的效应有类似中医理论中的... 详细信息

现代医学认为,脑主导机体的一切生命过程和精神活动,且与周围环境的平衡和调节存在关系。而中医认为“心者,君主之官,神明出焉”,心有主宰身体和神志的功能。褪黑素(MT)是脑室内松果体分泌的一种激素,其在人体的效应有类似中医理论中的“心”“神”作用。如何理解并且融通中医和现代医学两个不同的理论体系,是目前在临床和科研中的重要问题。“心脑一体观”是结合不同理论体系的对同一个生理现象的探讨。本研究基于“心脑一体观”探讨MT失调所致疾病的相关研究,阐释针灸通过调理“心”“神”相关的穴位组合,不仅可改善失眠、抑郁、肥胖、血管性痴呆、胃溃疡等疾病症状,同时具有调节MT水平的作用,为临床针灸治疗MT相关疾病的腧穴配伍提供理论依据。

关键词：心脑一体观褪黑素针灸松果体

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Understanding and Exploiting Information Spreading and Integrating Technologies

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Journal of Computer Science & Technology 2011年第5期26卷 829-836页

作者： Petter Holme mikael Huss IceLab Department of PhysicsUme a University901 87 Ume aSweden Department of Energy Science Sungkyunkwan University Science of Life Laboratory Stockholm Karolinska Institute Science ParkBox 1031171 21 SolnaSweden Department of Biochemistry and Biophysics The Arrhenius Laboratories for Natural SciencesStockholm University 106 91 StockholmSweden

Our daily life leaves an increasing amount of digital traces,footprints that are improving our ***-mining tools,like recommender systems,convert these traces to information for aiding decisions in an ever-increasing number of areas in our *** feedback loop from what we do,to the information this produces,to decisions what to do next,will likely be an increasingly important factor in human behavior on all levels from individuals to *** this essay,we review some effects of this feedback and discuss how to understand and exploit them beyond mapping them on more well-understood *** take examples from models of spreading phenomena in social media to argue that analogies can be deceptive,instead we need to fresh approaches to the new types of data,something we exemplify with promising applications in medicine.

关键词： modeling and prediction computer-supported collaborative work health care

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Effects of Fresh Cupressus sempervirens Leaves Infusion on Growth Performance, Intestinal Microbiota and Haemato-Biochemical Parameters in Broilers

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Open Journal of Animal Sciences 2024年第2期14卷 70-87页

作者： Donfack mikael Noumbissi Marie Noël Bertine Ciemeni Michelle Aimee Tindo Tsamene Romario Evelyn Ngwa Bih Djamen Tchantchou Chamberlin Nyembo Kondo Camile Tsafong Jeatsa Franklain Necdem Tsafack Boris Kana Jean Raphaël Animal Nutrition and Production Research Unit Department of Animal Sciences Faculty of Agronomy and Agricultural Sciences University of Dschang Dschang Cameroon Department of Animal Sciences and Plant Technology Faculty of Agronomic Sciences La Sapientia Catholic University of Goma Goma Democratic Republic of Congo

The accumulation of growth-promoting antibiotic residues in animal products and the resistance developed by bacteria in poultry farms has led to a search for natural compounds derived from plants. This study was designed to promote the production performance of broiler chickens using fresh Cupressus sempervirens leaves infusion. Fresh Cupressus sempervirens leaves were harvested, washed, chopped and ground to a paste using a blender and fermented for three days in a closed container at a rate of 500 g/L of water. The solution obtained was filtered and added at the rate of 2, 4, 6, 8 and 10 ml/L of drinking water. The chickens fed on the graded level of the solution were compared to a control ration without an additive and positive control group supplemented with 1 g antibiotic/kg feed. At the finisher phase and throughout the study period, water intake increased significantly (P 0.05) affected by the inclusion of Cupressus sempervirens infusion. Haematological parameters significantly (P < 0.05) increase independently of the rate of incorporation of the infusion into the drinking water, with the exception of RBCs, MCHT and PCT. Serum content in total protein, globulins, LDL cholesterol and triglycerides were significantly (P < 0.05) high with 8 and 10 ml Cupressus sempervirens infusion/litre drinking water as compared to all other treatments. AST, ALT, urea, creatine, albumin, total cholesterol and HDL-cholesterol were not significantly affected. The lactic acid bacteria load increased significantly (P E. coli and salmonella counts decreased significantly (P < 0.05)

关键词： Broilers Cupressus sempervirens Growth Performance Haemato-Biochemical Parameters Intestinal Microbiota

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High power devices in wide bandgap semiconductors

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Science China(Information Sciences) 2011年第5期54卷 1087-1093页

作者： STLING mikael School of ICT KTH Royal Institute of Technology E229 SE-16440 Kista Sweden

Silicon carbide (SiC) semiconductor devices for high power applications are now commercially available as discrete devices. Recently Schottky diodes are offered by both USA and Europe based companies. Active switching devices such as bipolar junction transistors (BJTs), field effect transistors (JFETs and MOSFETs) are now reaching the market. The interest is rapidly growing for these devices in high power and high temperature applications. The main advantages of wide bandgap semiconductors are their very high critical electric field capability. From a power device perspective the high critical field strength can be used to design switching devices with much lower losses than conventional silicon based devices both for on-state losses and reduced switching losses. This paper will review the current state of the art in active switching device performance for both SiC and GaN devices. SiC material quality and epitaxy processes have greatly improved and degradation free 100 mm wafers are readily available. This is encouraging since also bipolar devices now are attractive with good long term stability. SiC wafers still have a too high cost to be fully cost effcient. However, the SiC wafer roadmap looks very favorable as volume production takes off. For GaN materials the main application area is geared towards the lower power rating level up to 1 kV on mostly lateral FET designs. The cost advantage is interesting for GaN when grown on Si substrates to bring down costs.

关键词： high power devices SiC GaN MOSFET JFET BJT IGBT Schottky on-state loss switch loss

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THE BLOCH SPACE ON THE UNIT BALL OF A HILBERT SPACE: MAXIMALITY AND MULTIPLIERS

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Acta Mathematica Scientia 2021年第3期41卷 899-906页

作者： Pablo GALINDO mikael LINDSTRÖM Departamento de Análisis Matemático Universidad de Valencia.C/Dr.Moliner 50.46.100BurjasotValenciaSpain Department of Mathematics Abo Akademi University.FI-20500ÅboFinland

We prove that, as in the finite dimensional case, the space of Bloch functions on the unit ball of a Hilbert space contains, under very mild conditions, any semi-Banach space of analytic functions invariant under automorphisms. The multipliers for such Bloch space are characterized and some of their spectral properties are described.

关键词： Analytic functions on Hilbert space invariance under automorphisms multiplier

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DIFFERENT TYPES OF MICROFIBRILLATED CELLULOSE AS FILLER MATERIALS IN POLYSODIUM ACRYLATE SUPERABSORBENTS

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Chinese Journal of Polymer Science 2011年第4期29卷 407-413页

作者： mikael Larsson Qi Zhou Anette Larssona Department of Chemical and Biological Engineering Chalmers University of Technology 41296 Gothenburg Sweden Wallenberg Wood Science Center Royal Institute of Technology SE-100 44 Stockholm Sweden School of Biotechnology Royal Institute of Technology SE-106 91 Stockholm Sweden

Three types of microfibrillated cellulose （MFC） with differences in structure and surface charge were used at low concentration as filler materials in polysodium acrylate superabsorbents （SAPs）. The swelling of the composite hydrogels was determined in 0.9% NaCl solution as well as in deionized water. The shear modulus of the samples was determined through uniaxial compression analysis after synthesis and after swelling in 0.9% NaC1 solution. Furthermore, the ability to retain filler effects after washing was investigated. The results showed that all of the investigated MFCs had a strong reinforcing effect on the shear modulus after synthesis. The filler effect on swelling and on the associated shear modulus of swollen samples showed a more complicated dependence on structure and surface charge. Finally, it was found that the filler effects were reasonably retained after washing and subsequent drying. The results confirm that MFC holds great potential as a filler material in superabsorbent applications. Furthermore, the results provide some insight on how the structural properties and surface charge of MFC will affect gel properties depending on swelling conditions. This information should be useful in evaluating the use of different types of MFC in future applications.

关键词： SAP MFC Microfibrillated cellulose Polyacrylic acid Hydrogels.

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Substance graphs are optimal simple-graph representations of metabolism

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Chinese Science Bulletin 2010年第27期55卷 3161-3168页

作者： HOLME Petter HUSS mikael Department of Physics Ume University Department of Energy Science Sungkyunkwan University Science for Life Laboratory Stockholm Box 1031 171 21 SolnaSweden Computational and Systems Biology Genome Institute of Singapore

One approach to study the system-wide organization of biochemistry is to use statistical graph *** such heavily simplified methods,which disregard most of the dynamic aspects of biochemistry,one is faced with fundamental *** such question is how the chemical reaction systems should be reduced to a graph retaining as much functional information as possible from the original reaction *** these graph representations,should the edges go between substrates and products,or substrates and substrates,or both?Should vertices represent substances or reactions?Different representations encode different information about the reaction system and affect network measures in different *** paper investigates which representation reflects the functional organization of the metabolic system in the best way,according to the defined *** different graph representations of metabolism(three where the vertices are metabolites,one where the vertices are reactions)are evaluated using data from different organisms and *** graph representations are evaluated by comparing the overlap between clusters(network modules)and annotated functions,and also by comparing the set of identified currency metabolites with those that other authors have identified using qualitative biological *** is found that a"substance network",where all metabolites participating in a reaction are connected,is better than others,evaluated with respect to both the functional overlap between modules and functions and to the number and identity of the identified currency metabolites.

关键词：图形表示代谢物物质生物数据库反应体系化学反应系统顶点表示代谢产物

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District heating system operation in power systems with high share of wind power

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Journal of Modern Power Systems and Clean Energy 2017年第6期5卷 850-862页

作者： Ilias DIMOULKAS mikael AMELIN Fabian LEVIHN School of Electrical Engineering Electric Power and Energy SystemsKTH Royal Institute of TechnologyStockholmSweden Fortum Va¨rme StockholmSweden School of Industrial Engineering and Management Industrial Economics and ManagementKTH Royal Institute of TechnologyStockholmSweden

The integration of continuously varying and not easily predictable wind power generation is affecting the stability of the power system and leads to increasing demand for balancing *** this study,a short-term operation model of a district heating system is proposed to optimally schedule the production of both heat and power in a system with high wind power *** application of the model in a case study system shows the increased flexibility offered by the coordination of power generation,consumption and heat storage units which are available in district heating systems.

关键词： District heating systems Combined heat and power(CHP) Flexible power system operation Heat storage

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