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Up-regulation of α-catenin is associated with increased lymph node involvement in colorectal cancer

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World Journal of Gastroenterology 2008年第31期14卷 4903-4908页

作者： Adam Elzagheid Abdelbaset Buhmeida Eija Korkeila Yrj Collan Kari Syrjnen Seppo Pyrhnen Department of Pathology University of Turku Kiinamyllynkatu 10 Turku FIN-20520 Finland Department of Pathology Faculty of Medicine Al-Arab Medical University Benghazi Libya Department of Oncology and Radiotherapy Turku University Hospital Savitehtaankatu 1 PB 52 Turku FIN-20521 Finland Department of Pathology University of Turku Kiinamyllynkatu 10 Turku FIN-20520 Finland

AIM: To investigate the changing pattern of α-catenin expression and its relationship to clinical and pathological features of colorectal cancer (CRC) patients. METHODS: Archival tumor samples were analyzed using immunohistochemistry (IHC) for α-catenin in 91 patients with advanced CRC. RESULTS: The values of α-catenin membrane index (MI) and cytoplasmic index (CI) were significantly related to the depth of tumor invasion (P = 0.027, P = 0.020, respectively), high indices being associated with increased depth of the primary tumor invasion (T3 and T4). Similarly, patients with high α-catenin expression had a signifi cantly increased risk of lymph node metastasis (32/39 vs 37/52 for MI and 37/45 vs 32/46 for CI) (P = 0.001, P = 0.0001, respectively, for LNN status). An altered expression (i.e., cytoplasmic pattern) was also related (P = 0.047) to the response to chemotherapy; patients with low CI were more responsive (CR: 7/46) than patients with high CI values (CR: 0/45). There was a marginal effect on survival in patients time with metastases (SWM) (P = 0.087); patients with low CI showing slightly longerSWM, but no such effect on disease free survival (DFS) or disease specifi c survival (DSS). As to co-expression with another member of the adhesion complex (β-catenin), high α-catenin/β-catenin MI index was of marginal signifi cance in predicting longer DSS (P = 0.063, log-rank). CONCLUSION: The results implicate that high α-catenin expression is intimately involved in the key regulatory mechanisms leading to invasive phenotype, lymph node metastases, and progressive disease in CRC.

关键词： Colorectal carcinoma Alpha-catenin Membrane staining Cytoplasmic staining Prognosis

“I Want to Feel That I Live in China”:Imaginaries and Hospitality in International Students’(mis-)Encounters at a Top Chinese University

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Frontiers of Education in China 2020年第4期15卷 588-620页

作者： Fred DERVIN Anu HÄRKÖnen Mei YUAN Ning CHEN Wan ZHANG Faculty of Educational Sciences University of HelsinkiHelsinki 00014Finland Turku University of Applied Sciences Faculty of Educational SciencesUniversity of HelsinkiHelsinki 00014Finland School of Education Minzu University of ChinaBeijing 100081China School of Experimental Art Tianjin Academy of Fine ArtsTianjin 300141China

Research on international students’experiences abroad has tended to rely on models of adjustment,integration and/or acculturation to describe their(mis-)encounters with different kinds of people(e.g.,co-nationals,locals and other international students).This paper proposes to use the more fluid concepts of imaginaries and hospitality,leaving behind stages and phases of adaption and acculturation,and focusing on the influence of the Structure on their *** on a discursive pragmatic analysis of interview data with 20 international students at a top Chinese university,the authors review how the students describe the kind of hospitality experienced at this institution and the influence that it has on their(mis-)***,differentialist and essentialist imaginaries(static and fixed views of Chineseness)are often used to justify the lack of encounters and the“segregation”and somewhat“positive discrimination”that they ***,the paper shows that,amongst others,the institutional hospitality management for international students leads to closed contexts of encounters and feelings of *** the study serves as a case study and cannot be generalized to the many and varied experiences of international students in other universities in China,some recommendations are made to solve,at least in part,misconceptions about what interculturality and hospitality entail in the internationalization of higher education.

关键词： study abroad imaginaries interculturality hospitality international students culturalism

Nuclear β-catenin expression as a prognostic factor in advanced colorectal carcinoma

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World Journal of Gastroenterology 2008年第24期14卷 3866-3871页

作者： Adam Elzagheid Abdelbaset Buhmeida Eija Korkeila Yrj Collan Kari Syrjnen Seppo Pyrhnen Department of Pathology Faculty of Medicine Al-Arab Medical University Department of Oncology and Radiotherapy Turku University Hospital Department of pathology University of Turku

AIM： To investigate the changing pattern of β-catenin expression and its prognostic value in advanced colorectal cancer （CRC）. METHODS： Archival tumor samples were analyzed for β-catenin using immunohistochemistry （IHC） in 95 patients with advanced CRC. RESULTS： Membranous β-catenin expression was found in the normal colorectal epithelium. Almost 100% of CRC cases showed membranous and cytoplasmic expression, and 55 （58%） cases showed nuclear expression. In univariate （Kaplan-Meier） survival analysis, only the nuclear index （NI） was a significant predictor of disease free survival （DFS）（P = 0.023; n = 35）, with a NI above the median associated with longer DFS （34.2 too） than those with a NI below the median （15.5 too）（P = 0.045, ANOVA）. The other indices were not significant predictors of DFS, and none of the three tested indices （for membranous, cytoplasmic, or nuclear expression） predicted diseasespecific survival （DSS）. However, when dichotomized as positive or negative nuclear expression, the former was a significant predictor of more favorable DFS （P = 0.041） and DSS （P = 0.046）. CONCLUSION： Nuclear β-catenin expression provides additional information in predicting patient outcome in advanced CRC.

关键词： Colorectal carcinoma β-catenin membranestaining Cytoplasmic staining, Nuclear staining Immunohistochemistry Prognosis Disease-freesurvival Disease-specific survival

Allocation of Mobile Chippers for a Concentrated Bioenergy Demand

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Open Journal of Forestry 2019年第4期9卷 283-295页

作者： mika Yoshida Institute of Wood Technology Akita Prefectural University Akita Japan

Allocation of mobile chippers is a tactical problem of management in a bioenergy supply chain. It influences the entire supply cost of the wood chip since the transportation distance and the chipping productivity decide the transportation cost. Great and concentrated demands of woody biomass require multiple suppliers, and there should be the best allocation of mobile chippers which minimize the entire supply cost. This study aims to clarify better management of the supply chain consisting of multiple players for a great and concentrated demand for wood chip. The model was a supply chain for a typical biomass power plant with 5.8 MW capacity. Suppliers were assumed to select mobile chippers from two sizes, 140-kW and 353-kW. By the model simulation, it was clarified that the well-considered allocation of two different mobile chippers could reduce the entire supply cost less than the conventional system using a fixed chipper at the power plant. The best management was to use only the 353-kW chippers, and secondly to allocate the less productive chippers closer to the demand to prevent the incline of the transportation cost. However, the possible conflict was also specified as the increased cost of the suppliers using more productive chippers in the second best allocation strategy. This result emphasizes the necessity of resolving such conflict by making the collaborative relationship among stakeholders which has been pointed out by other researches as well to sustain the better condition of the supply chain.

关键词： Chipper Allocation Chip Transportation Stakeholder’s Benefit Stakeholder Collaboration Supply Chain Management

Governing the Horn’s External Linkages: Agency, Domestic Politics and Local Power in the Horn of Africa - Gulf Relations

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Asian Journal of Middle Eastern and Islamic Studies 2023年第4期17卷 386-403页

作者： Aleksi Ylönen Centre for International Studies(CEI-Iscte) Iscte-Instituto Universitário de LisboaLisbonPortugal

The Horn of Africa and the Persian Gulf have millennial relations characterised by mutual interaction and ***,from the Cold War period onwards,international relations scholars focus-ing on strategic and security analysis have used a realist approach to depict these relations as largely one-way involvement and influ-ence from the Gulf to the Horn of ***,this approach por-trays the Horn of Africa as a Gulf and other middle and great powers’strategic chessboard and fails to account for the reality of political dynamics in the Horn of Africa and the agency of the local state and non-state actors in their external *** article argues that the realist approach’s depiction of foreign relations mainly as power struggles between unitary state actors is reduc-tionist and presents an inadequate framework for the analysis of the Horn of Africa’s complex external relationships involving various state and powerful societal(non-state)*** privileges struc-ture over agency disproportionally,requiring recalibration of the realist framework’s conceptualisation of the‘state’and‘power’.As a result,the article proposes that a more nuanced actor-based account which includes domestic political dynamics and locally prominent internationally active societal actors is necessary for a more realistic analysis of the Horn’s external relations.

关键词： Horn of Africa realism state power external relations state and societal actors

Synchrotron radiation investigations of the Sr_2MgSi_2O_7:Eu^(2+),R^(3+) persistent luminescence materials

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Journal of Rare Earths 2009年第4期27卷 529-538页

作者： Tuomas Aitasalo Jukka Hassinen Jorma Hls Taneli Laamanen mika Lastusaari Marja Malkamki Janne Niittykoski Pavel Novák Department of Chemistry University of Turku FI-20014 Turku Finland Turku University Centre for Materials and Surfaces (MatSurf) Turku Finland Graduate School of Materials Research (GSMR) Turku Finland Institute of Physics Academy of Sciences of the Czech Republic CZ-16253 Prague 6 Czech Republic

The electronic and defect energy level structure of polyerystalline Sr2MgSi2OT：Eu^2＋,R^3＋ persistent luminescence materials were studied with thermoluminescence and different synchrotron radiation spectroscopies （UV-VUV emission and excitation, X-ray absorption near-edge spectroscopy （XANES） and extended X-ray absorption f＇me structure （EXAFS））. Special attention was paid on the effect of the R3＋ co-dopants on the persistent luminescence properties of the materials. Theoretical calculations using the density functional theory （DFT） were carried out simultaneously with the experimental work. The experimental band gap energy （Eg） value of ca. 7.1 eV agreed very well with the DFT value of 6.7 eV. The variation of the Eg value was attempted to relate with the trap structure as well as with the different properties of the R3＋ co-dopants. The trap level energy distribution depended strongly on the R3＋ co-dopant except for the shallowest trap energy above the room temperature remaining practically the same, however. The different processes in the mechanism of persistent luminescence from Sr2MgSi2OT：Eu^2＋,R^3＋ were assembled and their contributions discussed.

关键词： strontium magnesium disilicate europium persistent luminescence synchrotron radiation thermoluminescence mechanism rare earths

制备条件对稀土掺杂TiO_2物理性质和光催化降解吡唑草胺性能的影响（英文）

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催化学报 2015年第10期36卷 1679-1685页

作者： Marcela Kralova Irina Levchuk Vit Kasparek mika Sillanpaa Jaroslav Cihlar 布尔诺理工大学中欧科技学院拉普兰塔理工大学绿色化学实验室

多相光催化是一种非常有效的降解各种水污染物的方法.本文以稀土(镝和镨)掺杂的TiO2为光催化剂,考察了制备条件对其物理性质和光催化性能的影响.采用溶胶-凝胶法和不同条件(反应温度450,550,650 oC;反应时间4,8,12 h)的固态反应法制备了... 详细信息

多相光催化是一种非常有效的降解各种水污染物的方法.本文以稀土(镝和镨)掺杂的TiO2为光催化剂,考察了制备条件对其物理性质和光催化性能的影响.采用溶胶-凝胶法和不同条件(反应温度450,550,650 oC;反应时间4,8,12 h)的固态反应法制备了TiO2样品.运用X射线衍射分析了该样品的晶相,发现只存在锐钛矿相,并得到Raman光谱的证实.同时采用扫描电镜观察了样品的结构和粒径;以BET法计算了其比表面积;运用紫外-可见光漫反射光谱测得了样品的带隙能量.通过测量紫外光照射下常用除草剂吡唑草胺的降解速率评价了样品的光催化活性,反应过程中吡唑草胺的浓度用高效液相色谱分析.结果表明,稀土掺杂使得TiO2吸收边红移,并提高了其光催化活性;制备时最优的固态反应条件为550 oC反应8 h.

关键词：稀土掺杂二氧化钛镝镨合成条件光催化降解吡唑草胺

Zinc-Based Metal-Organic Frameworks for High-Performance Supercapacitor Electrodes:Mechanism Underlying Pore Generation

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Energy & Environmental Materials 2023年第2期6卷 100-112页

作者： Shigeyuki Umezawa Takashi Douura Koji Yoshikawa Daisuke Tanaka Vlad Stolojan S.Ravi P.Silva mika Yoneda Kazuma Gotoh Yasuhiko Hayashi Seiwa Electric Mfg.Co.Ltd. Kyoto 610-0192Japan Graduate School of Natural Science and Technology Okayama UniversityOkayama 700-8350Japan School of Science and Technology Kwansei Gakuin UniversityHyogo 669-1337Japan JST PRESTO2-1 GakuenHyogo 669-1337Japan Advanced Technology Institute University of SurreyGuilfordSurreyGU27XHUK

Heat treatment of metal-organic frameworks(MOFs)has provided a wide variety of functional carbons coordinated with metal *** this study,two kinds of zinc-based MOF(ZMOF),C_(16)H_(10)O_(4)Zn(ZMOF1)and C_(8)H_(4)O_(4)Zn(ZMOF2),were ***1 and ZMOF2 were carbonized at 1000℃,forming CZMOF1 and CZMOF2,*** specific surface area(S_(BET))of CZMOF2 was~2700 m^(2)g^(−1),much higher than that of CZMOF1(~1300 m^(2)g^(−1)).A supercapacitor electrode based on CZMOF2 achieved specific capacitances of 360,278,and 221 F g^(−1)at 50,250,and 1000 mA g^(−1)in an aqueous electrolyte(H2SO_(4)),respectively,the highest values reported to date for ZMOF-derived electrodes under identical *** practical applicability of the CZMOF-based supercapacitor was verified in non-aqueous *** initial capacitance retention was 78%after 100000 charge/discharge cycles at 10 A g^(−1).Crucially,the high capacitance of CZMOF2 arises from pore generation during *** 1000℃,pore generation is dominated by the Zn/C ratio of ZMOFs,as carbon atoms reduce the zinc oxides formed during *** 1000℃,a high O/C ratio becomes essential for pore generation because the oxygen functional groups are *** findings will provide insightful information for other metal-based MOFderived multifunctional carbons.

关键词： metal-organic frameworks pore generation porous carbons supercapacitor zinc oxides

Diversity of bacterial lactase genes in intestinal contents of mice with antibiotics-induced diarrhea

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World Journal of Gastroenterology 2017年第42期23卷 7584-7593页

作者： Cheng-Xing Long Lu He Yan-Fang Guo Ya-Wei Liu nen-Qun Xiao Zhou-Jin Tan Department of Microbiology Hunan University of Chinese Medicine College of Mathematics and Finance Hunan University of HumanitiesScience and Technology Loudi 417000Hunan Province China

AIM To investigate the diversity of bacterial lactase genes in the intestinal contents of mice with antibiotics-induced *** Following 2 d of adaptive feeding, 12 specific pathogenfree Kunming mice were randomly divided into the control group and model group. The mouse model of antibiotics-induced diarrhea was established by gastric perfusion with mixed antibiotics(23.33 m L·kg^(-1)·d^(-1)) composed of gentamicin sulfate and cephradine capsules administered for 5 days, and the control group was treated with an equal amount of sterile water. Contents of the jejunum and ileum were then collected and metagenomic DNA was extracted, after which analysis of bacterial lactase genes using operational taxonomic units(OTUs) was carried outafter amplification and *** OTUs were 871 and 963 in the model group and control group, respectively, and 690 of these were identical. There were significant differences in Chao1 and ACE indices between the two groups(P nent analysis, principal coordination analysis and nonmetric multidimensional scaling analyses showed that OTUs distribution in the control group was relatively intensive, and differences among individuals were small, while in the model group, they were widely dispersed and more diversified. Bacterial lactase genes from the intestinal contents of the control group were related to Proteobacteria, Actinobacteria, Firmicutes and unclassified bacteria. Of these, Proteobacteria was the most abundant phylum. In contrast, the bacterial population was less diverse and abundant in the model group, as the abundance of Bradyrhizobium sp. BTAi1, Agrobacterium sp. H13-3, Acidovorax sp. KKS102, Azoarcus sp. KH32 C and Aeromonas caviae was lower than that in the control group. In addition, of the known species, the control group and model group had their own unique genera, *** Antibiotics reduce the diversity of bacterial lactase genes in the intestinal contents, decreas

关键词： Antibiotics-induced diarrhea Lactase genes Gene diversity Intestinal bacteria High-throughput sequencing