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Trace elements and rare earth elements in wet deposition of Lijiang,*** region,southeastern edge of the Tibetan Plateau

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Journal of Environmental Sciences 2017年第2期29卷 18-28页

作者： Junming Guo Shichang Kang Jie Huang mika Sillanpaa Hewen Niu Xuejun Sun Yuanqing He Shijing Wang Lekhendra Tripathee Key Laboratory of Tibetan Environment Changes and Land Surface Processes Institute of Tibetan Plateau ResearchChinese Academy of Sciences(CAS)Beijing 100101China State Key Laboratory of Cryospheric Sciences Cold and Arid Regions Environmental and Engineering of Research InstituteCASLanzhou 730000China CAS Center for Excellence in Tibetan Plateau Earth Sciences Beijing100101China Laboratory of Green Chemistry Lappeenranta Uniuersity of TechnologyMikkeli 50130Finland University of Chinese Academy of Sciences Beijing 100049China

In order to investigate the compositions and wet deposition fluxes of trace elements and rare earth elements（REEs） in the precipitation of the southeastern edge of the Tibetan Plateau, 38 precipitation samples were collected from March to August in 2012 in an urban site of Lijiang city in the Mt. Yulong region. The concentrations of most trace elements and REEs were higher during the non-monsoon season than during the monsoon season,indicating that the lower concentrations of trace elements and REEs observed during monsoon had been influenced by the dilution effect of increased precipitation. The concentrations of trace elements in the precipitation of Lijiang city were slightly higher than those observed in remote sites of the Tibetan Plateau but much lower than those observed in the metropolises of China, indicating that the atmospheric environment of Lijiang city was less influenced by anthropogenic emissions, and, as a consequence, the air quality was still relatively good. However, the results of enrichment factor and principal component analysis revealed that some anthropogenic activities（e.g., the increasing traffic emissions from the rapid development of tourism） were most likely important contributors to trace elements, while the regional/local crustal sources rather than anthropogenic activities were the predominant contributors to the REEs in the wet deposition of Lijiang city. Our study was relevant not only for assessing the current status of the atmospheric environment in the Mt. Yulong region, but also for specific management actions to be implemented for the control of atmospheric inputs and the health of the environment for the future.

关键词： Trace elements Rare earth elements Wet deposition Seasonal variation Lijiang city Tibetan Plateau

Promoter Region Analysis of STAMP1/STEAP2 Gene-Silencing of STAMP1/STEAP2 Gene Triggers P53 Upregulation

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CellBio 2023年第1期12卷 1-9页

作者： Ceren Gönen Department of Pharmacology Faculty of Pharmacy Ege University Izmir Türkiye

Prostate cancer is the most commonly diagnosed cancer and the second leading cause of cancer mortality in men in the Western World. In the initial stages, prostate cancer is dependent on androgens for growth which is the basis for androgen ablation therapy. The effects of androgens are mediated by the Androgen Receptor (AR). Therefore, studies focus on the identification of AR-regulated genes that are also highly expressed in the prostate. STAMP family genes STAMP1/STEAP2 and STAMP2/STEAP4 have only expressed in androgen receptor-positive cells, the role of AR in STAMP family gene expression is an important question. STEAP (Six Transmembrane Epithelial Antigen of Prostate) is the first characterized prostate of enriched six transmembrane gene, expressed in metastatic prostate cancer samples, it is tempting to speculate that STAMP/STEAP family genes may be involved in similar functions with a role for both the normal biology and pathophysiology of the prostate. Using siRNA technology in LNCaP cells expressing STAMP genes per se, an apoptosis panel including pro-apoptotic and/or apoptotic molecules was assayed by RT-PCR, By this research project, prostate-specific STAMP gene family and its regulatory effects on the p53- and caspase-related pathways were characterized.

关键词： LNCaP STAMP1/STEAP2 P53 RT-PCR

Responses Taken by Silencing of NFkappaB, STAMP1 and STAMP2 Genes and Expression of NFkB, Act-1, p53 and p73 at -/+ TNFalpha Induced LNCaP Cells

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Journal of Cancer Therapy 2022年第12期13卷 685-700页

作者： Ceren Gönen Department of Pharmacology Faculty of Pharmacy Ege University Izmir Türkiye

Prostate cancer is the most commonly diagnosed cancer and the second leading cause of cancer mortality in men in the Western World. The effects of androgens are mediated by the Androgen Receptor (AR). Therefore, studies focus on the identification of AR-regulated genes that are also highly expressed in the prostate. STAMP family genes STAMP1/STEAP2 and STAMP2/STEAP4 have only expressed in androgen receptor-positive cells, the role of AR in STAMP family gene expression is an important question. STEAP (Six Transmembrane Epithelial Antigens of Prostate) is the first characterized prostate enriched six transmembrane genes, expressed in metastatic prostate cancer samples, it is tempting to speculate that STAMP/STEAP family genes may be involved in similar functions with a role for both the normal biology and pathophysiology of the prostate. Using siRNA technology in LNCaP cells expressing STAMP genes per se, an apoptosis panel including pro-apoptotic and/or apoptotic molecules was assayed by RT-PCR. In this research project, the prostate-specific STAMP gene family and its regulatory effects on the nuclear factor kappa B and caspase-related pathways were characterized. Considering that the beta-actin response in the control group was high in the immunolabeling studies, an increase in the induction of Tumor Necrosis Factor (TNF) was detected in the signals received with the vital proteins NFkB and akt, which were silenced by siRNA, which means that STAMP genes potentiate vital proteins.

关键词： Promoter Analysis RNA/siRNA Regulation of Gene Expression

Vascular anomaly in the levator aponeurosis of neurofibromatosis type 1

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International Journal of Ophthalmology(English edition) 2017年第4期10卷 656-657页

作者： Satoru Kase Toshiya Shinohara mika Noda Susumu Ishida Manabu Kase Department of Ophthalmology Teine Keijinkai HospitalSapporo 006-0811 Japan Department of Ophthalmology Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo 060-8638 Japan Department of Surgical Pathology Teine Keijinkai HospitalSapporo 006-0811 Japan

Dear Editor,I am Satoru Kase,from the Department of Ophthalmology,Faculty of Medicine and Graduate School of Medicine,Hokkaido University,Sapporo City,Japan.I write to present a case of neurofibromatosis type 1（NF1）... 详细信息

关键词： Vascular anomaly in the levator aponeurosis of neurofibromatosis type 1 NF Figure type

Effects of alginate and laminaran on the microbiota and antioxidant properties of human faecal cultures

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Food Bioscience 2022年第3期47卷 1244-1251页

作者： Gayang Lee mika Harada Yuko Midorikawa Mahiro Yamamoto Ayaka Nakamura Hajime Takahashi Takashi Kuda Department of Food Science and Technology Tokyo University of Marine Science and Technology4-5-7 KonanMinato-kuTokyo108-8477Japan

Alginate and laminaran are water soluble dietary fibres in brown *** a previous study,pure cultures of Bacteroides xylanisolvens,Bacteroides uniformis,and Erysipelaclostridium ramosum increased antioxidant capacities in the broth with alginate and/or laminaran *** study was conducted to evaluate the presence of the alginate-and laminaran-responsive human gut indigenous bacteria(RIB)and their ***,human stool samples were cultured in media without(control),or with 1%(w/v)alginate or laminaran at 37℃ for 24 h under anaerobic *** showed that during incubation,the pH of the culture reduced with the *** production was clearly suppressed via laminaran supplementation in the faecal sample *** 16S rRNA(V4)gene amplicon sequencing confirmed that ***-,*** and ***-like bacteria were alginate-and/or laminaran-RIB in human gut,although their read numbers differed among ***,some butyrate-producers,such as Faecalibacterium and Roseburia,were also detected as the RIB in alginate and laminaran cultures,*** increased 1,1-diphenyl-2-picrylhydrazyl and superoxide anion radical-scavenging capacities and the Fe-reducing power of the culture ***,the fermented cultures increased the nitric oxide secretion in macrophage like RAW 264.7 cells *** results suggest that the interaction of alginate and laminaran with their RIB may have desirable effects on the host as next generation prebiotics when brown algae are ingested.

关键词： Alginate Laminaran Human gut microbiota Antioxidant capacity Faecal culture

Why Are Children Bored at School?

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新世纪智能 2018年第3期 35-36页

作者： mika

词数:345阅读难度:建议阅读时间:4分钟Well,it used to be *** used to be about fun and rest,but now we’re just running across the school to get to the fourth *** used to go home and see our families but now it’s being i... 详细信息

关键词： Why Are Children Bored at School

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Plants Work as Spies

新世纪智能 2018年第6期 35-36页

作者： mika

词数:420阅读难度:★★★★★建议阅读时间:7分钟Traditionally,most spying and intelligence gathering has been done by highly trained human *** the US military has a plan to enlist(征募)a smart network of plants to help it stay one step ahead of its *** flora won’t be sneaking into secret labs or engaging in close combats,but will be used to monitor the environment for

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The China Editor in BBC Quits Her Job

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新世纪智能 2018年第12期 34-35页

作者： mika

Staying moderately active benefits our brains

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新世纪智能 2019年第55期 34-35页

作者： mika 不详

Scientists studying Alzheimer's have found that staying moderately active can lead to healthier brain functions in those at risk of developing the disease,potentially giving us another clue how to beat the *** particular the research looked at glucose metabolism,the process that gives brain cells the right amount of fuel,and that also happens to break down with the onset of Alzheimer's.

关键词： metabolism Alzheimer moderately