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Predictive factors for the failure of endoscopic stent-instent self-expandable metallic stent placement to treat malignant hilar biliary obstruction

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World Journal of Gastroenterology 2017年第34期23卷 6273-6280页

作者： Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Ko Watanabe Jun Nakamura Hitomi Kikuchi Yuichi Waragai mika Takasumi Yuki Sato Takuto Hikichi Hiromasa Ohira Department of Gastroenterology Fukushima Medical UniversitySchool of Medicine Department of Endoscopy Fukushima Medical University Hospital

AIM To investigate the factors predictive of failure when placing a second biliary self-expandable metallic stents(SEMSs). METHODS This study evaluated 65 patients with an unresectable malignant hilar biliary obstruction who were examined in our hospital. Sixty-two of these patients were recruited to the study and divided into two groups: the success group, which consisted of patients in whom a stent-in-stent SEMS had been placed successfully, and the failure group, which consisted of patients in whom the stent-in-stent SEMS had not been placed successfully. We compared the characteristics of the patients, the stricture state of their biliary ducts, and the implemented endoscopic retrograde cholangiopancreatography(ERCP) procedures between the two *** The angle between the target biliary duct stricture and the first implanted SEMS was significantly larger in the failure group than in the success group. There were significantly fewer wire or dilation devices(ERCP catheter, dilator, or balloon catheter) passing the first SEMS cell in the failure group than in the success group. The cut-off value of the angle predicting stent-in-stent SEMS placement failure was 49.7 degrees according to the ROC curve(sensitivity 91.7%, specificity 61.2%). Furthermore, the angle was significantly smaller in patients with wire or dilation devices passing the first SEMS cell than in patients without wire or dilation devices passing the first SEMS cell. CONCLUSION A large angle was identified as a predictive factor for failure of stent-in-stent SEMS placement.

关键词： Endoscopic stent-in-stent self-expandable metallic stent placement Predictive factor Endoscopic retrograde cholangiopancreatography Malignant hilar biliary obstruction Self-expandable metallic stent

Unsedated transnasal small-caliber esophagogastroduoden oscopy in elderly and bedridden patients

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World Journal of Gastroenterology 2009年第44期15卷 5586-5591页

作者： mika Yuki Yuji Amano Yoshinori Komazawa Hiroyuki Fukuhara Toshihiro Shizuku Shun Yamamoto Yoshikazu Kinoshita Division of Internal Medicine Izumo-City General Medical Center613 Nadabunn-choIzumo-shi Shimane 693-0003Japan Division of Endoscopy Shimane University Hospital89-1 Enya-choIzumo-shiShimane 693-8501Japan Division of Internal Medicine Unnan Municipal General Hospital96-1 Iida-choUnnan-shiShimane 699-1221Japan Second Department of Internal Medicine Shimane UniversitySchool of Medicine89-1 Enya-choIzumo-shiShimane 693-8501Japan

AIM： To evaluate the safety of unsedated transnasal small-caliber esophagogastroduodenoscopy （EGD） for elderly and critically ill bedridden patients. METHODS： One prospective randomized comparative study and one crossover comparative study between transnasal small-caliber EGD and transoral conventional EGD was done （Study 1）. For the comparative study, we enrolled 240 elderly patients aged 〉 65 years old. For the crossover analysis, we enrolled 30 bedridden patients with percutaneous endoscopic gastrostomy （PEG）（Study 2）, We evaluated cardiopulmonary effects by measuring arterial oxygen saturation （SpO2） and calculating the rate-pressure product （RPP）（pulse rate x systolic blood pressure/100） at baseline, 2 and 5 min after endoscopic intubation in Study 1. To assess the risk for endoscopy-related aspiration pneumonia during EGD, we also measured blood leukocyte counts and serum C-reactive protein （CRP） levels before and 3 d after EGD in Study 2. RESULTS： In Study 1, we observed significant decreases in SpO2 during conventional transoral EGD, but not during transnasal small-caliber EGD （0.24% vs -0.24% after 2 min, and 0.18% vs -0.29% after 5 min, P = 0.034, P = 0.044）. Significant differences of the RPP were not found between conventional transoral and transnasal small-caliber EGD. In Study 2, crossover analysis showed statistically significant increases of the RPP at 2 min after intubation and the end of endoscopy （26.8 and 34.6 vs 3.1 and 15.2, P = 0.044, P = 0.046）, and decreases of SpO2 （-0.8% vs -0.1%, P = 0.042） during EGD with transoral conventional in comparison with transnasal small-caliber endoscopy. Thus, for bedridden patients with PEG feeding, who were examined in the supine position, transoral conventional EGD more severely suppressed cardiopulmonary function than transnasal small-caliber EGD. There were also significant increases in the markers of inflammation, blood leukocyte counts and serum CRP values, in bedridden patients after transoral co

关键词： Aged Aspiration pneumonia Gastrointestina endoscopy Critical illness

Relationship between Nonexercise Activity Thermogenesis and Calf Circumference in Older Women

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Open Journal of Therapy and Rehabilitation 2024年第3期12卷 213-223页

作者： Michio Wachi Takumi Jiroumaru mika Suzuki Shinichi Noguchi Ayako Satonaka Department of Physical Therapy Bukkyo University Kyoto City Japan Department of Physical Therapy Biwako Professional University of Rehabilitation Higashiomi City Japan Graduate School of Medicine Nagoya University Nagoya City Japan Faculty of Health and Medical Science Aichi Syukutoku University Nagakute City Japan

Purpose: Frailty is a state of declined vitality of the body and mind with age in which life functions are impaired. In addition, there is a difference in the susceptibility of older women to frailty compared with that of older men. Therefore, assessing and encouraging physical activity in older adults before they become frail is essential. We aimed to clarify the relationship between calf circumference and body composition and assess the potential association between calf circumference and physical activity indices in older women. Methods: This cross-sectional study included 18 healthy older adults (age 69.0 ± 5.7 years). The physical characteristics, calf circumference, body composition, calf muscle thickness, and physical activity questionnaire that included items on exercise-related activity thermogenesis (EAT) and nonexercise activity thermogenesis (NEAT) were assessed. The association between calf circumference and these additional measures was examined. Results: Positive and significant correlations were found between the calf circumference and body weight, body mass index (BMI), skeletal muscle mass, skeletal muscle mass index, calf muscle thickness, total questionnaire score, and NEAT score (r = 0.66 - 0.87). However, no significant correlations were observed between the calf circumference and EAT scores. Conclusion: Calf circumference in older women may reflect NEAT activity. Improving NEAT activity is an important health-promoting factor in older women.

关键词： Nonexercise Activity Thermogenesis Frailty Calf Circumference Older Women

Advances in the development of new biomarkers for Alzheimer’s disease

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Translational Neurodegeneration 2022年第1期11卷 601-624页

作者： Timofey O.Klyucherev Pawel Olszewski Alena A.Shalimova Vladimir N.Chubarev Vadim V.Tarasov Misty M.Attwood Stina Syvänen Helgi B.Schiöth Department of Neuroscience Functional PharmacologyUniversity of Upp-salaUppsalaSweden Department of Pharmacology Institute of PharmacyI.M.Sechenov First Moscow State Medical UniversityMoscowRussia Institute of Translational Medicine and Biotechnology I.M.Sechenov First Moscow State Medical UniversityMoscowRussia Department of Public Health and Caring Sciences Rudbeck LaboratoryUppsala UniversityUppsalaSweden.

Alzheimer’s disease(AD)is a complex,heterogeneous,progressive disease and is the most common type of neurodegenerative *** prevalence of AD is expected to increase as the population ages,placing an additional burden on national healthcare *** is a large need for new diagnostic tests that can detect AD at an early stage with high specificity at relatively low *** development of modern analytical diagnostic tools has made it possible to determine several biomarkers of AD with high specificity,including pathogenic proteins,markers of synaptic dysfunction,and markers of inflammation in the *** is a considerable potential in using microRNA(miRNA)as markers of AD,and diagnostic studies based on miRNA panels suggest that AD could potentially be determined with high accuracy for individual *** of the retina with improved methods of visualization of the fundus are also showing promising results for the potential diagnosis of the *** review focuses on the recent developments of blood,plasma,and ocular biomarkers for the diagnosis of AD.

关键词： Alzheimer’s disease Amyloid beta peptides Biomarkers Blood Cytokines Inflammation MicroRNA Ocular biomarkers

Low circulating levels of gastrin-17 in patients with Barrett's esophagus

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World Journal of Gastroenterology 2005年第38期11卷 5988-5992页

作者： Pentti Sipponen Matti Vauhkonen Timo Helske Ilpo Kriinen Matti Hrknen Division of Pathology Department Internal Medicine Department of Clinical Chemistry

AIM: To examine whether the fasting levels of serum gastrin-17 (G-17) are lower in Barrett's esophagus (BE)patients than in non-Barrett ***: Nineteen patients with BE (presenting with a tubular segment ≥2 cm long in lower esophagus and intestinal metaplasia of incomplete type ('specialized columnar epithelium') in endoscopic biopsies from the tubular segment below the squamocolumnar junction were collected prospectively from outpatients referred to diagnostic gastroscopy. The controls comprised 199 prospectively collected dyspeptic outpatients without BE or any endoscopically visible lesions in the upper GI *** levels of serum G-17 (G-17fast) were assayed with an EIA test using a Mab highly specific to amidated G-17. None of the patients and controls received therapy with PPIs or other antisecretory ***: The mean and median levels of G-17fast in serum were significantly lower (P = 0.001) in BE patients than in controls. The positive likelihood ratios (LR+) of low G-17fast to predict BE in the whole study population at G-17fast levels ＜0.5, ＜1, or ＜1.5 pmol/L were 3.5, 3.0,and 2.8, respectively. Among patients and controls with healthy stomach mucosa, the LR+ were 5.6, 3.8, and 2.6,respectively. In the whole study population, serum G-17 was below 2 pmol/L in 15 of 19 BE patients (79%). The corresponding prevalence was 66 of 199 (33%) in controls (P＜0.001). The G-17fast was 5 pmol/L or more in only one of the 19 BE patients (5%). In controls, 76 of the 199 patients (38%) had such high serum G-17fast levels (P＜0.01).CONCLUSION: Serum levels of G-17fast tend to be lower in native patients with BE than in healthy controls.

关键词： Gastrin-17 Barrett's esophagus Chronic gastritis Atrophic gastritis Diagnostics

On-treatment predictions of success in peg-interferon/ribavirin treatment using a novel formula

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World Journal of Gastroenterology 2010年第1期16卷 89-97页

作者： Hidetsugu Saito Hirotoshi Ebinuma Keisuke Ojiro Kanji Wakabayashi mika Inoue Shinichiro Tada Toshifumi Hibi Department of Internal Medicine School of MedicineKeio University

AIM:To predict treatment success using only simple clinical data from peg-interferon plus ribavirin therapy for chronic hepatitis C. METHODS:We analyzed the clinical data of 176 patients with chronic hepatitis and hepatitis C virus genotype 1 who received 48 wk standard therapy, derived a predictive formula to assess a sustained virological response of the individual patient using a logistic regression model and confirmed the validity of this *** formula was constructed using data from the first 100 patients enrolled and validated using data from the remaining 76 patients. RESULTS:Sustained virological response was obtained in 83(47.2%)of the patients and we derived formulae to predict sustained virological response at pretreatment and weeks 4,12 and *** likelihood of sustained virological response could be predicted effectively bythe formulae at weeks 4,12 and 24(the area under the curve of the receiver operating characteristic:0.821, 0.802,and 0.891,respectively),but not at baseline (0.570).The formula at week 48 was also constructed and validation by test data achieved good prediction with 0.871 of the area under the curve of the receiver operating *** by this formula was always superior to that by viral kinetics. CONCLUSION:These results suggested that our formula combined with viral kinetics provides a clear direction of therapy for each patient and enables the best tailored treatment.

关键词： Logistic regression analysis Predictive formula Prolongation of the therapy Response-guided therapy Viral kinetics

Industrial minerals and rocks, aggregates and natural stones in the Nordic countries

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Episodes 2008年第1期31卷 133-139页

作者： Kurt Johansson Rune B. Larsen Markku J. Lehtinen Lars Persson mika Raeisaenen Stig A. Schack Pedersen Paer Weihed Nils-Gunnar Wik Swedish Stone Industries Federation Industrigatan 6 SE-291 36 Kristianstad Sweden. NTNU NO-7491 Trondheim. Norway. Nordkalk Oyj Abp Poikkitie 1 FI-53500 Lappeenranta Finland. Geological Survey of Sweden SE-751 87 Uppsala Sweden. Geological Survey of Finland PO Box 96 FI-02151 Espoo Finland. Geological Survey of Denmark and Greenland Ф. Voldgade 10 DK-1350 Cph. Denmark. Division of Ore Geology and Applied Geophysics Lulea University of Technology SE-971 87 Lulea Sweden. Geological Survey of Sweden SE-223 50 Lund Sweden.

The Nordic countries, including Greenland, have a long tradition in mining. The industrial minerals sector is expanding in most Nordic countries and extensive development has taken place during the last few years. The main commodities mined are carbonate rocks, quartz, feldspar, apatite, olivine and talc. A number of diferent types of dimension stones are quarried in all countries. Rock aggregates are increasingly important, replacing sand and gravel aggregate as construction materials in some countries due to the need to protect ground water supplies.

关键词：工业矿产岩石集合体天然石材北欧地区

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运转平稳行星减速器的模块系统

工程设计学报 2005年第6期12卷 379-380,383页

作者： Martin mika 毛谦德刘耀乙 Zeitlauf(时代)责任有限公司北京理工大学机械与车辆工程学院 100081 北京理工大学科学技术学院 100081

在2004年汉诺威博览会上,时代(Ze itlau f)公司首次展出了具有实际意义的行星减速器结构系列“Perfor-m ax”.该系列由于高运转平稳性、高功率密度和高寿命,在市场上脱颖而出.结构系列一直是按照模块系统建造的,从而明显地减少了必需的... 详细信息

在2004年汉诺威博览会上,时代(Ze itlau f)公司首次展出了具有实际意义的行星减速器结构系列“Perfor-m ax”.该系列由于高运转平稳性、高功率密度和高寿命,在市场上脱颖而出.结构系列一直是按照模块系统建造的,从而明显地减少了必需的组件数和加工步骤.

关键词：运转平稳性行星减速器模块系统汉诺威博览会高功率密度实际意义系统建造高寿命结构组件

Involvement of mitochondrial swelling in cytochrome c release from mitochondria treated with calcium and Alloxan

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Journal of Biophysical Chemistry 2011年第1期2卷 10-18页

作者： Takuya Ichimura mika Ito Kiyoshi Takahashi Kyohei Oyama Koichi Sakurai 不详

An early event in the induction of apoptosis is cytochrome c (Cyt c) release from mitochondria. We investigated the involvement of mitochonrial permeability transition (MPT) and mitochondrial swelling in Cyt c release from mitochondria treated with alloxan and/or calcium (Ca2+). When mitochondria were treated with a high concentration of Ca2+. alone or Ca2+. with alloxan (alloxan-Ca2+), the MPT was accompanied by mitochondrial swelling and the release of Cyt c. Cyclosporin A prevented the induction of MPT but only slightly decreased the release of Cyt c. High molecular weight polyethylene glycol almost completely inhibited MPT-dependent osmotic mitochondrial swelling and Cyt c release. However, MPT-independent mitochondrial swelling and Cyt c release induced by exogenous K+. were inhibited by the high molecular weight polyethylene glycol. Ruthenium red strongly decreased the amount of Cyt c released. These results suggest that mitochondrial swelling but not MPT is necessary for Cyt c release induced by Ca2+ alone or alloxan and Ca2+.

关键词： Mitochondrial Swelling Cytochrome C Release Calcium Alloxan Mitochondrial Permeability Transition