检索结果-南通市图书馆

Toremifene in the treatment of breast cancer

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2014年第3期5卷 393-405页

作者： mika VJ Mustonen Seppo Pyrh?nen Pirkko-Liisa Kellokumpu-Lehtinen Orion Corporation Orion PharmaFIN-02101EspooFinland Department of Oncology and Radiotherapy Turku University Hospital and University of TurkuFIN-20520TurkuFinland Department of Oncology University of TampereSchool of MedicineTampere University HospitalFIN-33520TampereFinland

Although more widespread screening and routine adjuvant therapy has improved the outcome for breast cancer patients in recent years, there remains considerable scope for improving the efficacy, safety and tolerability of adjuvant therapy in the early stage disease and the treatment of advanced disease. Toremifene is a selective estrogen receptor modifier(SERM) that has been widely used for decades in hormone receptor positive breast cancer both in early and late stage disease. Its efficacy has been well established in nine prospective randomized phase Ⅲ trials compared to tamoxifen involving more than 5500 patients, as well as in several large uncontrolled and non-randomized studies. Although most studies show therapeutic equivalence between the two SERMs, some show an advantage for toremifene. Several meta-analyses have also confirmed that the efficacy of toremifene is at least as good as that of tamoxifen. In terms of safety and tolerability toremifene is broadly similar to tamoxifen although there is some evidence that toremifene is less likely to cause uterine neoplasms, serious vascular events andit has a more positive effect on serum lipids than does tamoxifen. Toremifene is therefore effective and safe in the treatment of breast cancer. It provides not only a useful therapeutic alternative to tamoxifen, but may bring specific benefits.

关键词： Breast cancer Toremifene tamoxifen Adjuvant treatment Advanced breast cancer

CFD simulations of gas-solid flow in an industrial-scale circulating fluidized bed furnace using subgrid-scale drag models

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2015年第1期13卷 66-75页

作者： Srujal Shah Kari My?h?nen Sirpa Kallio Timo Hypp?nen Department of Energy Technology Lappeenranta University of Technology VTT Technical Research Centre of Finland

Mesoscale flow structures such as clusters and streamers of particles are characteristic features of gas-solid flow in fluidized beds. Numerical simulations of gas-solid flows for industrial-scale fluidized beds are often performed using the Eulerian description of phases. An accurate prediction of this type of flow structure using the Eulerian modeling approach requires a sufficiently fine mesh resolution. Because of the long computational time required when using fine meshes, simulations of industrial-sized units are usually conducted using coarse meshes, which cannot resolve the mesoscale flow structures. This leads to an overestimation of the gas-solid drag force and a false prediction of the flow field. For these cases, a cor- rection must be formulated for the gas-solid drag. We have simulated a large-scale circulating fluidized bed furnace using different gas-solid drag models and compared the model results with measurements.

关键词： Circulating fluidized bed Computational fluid dynamics Two-fluid model Drag correlation Modeling

Synthesis of malachite@clay nanocomposite for rapid scavenging of cationic and anionic dyes from synthetic wastewater

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2017年第1期29卷 97-110页

作者： Varsha Srivastava mika Sillanpää Laboratory of Green Chemistry School of Engineering ScienceLappeenranta University of TechnologySammonkatu 12FI 50130MikkeliFinland

Synthesis of malachite@clay nanocomposite was successfully carried out for the removal of cationic（Methylene Blue,MB） and anionic dyes（Congo Red,CR） from synthetic *** was characterized by TEM,SEM,FT-IR,EDS analysis and zeta *** analysis indicated that the particle diameter of nanocomposite was in the range of 14 to23 *** important parameters *** time,concentration of dyes,nanocomposite dosage,temperature and solution pH were optimized to achieve maximum adsorption *** the case of MB,removal decreased from 99.82%to 93.67%while for CR,removal decreased from 88.55%to 75.69%on increasing dye concentration from 100 to 450 mg/*** study confirmed the higher removal of CR in acidic range while MB removal was higher in alkaline *** study revealed the applicability of pseudo-second-order model for the adsorption of both *** values of AG0 for both systems suggested the feasibility of dye removal and support for spontaneous adsorption of CR and MB on *** showed 277.77 and 238.09 mg/g Langmuir adsorption capacity for MB and CR *** of dyes from the dye loaded nanocomposite was easily carried out with *** results indicate that the prepared malachite@clay nanocomposite is an efficient adsorbent with high adsorption capacity for the aforementioned dyes.

关键词： Adsorption Bentonite Dyes Kinetic study Methylene blue Congo red

Recent progress of CERN 39-cryogenic tracking detectors collaboration

在线全文

学校读者我要写书评

暂无评论

中国有色金属学会会刊：英文版 2006年第B01期16卷 137-140页

作者： J.Hrknen Helsinki Institute of Physics CERN /EPCH-1211 GenevaSwitzerland

Significant progress was made by the CERN RD39 collaboration in the development of super radiation-hard cryogenic silicon detectors for applications in experiments at LHC, in particular after its future luminosity upgrade. The detailed modeling shows that the electric field in irradiated silicon detectors can easily be manipulated by the filling state of two deep defect levels at cryogenic temperature. Advanced radiation hard detectors using charge or current injection and the current injected detectors(CID) were developed by RD39. The results show that CID detectors can be operated at the temperature of 100?200 K with much improved charge collection efficiency(CCE) as compared with RT operation. Future studies are developing ultra-hard cryogenic silicon detectors for the LHC upgrade, where the radiation hardness is required up to 1016 neq/cm2, at which trapping will limit the charge collection depth to the range of 20 to 50 μm regardless of the depletion depth. The key of our approach is to use freeze-out trapping to affect CCE.

关键词：欧洲原子能研究机构 CERN39协作组低温跟踪俘获粒子探测器研究进展

Challenges and opportunities in the production of magnesium parts by directed energy deposition processes

在线全文

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2024年第5期12卷 1663-1686页

作者： Gürel Cam Ali Günen Iskenderun Technical University Faculty of Engineering and Natural SciencesDepartment of Mechanical Engineering31200 Iskenderun-HatayTurkey Iskenderun Technical University Faculty of Engineering and Natural SciencesDepartment of Metallurgy and Materials Engineering31200 Iskenderun-HatayTurkey

Mg-alloys have gained considerable attention in recent years for their outstanding properties such as lightweight,high specific strength,and corrosion resistance,making them attractive for applications in medical,aerospace,automotive,and other transport ***,their widespread application is hindered by their low formability at room temperature due to limited slip *** Mg-alloys have low mechanical properties due to the presence of casting defects such as porosity and anisotropy in addition to the high *** casting methods benefit from established process optimization techniques for these problems,additive manufacturing methods are increasingly replacing casting methods in Mg alloys as they provide more precise control over the microstructure and allow specific grain orientations,potentially enabling easier optimization of anisotropy properties in certain *** metal additive manufacturing(MAM)technology also results in some manufacturing defects such as inhomogeneous microstructural evolution and porosity and additively manufactured Mg alloy parts exhibit lower properties than the wrought parts,they in general exhibit superior properties than the cast ***,MAM is a promising technique to produce Mg alloy *** energy deposition processes,particularly wire arc directed energy deposition(WA-DED),have emerged as an advantageous additive manufacturing(AM)technique for metallic materials including magnesium alloys,offering advantages such as high deposition rates,improved material efficiency,and reduced production costs compared to subtractive ***,the inherent challenges associated with magnesium,such as its high reactivity and susceptibility to oxidation,pose unique hurdles in the application of this *** review paper delves into the progress made in the application of DED technology to Mg-alloys,its challenges,and ***,the predominant imperfections,notably inhomo

关键词： Additive manufacturing DED processes Arc-DED Wire arc additive manufacturing(WAAM) 3-D printing High deposition rate

The role of GI-supported methods in crisis management

在线全文

学校读者我要写书评

暂无评论

International Journal of Digital Earth 2010年第4期3卷 340-354页

作者： Hannes Seppänen Kirsi Virrantaus Department of Surveying Aalto University School of Science and TechnologyP.O.Box 11200Aalto 00076Finland

Crisis and disaster management has become an important research field in GIS during recent *** assessment and situation picture-related work are particularly important areas of *** are distinct phases in different crises;these can be roughly divided into mitigation,preparedness,response,and *** this paper a general classification of methods in each phase is given with examples on recent or ongoing research *** framework is based on literature and experiences from crisis and disaster-related *** case studies are based on those *** goal is to clarify the role and usability of various GI-supported methods in the crisis management process by outlining a theoretical framework and presenting examples of the developed *** increasing amount of spatially related geographic information is a huge potential to the GI analysis and modeling methods;the concept of digital earth is the underlying mainstream that gives lots of promise to the research and development work in this field.

关键词： geo-spatial science geoinformatics GIS digital earth crisis management

On the Function of Wall Sculpturing in Xylem Conduits

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2009年第4期6卷 324-329页

作者： mika M.Kohonen se Helland Department of Physical Sciences University of HullCottingham RoadHU6 7RX UK

The water-conducting network of capillaries in vascular plants has evolved over hundreds of millions of years in order to be able to cope with bubble clogging,a problem which also affects modern microfluidic *** of anatomical studies have revealed that plants growing in habitats in which the formation of bubbles,or emboli,is likely to be a frequent occurrence often have various forms of geometrical sculpturing on the internal surfaces of the xylem *** possible function of such wall sculpturing has long been the subject of *** have investigated the hypothesis that wall sculpturing is a functional adaptation designed to increase the wettability of the walls of xylem conduits,an effect which could be described as the inverse of the well-known *** results show that wall sculpturing does enhance ***,theoretical calculations reveal that the geometric parameters of various types of wall sculpturing are such that the resulting surfaces are sufficiently rough to enhance wettability,but not significantly *** results provide an appealing answer to the long-standing debate on the function of wall sculpturing in xylem conduits,and may provide biomimetic clues for new approaches to the removal of bubbles in microfluidic channels.

关键词： xylem wettability capillary wall sculpturing bubble emboli microfluidic

Personal Information Self-Management:A Survey of Technologies Supporting Administrative Services

在线全文

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 2021年第3期36卷 664-692页

作者： Paul Marillonnet Maryline Laurent mikaël Ates Entr'ouvert Paris 75014France SAMOVAR Télécom SudParisInstitut Polytechnique de ParisEvry 91000France

This paper presents a survey of technologies for personal data self-management interfacing with administrative and territorial public service *** classifies a selection of scientific technologies into four categories of solutions:Personal Data Store(PDS),Identity Manager(IdM),Anonymous Certificate System and Access Control Delegation *** category,along with its technological approach,is analyzed thanks to 18 identified functional criteria that encompass architectural and communication aspects,as well as user data lifecycle *** originality of the survey is ***,as far as we know,there is no such thorough survey covering such a panel of a dozen of existing ***,it is the first survey addressing Personally Identifiable Information(PII)management for both administrative and private service ***,this paper achieves a functional comparison of solutions of very different technical *** outcome of this paper is the clear identification of functional gaps of each *** a result,this paper establishes the research directions to follow in order to fill these functional gaps.

关键词： personal information management privacy enforcement user-centric solution technological survey

Lignin Biosynthesis Studies in Plant Tissue Cultures

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2010年第2期52卷 176-185页

作者： Anna Krknen Sanna Koutaniemi Department of Applied Biology 00014 University of HelsinkiFinland MTT Agrifood Research Finland 92400 RuukkiFinland Department of Applied Chemistry and Microbiology 00014 University of HelsinkiFinland

Lignin, a phenolic polymer abundant in cell walls of certain cell types, has given challenges to scientists studying its structure or biosynthesis. In plants lignified tissues are distributed between other, non-lignified tissues, Characterization of native lignin in the cell wall has been difficult due to the highly cross-linked nature of the wall components. Model systems, like plant tissue cultures with tracheary element differentiation or extracellular lignin formation, have provided useful information related to lignin structure and several aspects of lignin formation. For example, many enzyme activities in the phenylpropanoid pathway have been first identified in tissue cultures. This review focuses on studies where the use of plant tissue cultures has been advantageous in structural and biosynthesis studies of lignin, and discusses the validity of tissue cultures as models for lignin biosynthesis.

关键词： cell Lignin Biosynthesis Studies in Plant Tissue Cultures