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Postrecurrence Clinical Outcome of Patients with Stage I Epithelial Ovarian Cancer Who Underwent Fertility-Sparing Surgery Compared to Those with Radical Surgery

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Surgical Science 2013年第1期4卷 118-124页

作者： Hiroaki Kajiyama Kiyosumi shibata mika Mizuno Eiko Yamamoto Michiyasu Kawai Tetsuro Nagasaka Fumitaka Kikkawa Department of Medical Laboratory Sciences School of Health Science Nagoya University Graduate School of Medicine Nagoya Japan Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine Nagoya Japan Department of Obstetrics and Gynecology Toyohashi Municipal Hospital Toyohashi Japan

Background: To examine the difference in the survival of patients with recurrent ovarian cancer who received fertility-sparing surgery (FSS) and those receiving radical surgery. Methods: Clinicopathologic data on a total of 90 patients with stage I recurrent ovarian cancer collected under the central pathological review system were subjected to survival analyses. Patients were divided into 2 groups: 1) FSS (N = 11), 2) Radical (N = 79). Results: Five-year overall survival rates of patients in the two groups were as follows: 40.8% (FSS)/44.2% (Radical), respectively. There was no significant difference in overall survival among the groups (P = 0.887). Additionally, three-year postrecurrence survival rates of patients in the two groups were 24.8% (FSS) and 25.3% (Radical) (P = 0.730). Furthermore, we accumulated 137 patients {FSS (N = 58), Radical group (N = 79)} with stage I recurrent ovarian cancer from the current study and six representative reports in the literature. Patients who experienced recurrence in the remaining ovary alone (FSS) showed a more favorable prognosis than those who had extra-ovarian site recurrence (overall survival: P = 0.021, postrecurrence survival: P = 0.069). Conclusions: Although our retrospective analysis was very preliminary, we could propose the hypothesis that patients with stage I recurrent ovarian cancer who undergo FSS may not show poorer survival rates than patients who receive radical surgery.

关键词： Recurrent Ovarian Cancer Fertility-Sparing Surgery Overall Survival Postrecurrence Survival

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Interplay between epidermal stem cell dynamics and dermal deformation

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npj Computational Materials 2018年第1期4卷 280-288页

作者： Yasuaki Kobayashi Yusuke Yasugahira Hiroyuki Kitahata mika Watanabe Ken Natsuga Masaharu Nagayama Center for Simulation Sciences Ochanomizu UniversityTokyo 112-8620Japan Graduate School of Science Hokkaido UniversitySapporo 060-0810Japan Department of Physics Chiba UniversityChiba 263-8502Japan Department of Dermatology Graduate School of MedicineHokkaido UniversitySapporo 060-8638Japan Research Institute for Electronic Science Hokkaido UniversitySapporo 060-0812Japan

Tissue growth is a driving force of morphological changes in living *** the buckling instability is known to play a crutial role for initiating spatial pattern formations in such growing systems,little is known about the rationale for succeeding morphological changes beyond this *** mammalian skin,the dermis has many protrusions toward the epidermis,and the epidermal stem cells are typically found on the tips of these *** the initial instability may well be explained by the buckling involving the dermis and the basal layer,which contains proliferative cells,it does not dictate the direction of these protrusions,nor the spatial patterning of epidermal stem *** we introduce a particle-based model of self-replicating cells on a deformable substrate composed of the dermis and the basement membrane,and investigate the relationship between dermal deformation and epidermal stem cell pattering on *** show that our model reproduces the formation of dermal protrusions directing from the dermis to the epidermis,and preferential epidermal stem cell distributions on the tips of the dermal protrusions,which the basic buckling mechanism fails to *** argue that cell-type-dependent adhesion strengths of the cells to the basement membrane are crucial factors influencing these patterns.

关键词： buckling rational initiating

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A comparison of the pre-calling period between Japanese and southeastern Asian populations of Spodoptera litura

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Insect Science 2006年第3期13卷 211-216页

作者： mika MURATA HIROYUKI MATSUKI RYOHEI YAMAOKA SUMIO TOJO Food Entomology Laboratory National Food Research Institute Independent Administrative Institution Tsukuba Ibaraki Venture Laboratory Faculty of Agriculture SagaUniversity Saga Japan Faculty of Textile Science Kyoto Institute of Technology Kyoto

The pre-calling behavior of female adults of the common cutworm, Spodoptera litura （Lepidoptera： Noctuidae） collected in southern Japan and southeastern Asian countries was investigated. Most females started calling on days 1-4 after adult emergence. In three populations obtained in Saga prefecture in Kyushu mainland, Japan, two different patterns of pre-calling period （PCP） were observed： one was the above-mentioned pattern shown by most individuals, and the other was a pattern in which females sexually matured within several hours after emergence. Diel periodicity was shown in the time of calling activity, and its pattern varied among the populations. Pre-calling period was stable over successive generations in the laboratory.

关键词： geographical variation long distance migration pre-calling period Spodoptera litura

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Excessive ammonia inhibited transcription of MsU2 gene and furthermore affected accumulation distribution of allantoin and amino acids in alfalfa Medicago sativa

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Journal of Integrative Agriculture 2015年第7期14卷 1269-1282页

作者： WANG Li JIANG Lin-lin Nomura mika Tajima Shigeyuki CHENG Xian-guo College of Life Science Shanxi Normal University Key Laboratory of Plant Nutrition and Fertilizers Agriculture of Ministry/Insititute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural Sciences Faculty of Agriculture Kagawa University 2393 Ikenobe Miki-choKita-gun Kagawa 761-0795 Japan

In legume plants, uricase gene （Nodulin-35） plays a positive role in metabolism of ureide and amide compounds in symbiotic nitrogen-fixing in the nodules. In this study, a pot experiment was performed to examine the effects of ammonium application on the transcription of MsU2 gene and distribution of major nitrogen compounds in alfalfa Medicago sativa. Data showed that alfalfa plant has a significant difference in contents of nitrogen compounds in xylem saps compared with soybean plant, and belongs to typical amide type legume plants with little ureide accumulation, and the accumulation of asparagines and ureide in the tissues of alfalfa is mainly gathered in the nodules. Northern blotting showed that excessive ammonium significantly inhibited the transcription of MsU2 gene in the nodules and roots, and mRNA accumulation of MsU2 gene in the plants exposed to excessive ammonium decreased gradually with culture time extension, indicating that application of ammonium significantly inhibited the transcription of MsU2 gene in the alfalfa plants. Although the application of exces- sive ammonium increased the contents of amino acids in various tissues of alfalfa, the accumulation of allantoin reflecting the strength of uricase activity is remarkably reduced in the xylem saps, stems and nodules when alfalfa plants exposed to excessive ammonium, suggesting that application of excessive ammonium generated a negative effect on symbiosis fixing-nitrogen system due to inhibition of ammonium ion on uricase activity in the nodules of alfalfa. This result seems to imply that application of excessive ammonium in legume plants should not be proposed to avoid affecting the ability of fixing nitrogen in the nodules of legume plants, and reasonable dose of ammonium should be recommended to effectively utilize the fixed N from atmosphere in legume plant production.

关键词： alfalfa amino acids ammonium MsU2 gene allantoin

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Export of dissolved carbonaceous and nitrogenous substances in rivers of the “Water Tower of Asia”

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Journal of Environmental Sciences 2018年第3期30卷 53-61页

作者： Bin Qu mika Sillanpaa Shichang Kang Fangping Yan Zhiguo Li Hongbo Zhang Chaoliu Li Laboratory of Green Chemistry Lappeenranta University of Technology Mikkeli 50130 Finland Key Laboratory of Tibetan Enuironment Changes and Land Surface Processes Institute of Tibetan Plateau Research Chinese Academy of Sciences Beijing 100101 China State Key Laboratory of Cryospheric Sciences Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou Gansu 730000 China Shangqiu Normal University Shangqiu He'nan 476000 China CAS Center for Excellence in Tibetan Plateau Earth Sciences Chinese Academy of Sciences Beijing 100085 China

Rivers are critical links in the carbon and nitrogen cycle in aquatic,terrestrial,and atmospheric *** riverine carbon and nitrogen exports in nine large rivers on the Tibetan Plateau—the＂Water Tower of Asia＂—were investigated in the monsoon season from 2013 to *** with the world average,concentrations of dissolved inorganic carbon（DIC,30.7 mg/L）were high in river basins of the plateau due to extensive topographic relief and intensive water *** concentrations of dissolved organic carbon（DOC,1.16 mg/L）were likely due to the low temperature and unproductive land vegetation *** concentrations of riverine DIN（0.32 mg/L）and DON（0.35 mg/L）on the Tibetan Plateau were close to the world ***,despite its predominantly pristine environment,discharge from agricultural activities and urban areas of the plateau has raised riverine N *** addition,DOC/DON ratio（C/N,~6.5）in rivers of the Tibetan Plateau was much lower than the global average,indicating that dissolved organic carbon in the rivers of this region might be more ***,along with global warming and anthropogenic activities,increasing export of bioavailable riverine carbon and nitrogen from rivers of the Tibetan Plateau can be expected in the future,which will possibly influence the regional carbon and nitrogen cycle.

关键词： Dissolved carbon Dissolved nitrogen Rivers The Tibetan Plateau

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Causes, effects and control of seasonal frost action in railways

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Research in Cold and Arid Regions 2013年第4期5卷 363-367页

作者： Antti Nurmikolu mika Silvast Railway Track Structures Tampere University of TechnologyTampere Finland Professor Railway Division Roadscanners OyTampere Finland Director

Seasonally cold climate and resulting frost action set great demands to railway track substructure in order to maintain Irack geomelry. Chal- lenges culminate on high-speed lines, where the tolerances for roughness are the tightest. Problems may result in highly increased Irack maintenance and need for temporary speed reslrictions. The causes of frost action can be associated with subsoil, subballast or ballast. The major concern in frost protection is to avoid the freezing of frost susceptible subsoil by using sufficient thickness of subballast and relying on non-fi＇ost-susctible subballast material. This paper provides an overview of the main research findings on the role of ballast, subballast and subsoil in frost acedon. In new comlruclion the material specificalions, design procedures and construction methods have been developed to ensure adequate performance of Irack subscatt, but special challenges exist in managing existing Wacks that were not designed for modem requirements. In order to perform cost-effective and sustainable track maintenance, it is necessary to recognize the problem areas and define the root-causes of problems. For locating the problem sections and defining the causes of defects, a sophisticated analysis based on integration of track geometry and ground penetrating radar （GPR） data has been developed and is summarized in this paper,

关键词： frost action railway Irack ballast subballast subsoil frost susceptibility ground peneWating radar, track geometry Irackmaintenance

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A rice mutant displaying a heterochronically elongated internode carries a 100 kb deletion

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Journal of Genetics and Genomics 2011年第3期38卷 123-128页

作者： mika Hayashi-Tsugane Masahiko Maekawa Qian Qian Hirokazu Kobayashi Shigeru Iida Kazuo Tsugane National Institute for Basic Biology Okazaki 444-8585 Japan Graduate School of Nutritional and Environmental Sciences University of Shizuoka Shizuoka 422-8526 Japan Institute of Plant Science and Resources Okayama University Kurashiki 710-0046 Japan Global Center of Excellence Program University of Shizuoka Shizuoka 422-8526 Japan Graduate School of Pharmaceutical Sciences University of Shizuoka Shizuoka 422-8526 Japan The Graduate University for Advanced Studies (Sokendai) Okazaki 444-8585 Japan

We have isolated a recessive rice mutant, designated as indeterminate growth （ing）, which displays creeping and apparent heterochronic phenotypes in the vegetative period with lanky and winding culms. Rough mapping and subsequent molecular characterization revealed that the ing mutant carries a large deletion, which corresponds to a 103 kb region in the Nipponbare genome, containing nine annotated genes on chromosome 3. Of these annotated genes, the SLR1 gene encoding a DELLA protein is the only one that is well characterized in its function, and its null mutation, which is caused by a single base deletion in the middle of the intronless SLR1 gene, confers a slender phenotype that bears close resemblance to the ing mutant phenotype. The primary cause of the ing mutant phenotype is the deletion of the SLR1 gene, and the ing mutant appears to be the first characterized mutant having the entire SLR1 sequence deleted. Our results also suggest that the deleted region of 103 kb does not contain an indispensable gene, whose dysfunction must result in a lethal phenotype.

关键词： Heterochronic Elongated intemode Large deletion Map-based cloning Rice genome

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Biliary metal stents should be placed near the hilar duct in distal malignant biliary stricture patients

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World Journal of Gastroenterology 2022年第17期28卷 1860-1870页

作者： Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Yoshinori Okubo Jun Nakamura mika Takasumi Minami Hashimoto Tsunetaka Kato Ryoichiro Kobashi Takumi Yanagita Takuto Hikichi Hiromasa Ohira Department of Gastroenterology Fukushima Medical UniversityFukushima 9601295Japan Department of Endoscopy Fukushima Medical University HospitalFukushima 9601295Japan

BACKGROUND Endoscopic biliary drainage using a self-expandable metallic stent(SEMS)has been widely performed to treat distal malignant biliary obstruction(DMBO).However,the optimal position of the stent remains *** To determine the ideal position for SEMS *** In total,135 DMBO patients underwent SEMS(uncovered or covered)placement over a ten-year period.A total of 127 patients with biliary obstruction between the junction of the cystic duct and Vater’s papilla were *** SEMS was placed through the upper common bile duct 2 cm from the biliary hilar duct in 83 patients(Hilar group)or near the top of the biliary obstruction in 44 patients(Lower group).Technical and functional success,adverse events,and risk factors for SEMS dysfunction were *** The stent patency period was significantly longer in the Hilar group than in the Lower group(P value<0.01).In multivariate analysis,the only statistically significant risk factor for SEMS dysfunction was being in the Lower group(hazard ratio:9.94,95%confidence interval:2.25–44.0,P<0.01).CONCLUSION A longer patency period was achieved by positioning the SEMS near the biliary hilar duct.

关键词： Endoscopic biliary drainage Malignant biliary obstruction Uncovered self-expandable metallic stent Covered self-expandable metallic stent Biliary hilar duct Patency period

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Synthesis of novel adsorbent by intercalation of biopolymer in LDH for the removal of arsenic from synthetic and natural water

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Journal of Environmental Sciences 2020年第5期32卷 246-261页

作者： Hanen Bessaies Sidra Iftekhar Bhairavi Doshi Jamel Kheriji Mohamed Chaker Ncibi Varsha Srivastava mika Sillanpaa Bechir Hamrouni Laboratory of Desalination and Water Treatement LR19ES01 Faculty of Sciences of TunisTunis El Manar University2092El Manar ITunisia Department of Separation Science Lappeenranta-Lahti University of Technology(LUT)Sammonfeatu 12FI-50130MikkeliFinland International Water Research Institute MohammedⅥPolytechnic UniversityCity Ben Guerir 43150Morocco Department of Civil and Environmental Engineering Florida International UniversityMiamiFL 33174USA Department of Environmental Engineering University of Engineering and TechnologyTaxilaPakistan

This study focuses on the synthesis of nanocomposites named CCA and CZA that were prepared by the incorporation of cellulose(CL)in the Ca/Al and Zn/Al layered double hydroxide(LDH),*** materials were then used for the uptake of As(Ⅲ)and As(V)from aqueous *** of both nanocomposites(CCA and CZA)was done using FTIR and Raman analysis to identify the functional groups,N2 adsorption-desorption isotherms to determine the specific surface area and pore geometry and XPS analysis to obtain the surface atomic *** other characters were investigated using simultaneous TGA and DTA and elemental chemical analysis(CHNS/O).The crystallinity of the prepared nanocomposites was displayed by XRD ***,the sheet-like structure of the LDHs and the irregularity of surface morphology with porous structure were observed by TEM and SEM *** of maximum adsorption capacity was adjusted using different parameters including pH,contact time and adsorbent *** pseudo-second-order model was in good fitting with kinetics *** adsorption isotherm results showed that CZA exhibits better adsorption capacity for As(Ⅲ)than CCA and the Langmuir isotherm model described the data well for both *** studies illustrated the endothermic nature of CCA and exothermic nature on CZA,as well as the fact that the adsorption process is spontaneous.A real water sample collected from well located in Gabes(Tunisia),has also been *** obtained experimental results were confirmed that these sorbents are efficient for the treatment of hazardous toxic species such as.

关键词： Layered double hydroxide Adsorption Arsenic removal Kinetics Natural water treatment

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Unsedated transnasal small-caliber esophagogastroduoden oscopy in elderly and bedridden patients

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World Journal of Gastroenterology 2009年第44期15卷 5586-5591页

作者： mika Yuki Yuji Amano Yoshinori Komazawa Hiroyuki Fukuhara Toshihiro Shizuku Shun Yamamoto Yoshikazu Kinoshita Division of Internal Medicine Izumo-City General Medical Center613 Nadabunn-choIzumo-shi Shimane 693-0003Japan Division of Endoscopy Shimane University Hospital89-1 Enya-choIzumo-shiShimane 693-8501Japan Division of Internal Medicine Unnan Municipal General Hospital96-1 Iida-choUnnan-shiShimane 699-1221Japan Second Department of Internal Medicine Shimane UniversitySchool of Medicine89-1 Enya-choIzumo-shiShimane 693-8501Japan

AIM:To evaluate the safety of unsedated transnasal small-caliber esophagogastroduodenoscopy(EGD)for elderly and critically ill bedridden patients. METHODS:One prospective randomized comparative study and one crossover comparative study between transnasal small-caliber EGD and transoral conventional EGD was done(Study 1).For the comparative study, we enrolled 240 elderly patients aged>65 years old. For the crossover analysis,we enrolled 30 bedridden patients with percutaneous endoscopic gastrostomy (PEG)(Study 2).We evaluated cardiopulmonary effects by measuring arterial oxygen saturation(SpO2)and calculating the rate-pressure product(RPP)(pulse rate×systolic blood pressure/100)at baseline,2 and 5 min after endoscopic intubation in Study *** assess the risk for endoscopy-related aspiration pneumoniaduring EGD,we also measured blood leukocyte counts and serum C-reactive protein(CRP)levels before and 3 d after EGD in Study 2. RESULTS:In Study 1,we observed significant decreases in SpO2 during conventional transoral EGD, but not during transnasal small-caliber EGD(0.24%vs -0.24%after 2 min,and 0.18%vs-0.29%after 5 min, P=0.034,P=0.044).Significant differences of the RPP were not found between conventional transoral and transnasal small-caliber *** Study 2,crossover analysis showed statistically significant increases of the RPP at 2 min after intubation and the end of endoscopy (26.8 and 34.6 vs 3.1 and 15.2,P=0.044,P=0.046), and decreases of SpO2(-0.8%vs-0.1%,P=0.042) during EGD with transoral conventional in comparison with transnasal small-caliber ***,for bedridden patients with PEG feeding,who were examined in the supine position,transoral conventional EGD more severely suppressed cardiopulmonary function than transnasal small-caliber *** were also significant increases in the markers of inflammation, blood leukocyte counts and serum CRP values,in bedridden patients after transoral conventional EGD,but not after transnasal small-caliber EGD perfo

关键词：胃造口术胃疾病 PEG 治疗患者

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