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Clinical Characteristics of Respiratory Tract-Associated Streptococcus pyogenes at General Japanese Hospital in 2014

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Journal of Biosciences and Medicines 2015年第12期3卷 26-31页

作者： Masaaki Minami Ryoko Sakakibara Taichi Imura mika Watanabe Hideo Morita Naoto Kanemaki Michio Ohta Department of Bacteriology Graduate School of Medical Sciences Nagoya City University Nagoya Japan Department of Clinical Investigation Daido Hospital Nagoya Japan Department of Gastroenterology Daido Hospital Nagoya Japan School of Nursing Sugiyama Jyogakuen University Nagoya Japan

Streptococcus pyogenesis most popularpathogen caused respiratory tract infection disease. This study was conducted to find out the recent clinical characteristics of Streptococcus pyogenes isolates from respiratory tract at Japanese hospital in 2014. Streptococcus pyogenes was identified by standard laboratory procedure. Antimicrobial susceptibility testing was performed by micro dilution assay according to CLSI recommendation. Respiratory tract isolates were defined as isolation from pharynx, nasal discharge, tonsillar, and sputum. Total one hundred sixty-one Streptococcus pyogenes were isolated among which 136 were from respiratory tract and 25 were from non- respiratory tract. Respiratory tract-associated Streptococcus pyogenes was isolated among which 102 were from male and 59 were from female. The age incidence among 0 - 1 years age group was 8, among 1 - 18 years age group, 131 (p < 0.01), among 19 - 64 years age group, 17 (p < 0.01), and in 65-years it was 5. Although we investigated the relationship between season and bacterial isolation, we did not find any significant differences between respiratory tract and no respiratory tract isolation. However, our study revealed that clarithromycin was less antimicrobial effective in respiratory tract disease than in no respiratory tract disease significantly (p < 0.01). Although several antibiotics such as penicillin are still effective against Streptococcus pyogenes, incidence of Streptococcus pyogenes infection is not decreasing worldwide. Our study suggests the need for continuous epidemiological surveillance of Streptococcus pyogenes.

关键词： Streptococcus pyogenes Susceptibility Antimicrobial Resistance Epidemiology Clarithromycin

Dysbiosis of the duodenal microbiota as a diagnostic marker for pancreaticobiliary cancer

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 2088-2100页

作者： Mitsuru Sugimoto Kazumichi Abe Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Ko Watanabe Jun Nakamura Hitomi Kikuchi mika Takasumi Minami Hashimoto Tsunetaka Kato Ryoichiro Kobashi Takuto Hikichi Hiromasa Ohira Department of Gastroenterology Fukushima Medical University School of MedicineFukushima 960-1295Japan Department of Endoscopy Fukushima Medical University HospitalFukushima 960-1295Japan

BACKGROUND Pancreaticobiliary cancer(PB Ca)is a lethal disease,and a useful diagnostic marker is urgently needed.A correlation between the human microbiota and malignant gastrointestinal diseases was recently *** To investigate the efficacy of the duodenal microbiota for diagnosing PB *** We recruited 22 patients with benign pancreaticobiliary diseases(benign group)and 12 patients with PB Ca(malignant group).The duodenal microbiota of each patient was analyzed by the 16S rDNA terminal restriction fragment length polymorphism *** characteristics,tumor markers,and relative abundances of the duodenal microbiota were compared between the benign and malignant *** Cancer antigen 19-9(CA19-9),Bifidobacterium,Clostridium cluster XVIII,and Prevotella levels differed significantly between the benign and malignant *** cluster XVIII had the greatest area under the receiver operating characteristic curve(AUC)among the four factors with respect to diagnosing PB Ca(cutoff value:3.038%;sensitivity:58.3%;specificity:95.2%;AUC:0.81).The combination of Clostridium cluster XVIII(cutoff value:3.038%)and CA19-9 Levels(cutoff value:18.8 U/mL)showed 91.7%sensitivity and 71.4%specificity for diagnosing PB *** The duodenal microbiota may be useful for PB Ca screening.

关键词： Pancreaticobiliary cancer Diagnostic marker Duodenal microbiota Clostridium cluster XVIII Cancer antigen 19-9

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图书馆的新意义

建筑实践 2013年第6期 8-15页

作者：翁玫 mika Huisman

提到图书馆的设计,很多人的关注点还停留在图书馆的传统功能性上,但随着社会变迁和新的交流模式的发展,图书馆的作用正在转变,因为信息很容易通过互联网和其它电子媒介获得,图书馆不用再扮演寻找信息的主要角色,而图书馆作为人与人交流... 详细信息

提到图书馆的设计,很多人的关注点还停留在图书馆的传统功能性上,但随着社会变迁和新的交流模式的发展,图书馆的作用正在转变,因为信息很容易通过互联网和其它电子媒介获得,图书馆不用再扮演寻找信息的主要角色,而图书馆作为人与人交流信息的场所的意义将会被突出,这就要求设计师改变图书馆的活动空间内容。更重要的是,鼓励使用者主动的,而不是被动的接受信息和服务。换句话说,图书馆已经成为一个多功能的,灵活的且适应性强的公共空间,而一个

关键词：图书馆建筑物阿尔托市政中心

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Meilahti医院/新入口大厅

建筑技艺 2013年第6期19卷 86-97页

作者： Jussi Tiainen mika Huisman Lahdelma&Mahlamaki建筑师事务所

两个合伙人丨Imari Lahdelma和Rainer Mahlam自ki从1986年就开始一起工作,同时都进行建筑学教学工作。事务所在建筑的各方面都有着丰富的经验,尤其在公共建筑方面,从小规模的博物馆、学校和图书馆,到非常庞大的展览中心和大学建筑。亊... 详细信息

两个合伙人丨Imari Lahdelma和Rainer Mahlam自ki从1986年就开始一起工作,同时都进行建筑学教学工作。事务所在建筑的各方面都有着丰富的经验,尤其在公共建筑方面,从小规模的博物馆、学校和图书馆,到非常庞大的展览中心和大学建筑。亊务所的工作从建筑竞赛幵始,这也是工作的一个重要组成部分。目前亊务所已经获得了35个竞赛一等奖和57个其他奖项。

关键词：入口大厅重要组成部分公共建筑图书馆建筑设备公司建筑师事务所建筑学教学工作博物馆合伙人

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水稻不透明突变体Wx基因在特定组织中的不同表达

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国外作物育种 1999年第3期18卷 15-18页

作者： mika.,I

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阿莫斯·瑞克斯美术馆

城市环境设计 2023年第5期 140-153页

作者： mika Huisman Tuomas Uusheimo JKMM

阿莫斯·瑞克斯美术馆坐落在芬兰赫尔辛基市中心,正对着建于20世纪20年代的新古典主义风格的国会大厦,斜对面是斯蒂芬·霍尔(Steven Holl)设计的芬兰当代艺术博物馆(Kiasma)。20世纪30年代建造的玻璃宫(Lasipalatsi)是进入美术馆的入口...

阿莫斯·瑞克斯美术馆坐落在芬兰赫尔辛基市中心,正对着建于20世纪20年代的新古典主义风格的国会大厦,斜对面是斯蒂芬·霍尔(Steven Holl)设计的芬兰当代艺术博物馆(Kiasma)。20世纪30年代建造的玻璃宫(Lasipalatsi)是进入美术馆的入口之一,它是芬兰重要的功能主义建筑,由餐厅、商店、拜奥·瑞克斯电影院(Bio Rex)和后面的开放广场组成。包含玻璃宫在内,美术馆总共有1.3万m2,设计非常大胆地将所有新建部分都放到地下,包含有一个6230m2的展览空间。受所在区域的历史敏感性影响——基地周边有一座建于19世纪的新古典主义兵营,它是历史保护建筑,

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Pancreatic neuroendocrine tumor Grade 1 patients followed up without surgery:Case series

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World Journal of Clinical Oncology 2017年第3期8卷 293-299页

作者： Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Ko Watanabe Jun Nakamura Hitomi Kikuchi Yuichi Waragai mika Takasumi Satoshi Kawana Yuko Hashimoto Takuto Hikichi Hiromasa Ohira Department of Gastroenterology Fukushima Medical UniversitySchool of Medicine Department of Endoscopy Fukushima Medical University Hospital Department of Diagnostic Pathology Fukushima Medical UniversitySchool of Medicine

Among the three grades of neuroendocrine tumors(NETs),the prognosis for Grade 1(G1) with surgery is very ***,we evaluated the prognoses of pancreatic NET(PNET) G1 patients without surgery.A total of 8 patients who were diagnosed with NET G1,with an observation period of more than 6 mo until surgery or without surgery,were *** patients who underwent surgery were ultimately diagnosed using specimens obtained during the surgery,whereas the patients who did not undergo surgery were diagnosed using specimens obtained by endoscopic ultrasonography-guided fine needle ***,we mainly evaluated the observation period and tumor *** observation period for the five cases with surgery ranged from 6-80 mo,and tumor growth was observed in one *** contrast,the observation period for the three cases without surgery ranged from 17-54 mo,and tumor growth was not ***,although the first-choice treatment for NETs is surgery,our experience includes certain NET G1 patients who were followed up without surgery.

关键词： Pancreatic neuroendocrine tumors Metastasis Neuroendocrine tumors Grade 1 Follow-up Surgery

Involvement of miR-214 and miR-375 in Malignant Features of Non-Small-Cell Lung Cancer by Down-Regulating CADM1

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Journal of Cancer Therapy 2012年第4期3卷 379-387页

作者： Megumi Ishimura mika Sakurai-Yageta Tomoko Maruyama Tomoko Ando Masashi Fukayama Akiteru Goto Yoshinori Murakami Department of Pathology Graduate School of Medicine The University of Tokyo Tokyo Japan Division of Molecular Pathology The University of Tokyo Tokyo Japan Laboratory of Pathology Institute of Medical Science The University of Tokyo Tokyo Japan

A tumor suppressor gene, CADM1, encoding an immunoglobulin superfamily cell adhesion molecule, is inactivated in various cancers, including non-small-cell lung cancer (NSCLC). Although promoter methylation is one of the mechanisms to suppress CADM1 expression, about half of tumors lacking CADM1 expression do not show methylation of the gene promoter. We herein investigated the possible involvement of microRNA (miRNA) in the down-regulation of CADM1. Using computational algorithms, miR-214 and miR-375 were identified as candidate miRNAs targeting CADM1. A luciferase reporter assay demonstrated that miR-214 and miR-375 repressed the promoter activity through 3’-UTR of CADM1. Quantitative RT-PCR analysis demonstrated that miR-214 and miR-375 was highly expressed in 21 (62%) and 17 cases (50%) of 34 primary NSCLCs. Notably, increased expression of miR-214 was preferentially observed in tumors with advanced pathological stages and in those lacking CADM1 expression but were not associated with the promoter methylation, suggesting that miR-214-mediated silencing would be another mechanism to suppress CADM1 expression. On the other hand, introduction of miR-214 or miR-375 into NSCLC cells decreased CADM1 protein expression. Furthermore, overexpression of miR-214 enhanced anchorage-independent growth of NSCLC cells, A549, whereas transfection of miRNA inhibitor, miR-214 or miR-375, significantly suppressed the in vitro wound healing activity of HCC827 cells. These findings suggest that overexpression of miR-214 and miR-375 could participate in the malignant features of NSCLC through down-regulating CADM1 and would provide a potential target for the treatment of a subset of NSCLC.

关键词： CADM1 miR-214 miR-375 Non-Small-Cell Lung Cancer

The liver-to-spleen ratio is a risk factor predicting oxygen demand in COVID-19 patients

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Infectious Medicine

Infectious Medicine 2023年第2期2卷 105-111页

作者： Hiromasa Nakayasu Shogo Sakurai Shuichi Sugiyama Kotaro Shiratori Kohei Okawa Yoshihiro Kitahara Shingo Takahashi Toshihiro Masuda Yutaro Kishimoto mika Saigusa Akito Yamamoto Taisuke Akamatsu Satoru Morita Kazuhiro Asada Toshihiro Shirai Department of Respiratory Medicine Shizuoka General Hospital4-27-1 Kita-AndoAoi420-0805 ShizuokaJapan

Background:We aimed to investigate risk factors predicting oxygen demand in COVID-19 ***:Patients admitted to Shizuoka General Hospital with COVID-19 from August 2020 to August 2021 were ***,we divided patients into groups with and without oxygen ***,we compared patients’clinical characteristics and laboratory and radiological findings to determine factors predicting oxygen ***:One hundred seventy patients with COVID-19(aged 58±15 years,57 females)were *** comorbidities were cardiovascular diseases(47.6%),diabetes mellitus(28.8%),and dyslipidemia(26.5%).Elder age,higher body mass index,cardiovascular diseases,diabetes mellitus,lower lymphocyte count,albumin,hep-atic attenuation value,and the liver-to-spleen ratio(L/S),higher D-dimer,aspartate aminotransferase,lactate dehydrogenase,troponin-T,C-reactive protein,KL-6,chest and abdominal circumference,and visceral fat were found in patients with oxygen *** to the multivariate logistic regression analysis,L/S,lympho-cyte count,D-dimer,and abdominal circumference under the diaphragm were independent risk factors predicting oxygen demand in COVID-19 ***:On admission,L/S,lymphocyte count,D-dimer,and abdominal circumference were predictive factors for oxygen *** factors may help in the appropriate triage of COVID-19 patients in the decision to admit them to the hospital.

关键词： COVID-19 SARS-CoV-2 Oxygen demand The liver-to-spleen ratio Abdominal circumference