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Surgical Science 2012年第10期3卷 463-468页

作者： Kiyosumi Shibata Hiroaki Kajiyama mik mizuno Eiko Yamamoto Fumitaka Kikkawa Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine Nagoya Japan

Objective: To identify prognostic factors in patients with locally advanced cervical cancer treated with concurrent chemoradiotherapy (CCRT). Methods and Materials: We analyzed 76 patients with FIGO stage IB2 - IVb cervical cancer treated with CCRT between 2001 and 2006 at the Nagoya University Hospital. Patients with an advanced cervical cancer treated with CCRT. Overall survival (OS) and Progression-free survival (PFS) rates were estimated using the Kaplan-Meier method. The log-rank test was used to test differences in survival. Fisher's exact test was employed for univariate analysis. The Cox proportional hazard model was used for multivariate analysis. Results: The median age was 52, and the median follow-up period was 36 months. The 5 - year OS and PFS rates of all patients were 88.2% and 72.4%, respectively. Twenty-one of the 76 patients were diagnosed with recurrence. A higher serum CEA before CCRT was an independent predictive factor for a poor prognosis on multivariate analysis. Conclusions: A high level of serum CEA was a predictive factor for a poor prognosis. New strategies should be considered to control disease in this group of patients.

关键词： Cervical Cancer Chemoradiotherapy Recurrence Prognostic Factor Carcinoembryonic Angtigen (CEA)

Initial Error Growth and Predictability of Chaotic Low-dimensional Atmospheric Model

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International Journal of Automation and computing 2014年第3期11卷 256-264页

作者： Hynek Bednár Ale Raidl Jiri mikovsk Department of Meteorology and Environment Protection Faculty of Mathematics and Physics Charles University in Prague

The growth of small errors in weather prediction is exponential on average. As an error becomes larger, its growth slows down and then stops with the magnitude of the error saturating at about the average distance between two states chosen *** paper studies the error growth in a low-dimensional atmospheric model before, during and after the initial exponential divergence occurs. We test cubic, quartic and logarithmic hypotheses by ensemble prediction method. Furthermore, the quadratic hypothesis suggested by Lorenz in 1969 is compared with the ensemble prediction method. The study shows that a small error growth is best modeled by the quadratic hypothesis. After the error exceeds about a half of the average value of variables, logarithmic approximation becomes superior. It is also shown that the time length of the exponential growth in the model data is a function of the size of small initial error and the largest Lyapunov exponent. We conclude that the size of the error at the least upper bound(supremum) of time length is equal to 1 and it is invariant to these variables. Predictability, as a time interval, where the model error is growing, is for small initial error, the sum of the least upper bound of time interval of exponential growth and predictability for the size of initial error equal to 1.

关键词： Chaos planetary atmospheres prediction methods error analysis modeling.

Ecosystem services and legal protection of private *** or solution?

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Geography and Sustainability 2020年第3期1卷 173-180页

作者： Katažyna mikša Marius Kalinauskas Miguel Inácio Eduardo Gomes Paulo Pereira Environmental Management Laboratory Mykolas Romeris UniversityVilnius LT-08303Lithuania Institute of International and European Union Law Mykolas Romeris UniversityVilnius LT-08303Lithuania

Ecosystem services(ES)delivery in quantity and quality are essential to improve human ***,often a considerable part of ES provisioning depends on the use of private land(e.g.,flood retention,carbon sequestration,water purification).In this context,the operationalization and implementation of ES concept may collide with legal property ***,it is essential to find constructive mechanisms to engage and encour-age private owners to implement sustainable land uses to reduce the onsite and offsite impacts of their *** paper aims to identify if ES delivery can be constrained by legal private land and how it can be *** is undeniable that land-use changes(e.g.,urbanization,agriculture intensification,and land abandonment)affect the territory’s capacity to deliver ES in quality and *** changes,especially land abandonment,are in-creasing the tradeoffs among ES(e.g.,between carbon sequestration and water yield).Land-use planning should consider these ***,incorporating ES into spatial plans is crucial for stakeholders to understand the impacts of land-use change in the loss of ES *** information can be transmitted through maps that communicate the message in a simplified *** owners can easily perceive the ES relevance that their land can provide if an understandable message is *** this can be a good solution,conflicts can appear even with the implementation of schemes such as Payment for ES(PES).PES is not always effective and can im-pose losses to farmers,disregard their cultural traditions,or not prevent poverty *** this context,it is crucial to consider local specificities to safeguard PES’s success,create a“win-win”and transform a problem into a *** owners’active participation in implementing sustainable practices or a determined land-use in their properties is vital to achieving global targets such as sustainable development goals.

关键词： Ecosystem services Law Private land Sustainability Land-use change

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AMD新一代SIMD指令集剖析

微型计算机 2011年第21期31卷 119-124页

作者： mik

对处理器来说指令集是赋予硬件活力的催化剂，就像灵魂之于肉体。因此．AMD与Intel在指令集研发的斗争上从来没有停息过，只是随着AMD的推土机微架构逐渐浮出水面．x86领域的SIMD（Single Instruction Multiple Data单指令多数据流）指... 详细信息

对处理器来说指令集是赋予硬件活力的催化剂，就像灵魂之于肉体。因此．AMD与Intel在指令集研发的斗争上从来没有停息过，只是随着AMD的推土机微架构逐渐浮出水面．x86领域的SIMD（Single Instruction Multiple Data单指令多数据流）指令之争将暂时告一段落。据现有消息来看推土机架构的指令集规格比Sandy Bridge乃至后续的Ivy Bridge都要完整。这不禁让人好奇，以XOP、FMA4等为代表的AMD新一代指令集到底有何特点和优势．能有如此的前瞻性。

关键词：指令集 AMD SIMD Multiple Bridge 单指令多数据流 Intel 微架构

Intralesional steroid is beneficial in benign refractory esophageal strictures:A meta-analysis

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World Journal of Gastroenterology 2018年第21期24卷 2311-2319页

作者： László Szapáry Benedek Tinusz Nelli Farkas Katalin Márta Lajos Szakó Agnes Meczker Roland Hágendorn Judit Bajor Aron Vincze Zoltan Gyongyi Alexandra mikó Dezso Csupor Péter Hegyi Balint Eross Institute for Translational Medicine Medical SchoolUniversity of PécsPécs 7624Hungary Institute of Bioanalysis Medical SchoolUniversity of PécsPécs 7624Hungary Department of Gastroenterology First Department of MedicineMedical SchoolUniversity of PécsPécs 7624Hungary Department of Public Health Medicine Medical SchoolUniversity of PécsPécs 7624Hungary Department of Pharmacognosy Faculty of PharmacyUniversity of SzegedSzeged 6720Hungary

AIM To analyze the effect of intralesional steroid injections in addition to endoscopic dilation of benign refractory esophageal *** A comprehensive search was performed in three databases from inception to 10 April 2017 to identify trials, comparing the efficacy of endoscopic dilation to dilation combined with intralesional steroid injections. Following the data extraction, meta-analytical calculations were performed on measures of outcome by the randomeffects method of Der Simonian and Laird. Heterogeneity of the studies was tested by Cochrane's Q and I^2 statistics. Risk of quality and bias was assessed by the Newcastle Ottawa Scale and JADAD assessment *** Eleven articles were identified suitable for analyses, involving 343 patients, 235 cases and 229 controls in total. Four studies used crossover design with 121 subjects enrolled. The periodic dilation index(PDI) was comparable in 4 studies, where the pooled result showed a significant improvement of PDI in the steroid group(MD:-1.12 dilation/month, 95% CI:-1.99 to -0.25 P = 0.012; I^2 = 74.4%). The total number of repeat dilations(TNRD) was comparable in 5 studies and showed a non-significant decrease(MD:-1.17, 95%CI:-0.24-0.05, P = 0.057; I^2 = 0), while the dysphagia score(DS) was comparable in 5 studies and did not improve(SMD: 0.35, 95%CI:-0.38, 1.08, P = 0.351; I^2 = 83.98%) after intralesional steroid *** Intralesional steroid injection increases the time between endoscopic dilations of benign refractory esophageal strictures. However, its potential role needs further research.

关键词： Intralesional steroid Meta-analysis Benign refractory esophageal stricture Dilation

Restoration of energy level in the early phase of acute pediatric pancreatitis

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World Journal of Gastroenterology 2017年第6期23卷 957-963页

作者： Dóra Mosztbacher Nelli Farkas Margit Solymár Gabriella Pár Judit Bajor ákos Szucs József Czimmer Katalin Márta Alexandra mikó Zoltán Rumbus Péter Varjú Péter Hegyi Andrea Párniczky First Department of Pediatrics Semmelweis University Institute for Translational Medicine University of Pécs Institute for Bioanalyses University of Pécs Department of Gastroenterology First Department of MedicineUniversity of Pécs Department of Translational Medicine First Department of MedicineUniversity of Pécs First Department of Surgery Semmelweis University Hungarian Academy of Sciences-University of Szeged Momentum Gastroenterology Multidisciplinary Research Group Heim Pál Children’s Hospital

Acute pancreatitis (AP) is a serious inflammatory disease with rising incidence both in the adult and pediatric populations. It has been shown that mitochondrial injury and energy depletion are the earliest intracellular events in the early phase of AP. Moreover, it has been revealed that restoration of intracellular ATP level restores cellular functions and defends the cells from death. We have recently shown in a systematic review and meta-analysis that early enteral feeding is beneficial in adults; however, no reviews are available concerning the effect of early enteral feeding in pediatric AP. In this minireview, our aim was to systematically analyse the literature on the treatmentof acute pediatric pancreatitis. The preferred reporting items for systematic review(PRISMA-P) were followed, and the question was drafted based on participants, intervention, comparison and outcomes: P: patients under the age of twenty-one suffering from acute pancreatitis; I: early enteral nutrition (per os and nasogastric- or nasojejunal tube started within 48 h); C: nil per os therapy; O: length of hospitalization, need for treatment at an intensive care unit, development of severe AP, lung injury (including lung oedema and pleural effusion), white blood cell count and pain score on admission. Altogether, 632 articles (Pub Med: 131; EMBASE: 501) were found. After detailed screening of eligible papers, five of them met inclusion criteria. Only retrospective clinical trials were available. Due to insufficient information from the authors, it was only possible to address length of hospitalization as an outcome of the study. Our mini-meta-analysis showed that early enteral nutrition significantly(SD = 0.806, P = 0.034) decreases length of hospitalization compared with nil per os diet in acute pediatric pancreatitis. In this minireview, we clearly show that early enteral nutrition, started within 24-48 h, is beneficial in acute pediatric pancreatitis. Prospective studies and better pres

关键词： pediatric pancreatitis enteral nutrition nil per os diet ATP restoration length of hospitalization

Chronic kidney disease severely deteriorates the outcome of gastrointestinal bleeding: A meta-analysis

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World Journal of Gastroenterology 2017年第47期23卷 8415-8425页

作者： Roland Hágendorn Nelli Farkas Aron Vincze Zoltán Gyongyi Dezso Csupor Judit Bajor Bálint Eross Péter Csécsei Andrea Vasas Zsolt Szakács László Szapáry Péter Hegyi Alexandra mikó Department of Gastroenterology First Department of MedicineUniversity of Pécs Institute of Bioanalysis University of Pécs Department of Public Health Medicine University of Pécs Department of Pharmacognosy Faculty of PharmacyUniversity of Szeged Institute for Translational Medicine University of Pécs Department of Neurology University of Pécs

AIM To understand the influence of chronic kidney disease(CKD) on mortality, need for transfusion and rebleeding in gastrointestinal(GI) bleeding *** A systematic search was conducted in three databases for studies on GI bleeding patients with CKD or endstage renal disease(ESRD) with data on outcomes of mortality, transfusion requirement, rebleeding rate and length of hospitalization(LOH). Calculations were performed with Comprehensive Meta-Analysis software using the random effects model. Heterogeneity was tested by using Cochrane's Q and I2 statistics. Mean difference(MD) and OR(odds ratio) were ***1063 articles(EMBASE: 589; PubM ed: 459; Cochrane: 15) were found in total. 5 retrospective articles and 1 prospective study were available for analysis. These 6 articles contained data on 406035 patients, of whom 51315 had impaired renal function. The analysis showed a higher mortality in the CKD group(OR = 1.786, 95%CI: 1.689-1.888, P < 0.001) and the ESRD group(OR = 2.530, 95%CI: 1.386-4.616, P = 0.002), and a rebleeding rate(OR = 2.510, 95%CI: 1.521-4.144, P < 0.001) in patients with impaired renal function. CKD patients required more unit red blood cell transfusion(MD = 1.863, 95%CI: 0.812-2.915, P < 0.001) and spent more time in hospital(MD = 13.245, 95%CI: 6.886-19.623, P < 0.001) than the *** ESRD increases mortality, need for transfusion, rebleeding rate and LOH among GI bleeding patients. Prospective patient registries and observational clinical trials are crucially needed.

关键词： Gastrointestinal bleeding Chronic kidney disease Mortality Blood transfusion Rebleeding

Body-mass index correlates with severity and mortality in acute pancreatitis: A meta-analysis

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World Journal of Gastroenterology 2019年第6期25卷 729-743页

作者： Dalma Dobszai Péter Mátrai Zoltan Gyongyi Dezso Csupor Judit Bajor Balint Eross Alexandra mikó Lajos Szakó Agnes Meczker Roland Hágendorn Katalin Márta Andrea Szentesi Péter Hegyi on behalf of the Hungarian Pancreatic Study Group Institute for Translational Medicine Medical SchoolUniversity of PécsPécs 7624Hungary Clinical Medicine Doctoral School University of SzegedSzeged 6720Hungary Institute for Bioanalysis Medical SchoolUniversity of PécsPécs 7624Hungary Department of Public Health Medicine Medical SchoolUniversity of PécsPécs 7624Hungary Department of Pharmacognosy University of SzegedSzeged 6720Hungary Division of Gastroenterology First Department of MedicineUniversity of PécsMedical SchoolPécs 7624Hungary János Szentágothai Research Center University of PécsPécs 7624 Hungary MTA-SZTE Momentum Translational Gastroenterology Research Group University of SzegedSzeged 6720Hungary 不详

BACKGROUND Obesity rates have increased sharply in recent decades. As there is a growing number of cases in which acute pancreatitis(AP) is accompanied by obesity, we found it clinically relevant to investigate how body-mass index(BMI) affects the outcome of the *** To quantify the association between subgroups of BMI and the severity and mortality of *** A meta-analysis was performed using the Preferred Reporting Items for Systematic Review and Meta-Analysis(PRISMA) Protocols. Three databases(PubMed, EMBASE and the Cochrane Library) were searched for articles containing data on BMI, disease severity and mortality rate for AP. Englishlanguage studies from inception to 19 June 2017 were checked against our predetermined eligibility criteria. The included articles reported all AP cases with no restriction on the etiology of the disease. Only studies that classified AP cases according to the Atlanta Criteria were involved in the severity analyses. Odds ratios(OR) and mean differences(MD) were pooled using the random effects model with the DerSimonian-Laird estimation and displayed on forest plots. The meta-analysis was registered in PROSPERO under number *** A total of 19 articles were included in our meta-analysis containing data on 9997 patients. As regards severity, a subgroup analysis showed a direct association between AP severity and BMI. BMI 25 had an almost three-fold increased risk for severe AP in comparison to normal BMI(OR = 2.87, 95%CI: 1.90-4.35, P < 0.001). Importantly,the mean BMI of patients with severe AP is higher than that of the non-severe group(MD = 1.79, 95%CI: 0.89-2.70, P < 0.001). As regards mortality, death rates among AP patients are the highest in the underweight and obese subgroups. A BMI < 18.5 carries an almost two-fold increase in risk of mortality compared to normal BMI(OR = 1.82, 95%CI: 1.32-2.50, P < 0.001). However, the chance of mortality

关键词： Acute pancreatitis Body-mass index Obesity Severity Mortality Prognostic Meta-analysis

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用病原菌滤液鉴定菜豆对菌核病的生理抗性

农业新技术新方法译丛 1993年第1期 26-28页

作者： mik.,PN 王勇

Only mothers feed mature offspring in European Ceratina bees

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Insect Science 2021年第5期28卷 1468-1481页

作者： Michael mikat Jitka Waldhauserova Tereza Frankova Katerina Cermakova Vojtech Broz Simon Zeman Marcela Dokulilova Jakub Straka Department of Zoology Faculty of ScienceCharles UniversityPragueCzech Republic Jihlava Grammar School JihlavaCzech Republic Department of Ecology Faculty of ScienceCharles UniversityPragueCzech Republic

Parental care directed to adult offspring is uncommon in *** parental care has been documented in Xylocopinae bees(Hymenoptera:Apidae).Moreover,some Ceratina bees(Xylocopinae)are known to feed mature siblings,and feeding of mature siblings is achieved by dwarf eldest daughters when mothers *** daughters are intentionally malnourished by mothers and usually originate from the first brood ***,we examined the pattern of care prov ided to young adults in three small European carpenter bees:Ceratina(Ceratina)cucurbitina,C.(Euceratina)chalybea,and C.(E.)*** of nest departures and arrivals were performed to study foraging *** detected intensive foraging behavior of mothers in all three studied ***,we did not observe regular foraging bchavior of daughters in any *** experimental removal of mothers in *** led to the emigration of young adults and did not initiate foraging activity in *** conclude that the feeding of siblings does not occur in these species unlike in the American species *** detected female-biased sex ratios in the first brood cell in *** and *** offspring in the first brood cell was smaller than other female offspring only in *** results show that a female-biased sex ratio and the small size of daughters in the first brood cell do not provide sufficient ev idence for demonstrating the existence of an altruistic daughter and also that the pattern of maternal investment is not exclusively shaped by social interactions.

关键词： foraging trip Hymenoptera maternal care provisioning sociality Xylocopinae