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Open Journal of Blood Diseases 2024年第1期14卷 8-16页

作者： Brah moustapha maman Amadou Djibrilla-Almoustapha moustapha Elhadji-Chefou Abdoul-Aziz Garba Badé Malam-Abdou Department of Medicine Université André Salifou de Zinder Zinder Niger Department of Medicine H&#244pital National de Zinder Zinder Niger Department of Medicine Université Abdou Moumouni de Niamey Niamey Niger Department of Medicine Université Dan Dicko Dan Koulodo de Maradi Maradi Niger

Introduction: Since it is impossible to establish a diagnosis in the presence of hyperlymphocytosis not secondary to lymphocytic hyperactivation, we considered a B-lymphoid hematopathy with a non-specific phenotypic profile. We report one case of this. Observation: This is a forty-eight (48) year old patient with hyperlymphocytosis at 139,000 elements per cubic millimeter, heterogeneous splenomegaly at 25.6 cm in diameter on abdominal ultrasound without detectable deep or peripheral lymphadenopathy. Peripheral blood cytology shows lymphocyte cell proliferation suggestive of the circulating phase of chronic lymphoproliferative B syndrome. The expression profile of cell membrane markers did not allow for the definition of a specific phenotypic profile. Faced with this immunophenotyping result, we considered a B-lymphoid hemopathy with a non-specific phenotypic profile. After three courses, the MINICHOP treatment was used to achieve partial remission with wasting of more than 80% of the evaluable masses. Conclusion: Despite the contribution of immunophenotyping in the diagnosis of lymphoproliferative syndromes, it is possible to consider the diagnosis of a B-lymphoid hemopathy with a phenotypic non-specific profile of CD45+, monotypic kappa, CD19+, FMC7+, CD22+, CD5−, CD79b−, CD23−, CD43−, CD38−, CD200−.

关键词： Hyperlymphocytosis CLL Immunophenotyping MINICHOP

Sickle Cell Disease in the Zinder Region in 2023: Prevalence and Sociodemographic Factors

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Open Journal of Blood Diseases 2024年第1期14卷 1-7页

作者： Brah moustapha maman Amadou Djibrilla-Almoustapha moustapha Elhadji-Chefou Illa Hamidine Moussa Diongolé Hassane Badé Malam-Abdou Department of Medicine Université André Salifou de Zinder Zinder Niger Department of Medicine H&#244pital National de Zinder Zinder Niger Department of Medicine Université Abdou Moumouni de Niamey Niamey Niger Department of Medicine Université Dan Dicko Dan Koulodo de Maradi Maradi Niger

Introduction: In view of the number of sickle cell patients and due to a low production of descriptive studies, we decided to determine the prevalence of genes S and C of the disease in the Zinder region. The objective was to contribute to improving the management of sickle cell disease in Zinder. Methodology: This was a systematic screening by the “Sickle Scan” test of any blood donor admitted to the Zinder Regional Blood Transfusion Center during the 6-month study period, from January to June 2023. The Sickle Scan is a qualitative lateral flow chromatography immunoassay using whole blood samples that aid in the rapid diagnosis of sickle cell disease. Results: The study was carried out on 613 samples during the period concerned. The frequency of sickle cell genes was 26.9% (n = 165) in all samples collected, with 23.1% (n = 142) and 3.8% (n = 23) for the S gene and the C gene, respectively. The 18 - 30 age group was the most represented with 64.4% (n = 395) cases. The median age of blood donors was 26 years ± 10 years (min = 18 years/max = 60 years). The sex ratio was 2.5. Donors of Nigerien nationality accounted for 84.1% (n = 516). There is a predominance of blood donors with an average monthly income between 34,000 and 70,000 CFA francs in 44.3% (n = 272), lived in permanent housing with drinking water supply. Sickle cell trait (SMA) was found in 22.5% (n = 138). Conclusion: The analysis of these results highlights a high frequency of the S gene for sickle cell disease. The population with an average monthly income is the most affected, with a male predominance.

关键词： Sickle Cell Anemia Blood Donors Sickle Scan

Acute Leukemia in Niger: Epidemiological, Diagnostic and Therapeutic Aspects

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Open Journal of Blood Diseases 2024年第3期14卷 81-90页

作者： Amadou Djibrilla-Almoustapha Badé Malam-Abdou Abdourahamane Yacouba Moussa Souley moustapha maman Brah moustapha Elhadji-Chefou Boubacar Marou-Soumana Samaila Aboubacar Ousseini Fanta maman Rabiou Badé Oumarou Adamou-Chaibou Department of Hematology-Oncology National Hospital of Niamey Niamey Niger Faculty of Health Sciences University of Abdou Moumouni Niamey Niger Department of Medicine Zinder Hospital Regional Niger Departtment of Biology Amirou Boubacar Diallo National Hospital Niamey Niger Faculty of Health Sciences University of Dan Dicko Dankouloudo of Maradi Maradi Niger Laboratory of Biology National Hospital of Niamey Niamey Niger

Objective: Improve the care of patients followed for acute leukemia in the Oncohematology department of the National Hospital of Niamey. Methods: This was a prospective study, over a period of 2 years from January 1, 2018 to December 31, 2019, in patients with acute leukemia in the Oncohematology department of the National Hospital of Niamey (HNN), whose diagnosis was made on a blood smear associated with a myelogram and immunophenotyping and who were consenting. Results: We collected 25 cases of acute leukemia confirmed by myelogram and immunophenotyping. The mean age of the patients was 31.32 years, with a predominance of women, a sex ratio of 0.92. Pupils and students were in the majority with 40% and most came from the Niamey region, i.e. 68%. Anemic syndrome was the most common clinical sign in 96%. ALL predominated in 64% of cases. On the blood count, the hyperleukocytosis was more marked in AML (mean white count: 197256.6 elts/mm3) than in ALL (137891.6 elts/mm3), it was the same for thrombocytopenia which is more marked in AML (75588.89/mm3) than in ALL (52156.25/mm3). Therapeutically, 52% of patients received chemotherapy. The mean overall survival was 16.223 ± 3.191 months, including a mean survival for AML of 6.853 ± 1200 months compared to 21.720 ± 5.920 months for ALL. Conclusion: Acute leukemia still remains a major problem in our context, due to the precariousness of limited financial, diagnostic and therapeutic resources. Thus reflecting in our results, the increasing number of cases, the diagnostic delay and the guarded prognosis. This is the reality in several other countries in the sub-region and even in certain developed countries.

关键词： Acute Leukemia ALL AML Hematology-Niamey National Hospital (HNN) Niger

Primary Non-Hodgkin’s Malignant Lymphoma of the Uterus at the Reference Hospital of Maradi/Niger: A Case Report

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Open Journal of Blood Diseases 2024年第2期14卷 43-46页

作者： moustapha Elhadji-Chefou Badé Malam-Abdou Amadou Djibrilla-Almoustapha maman Brah moustapha Oumou Kimso Ibrahim Timi Liman Elhadji Ali Issa Abdou Amadou Borges Moreno Yuribet Facult des Sciences de la Sant Universit Dan Dicko Dankoulodo de Maradi Maradi Niger Hopital de Reference de Maradi Maradi Niger Facult des Sciences de la Sant Universit Abdou Moumouni de Niamey Niamey Niger Facult des Sciences de la Sant Universit Andr Salifou de Zinder Zinder Niger

Malignant non-Hodgkins lymphoma (MHNL) of the uterus is uncommon. We report a case diagnosed on the basis of histologic and immunohistochemical studies of a hysterectomy specimen induced by a very painful pelvic mass in a 50-year-old patient with no previous history of the disease. It was classified as Ann Arbor IV Bb after imaging, given the medullary infiltration and signs of clinical and biological evolutivity: the patient had received two courses of chemotherapy, CHOP protocol. She died 23 days after the second treatment due to a hypertensive crisis.

关键词： Malignant Non-Hodgkin’s Lymphoma Uterus Referral Hospital Maradi/Niger

Analysis and Control of the Vehicle Roll Dynamics Using Sum of Squares Polynomial Approach

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Journal of Systems Science & Complexity 2024年

作者： IBEN AMMAR Imen DOUMIATI moustapha TALJ Reine CHOKOR Abbas MACHMOUM Mohamed ESEO-IREENA Institut de Recherche en énergie électrique de Nantes Atlantique IREENA UR 4642 37 Boulevard de l’Université-BP406 Sorbonne Universités Université de Technologie de Compiègne CNRS Institut de Recherche en énergie électrique de Nantes Atlantique IREENA UR 4642 37 Boulevard de l’Université-BP 406

The safety of vehicle travel relies on good stability performance, making vehicle motion control a vital technology in vehicles. This paper focuses on investigating the impact of roll control on vehicle performance, particularly in terms of avoiding rollover and ensuring lateral stability. By introducing a feedback roll moment, the roll motion can be effectively controlled. The paper considers two roll reference generators: A static one aimed at zero roll, and a dynamic one based on the vehicle's lateral acceleration. The static roll reference generator enhances stability by employing a fixed reference, particularly beneficial during routine driving conditions. In contrast, the dynamic roll reference generator continually adapts the roll angle reference in response to real-time vehicle dynamics and driving conditions. These proposed reference generators can be paired with varying suspension systems — Static reference could be achieved using semi-active suspensions, while the dynamic one is integrated into advanced active suspension systems, offering heightened adaptability and *** address the roll control objectives, this paper proposes a novel sum of squares(SOS) integral polynomial tracking control. The proposed controller satisfies control bounds and considers control constraints during the design phase. The effectiveness and robustness of the proposed control scheme are evaluated through numerical simulations using a full vehicle nonlinear model in Matlab/Simulink. The results of these simulations are compared to super-twisting sliding mode and Lyapunov-based controllers.

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An Application of Machine Learning Methods to Detect Mango Varieties

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Open Journal of Applied Sciences 2024年第7期14卷 1666-1690页

作者： Abou Bakary Ballo moustapha Diaby Adama Coulibaly Department of Mathematics and Computer Science University FLIX HOUPHOUT-BOIGNY Abidjan Cte dIvoire African College of Information and Communication Technologies Abidjan Cte dIvoire

The mango, a fruit of immense economic and dietary significance in numerous tropical and subtropical regions, plays a pivotal role in our agricultural landscape. Accurate identification is not just a necessity, but a crucial step for effective classification, sorting, and marketing. This study delves into the potential of machine learning for this task, comparing the performance of four models: MobileNetV2, Xception, VGG16, and ResNet50V2. These models were trained on a dataset of annotated mango images, and their performance was evaluated using precision, accuracy, F1 score, and recall, which are standard metrics for image classification. The Xception model, with its exceptional performance, outshone the other models on all performance indicators. It achieved a staggering accuracy of 99.47%, an F1 score of 99.43%, and a recall of 99.43%, showcasing its remarkable ability to accurately identify mango varieties. MobileNetV2 followed closely with performances of 98.95% accuracy, 98.85% F1 score, and 98.86% recall. ResNet50V2 also delivered satisfactory results with 97.39% accuracy, 97.08% F1 score, and 97.17% recall. VGG16, however, was the least effective, with a precision rate of 83.25%, an F1 score of 83.25%, and a recall of 85.47%. These results confirm the superiority of the Xception model in detecting mango varieties. Its advanced architecture allows it to capture more distinguishing features of mango images, leading to greater precision and reliability. Xception’s robustness in identifying true positives is another advantage, minimizing false positives and contributing to more accurate classification. This study highlights the promising potential of machine learning, particularly the Xception model, for accurately identifying mango varieties.

关键词： Machine Learning Recognition Mango Varieties Algorithms Feature Extraction Convolution Training Classification

Asthma Attack Revealing Sickle Cell Disease

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Open Journal of Pediatrics 2024年第5期14卷 865-868页

作者： Khaoula Achir Ilham Tadmori moustapha Hida Pediatric Department of CHU Hassan II in Fez Fez Morocco

Sickle cell disease is a genetic disorder characterized by the presence of hemoglobin S (HbS) and a significant reduction in normal hemoglobin A (HbA) in red blood cells. In deoxygenated conditions, HbS molecules polymerize, causing vascular occlusions and hemolysis. Pulmonary complications associated with this disease result from vascular occlusion, ischemia-reperfusion, and inflammation. Literature reports that asthma is observed in 30% to 70% of patients with sickle cell disease. We present the case of a boy whose sickle cell disease diagnosis was established following an asthma attack.

关键词： Sickle Cell Disease Asthma Morbidity

Precocious Puberty in a 5-Year-Old Girl with a Giant Hypothalamic Hamartoma Discovered Perinatally: Case Report

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Open Journal of Endocrine and Metabolic Diseases 2024年第4期14卷 101-106页

作者： Ghita Bourkadi Sanae Habibi Sana Abourazzak moustapha Hida Department of Endocrinology Diabetology Metabolic Diseases and Nutrition Hassan II University Hospital Fez Morocco Department of Pediatrics Hassan II University Hospital Fez Morocco Faculty of Medicine and Pharmacy Sidi Mohamed Ben Abdellah University Fez Morocoo

Background: Hypothalamic hamartoma is a rare non-neoplastic lesion, typically identified in early childhood during investigations for precocious puberty and/or gelastic seizures. However, cases of diagnosis even earlier or during fetal development have been documented. Case Presentation: A newborn girl was diagnosed with hydrocephalus during pregnancy. An MRI revealed a large oval hypothalamic process, which suggested a hypothalamic hamartoma. At the age of 2, she experienced alternating crying and laughing seizures, followed by a decrease in visual acuity. Due to involvement of the optic pathways, surgery was not performed and she underwent antiepileptic medicines and gamma knife radiotherapy. At the age of 5 years and 3 months, she presented with breast development and laboratory tests confirmed central precocious puberty. Quarterly injections of GnRH agonists have since been administered with favorable results. Conclusion: Early-diagnosed hypothalamic hamartomas require close monitoring, by an experienced multidisciplinary, to promptly detect and treat potential complications, especially precocious puberty, and prevent any undesirable impact on final height.

关键词： Perinatally-Hypothalamic Hamartoma-Giant-Precocious Puberty

Epdemiology and Treatment of Pseudarthrosis of Long Bones in the Servce D Orthopedics-Traumatology of the University Hospital of Donka

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Open Journal of Orthopedics 2024年第3期14卷 133-138页

作者： Camara Nouhou Mangué Diallo Mamadou moustapha moustapha Alhassane Diallo Alpha Mamadou Fela Sidimé Sory Camara Abdoulaye Kolié Germain Lamah Léopold Service d’Orthopédie-Traumatologie Centre Hospitalier Universitaire de Donka Conakry Republic of Guinea

Introduction: Pseudarthrosis (PSA) of the diaphysis of long bones still remains a current problem, despite improvements in the treatment of these fractures. Our study aims to study the epidemiological and therapeutic aspects of PSA of the diaphysis of long bones. Method: This retrospective work concerns 30 cases of non-union of the diaphysis of long bones treated in the orthopedic and trauma surgery department at Donka National Hospital, during a period of 18 months from January 1, 2019 to June 30, 2020. Results: We recruited 30 patients, 80% of whom were male, with an average age of 39.9 years. Public road accidents (AVP) represented the main cause of fractures of the diaphysis of long bones 87%, they were open in 25 cases or 83%. The fractures were located in the middle 1/3 of the diaphysis of the long bones in 50% of cases. Treatment of initial fractures was traditional in 21 cases, orthopedic in 2 cases and surgical in 7 cases. It was aseptic nonunion in 28 cases (93%) and septic nonunion in 2 cases. They were hypertrophic in 7 cases, slightly hypertrophic in 5 cases, oligotrophic in 11 cases, atrophic in 6 cases and with bone defect in 1 case. The treatment was based on osteosynthesis including 16 cases of screwed “PV” plate: 7 cases of centromedullary “ECM” nailing, 2 cases of external fixator, 1 case of broaching and 4 cases of Plastering. The results according to ASAMI criteria on an anatomical level were excellent in 19 cases, good in 3 cases and poor in 3 cases, with a union rate of 76%. And 5 patients undergoing consolidation. Conclusion: Based on the literature data and the experience of our department, the true treatment of PSA requires correct management of the initial fracture without forgetting the interest in preventing AVP which appears to be an element essential, making it possible to reduce the incidence of fractures of the diaphysis.

关键词： Pseudarthrosis Aseptic-Septic-Diaphysis Long Bones Screwed Plate Intramedullary Nailing Bone Graft Osteo-Muscular Decortication