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国际眼科杂志 2009年第8期9卷 1431-1434页

作者：姜彩辉张卯年 mihoko suzuki Motohiro Kamei 解放军总医院眼科中国北京市100853 大阪大学医学院眼科日本大阪565-0871

目的:探讨视盘内注射组织凝血酶原激活剂的电生理学安全性。方法:首先将记录VEP的电极植入兔颅骨内。经兔睫状体扁平部将25μg tPA,12.5μg tPA及BSS注入视神经内0.1mL,并与第四组正常眼作比较(n=6)。注入后1,3,7,14和24d行裂隙灯及间... 详细信息

目的:探讨视盘内注射组织凝血酶原激活剂的电生理学安全性。方法:首先将记录VEP的电极植入兔颅骨内。经兔睫状体扁平部将25μg tPA,12.5μg tPA及BSS注入视神经内0.1mL,并与第四组正常眼作比较(n=6)。注入后1,3,7,14和24d行裂隙灯及间接眼底镜检查,记录VEP及ERG。结果:检查未发现视神经内注射tPA对视神经和视网膜有明显的毒性作用和其它损伤。各组VEP第1个波峰的潜伏期分别是24.6±1.5, 24.1±1.9, 24.0±2.0和24.6±1.3mS(P=0.4112);振幅分别是124±42, 145±41, 132±48和117±29μV(P=0.0649)。各组ERG的a波的潜伏期分别是6.0±0.4, 5.9±0.4, 5.9±0.5和5.8±0.3mS(P=0.6279);振幅分别是110±14, 112±15, 110±16和108±11μV(P=0.7248)。b波的振幅分别是151±12,148±14, 144±16和141±20μV(P=0.0957)。结论:经睫状体扁平部向兔视神经内注射tPA,安全可行。

关键词：组织凝血酶原激活剂视神经内注射视网膜中央静脉阻塞 VEP ERG

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蓝光照射导致氧化磷脂及MCP-1在鼠视网膜内蓄积增加

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中国组织化学与细胞化学杂志 2015年第3A期23卷 224-228页

作者：徐静娴张贤亮臧博铃木三保子贾心善张劲松中国医科大学附属第四医院眼科中心中国医科大学眼科医院辽宁省晶状体学重点实验室沈阳110005 大阪大学医学院眼科教研室中国医科大学基础医学院病理教研室沈阳110001

目的探讨蓝光照射是否会导致氧化磷脂和单核细胞趋化蛋白-1(MCP-1)在不同年龄鼠视网膜内蓄积增加。方法对2m和12m的C57/BL6鼠,应用波长为480nm的蓝色二极管光源以2mW/cm2的强度持续照射1w后,将各组鼠眼球摘除,应用RT-PCR、ELISA及免疫... 详细信息

目的探讨蓝光照射是否会导致氧化磷脂和单核细胞趋化蛋白-1(MCP-1)在不同年龄鼠视网膜内蓄积增加。方法对2m和12m的C57/BL6鼠,应用波长为480nm的蓝色二极管光源以2mW/cm2的强度持续照射1w后,将各组鼠眼球摘除,应用RT-PCR、ELISA及免疫组织化学染色等方法检测氧化磷脂及MCP-1在鼠眼内的含量及存在部位。结果接受蓝光照射的2m和12m的鼠视网膜内氧化磷脂含量明显增加,其中12m鼠视细胞外节氧化磷脂的含量明显高于2m鼠。蓝光照射后,RT-PCR、ELISA检测显示:2m和12m的鼠在视网膜色素上皮层及脉络膜层MCP-1的含量明显增加,其中12m鼠含量更高。结论蓝光照射后,高龄鼠比低龄鼠视网膜内更容易蓄积氧化磷脂和MCP-1,蓝光照射可能在AMD的发病中起到重要的作用。

关键词：蓝光照射氧化磷脂 MCP-1 AMD

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Tuberous sclerosis patient with neuroendocrine carcinoma of the esophagogastric junction:A case report

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World Journal of Gastroenterology 2020年第45期26卷 7263-7271页

作者： Natsuki Ishida Takahiro Miyazu Satoshi Tamura Satoshi suzuki Shinya Tani mihoko Yamade Moriya Iwaizumi Satoshi Osawa Yasushi Hamaya Kazuya Shinmura Haruhiko Sugimura Katsutoshi Miura Takahisa Furuta Ken Sugimoto First Department of Medicine Hamamatsu University School of MedicineHamamatsu 431-3192Japan Department of Endoscopic and Photodynamic Medicine Hamamatsu University School of MedicineHamamatsu 431-3192Japan Department of Laboratory Medicine Hamamatsu University School of MedicineHamamatsu 431-3192Japan Haruhiko Sugimura Department of Tumor PathologyHamamatsu University School of MedicineHamamatsu 431-3192Japan Department of Health Science Hamamatsu University School of MedicineHamamatsu 431-3192Japan Center for Clinical Research Hamamatsu University School of MedicineHamamatsu 431-3192Japan

BACKGROUND Tuberous sclerosis complex(TSC)is a rare inherited disease with non-cancerous tumor growths in the skin,brain,kidneys,heart,and *** co-occurrence of neuroendocrine neoplasm(NEN)with TSC is even *** have been few reports on the relationship between TSC and neuroendocrine tumors(NETs),and fewer on the relationship between TSC and neuroendocrine carcinoma(NEC),a subtype of *** is the first reported case of NEC occurring at the esophagogastric junction in a patient with *** SUMMARY A 46-year-old woman visiting our hospital for the treatment of TSC was admitted to the emergency department with tarry stools and *** tomography scans revealed thickness of the gastric cardia,multiple metastatic lesions of the liver,and enlarged lymph nodes near the lesser curvature of the *** revealed a type 3 tumor located from the esophagogastric junction to the fundus,and the pathological diagnosis by biopsy was *** patient was treated with seven courses of cisplatin+irinotecan,followed by eight courses of ramucirumab+nab-paclitaxel,one course of nivolumab,and two courses of S-1+***-three months after the first treatment,the patient died because of disease progression and deterioration of the general *** This case of NEC occurring in a patient with TSC indicates a difference in the occurrence of NETs and NECs.

关键词： Tuberous sclerosis complex Neuroendocrine carcinoma Neuroendocrine tumor mTOR inhibitor Esophagogastric junction Chemotherapy Case report

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Differences in Self-Assessment Regarding Eating Behaviors among Female University Students Living in Japan, Korea, and Austria

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Food and Nutrition Sciences 2012年第12期3卷 1673-1681页

作者： mihoko Tominaga Masanori Taguchi Akiko suzuki Yoshiko Ikawa Ho-Sook Youn Kyubok Cho Johannes Scherling Roswith Roth Department of Interdisciplinary Studies Dokkyo University Saitama Japan Department of Nutrition Sciences University of Nagasaki Nagasaki Japan Department of Psychology University of Graz Graz Austria Graduate School of Education Hiroshima University Hiroshima Graduate School of Education Hiroshima University Hiroshima Japan Institute of English and American Studies University of Graz Graz Austria Japanese Department Cyber Hankuk University of Foreign Studies Seoul Korea Korea Education & Research Information Service Seoul Korea

Objective: To investigate cross-cultural differences in self-assessments of eating behaviors of female university students who bear responsibility for their own eating behaviors and who will, in the future, likely determine a family’s eating style. Design: A cross-cultural comparison. Setting: Japan, South Korea, and Austria. Subjects: Female university students from Japan (n = 276), Korea (n = 103), and Austria (n = 127). The survey comprised a questionnaire containing ten sections about eating behaviors (eating habits, regular meal times, and frequency of food intake) and eating attitudes. Results: Eating behaviors and attitudes differed significantly among the three cultures. Japanese students practiced healthier eating behaviors than did Korean and Austrian students, on the basis of their variety of food intake and regular consumption of three meals, but rated themselves lower on healthy eating behaviors. Austrian students tended to have more independent attitudes toward eating and food preparation (e.g., “I want to eat only my favorite dishes”) than Japanese or Korean students. Conclusions: Effects of cultural differences in psychological processes, such as self-cognition, emotion, motivation, and values, on self-assessment of eating behaviors is suggested.

关键词： Differences in Self-Assessment Regarding Eating Behaviors among Female University Students Living in Japan Korea and Austria

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