检索结果-南通市图书馆

Novel diamond shuttle to deliver flexible neural probe with reduced tissue compression

Microsystems & Nanoengineering 2020年第1期6卷 903-915页

作者： Kyounghwan Na Zachariah J.Sperry Jiaao Lu mihaly voroslakos Saman S.Parizi Tim M.Bruns Euisik Yoon John P.Seymour Electrical Engineering&Computer Science Department University of MichiganAnn ArborMI 48105USA Biomedical Engineering Department University of MichiganAnn ArborMI 48105USA Biointerfaces Institute University of MichiganAnn ArborMI 48105USA The Neuroscience Institute New York UniversityNew YorkNY 10016USA Center for Nanomedicine Institute for Basic Science(IBS)Seoul 03722Korea Graduate Program of Nano Biomedical Engineering(Nano BME) Yonsei-IBS InstituteYonsei UniversitySeoul 03722Korea Vivian L Smith Department of Neurosurgery University of Texas Health Science CenterHoustonTX 77030USA Department of Electrical and Computer Engineering Rice UniversityHoustonTX 77005USA

The ability to deliver flexible biosensors through the toughest membranes of the central and peripheral nervous system is an important challenge in neuroscience and neural *** devices implanted through dura mater and thick epineurium would ideally create minimal compression and acute damage as they reach the neurons of *** demonstrate that a three-dimensional diamond shuttle can be easily made with a vertical support to deliver ultra-compliant polymer microelectrodes(4.5-µm thick)through dura mater and thick *** diamond shuttle has 54%less cross-sectional area than an equivalently stiff silicon shuttle,which we simulated will result in a 37%reduction in blood vessel *** also discovered that higher frequency oscillation of the shuttle(200Hz)significantly reduced tissue compression regardless of the insertion speed,while slow speeds also independently reduced tissue *** and recording performance are demonstrated in rat and feline models,but the large design space of these tools are suitable for research in a variety of animal models and nervous system targets.

关键词： sectional neural thick

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Systemic phosphatidylcholine pretreatment protects canine esophageal mucosa during acute experimental biliary reflux

引用

World Journal of Gastroenterology 2006年第2期12卷 271-279页

作者： Gabor Eros Jozsef Kaszaki Miklos Czobel mihaly Boros Institute of Surgical Research University of SzegedHungary

AIM： To characterize the consequences of short-term exposure to luminal bile on mucosal mast cell reactions in a canine model, and to determine the effects of systemic phosphatidylcholine pretreatment in this condition. METHODS： Twenty mongrel dogs were used for experiments. Group 1 （n =5） served as a salinetreated control, while in group 2 （n = 5） the esophagus was exposed to bile for 3 h. In group 3 （n =5） the animals were pretreated with 7-nitroindazole to inhibit the neuronal isoform of nitric oxide synthase. In group 4 （n = 5） phosphatidylcholine solution （50 rng/kg） was administered iv before the biliary challenge. Mucosal microcirculation was observed by intravital videomicroscopy. Myeloperoxidase and nitric oxide synthase activities, the degrees of mast cell degranulation and mucosal damage were evaluated via tissue biopsies. RESULTS： Exposure to bile evoked significant mast cell degranulation and leukocyte accumulation. The red blood cell velocity and the diameter of the postcapillary venules increased significantly. The tissue ATP content and constitutive nitric oxide synthase activity decreased, while the inducible nitric oxide synthase activity increased significantly as compared to the control values. 7-nitroindazole treatment significantly exacerbated the mucosal mast cell degranulation and tissue damage. Tn contrast, phosphatidylcholine pretreatment prevented the bile-induced ATP depletion, the inducible nitric oxide synthase and myeloperoxidase activity and the mast cell degranulation increased. CONCLUSION： The neuronal nitric oxide synthasemast cell axis plays an important role in the esophageal mucosal defense system. Systemic phosphatidylcholine pretreatment affords effective protection through ameliorating the bile-induced ATP depletion and secondary inflammatory reaction.

关键词： Esophagus Bile Neuronal nitric oxide Mast cell Microcirculation Inflammation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Modeling of Intel-critical Heat Treatment of DP and TRIP Steels

引用

材料热处理学报 2004年第5期 710-715页

作者： REGER mihaly,VERO Balazs,CSEPELI Zsolt Budapest Polytechnic Budapest Hungary Bay Zoltan Foundation Institute for Materials and technology Budapest Hungary Dunaferr Co. Innovation Management Dunaujvaros Hungary

The final microstructure of DP and TRIP assisted steels can evolve after hot working (hot rolling) or during post heat treatment process. In the formation of the final structure a number of different technological parameters have important roles, e.g. end temperature of rolling, cooling rates, temperature of intercritical annealing, etc. As a result of the individual factors and their combinations a lot of product technology routes are feasible. The effect of the different combinations of these technological parameters on the microstructure can be mapped by the special Jominy end-quench test (so called intercritical Jominy end-quench test) described in this paper. Unlike the traditional Jominy test, in this case there is a partial austenizing between A! and A3 temperatures which results in a given amount of ferrite in the microstructure before quenching. The method developed can be applied for mapping DP and TRIP assisted steels' microstructure in a wide range of technological parameters. The analysis of measured and calculated data can help us find the technological parameters optimal from the microstructural point of view.

关键词： dual-phase steel TRIP steel Jominy End Quench Method modeling

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Striking elevation in incidence and prevalence of inflammatory bowel disease in a province of western Hungary between 1977-2001

引用

World Journal of Gastroenterology 2004年第3期10卷 404-409页

作者： Laszlo Lakatos Gabor Mester Zsuzsanna Erdelyi mihaly Balogh Istvan Szipocs Gyorgy Kamaras Peter Laszlo Lakatos 1~(st) Department of Medicine Csolnoky F.Province HospitalVeszpremHungary Department of Medicine Grof Eszterhazy HospitalPapaHungary Department of Medicine Municipal HospitalTapolcaHungary Department of Infectious Diseases Magyar Imre HospitalAjkaHungary 1~(st) Department of Medicine Semmelweis UniversityBudapestHungary

AIM:An investigation into inflammatory bowel disease and colorectal cancer in Veszprem Province was conducted from 1977 to ***: Both hospital and outpatient records were collected and reviewed comprehensively. The majority of patients were followed up ***:The population of the province was decreased from 386000 to 376000 during the period. Five hundred sixty new cases of ulcerative colitis (UC), 212 of Crohn's disease (CD), and 40 of indeterminate colitis (IC) were diagnosed. The incidence rates increased from 1.66 to 11.01 cases per 100 000 persons for UC, from 0.41 to 4.68 for CD and from 0.26 to 0.74 for IC. The prevalence rate at the end of 2001 was 142.6 for UC and 52.9 cases per 100 000 persons for CD. The peak onset age in UC patients was between 30 and 40 years, in CD between 20 and 30 years. A family history of IBD was present in 3.4% in UC and 9.9% in CD *** increased the risk for CD (OR=1.94) while it decreased the risk for UC (OR=0.25). Twelve colorectal carcinomas were observed in this cohort, the cumulative colorectal cancer risk after 10 years in UC was 2%, after 20 years 8.8%, after 30 years 13.3%.CONCLUSION:The incidence and prevalence rates of IBD have increased steadily in Veszprem Province, now equivalent to that in Western European countries. Rapid increase in incidence rates supports a probable role for environmental factors. The rate of colorectal cancers in IBD is similar to that observed in Western countries.

关键词： Adult Age Distribution Colorectal Neoplasms Female Health Surveys Humans Hungary Incidence Inflammatory Bowel Diseases Male Middle Aged Prevalence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical Applications of Single Protein Nanoparticles

引用

Journal of Pharmacy and Pharmacology 2014年第11期2卷 652-659页

作者： Imre Hegedus mihaly Kalman Eszter Farago Endre Nagy Research Institute of Chemical and Process Engineering University of Pannonia Veszprem H-8200 Hungary Department of Anatomy Histology and Embryology Semmelweis University Budapest H-1450 Hungary Institute of Physical Chemistry Eotvos Lorand University Budapest H-1518 Hungary

The drug carrier function of single protein nanoparticles, i.e., each individual protein molecule covered by a very thin, porous and few nanometer thick polymer layer, has been investigated. This layer around protein molecule is very thin, about 3-5 nm thick and highly porous, thus it does not reduce seriously the enzymatic function of protein molecule. The spatial structure of encapsulated protein molecule, which is essential in its function, can be stabilized by this polymer layer. Bovine serum albumin was used as protein drug molecule and it was encapsulated with acrylamide-bisarylamide random copolymer. The polymerization, starting from the modified sites of the surface of bovine serum albumin molecules was initiated by TEMED （tetramethylethylenediamine）. These single albumin nanoparticles were painted with fluorescein isothiocyanate. This material was then injected into the inferior vena cava of rats. The treated rats were decapitated after 1 to 10 minutes and its brain was investigated by fluorescent microscopy. It was proved that bovine serum albumin molecules as drugs encapsulated in polymer nano-layer with a reduced size （about 10 nm） can pass through the blood brain barrier. The results suggest that this method is capable of transformation of biomacromolecules to access the brain tissue via the blood.

关键词： Single protein nanoparticles bovine serum albumin drug carrier blood-brain barrier.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Combined Treatment with Buserelin+Cabergoline in Patient with Prostate Cancer and Pituitary Macroprolactinoma

引用

Journal of Cancer Therapy 2010年第4期1卷 214-218页

作者： mihaly Gervain Erika Voros Andor HMolnar Gyongyi Karcsu-Kis Ferenc Laszlo Department of Urology City HospitalOroshazaHungary Euromedic Diagnostics SzegedHungary Department of Physiology Anatomy and NeurosciencesUniversity of SzegedSzegedHungary

Twelve years following hemicolectomy for colon adenocarcinoma, a 75-year-old patient with prostate cancer was treated for 4 weeks with the antiandrogen nilutamide and then with the long-acting GnRH agonist buserelin. The serum testosterone and prostate-specific antigen levels had decreased dramatically after 3 months of treatment. After 2 years of buserelin administration, the hormonal state was examined. Serum estradiol, testosterone, DHEA, DHEAS, FSH and LH levels proved to be suppressed, but the serum PRL concentration was extremely high (3 365 mIU/l). The pituitary MRI revealed a macroadenoma. The patient was treated with the dopamine agonist cabergoline, together with buserelin. After 9 months of this combined treatment, the prostate-specific antigen and testosterone levels were very low;the serum estradiol, DHEA, DHEAS, FSH and LH concentrations remained suppressed. The serum PRL level fell dramatically to 6.95 mIU/l, and a significant reduction in tumor size was observed on MRI. In conclusion: Combined buserelin + cabergoline treatment proved a highly successful procedure to cure this patient with prostate carcinoma and subsequent pituitary macroprolactinoma.

关键词： Prostate cancer Prolactinoma Buserelin Cabergoline

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Differential mercury volatilization by tobacco organs expressing a modi-fied bacterial merA gene

引用

Cell Research 2001年第3期11卷 231-236页

作者： HE YU KE, JIAN GE SUN, XIAN ZHONG FENG, mihaly CZAKU, LASZLO MARTON Depariment of Biological Sciences, University of South Carolina, 700 Sumter Street, Columbia, SC29208, USA National Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Phy 2National Laboratory of Plant Molecular Genetics Shanghai Institute of Plant Physiology and Ecology Chinese Academy of Sciences 300 Fenglin Road Shanghai 200032 China. 1Department of Biological Sciences University of South Carolina 700 Sumter Street Columbia SC29208 USA. 2National Laboratory of Plant Molecular Genetics Shanghai Institute of Plant Physiology and Ecology Chinese Academy of Sciences 300 Fenglin Road Shanghai 200032 China. 1Department of Biological Sciences University of South Carolina 700 Sumter Street Columbia SC29208 USA. 1Department of Biological Sciences University of South Carolina 700 Sumter Street Columbia SC29208 USA.

Mercury pollution is a major environmental problem accompanying industrial activities. Most of the mercury released ends up and retained in the soil as complexes of the toxic ionic mercury (Hg2+), which then can be converted by microbes into the even more toxic methylmercury which tends to bioaccumulate. Mercury detoxification of the soil can also occur by microbes converting the ionic mercury into the least toxic metallic mercury (Hg0) form, which then evaporates. The remediation potentia1 of transgenic plants carrying the MerA gene from E. coLi encoding mercuric ion reductase could be evaluated. A modified version of the gene, optimized for plant codon preferences (merApe9, Rugh et al. 1996), was introduced into tobacco by Agrobacterium-mediated leaf disk transformation. Transgenic seeds were resistant to HgCl2 at 50 μM and some of them (10-20% ) could germinate on media containing as much as 350 μM HgCl2, while the control plants were fully inhibited or died on 50 μM HgCl2. The rate of elemental mercury evolution from Hg2+ (added as HgCl2) was 5-8 times higher for transgenic plants than the control. Mercury volatilization by isolated organs standardized for fresh weight was higher (up to 5 times) in the roots than in shoots or the leaves. The data suggest that it is the root system of the transgenic plants that volatilizes most of the reduced mercury (Hg0). It also suggests that much of the mercury need not enter the vascular system to be transported to the leaves for volatilization. Thansgenic plants with the merApe9 gene may be used to mercury detoxification for environmental improvement in mercury-- contaminated regions more efficiently than it had been predicted based on data on volatilization of whole plants via the upper parts only (Rugh et al. 1996).

关键词： Environment heavy metals mercury remediation tobacco.

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

湖北恩施地区富硒植物中硒的形态研究

引用

吉林大学学报(地球科学版) 2015年第S1期 457-458页

作者：邵树勋 mihaly Dernovics 邓国栋米秀博龙胜桥中国科学院地球化学研究所矿床地球化学国家重点实验室 Department of Applied Chemistry Corvinus University of Budapest 贵州大学生命科学学院中国科学院大学地球科学学院中国科学院广州地球化学研究所

硒是人和动物所必需的微量元素,在人体内充当多种含硒酶,如作为谷胱甘肽过氧化酶的重要组分,保护细胞膜免受氧自由基氧化损害的作用,硒缺乏引发了许多严重影响人类健康的克山病、大骨节病、癌症、心血管病等疾病。但世界上大部分地区处... 详细信息

硒是人和动物所必需的微量元素,在人体内充当多种含硒酶,如作为谷胱甘肽过氧化酶的重要组分,保护细胞膜免受氧自由基氧化损害的作用,硒缺乏引发了许多严重影响人类健康的克山病、大骨节病、癌症、心血管病等疾病。但世界上大部分地区处在缺硒环境,我国70%地区缺硒,需要补硒。植物是人们摄取硒的主要来源,富硒植物中富含可开发利用的有机硒,可用于提取开发富硒保健食品、防癌抗癌的药物、超富集硒植物是用于修复硒污染生态环境的最佳材料。我国湖北恩施地区是世界上典型的高硒地球化学背

关键词：富硒食品最佳材料硒污染恩施地区有机硒硒缺乏氧化损害植物资源形态研究含硒酶

来源：

同方期刊数据库评论