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Novel diamond shuttle to deliver flexible neural probe with reduced tissue compression

Microsystems & Nanoengineering 2020年第1期6卷 903-915页

作者： Kyounghwan Na Zachariah J.sperry Jiaao Lu mihaly voros.akos.s.man s.parizi Tim M.Bruns Euisik Yoon John P.seymour Electrical Engineering&Computer science Department University of MichiganAnn ArborMI 48105USA Biomedical Engineering Department University of MichiganAnn ArborMI 48105USA Biointerfaces Institute University of MichiganAnn ArborMI 48105USA The Neuroscience Institute New York UniversityNew YorkNY 10016USA Center for Nanomedicine Institute for Basic Science(IBS)Seoul 03722Korea Graduate Program of Nano Biomedical Engineering(Nano BME) Yonsei-IBS InstituteYonsei UniversitySeoul 03722Korea Vivian L smith Department of Neurosurgery University of Texas Health Science CenterHoustonTX 77030USA Department of Electrical and Computer Engineering Rice UniversityHoustonTX 77005USA

The ability to deliver flexible biosensors through the toughest membranes of the central and peripheral nervous system is an important challenge in neuroscience and neural *** devices implanted through dura mater and thick epineurium would ideally create minimal compression and acute damage as they reach the neurons of *** demonstrate that a three-dimensional diamond shuttle can be easily made with a vertical support to deliver ultra-compliant polymer microelectrodes(4.5-µm thick)through dura mater and thick *** diamond shuttle has 54%less cross-sectional area than an equivalently stiff silicon shuttle,which we simulated will result in a 37%reduction in blood vessel *** also discovered that higher frequency oscillation of the shuttle(200Hz)significantly reduced tissue compression regardless of the insertion speed,while slow speeds also independently reduced tissue *** and recording performance are demonstrated in rat and feline models,but the large design space of these tools are suitable for research in a variety of animal models and nervous system targets.

关键词： sectional neural thick

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Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-segura Aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina silvera-simón manel M.santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

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Asymptotic false discovery control of the Benjamini-Hochberg procedure for pairwise comparisons

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science China Mathematics 2025年第1期 223-252页

作者： Weidong Liu Dennis Leung Qi-man shao school of Mathematical sciences Shanghai Jiao Tong University school of Mathematics and statistics University of Melbourne Department of statistics and Data science SICMSouthern University of Science and Technology

In a one-way analysis-of-variance(ANOVA) model,the number of pairwise comparisons can become large even with a moderate number of *** by this,we consider a regime with a growing number of groups and prove that,when testing pairwise comparisons,the Benjamini-Hochberg(BH) procedure can asymptotically control false discoveries,despite the fact that the involved t-statistics do not exhibit the wellknown positive dependence structure required for exact false discovery rate(FDR) *** Tukey's perspective that the difference between the means of any two groups cannot be exactly zero,our main result provides control over the directional false discovery rate and directional false discovery proportion.A key technical contribution of our work is demonstrating that the dependence among the t-statistics is sufficiently weak to establish the convergence result typically required for asymptotic FDR *** analysis does not rely on conventional assumptions such as normality,variance homogeneity,or a balanced design,thereby offering a theoretical foundation for applications in more general settings.

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searching For(2+1)-dimensional nonlinear Boussinesq equation from(1+1)-dimensional nonlinear Boussinesq equation

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Communications in Theoretical Physics 2023年第7期75卷 58-61页

作者： man Jia s Y Lou school of Physical science and Technology Ningbo UniversityNingbo315211China

A novel(2+1)-dimensional nonlinear Boussinesq equation is derived from a(1+1)-dimensional Boussinesq equation in nonlinear schr?dinger type based on a deformation *** integrability of the obtained(2+1)-dimensional Boussinesq equation is guaranteed by its Lax pair obtained directly from the Lax pair of the(1+1)-dimensional Boussinesq *** of the effects of the deformation,the(2+1)-dimensional Boussinesq equation admits a special travelling wave solution with a shape that can be deformed to be asymmetric and/or multivalued.

关键词： (2+1)-dimensional Boussinesq equation deformation algorithm lax integrable an implicit travelling wave solution

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An Overview on Materials and Techniques in 3D Bioprinting Toward Biomedical Application

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Engineered Regeneration 2021年第1期2卷 1-18页

作者： s.Vanaei M.s.parizi s.Vanaei F.salemizadehparizi H.R.Vanaei GREman INSA Centre Val de LoireBlois 41000France Nano Bioelectronics Devices Lab Cancer Electronics Research GroupSchool of Electrical and Computer EngineeringFaculty of EngineeringUniversity of TehranTehranIran Department of Biomedical Engineering Rochester Institute of TechnologyRochesterNYUnited States Arts et Metiers Institute of Technology CNAMLIFSEHESAM UniversityParisFrance Arts et Metiers Institute of Technology CNRSCNAMPIMMHESAM UniversityParisFrance

Three-dimensional(3D)bioprinting,an additive manufacturing based technique of biomaterials fabrication,is an innovative and auspicious strategy in medical and pharmaceutical *** ability of producing regenerative tissues and organs has made this technology a pioneer to the creation of artificial multi-cellular tissues/organs.A broad variety of biomaterials is currently being utilized in 3D bioprinting as well as multiple techniques employed by *** this review,we demonstrate the most common and novel biomaterials in 3D bioprinting technology further with introducing the related techniques that are commonly taking into account by *** addition,an attempt has been accomplished to hand over the most relevant application of 3D bioprinting techniques such as tissue regeneration,cancer investigations,*** presenting the most important *** main aim of this review paper is to emphasis on strengths and limitations of existence biomaterials and 3D bioprinting techniques in order to carry out a comparison through them.

关键词： 3D bioprinting Biology Biomaterial Bioinks Tissue engineering Organ regeneration

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Plant Communities and Factors Responsible for Vegetation Pattern in an Alpine Area of the Northwestern Himalaya

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Journal of Mountain science 2011年第6期8卷 817-826页

作者： man s.RANA s.s.sAmanT Y.s.RAWAT Department of Plant science Government Degree College G.B.Pant Institute of Himalayan Environment & Development Department of Botany D.S.B.CampusKumaun University

The study intended to describe the alpine vegetation of a protected area of the northwestern Himalaya and identify the important environmental variables responsible for species *** placed random plots covering different habitats and altitude to record species composition and environmental *** was classified using hierarchical cluster analysis and vegetation-environment relationships were evaluated with Canonical Correspondence *** communities,each in alpine shrub and meadows were delineated and well justified in the ordination *** species for the different communities were *** species richness and diversity were found in community IV among shrub communities and community II among the *** environmental variables explained 61.5% variation in shrub vegetation and 59.8% variation in *** variables explained higher variability (～35%) than spatial variables (～21%) in both shrubs and ***,among the spatial variables and carbon/nitrogen ratio and nitrogen among the soil variables explained maximum *** 40% variations left *** and species diversity among the other variables had significant correlation with ordination *** showed that altitude and C/N ratio played a significant role in species *** sampling efforts and inclusion of other non-studied variables are also suggested for better understanding.

关键词： species diversity Indicator species Environmental variable Ordination Explainedvariation

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Extraction,Utilization Pattern and Prioritization of Fuel Resources for Conservation in manali Wildlife sanctuary,Northwestern Himalaya

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Journal of Mountain science 2012年第4期9卷 580-588页

作者： man s.RANA sakshi B.RANA s.s.sAmanT Department of Plant sciences Government CollegeBanjar-Kullu175123Himachal PradeshIndia Department of Plant sciences Government CollegeKullu175101Himachal PradeshIndia G.B.Pant Institute of Himalayan Environment&Development Himachal UnitMohal-Kullu175126Himachal PradeshIndia

Fuelwood is the main source of the energy in mountainous ***,annual wood consumption is very *** on fuelwood resources,and their extraction and availability is very ***,present study was carried out to study the diversity of fuelwood species,annual collection,preference and availability of fuel species in the *** four species(25 trees and 9 shrubs) were extracted for fuel by the *** collection and species preference was highest for Picea smithiana,Cedrus deodara,Indigofera heterantha,Pinus wallchiana and sorbaria tomentosa,*** use index indicating use pressure was highest for ***,***,*** and Abies pindrow,*** native species,some non-native horticultural and agroforestry species such as Malus pumila,***,Celtis australis,*** also being used as *** species showed their availability in eight forest types whereas,population and regeneration status was ***,immediate actions are suggested to sustain current and future demand of *** afforestation of degraded,uncultivated and marginal lands through high quality and preferred fuel species might reduce pressure on wild and selective species.

关键词： Fuelwood Resource Use Index Communities Conservation

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Diversity,Distribution and Prioritization of Fodder species for Conservation in Kullu District,Northwestern Himalaya,India

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Journal of Mountain science 2007年第3期4卷 259-274页

作者： s. s. samant man singh manohar Lal shreekar Pant G.B.Pant Institute of Himalayan Environment & Development Himachal UnitMohal-Kullu175 126Himachal PradeshIndia

In the Indian Himalayan Region predominantly rural in character, livestock is one of the main sources of livelihood and integral part of the economy. Livestock mostly rely on fodder from wild. The diversity, distribution, utilization pattern, nativity, endemism, rarity, seasonality of availability, nutritive values, perceived economic values and pressure use index of livestock have not been studied. The present study attempts to enumerate 150 species of fodder representing trees (51 spp.), shrubs (54 spp.) and herbs (45 spp.). Poaceae (19 spp.) and Fabaceae (13 spp.) amongst families and salix (6 spp.), Ficus, Clematis, and Desmodium (5 spp., each) amongst genera are rich in species. Maximum species were found in the 1801 ~ 2600 m zone, and the remaining two zones showed relatively low diversity. Out of the 150 species, 109 are used in summer, 5 winter and 36 throughout year. During rainy season, mostly grasses are used as fodder. Only 83 species are native to the Himalayan region, one species, strobilanthus atropuroureus is endemic and 35 species are near endemic. The nutritive values of the fodder species were reviewed, and economic values and status of the species were also assessed. The pressure use index of the species was calculated on the basis of cumulative values of the utilization pattern, altitudinal distribution, availability, status, nativity and endemism. Amongst the species, Grewia oppositifoilia, Morus serrata, Indigofera heterantha, Quercus leucotrichphora, Ulmus villosa, U. wallichiana and Aesculus indica showed highest PUI indicating high preference and pressure. season wise prioritization of the species for different altitudinal zones has been done. Appropriate strategy and action plan have been suggested for the conservation and management of fodder species.

关键词： Diversity utilization native endemic nutritive and economic value pressure use index prioritization conservation Indian Himalayan Region

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BlockHDFs:Blockchain-integrated Hadoop distributed file system for secure provenance traceability

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Blockchain(Research and Applications) 2021年第4期2卷 30-36页

作者： Viraaji Mothukuri sai s.Cheerla Reza M.parizi Qi Zhang Kim-Kwang Raymond Choo College of Computing and software Engineering Kennesaw State UniversityKennesawGA30144USA IBM Thomas J.Research Center Yorktown HeightsNY10598USA Department of Information systems and Cyber security University of Texas at San AntonioSan AntonioTX78249USA

Hadoop Distributed File system(HDFs)is one of the widely used distributed file systems in big data analysis for frameworks such as *** allows one to manage large volumes of data using low-cost commodity ***,vulnerabilities in HDFs can be exploited for nefarious *** reinforces the importance of ensuring robust security to facilitate file sharing in Hadoop as well as having a trusted mechanism to check the authenticity of shared *** is the focus of this paper,where we aim to improve the security of HDFs using a blockchain-enabled approach(hereafter referred to as BlockHDFs).specifically,the proposed BlockHDFs uses the enterprise-level Hyperledger Fabric platform to capitalize on files'metadata for building trusted data security and traceability in HDFs.

关键词： Big data Hadoop Blockchain Hyperledger fabric Hadoop distributed file system(HDFs) Traceability security Privacy

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Relativistic atomic data for W XLVⅡ

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Chinese Physics B 2015年第5期24卷 305-312页

作者： sunny Aggarwal A.K.s.Jha Indu Khatri Narendra singh man Mohan Department of Physics and Astrophysics University of Delhi Department of Physics Shyamlal College University of Delhi

Energy levels, radiative rates, and lifetimes are calculated for all levels of 3s23p, 3s23d, 3s3p2, 3s3d2, 3s3p3d, 3p23d, 3s3d2, 3p3d2, 3p3, and 3d3 configurations of Al-like tungsten ion （W XLVII）. Multiconfigurational Dirac-Fock （MCDF） method is adopted for calculating energy levels and radiative rates. Oscillator strengths, radiative rates, and line strengths are reported for some E1 transitions from the ground level. Comparisons are made with the available data in the literature and good agreement has been found which confirms the reliability of our results.

关键词： atomic data multiconfigurational Dirac-Fock method transition probability

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