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Cross-Sectional Survey on Complementary and Alternative Medicine Awareness among Health Care Professionals and Students Using CHBQ Questionnaire in a Balkan Country

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Chinese Journal of Integrative Medicine 2013年第9期19卷 650-655页

作者： mihajlo B jakovljevic Vera Djordjevic Veroljub Markovic Olivera Milovanovic Nemanja K Rancic Snezana M Cupara Department of Pharmacology and Toxicology The Faculty of Medical Sciences University of Kragujevac Graduate School of Economics Hosei University Su Djok Balkan Su Jok Therapy Center Department of Pharmacy The Faculty of Medical Sciences University of Kragujevac Centre for Clinical Pharmacology Medical FacultyMilitary Medical AcademyUniversity of Defence

Objective： To conduct a study on attitudes, knowledge, and use of complementary and altemative medicine （CAM） therapies in Serbia. Available data about CAM therapies in the region are scarce, opinions lacking from health sector. Balkan region countries had a delay in issuing national policies on CAM therapies. Methods： The questionnaire used was based on previously validated CAM Health Belief Questionnaire （CHBQ）, formulated as 5-item Likert type scale, adjusted for local environment. Health care students and professionals were evaluated. The questionnaire comprehended 10 closed questions on attitudes, knowledge and use of CAM therapies. This survey was conducted in eight cities of Serbia, January 2010-July 2011. A total of 797 participants was included. The second group of participants was 145 healthcare professionals （50 academic staff, 64 clinical staff, 19 pharmacists, 6 other clinical branch specialists and 6 nurses）. Data were collected by an interview. Examinees could acquire maximum of 70 points, 35 representing neutral attitude. Restdts： Students of dentistry （54.65 ± 6.07） were better informed on CAM therapies than medicine students （50.26 ± 7.92）. Pharmacy students （51.16 ± 7.10） accepted low-scientific CAM. Pharmacists scored better than university professors （55.12±6.55 vs. 50.29± 9.50）. Primary health care professionals had better awareness than pharmacists in dispensing pharmacies. Both groups of participants preferred use of vitamins over any other CAM therapy. Conclusion： These pioneering efforts in the region exposed weaknesses in CAM attitudes of current and future health care professionals. Nevertheless, awareness on alternative medicine treatment choices is growing among Balkan prescribers. Supportive legal framework would facilitate dissemination of CAM medical practices.

关键词： survey complementary and alternative medicine health care students health care professionals,complementary and alternative medicine health belief questionnaire

Economic impact of traditional medicine practice worldwide

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Traditional Medicine Research 2017年第2期2卷 60-74页

作者： Ana V.Pejcic mihajlo(Michael)B.jakovljevic Faculty of Medical Sciences University of KragujevacKragujevacSerbia Health Economics and Pharmacoeconomics Faculty of Medical SciencesUniversity of KragujevacKragujevacSerbia.

The aim of this literature review was to summarize available findings from publications that reported expenditure on traditional/complementary and alternative medicine(TM/CAM)within a representative general population sample of a nation or a defined geographical area.A total of 24 publications met the inclusion criteria and were included in the *** expenditure on TM/CAM varies worldwide,but direct comparison of the findings of publications included in this review is limited due to the differences in the definitions of TM/CAM,inclusion of various forms of TM/CAM,use of different names and categorization,as well as differences in reported currencies and time periods in which data were *** about the expenditure on TM/CAM in most countries throughout the world are *** national studies should be conducted in order to provide up-to-date assessment of the TM/CAM related expenditure patterns and *** nomenclature,definition of TM/CAM and standardized instruments would provide basis for comparability of data of studies conducted in various regions and time periods.

关键词： Traditional medicine Complementary and alternative medicine Expenditure Economic impact

Association between innate immunity gene polymorphisms and neonatal sepsis development:a systematic review and meta-analysis

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World Journal of Pediatrics 2022年第10期18卷 654-670页

作者： Tamara Sljivancanin jakovljevic Jelena Martic Jelena Jacimovic Nadja Nikolic Jelena Milasin Tanja Lazić Mitrović Department of Neonatology The Obstetrics and Gynecology Clinic“Narodni Front”BelgradeSerbia School of Medicine University of BelgradeBelgradeSerbia Department of Neonatology Mother and Child Health Care Institute of Serbia“Dr Vukan Cupic”BelgradeSerbia Central Library School of Dental MedicineUniversity of BelgradeBelgradeSerbia Department of Human Genetics School of Dental MedicineUniversity of BelgradeBelgradeSerbia

Background The aim of this meta-analysis was to analyze all available data from studies investigating associations between polymorphisms in genes responsible for innate immunity and neonatal sepsis *** A comprehensive literature search,reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-S guidelines,was performed with no language *** derived using the PICO(population,intervention,comparison and outcomes)strategy,with data on the genotype distribution for innate immunity gene polymorphisms in newborns with and without *** were analyzed using Review *** Cochran–Mantel–Haenszel test was used to calculate odds ratios with 95%confidence *** was tested using the I2 *** From a total of 9428 possibly relevant articles,33 qualified for inclusion in this systematic *** to the STrengthening the REporting of Genetic Association Studies,23 studies were found to be of moderate quality,while 10 were of low *** results showed an association of the mannose-binding lectin(MBL)exon 1 genetic polymorphism with the risk of culture-proven ***-like receptor(TLR)4 rs4986791 genotype distribution suggests its association with the increased risk of culture-proven *** certainty of evidence per GRADE(Grading of Recommendations,Assessment,Development,and Evaluation)varied from very low to *** bias was not *** Out of the 11 investigated single-nucleotide polymorphisms,this meta-analysis found a possible association between the risk for culture-proven sepsis and MBL exon 1 and TLR4 rs4986791 *** is an evident need for larger well-designed,multicentric observational studies investigating inflammatory gene polymorphisms in neonatal sepsis.

关键词： Genetic Immunity Innate Neonatal sepsis Polymorphism

Preparatory training attenuates drastic response of the insulin-like growth factor binding protein 1 at the point of maximal oxygen consumption in handball players

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Journal of Sport and Health Science 2017年第3期6卷 372-377页

作者： Olgica Nedic Milos Sunderic Goran Miljus Zoran Valdevit Vladimir jakovljevic Marija Glibetic Vesna Vucic Institute for the Application of Nuclear Energy University of BelgradeBelgrade 11080Serbia Faculty of Sport and Physical Education University of BelgradeBelgrade 11000Serbia Department of Physiology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Centre of Research Excellence in Nutrition and Metabolism Institute for Medical ResearchUniversity of BelgradeBelgrade 11000Serbia

Background:Intensive exercise changes physiological need for glucose and several biochemical pathways responsible for its metabolism *** them are those which involve insulin,insulin-like growth factor(IGF-1),and IGF-binding proteins(IGFBPs).Different types and degrees of exercise,as well as an athlete's fitness,may induce a range of responses regarding concentrations and time needed for the *** idea of the work was to find out whether and how insulin/IGF axis responds to additional physical activity in the already trained subjects and if so,is the adaptation potentially beneficial from the aspect of metabolic ***:The effect of 4-week intensive training on campus(preparatory training) on the levels of insulin,IGF-1,and IGFBPs during maximal progressive exercise test(MPET) on a treadmill was compared to the results obtained during MPET conducted after a regular training season of a female elite handball team(n = 17,age:17 ± 1 years,height:171 ± 8 cm,weight:65 ± 8 kg,body mass index:22 ± 1 kg/m^2 at the beginning of the study;there were no significant changes at the end).Serum samples were obtained from players immediately before the test(basal),at the end of the test after reaching the point of maximal oxygen consumption(VO_(2max)),and after ***:The concentration of insulin decreased at VO_(2max),but remained higher in players after preparatory training(12.2 ± 2.5 m U/L vs.8.9 ± 4.4 m U/L,p = 0.049).The level of IGFBP-1 decreased in players at VO_(2max) in either case of training,but it remained much higher in tests performed after the preparatory regime than before(p = 0.029).Concentrations of IGF-1,IGFBP-2,-3,and-4 did not change ***:The inverse relation between insulin and IGFBP-1 was lost during MPET,as these 2 molecules changed in the same *** results obtained suggest less severe stress-induced depression of insulin and IGFBP-1 after preparatory *** another metabolic mechanism

关键词： Female IGF-binding proteins(IGFBPs) Insulin Insulin-like growth factor I(IGF-1) Progressive exercise test VO_(2max)

Mushroomβ-glucan and polyphenol formulations as natural immunity boosters and balancers:nature of the application

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Food Science and Human Wellness 2023年第2期12卷 378-396页

作者： Maja Kozarski Anita Klaus Leo van Griensven Dragica jakovljevic Nina Todorovic Wan Abd Al Qadr Imad Wan-Mohtar Jovana Vunduk Institute of Food Technology and Biochemistry Faculty of AgricultureUniversity of BelgradeBelgrade 11080Serbia Plant Research International Wageningen University and Research CentreWageningen 6700 AAThe Netherlands Institute of Chemistry Technology and MetallurgyUniversity of BelgradeBelgrade 11000Serbia Functional Omics and Bioprocess Development Laboratory Institute of Biological SciencesFaculty of ScienceUniversiti MalayaKuala Lumpur 50603Malaysia Institute of General and Physical Chemistry University of BelgradeBelgrade 11158Serbia

Mushrooms are experiencing a kind of renaissance as a part of the contemporary human *** valuable organisms are more than food,they fit in perfectly as a novel market group known as ***-balancing mushroom dietary fibers and secondary metabolites such as polyphenols are the main focus of the healthcare *** and cosmetic companies are increasingly using mushroom extracts rich in these *** review considers the basic molecular immunomodulatory mechanisms of action of the most commonly used mushroom dietary fibers,β-*** literature data on their bioavailability,metabolic transformations,preclinical and human clinical research,and safety are *** mechanisms of polyphenol ingredients are also *** molecules present great potential in the design of the new immunity balancer formulations according to their widespread structural ***,we draw attention to the perspectives of modern trends in mushroom nutraceutical and cosmeceutical formulations to strengthen and balance immunity.

关键词： Mushrooms β-Glucan Polyphenols Immunity boosters Superfood Natural cosmetics

Shaped Co^(2+) doped TiO_(2) nanocrystals synthesized from nanotubular precursor: Structure and ferromagnetic behavior

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Journal of Advanced Ceramics 2017年第3期6卷 220-229页

作者： M.VRANJES J.KULJANIN jakovljevic Z.KONSTANTINOVIC A.POMAR M.STOILJKOVIC M.MITRIC T.RADETIC Z.SAPONJIC Vinca Institute of Nuclear Sciences University of BelgradeP.O.Box 52211001 BelgradeSerbia Center for Solid State Physics and New Materials Institute of Physics BelgradeUniversity of BelgradePregrevica 11811080 BelgradeSerbia Institut de Ciència de Materials de Barcelona CSICCampus UAB08193 BellaterraSpain Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia

Co2+ doped TiO2 nanocrystals were synthetized by a hydrothermal treatment procedure applied to precursor dispersion of titania nanotubes and Co2+ ions. Mixture of polygonal and prolate spheroid-like nanocrystals was obtained. The results of X-ray diffraction (XRD) analysis showed that resulted nanocrystals retain anatase crystal phase for both dopant concentrations (1.69 and 2.5 at%), but the crystal lattice parameters were affected. Reflection spectra revealed altered optical properties compared to bare TiO2. Room temperature ferromagnetic ordering with saturation magnetic moment in the range of 0.001–0.002 μB /Co was observed for both measured films made of Co2+ doped TiO2 nanocrystals.

关键词： hydrothermal synthesis X-ray diffraction(XRD) transmission electron microscopy(TEM) doped TiO_(2) magnetic properties

Nitric oxide and tumour necrosis factor alpha in the process of pseudoexfoliation glaucoma

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International Journal of Ophthalmology(English edition) 2016年第8期9卷 1138-1142页

作者： Tatjana S.Sarenac Vulovic Sladjana M.Pavlovic Vladimir LJ.jakovljevic Katarina B.Janicijevic Nemanja S.Zdravkovic Department of Ophthalmology Clinical Center Kragujevac Center for Molecular Medicine and Stem Cell Research Faculty of Medical Sciences University of Kragujevac Department of Physiology Faculty of Medical SciencesUniversity of Kragujevac Faculty of Medical Sciences University of Kragujevac

AIMTo establish the role of nitric oxide (NO), ascorbic acid and tumour necrosis factor-α (TNF-α) in the pathogenesis of pseudoexfoliation glaucoma (XFG).METHODSOur study included 120 patients who were referred for cataract surgery. All patients were divided into four groups according to clinical findings: XFG, early and late pseudoexfoliation syndrome (XFS), and cataract (without pseudoexfoliation). Serum and aqueous humour levels of the ascorbic acid, NO and TNF-α were measured. The concentrations of the ascorbic acid and NO were measured by an appropriate spectrophotometric method. Enzyme-linked immunosorbent assay (ELISA) was used to determine TNF-α *** humour concentration of ascorbic acid was significantly lower in patients with late XFS (0.61±0.11 mmol/L) and XFG (0.48±0.15 mmol/L) compared to patients with early XFS (0.9±0.15 mmol/L) and cataract (1.16±0.22 mmol/L), while there was no difference in serum concentration in all examined groups. Aqueous humour concentration of NO was significantly higher in patients with XFG (77.7±11.4 µmol/L) compared to patients with early XFS (50.27±9.34 µmol/L) and cataract (49.77±7.1 µmol/L), while serum concentration was increased in the early stage of XFS (73.26±8.29 µmol/L). Aqueous humour level of proinflammatory cytokine TNF-α was increased in patients with XFS (early 460.04±18.32 pg/mL; late 502.42±53.23 pg/mL) and XFG (510.34±43.07 pg/mL), while there was no difference in serum level in all examined groups of *** ascorbic acid and elevated NO and inflammation related cytokine TNF-α level in aqueous humour of the patients with developed XFG suggest that oxidative stress induces local inflammation.

关键词： ascorbic acid nitric oxide pseudoexfoliation tumour necrosis factor alpha

Influence of detergent on metabolic activity of fungi Aspergillus niger

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Natural Science 2011年第6期3卷 466-470页

作者： Jelica Stojanovic Violeta jakovljevic Ivana Matovic Olgica Gajovic Zoran Mijuskovic Tomislav Nedeljkovic Faculty of Science University of KragujevacKragujevacSerbia Medical Faculty University of KragujevacKragujevacSerbia Military Medical Academy BelgradeSerbia

The aim of this study was to find out, among grate variety of fungi species from wastewater these which are resistant to effects of detergent and its component, ethoxyl-oleyl-cetyl alcohol and sodium tripolyphosphate. On inoculated fungi specie grown in vitro condition, in the presence of mentioned pollutant, the metabolic changes of bioproduction of different organic compounds, in various aging step of fungi, have been investigated. The results indicated sig-nificant changes in bioproduction of amino ac-ids and proteins of Aspergillus niger cultivated in the presence of detergent and its component, compared with control experiment. The results suggest that bioremediation by Aspergillus ni-ger are promising for biodegradation of deter-gents in aquatic systems.

关键词： Aspergillus Niger Detergent Bioproduction Wastewater Biodegradation

Nitroglycerine effects on portal vein mechanics and oxidative stress in portal hypertension

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World Journal of Gastroenterology 2012年第4期18卷 331-339页

作者： Andreja Vujanac Vladimir jakovljevic Dusica Djordjevic Vladimir Zivkovic Mirjana Stojkovic Dragan Celikovic Nebojsa Andjelkovic Aleksandra Jurisic Skevin Dragan Djuric Department of Physiology Faculty of MedicineUniversity of Kragujevac Department of Gastroenterology and Echosonography Unit Clinical Centre of Belgrade Internal Clinic Clinical Centre "Kragujevac"Faculty of MedicineUniversity of Kragujevac Department of Physical Medicine and Rehabilitation Faculty of MedicineUniversity of Kragujevac Institute of Medical Physiology Belgrade University School of Medicine

AIM:Тo examine the effects of nitroglycerine on portal vein haemodynamics and oxidative stress in patients with portal ***:Thirty healthy controls and 39 patients with clinically verified portal hypertension and increasedvascular resistance participated in the *** di-ameters,portal diameters and portal flow velocities were recorded using color flow imaging/pulsed Doppler ***-section area,portal flow and index of vascular resistance were *** collected blood samples,superoxide anion radical (O 2-),hydrogen per-oxide (H 2 O 2),index of lipid peroxidation (measured as TBARS) and nitric oxide (NO) as a marker of endothelial response (measured as nitrite-NO 2-) were ***-dependent analysis was performed at basal state and in 10th and 15th min after nitroglycerine (sublingual 0.5 mg) ***:Oxidative stress parameters changed sig-nificantly during the study.H 2 O 2 decreased at the end of study,probably via O 2-mediated disassembling in Haber Weiss and Fenton reaction;O 2-increased signifi-cantly probably due to increased diameter and tension and decreased shear rate *** O 2-and H 2 O 2 degradation products,like hydroxyl radical,initi-ated lipid *** blood flow was to some extent lower in patients than in controls due to double paradoxes,flow velocity decreased,shear rate decreased significantly indicating non Newtonian char-acteristics of portal blood ***:This pilot study could be a starting point for further investigation and possible implemen-tation of some antioxidants in the treatment of portal hypertension.

关键词： Portal hypertension Endothelium Nitroglycerine Oxidative stress Portal vein haemodynamics