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Oxaliplatin-induced neuropathy and colo-rectal cancer patient's quality of life:Practical lessons from a prospective cross-sectional,real-world study

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World Journal of Clinical Cases 2022年第10期10卷 3101-3112页

作者： Iulian Prutianu Teodora Alexa-Stratulat Elena Octaviana Cristea Andrei Nicolau Diana Cornelia Moisuc Alina Alexandra Covrig Karina Ivanov Adina Emilia Croitoru Monica Ionela Miron Mihaela Ioana Dinu Anca Viorica Ivanov mihai vasile marinca Iulian Radu Bogdan Gafton SC MNT Healthcare Europe SRL Iasi 700021Romania University of Medicine and Pharmacy Grigore T Popa Iasi Iasi 700483Romania Regional Oncology Institute Iasi Iasi 700483Romania Oral and Maxillo-facial Surgery University of Medicine and Pharmacy Grigore T Popa IasiIasi 700021Romania Department of Medical Oncology Fundeni Clinical InstituteBucuresti 022328Romania University of Medicine and Pharmacy“Grigore T Popa” Iasi 700021Romania Department of Surgery Department of Surgical OncologyUniversity of Medicine and Pharmacy“Grigore T Popa”Regional Institute of OncologyIasi 700021Romania

BACKGROUND Colon cancer is one the most common forms of cancer in both *** to important progress in the field of early detection and effective treatment,colon and rectal cancer survivors currently account for 10%of cancer survivors ***,the effects of anti-cancer treatments,especially oxaliplatinbased chemotherapy,on the quality of life(QoL)have been less *** the incidence of severe chemotherapy-induced neuropathy(CIPN)in clinical studies is below 20%,data from real-world studies is scarce,and CIPN is probably under-reported due to patient selection and the patients’fear that reporting side-effects might lead to treatment *** To determine the impact of CIPN on QoL in colorectal cancer patients with a recent history of oxaliplatin-based *** We performed a prospective cross-sectional study in two major Romanian oncology tertiary hospitals—the Regional Institute of Oncology Ia?i(Iasi,Romania)and the Fundeni Clinical Oncology Institute(Bucharest,Romania).All consecutive patients with colon or rectal cancer,undergoing Oxaliplatin-based chemotherapy that consented to enroll in the study,were assessed by means of two questionnaires—the EORTC QQ-CR29(quality of life in colon and rectal cancer patients)and the QLQ-CIPN20(assessment of neuropathy).Several demographical,social,clinical and treatment data were also *** analysis was performed by means of SPSS *** student t test was used to assess the relationship between the QLQ-CIPN20 and QLQ-CR29 *** Meyer-curves were used to report 3-year progression-free survival(PFS)in patients that discontinued chemotherapy vs those that completed the recommended *** Of the 267 patients that fulfilled the inclusion criteria in the pre-specified time frame,101(37.8%)agreed to participate in the clinical *** the time of the enrolment in the study,over 50%of the patients had recently interrupted their oxaliplatin-based chemotherapy,mo

关键词： Colorectal cancer Oxaliplatin Neuropathy Quality of Life Recurrence-free survival Cross-sectional study

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Celiac disease and Sjögren’s syndrome:A case report and review of literature

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World Journal of Clinical Cases 2020年第18期8卷 4151-4161页

作者： Daniel vasile Balaban Ancuta mihai Alina Dima Alina Popp Mariana Jinga Ciprian Jurcut Internal Medicine and Gastroenterology Carol Davila University of Medicine and PharmacyDr.Carol Davila Central Military Emergency University HospitalBucharest 020021Romania Internal Medicine Dr.Carol Davila Central Military Emergency University HospitalBucharest 010825Romania Pediatrics Carol Davila University of Medicine and PharmacyCarol Davila University of Medicine and PharmacyBucharest 020021Romania Alfred Rusescu Institute for Mother and Child Care Bucharest 020021Romania Tampere Center for Child Health Research University of Tampere and Tampere University HospitalBucharest 020021Romania

BACKGROUND Celiac disease(CD)is a systemic,chronic immune-mediated disease triggered by gluten ingestion in genetically-susceptible individuals,with a prevalence of 1%***'s syndrome(SS)is also a systemic autoimmune disease,mainly characterized by ocular and oral sicca symptoms and *** a common genetic background,CD and SS are known associated autoimmune diseases,but currently available guidelines are not reporting *** SUMMARY We report the case of a 39-year-old woman,who was in the care of her rheumatologist for 2 years with *** routine follow-up she was found to have iron deficiency,without *** had no gastrointestinal complaints and denied any obvious source of blood *** tissue transglutaminase antibodies were positive and endoscopy with duodenal biopsies revealed crypt hyperplasia and villous atrophy.A diagnosis of CD was set and gluten-free diet was *** We present a review of existing data in the literature regarding the association of the two diseases,summarizing prevalence studies of CD in SS patients and the other way *** recommendations and future research perspectives are also discussed,highlighting clinically relevant unanswered questions with respect to the association of CD with SS.

关键词： Celiac disease Sjögren syndrome Prevalence Autoimmunity Screening Antibodies Case report

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Dysregulation of genes involved in the long-chain fatty acid transport in pancreatic ductal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 199-206页

作者： Radu Cristian Poenaru Elena Milanesi Andrei Marian Niculae Anastasia-Maria Dobre Catalina Vladut mihai Ciocîrlan Daniel vasile Balaban Vlad Herlea Maria Dobre mihail Eugen Hinescu Faculty of Medicine Carol Davila University of Medicine and PharmacyBucharest 050474Romania Department of Radiobiology Victor Babes National Institute of PathologyBucharest 050096Romania Department of Pathology Victor Babes National Institute of PathologyBucharest 050096Romania Department of Gastroenterology Prof.Dr.Agrippa Ionescu Clinical Emergency HospitalBucharest 011356Romania Department of Pathology Fundeni Clinical InstituteBucharest 022258Romania

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is an aggressive lethal malignancy with limited options for treatment and a 5-year survival rate of 11%in the United *** for other types of tumors,such as colorectal cancer,aberrant de novo lipid synthesis and reprogrammed lipid metabolism have been suggested to be associated with PDAC development and *** To identify the possible involvement of lipid metabolism in PDAC by analyzing in tumoral and non-tumoral tissues the expression level of the most relevant genes involved in the long-chain fatty acid(FA)import into *** A gene expression analysis of FASN,CD36,SLC27A1,SLC27A2,SLC27A3,SLC27A4,SLC27A5,ACSL1,and ACSL3 was performed by qRT-PCR in 24 tumoral PDAC tissues and 11 samples from non-tumoral pancreatic tissues obtained via fine needle aspiration or via surgical *** genes were considered significantly dysregulated between the groups when the p value was<0.05 and the fold change(FC)was≤0.5 and≥*** We found that three FA transporters and two long-chain acyl-CoA synthetases genes were significantly upregulated in the PDAC tissue compared to the non-tumoral tissue:SLC27A2(FC=5.66;P=0.033),SLC27A3(FC=2.68;P=0.040),SLC27A4(FC=3.13;P=0.033),ACSL1(FC=4.10;P<0.001),and ACSL3(FC=2.67;P=0.012).We further investigated any possible association between the levels of the analyzed mRNAs and the specific characteristics of the tumors,including the anatomic location,the lymph node involvement,and the presence of metastasis.A significant difference in the expression of SLC27A3(FC=3.28;P=0.040)was found comparing patients with and without lymph nodes involvement with an overexpression of this transcript in 17 patients presenting tumoral cells in the lymph *** Despite the low number of patients analyzed,these preliminary results seem to be *** lipid metabolism through a broad strategy could be a beneficial way to treat this *** in vitro and in vivo s

关键词： Carcinoma Pancreatic ductal Fatty acid transport Gene expression Biomarkers

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Emerging role of the gut microbiome in post-infectious irritable bowel syndrome:A literature review

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World Journal of Gastroenterology 2023年第21期29卷 3241-3256页

作者： vasile Valeriu Lupu Cristina Mihaela Ghiciuc Gabriela Stefanescu Cristina Maria mihai Alina Popp Maria Oana Sasaran Laura Bozomitu Iuliana Magdalena Starcea Anca Adam Raileanu Ancuta Lupu Faculty of General Medicine “Grigore T.Popa”University of Medicine and PharmacyIasi 700115Romania Faculty of General Medicine Ovidius UniversityConstanta 900470Romania Faculty of General Medicine “Carol Davila”University of Medicine and PharmacyBucharest 020021Romania Faculty of General Medicine “George Emil Palade”University of MedicinePharmacyScience and TechnologyTargu Mures 540142Romania

Post-infectious irritable bowel syndrome(PI-IBS)is a particular type of IBS,with symptom onset after an acute episode of infectious *** infectious disease resolution and clearance of the inciting pathogen agent,10%of patients will develop *** susceptible individuals,the exposure to pathogenic organisms leads to a marked shift in the gut microbiota with prolonged changes in host-microbiota *** changes can affect the gut-brain axis and the visceral sensitivity,disrupting the intestinal barrier,altering neuromuscular function,triggering persistent low inflammation,and sustaining the onset of IBS *** is no specific treatment strategy for *** drug classes can be used to treat PI-IBS similar to patients with IBS in general,guided by their clinical *** review summarizes the current evidence for microbial dysbiosis in PI-IBS and analyzes the available data regarding the role of the microbiome in mediating the central and peripheral dysfunctions that lead to IBS *** also discusses the current state of evidence on therapies targeting the microbiome in the management of *** results of microbial modulation strategies used in relieving IBS symptomatology are *** studies on PI-IBS animal models reported promising ***,published data that describe the efficacy and safety of microbial targeted therapy in PI-IBS patients are *** research is required.

关键词： Gut microbiome Infectious gastroenteritis Irritable bowel syndrome Post infection syndrome Pathophysiology Inflammation

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The Influence of the ＂Terroir＂ Concerning the Quantity and Quality of Grapes Yield at White Grapevine Varieties Growing in the lasi Vineyard

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Journal of Life Sciences 2011年第8期5卷 646-653页

作者： Liliana Rotaru vasile Stoleru Feodor Filipov mihai Mustea Gabriela Petrea University of Agricultural Sciences and Veterinary Medicine of lasi Alee M. Sadoveanu No. 3 Iasi 700490 Romania

Abstract： Romania is famous of the potential of his vineyard, winemaking is a traditional occupation, in fact it can be said that there are many areas that can provide a vineyard product. Moreover, typicity and authenticity of a wine are defining conditions under conditions of fierce intemational competition to guarantee success of wine. There were concerns for determining areas with designation of origin from a vineyard that will produce quality wines, but the purpose of this study is to delimit the level of a vineyard small area that can ensure the achievement of a certain type of wine, a quality required by consumers. The research was made during 2006-2008 and revealed that the production of quality grapes and are influenced by different factors such as genetic, environmental and technological acting in complex. This is a first attempt to study characterize the concept of ＂terroir＂, as applied in the Copou vineyard from lasi county and provides information on the behavior of two varieties of grapes for wine： Feteasca Regala and Muscat Ottonel. Depending on the purpose, observations and calculations have found the influence of soil characteristics on several biochemical parameters and productive at varieties of Feteasca Regala and Muscat Ottonel （soluble carbohydrate content, total acidity, the average yield of grapes） for the purpose of knowledge than a more detailed wine center in northeast of Romania. The results of this study can be used to determine with precision small areas crop at the parcel that will produce quality wines.

关键词： Iasi terroir varieties behaviour interactions.

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传统技术与发展

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科学与社会 1983年第2期 90-91页

作者： vasile mihai 茂南布加勒斯特国际未来方法论和发展研究中心

布加勒斯特国际未来方法论和发展研究中心(ICMFDS)的年轻研究人员vasile mihai希望我们了解他对我们发表的琼·金佩尔(Jean Gimpel)写的一篇附有插图的文章的想法(《工作模型促进了农村发展》,第31卷,第4期)他的地址是;ICMFDS——Univer... 详细信息

布加勒斯特国际未来方法论和发展研究中心(ICMFDS)的年轻研究人员vasile mihai希望我们了解他对我们发表的琼·金佩尔(Jean Gimpel)写的一篇附有插图的文章的想法(《工作模型促进了农村发展》,第31卷,第4期)他的地址是;ICMFDS——University of Bucarest, Str. Academiei 14, 70109 Bucuresti, Romania。

关键词：技术转让佩尔工作模型技术管理不发达国家

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