检索结果-南通市图书馆

Oxaliplatin-induced neuropathy and colo-rectal cancer patient's quality of life:Practical lessons from a prospective cross-sectional,real-world study

引用

World Journal of Clinical Cases 2022年第10期10卷 3101-3112页

作者： Iulian Prutianu Teodora Alexa-Stratulat Elena Octaviana Cristea Andrei Nicolau Diana Cornelia Moisuc Alina Alexandra Covrig Karina Ivanov Adina Emilia Croitoru Monica Ionela Miron mihaela ioana dinu Anca Viorica Ivanov Mihai Vasile Marinca Iulian Radu Bogdan Gafton SC MNT Healthcare Europe SRL Iasi 700021Romania University of Medicine and Pharmacy Grigore T Popa Iasi Iasi 700483Romania Regional Oncology Institute Iasi Iasi 700483Romania Oral and Maxillo-facial Surgery University of Medicine and Pharmacy Grigore T Popa IasiIasi 700021Romania Department of Medical Oncology Fundeni Clinical InstituteBucuresti 022328Romania University of Medicine and Pharmacy“Grigore T Popa” Iasi 700021Romania Department of Surgery Department of Surgical OncologyUniversity of Medicine and Pharmacy“Grigore T Popa”Regional Institute of OncologyIasi 700021Romania

BACKGROUND Colon cancer is one the most common forms of cancer in both sexes.Due to important progress in the field of early detection and effective treatment,colon and rectal cancer survivors currently account for 10%of cancer survivors worldwide.However,the effects of anti-cancer treatments,especially oxaliplatinbased chemotherapy,on the quality of life(QoL)have been less evaluated.Although the incidence of severe chemotherapy-induced neuropathy(CIPN)in clinical studies is below 20%,data from real-world studies is scarce,and CIPN is probably under-reported due to patient selection and the patients’fear that reporting side-effects might lead to treatment cessation.AIM To determine the impact of CIPN on QoL in colorectal cancer patients with a recent history of oxaliplatin-based chemotherapy.METHODS We performed a prospective cross-sectional study in two major Romanian oncology tertiary hospitals—the Regional Institute of Oncology Ia?i(Iasi,Romania)and the Fundeni Clinical Oncology Institute(Bucharest,Romania).All consecutive patients with colon or rectal cancer,undergoing Oxaliplatin-based chemotherapy that consented to enroll in the study,were assessed by means of two questionnaires—the EORTC QQ-CR29(quality of life in colon and rectal cancer patients)and the QLQ-CIPN20(assessment of neuropathy).Several demographical,social,clinical and treatment data were also collected.Statistical analysis was performed by means of SPSS v20.The student t test was used to assess the relationship between the QLQ-CIPN20 and QLQ-CR29 results.Kaplan Meyer-curves were used to report 3-year progression-free survival(PFS)in patients that discontinued chemotherapy vs those that completed the recommended course.RESULTS Of the 267 patients that fulfilled the inclusion criteria in the pre-specified time frame,101(37.8%)agreed to participate in the clinical study.At the time of the enrolment in the study,over 50%of the patients had recently interrupted their oxaliplatin-based chemotherapy,most often due to neuropathy.Almost 85%of the resp

关键词： Colorectal cancer Oxaliplatin Neuropathy Quality of Life Recurrence-free survival Cross-sectional study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High plasma levels of COL10A1 are associated with advanced tumor stage in gastric cancer patients

引用

World Journal of Gastroenterology 2020年第22期26卷 3024-3033页

作者： Laura Necula Lilia Matei Denisa Dragu ioana Pitica Ana Iulia Neagu Coralia Bleotu Simona Dima Irinel Popescu Carmen C Diaconu mihaela Chivu-Economescu Department of Cellular and Molecular Pathology Stefan S.Nicolau Institute of VirologyBucharest 030304Romania Titu Maiorescu University Faculty of MedicineBucharest 040441Romania Fundeni Clinical Institute Bucharest 022328Romania

BACKGROUND Gastric cancer(GC)remains an aggressive malignancy with a high rate of mortality,being the third leading cause of cancer-related death.More than one million newly diagnosed cases and 782685 deaths due to GC were reported in 2018.GC is characterized by limited effective treatment options and the lack of consistent biomarkers for the diagnosis and prognosis of these patients.The discovery of new biomarkers useful in the early diagnosis of GC is mandatory.AIM To evaluate the potential of COL10A1 as a circulating biomarker for the diagnosis and prognosis of gastric adenocarcinoma patients.METHODS Plasma and tissue obtained from 49 patients with gastric adenocarcinoma have been used in exploring the expression of COL10A1.Real-time PCR and western blot techniques were used to evaluate COL10A1 level in gastric tumor tissue compared to normal adjacent tissue.The circulating level of COL10A1 was also evaluated by ELISA in plasma of gastric adenocarcinoma patients.Survival analysis was made in order to evaluate the potential of COL10A1 as a biomarker for the diagnosis and prognosis of gastric adenocarcinoma patients.RESULTS Our results showed a significant increase in COL10A1 gene expression and protein levels in gastric tumor tissue compared to adjacent normal tissue(P<0.05).COL10A1 seems to show an elevated expression from the beginning of carcinogenesis,in the early stages,and its increased level remains elevated during cancer progression.A significant increase of COL10A1 plasma level in gastric adenocarcinoma patients was also identified.Moreover,increased COL10A1 plasma level was associated with poor survival of the patients.Plasma COL10A1 performed a diagnostic value in GC with area under the receiver operating characteristic curve(AUC)of 0.9171(P=0.0002),sensitivity of 87.76%,and specificity of 100.0%.Furthermore,this study demonstrated the potential role of plasma COL10A1 in the early detection of GC,as in the early stage,we obtained an AUC of 0.8789(P=0.0030),sensitivity of 81.25%,and specificity of 100

关键词： Gastric cancer COL10A1 Circulating biomarkers Early diagnosis Poor prognosis Tumor stage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Giant androgen-producing adrenocortical carcinoma with atrial flutter: A case report and review of the literature

引用

World Journal of Clinical Cases 2021年第20期9卷 5575-5587页

作者： Mircea-Florin Costache Raluca-Elena Arhirii Simona-Juliette Mogos Corina Lupascu-Ursulescu Cezara-ioana Litcanu Adi-Ionut Ciumanghel Catalina Cucu Cristina-mihaela Ghiciuc Antoniu-Octavian Petris Nicolae Danila Surgery Clinic Saint Spiridon University Clinical Emergency HospitalIasi 700111Romania Cardiology Clinic Saint Spiridon University Clinical Emergency HospitalIasi 700111Romania Department of Endocrinology Faculty of MedicineGrigore T.Popa University of Medicine and PharmacyIasi 700115Romania Endocrinology Clinic Saint Spiridon University Clinical Emergency HospitalIasi 700111Romania Department of Radiology and Imaging Sciences Grigore T.Popa University of Medicine and PharmacyIasi 700115Romania Radiology Clinic Saint Spiridon University Clinical Emergency HospitalIasi 700111Romania Radiotherapy Clinic Regional Institute of OncologyIasi 700483Romania Anesthesia and Intensive Care Department Grigore T.Popa University of Medicine and PharmacyIasi 700115Romania Anesthesia and Intensive Care Department Saint Spiridon University Clinical Emergency HospitalIasi 700111Romania Histopatology Department Saint Spiridon University Clinical Emergency HospitalIasi 700111Romania Department of Pharmacology Clinical Pharmacology and AlgesiologyFaculty of MedicineGrigore T.Popa University of Medicine and PharmacyIasi 700115Romania Department of Cardiology Faculty of MedicineGrigore T.Popa University of Medicine and PharmacyIasi 700115Romania Surgery Clinic Faculty of MedicineGrigore T.Popa University of Medicine and PharmacyIasi 700115Romania

BACKGROUND Adrenocortical carcinoma(ACC),the second most aggressive malignant tumor,lacks epidemiological data worldwide;therefore,every new case can improve the understanding of the pathology and treatment of this malignancy.CASE SUMMARY We present the case of a 66-year-old Caucasian woman with a giant androgenproducing ACC(21 cm×17 cm×12 cm;2100 g),without metastases,which unusually presented with an acute onset of atrial flutter and congestive heart failure.The cardiac complications observed in our case support the hypothesis that androgen excess in women is a cardiovascular risk factor.Androgen excess in women can be a rare cause of reversible dilated cardiomyopathy,therefore a comprehensive approach to the patient is essential to improve the recognition of androgen-secreting ACC.The atrial flutter was remitted after initiation of drug treatment during admission.The severe heart failure was totally remitted at 6 mo after radical open surgery to remove the giant ACC.CONCLUSION Radical open surgery to remove a giant androgen-producing ACC was the firstline treatment to cure the excess of androgen,which determined the total remission of cardiac complications at 6 mo after surgery in the women of this case report.

关键词： Adrenocortical carcinoma Adrenalectomy Androgen secreting tumor Heart failure Atrial flutter Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Primary Small Bowel Melanoma or Small Bowel Metastasis with Vanishing Primary Cutaneous Lesion

引用

Case Reports in Clinical Medicine 2022年第3期11卷 63-71页

作者： Dana Criṣan Andreea Ardelean mihaela Coman Laurenţiu Stoicescu ioana Rusu Nadim Al Hajjar Tudor Pop Sorin Criṣ an Constantin Bodolea Lucreţ ia Avram Faculty of Medicine Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca Romania Clinical Municipal Hospital Cluj-Napoca Romania 3rd Medical Clinic “Octavian Fodor” Regional Institute of Gastroenterology and Hepatology Cluj Cluj-Napoca Romania

The small bowel represents one of the main sites for cutaneous melanoma metastasis;however, numerous cases of primary intestinal melanoma have recently been described. In view of this, we present the case of a 39-year-old woman admitted for nausea, heartburn, abdominal pain, change in bowel habits and weight loss. Contrast-enhanced CT revealed a small bowel mass. Surgical resection of a 6 cm ileal tumour with regional mesenteric lymphadenectomy and end-to-end anastomosis was performed. Histopathological findings indicated the presence of an ileal melanoma metastasis. Subsequent dermatological examination identified a cutaneous lesion on the right forearm, however no malignant cells were found at the histopathological exam. Whole body PET CT with FDG identified multiple frontal and parietal lesions. Genetic testing was positive for BRAF gene V600 E mutation. The patient underwent multiple neurosurgical procedures for the resection of cerebral metastases. Palliative external radiation and chemotherapy was also attempted. After approximately 2 years after the diagnosis, the patient died following multiple episodes of intracranial hypertension.

关键词： Melanoma Small Bowel Cerebral Metastasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Relationship between the Systemic Stress Produced by the Neuropsychic Strain and the Sensorial Integrity in Young People

The Relationship between the Systemic Stress Produced by the...

引用

The6thPan-PacificConfere...

作者： Ion Anghel mihaela Anghel Gabriela Anghel ioana Tatar Mircea Chiriac Department of Physiology Faculty of Medicine University "L.Blaga" SibiuROMANIA Department of Physiology Faculty of Medicine University "L.Blaga" SibiuROMANIA Department of Physiology Faculty of Medicine University "L.Blaga" SibiuROMANIA Department of Physiology Faculty of Medicine University "L.Blaga" SibiuROMANIA Department of Physiology Faculty of Medicine University "L.Blaga" SibiuROMANIA

＜正＞The stress, "disease of the 20th century", concernes today all the fields of human life. In spite of the efforts made to fight against it, the phenomenon presents a worrying tendency to expand. The neurosensorial strain is likely to have an increasing importance in the future, that is the reason why we decided to study in our paper the impact of some nervous activities upon the functional entity of the organism through the induced systemic distress. Our investigation has been performed on a group of Medicine students （15）, a group of Conservatory students （string instruments 15） and a group of blind pupils（12）. They were all examined both in conditions of relative

关键词： Stress Occupational overstrain Ergonomy

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

为弥漫的甲状腺腺病理的评估的 ARFI elastography : 初步的结果

引用

World Journal of Radiology 2012年第4期4卷 174-178页

作者： Ioan Sporea Roxana Sirli Simona Bota mihaela Vlad Alina Popescu ioana Zosin Department of Gastroenterology and Hepatology University of Medicine and Pharmacy Timisoara300736 TimisoaraRomania Department of Endocrinology University of Medicine and Pharmacy Timisoara300736 TimisoaraRomania

AIM:To assess whether acoustic radiation force impulse(ARFI)elastography can differentiate normal from pathological thyroid parenchyma.METHODS:We evaluated 136 subjects(mean age 45.8±15.6 years,106 women and 30 men):44(32.3%) without thyroid pathology,48(35.3%)with BasedowGraves’disease(GD),37(27.2%)with chronic autoimmune thyroiditis(CAT;diagnosed by specific tests),4(2.9%)with diffuse thyroid goiter and 3(2.2%)cases with thyroid pathology induced by amiodarone.In all patients,10 elastographic measurements were made in the right thyroid lobe and 10 in the left thyroid lobe,using a 1-4.5 MHZ convex probe and a 4-9 MHz linear probe,respectively.Median values were calculated for thyroid stiffness and expressed in meters/second(m/s).RESULTS:Thyroid stiffness(TS)assessed by means of ARFI in healthy subjects(2±0.40 m/s)was significantly lower than in GD(2.67±0.53 m/s)(P<0.0001) and CAT patients(2.43±0.58 m/s)(P=0.0002),but the differences were not significant between GDvs CAT patients(P=0.053).The optimal cut-off value for the prediction of diffuse thyroid pathology was 2.36 m/s.For this cut-off value,TS had 62.5%sensitivity,79.5% specificity,87.6%predictive positive value,55.5% negative predictive value and 72.7%accuracy for the presence of diffuse thyroid gland pathology(AUROC=0.804).There were no significant differences between the TS values obtained with linear vs convex probes and when 5 vs 10 measurements were taken in each lobe(median values).CONCLUSION:ARFI seems to be a useful method for the assessment of diffuse thyroid gland pathology.

关键词： Acoustic radiation force impulse elastography Thyroid stiffness Thyroid pathology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：