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Nanotechnology in aquaculture: Applications, perspectives and regulatory challenges

Aquaculture and Fisheries 2022年第2期7卷 185-200页

作者： Carlos Fajardo Gonzalo Martinez-rodriguez Julian Blasco Juan miguel Mancera Bolaji Thomas Marcos De Donato School of Tourism and Maritime Technology Polytechnic of Leiria(MARE-IPLeiria)Santuario de Nossa Senhora dos RemediosCampus 4Peniche2520-641Portugal Department of Biology Faculty of Marine and Environmental SciencesInstituto Universitario de Investi-gaci´on Marina(INMAR)Campus de Excelencia Internacional del Mar(CEI⋅MAR)University of Cadiz(UCA)Puerto Real11519Spain Institute of Marine Sciences of Andalusia(ICMAN) Department of Marine Biology and AquacultureSpanish National Research Council(CSIC)Puerto Real11519Spain Department of Biomedical Sciences Rochester Institute of TechnologyRochester14623USA Tecnologico de Monterrey Escuela de Ingenieria y CienciasQueretaro76130Mexico

Aquaculture is considered one of the most important food production systems both in terms of economic impact and food security,and the ongoing development of this industry is a key factor in the strategy to guarantee global nutritional ***,different types of nanotechnology-based systems have been employed to increase its production,efficiency and *** efforts have been made in the fields of health management,enhancement of fish and shellfish development by dietary supplementation with nutraceuticals,but also in the processing and preservation of seafood and water treatment,among ***,nanotechnology has a significant role to play in the improvement of the efficiency and the environmental impact of this *** this perspective,we propose to review the current situation of nanotechnology in the field of aquaculture and fisheries,emphasizing not only in current applications,and future prospects,but also in the ethical and governance aspects associated with this topic.

关键词： Health management Nano-regulation Nutraceuticals Preservation of seafood Risk assessment

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Induced pluripotent stem cell (iPS) technology:promises and challenges

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Chinese Science Bulletin 2009年第1期54卷 2-8页

作者： miguel A Esteban Laboratory of Regenerative Biology South China Institute for Stem Cell Biology and Regenerative MedicineGuangzhou Institute of Biomedicine and HealthChinese Academy of Sciences

In 2006,an article published in Cell by Shinya Yamanaka took by surprise the stem cell research community. By performing systematic retroviral transduction of factors enriched in embryonic stem (ES) cells,the authors demonstrated the reprogramming of mouse fibroblasts into an ES cell-like state. These cells,baptized iPS (induced pluripotent stem) cells,were immediately recognized as a ground-breaking discovery. Subsequently,the same authors and other groups reported a similar achievement with human fibroblasts. Two years later,the number of top quality papers on iPS is astonishing,and interest in the scientific community has risen to a fever pitch. But although iPS has the potential to revolutionize Regenerative Medicine,important questions still remain unanswered. Work from multiple laboratories worldwide including ours is focused on deciphering the molecular mechanisms of iPS,and trying to improve the technique to make it suitable for the clinic. In this review article we briefly discuss the past,present and future of iPS,with emphasis on urgent issues to be solved.

关键词：自身更新多能性胚胎干细胞多能干细胞

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Auctions to reveal consumers’willingness to pay for low-carbon hydrogen projects:combining lessons from renewables and natural-gas industries

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Clean Energy 2024年第4期8卷 103-110页

作者： miguel Vazquez Michelle Hallack SDA School of Management Bocconi UniversityVia Roberto Sarfatti1020136 MilanMIItaly Florence School of Regulation EUIVia Giovanni Boccaccio12150133 FirenzeFIItaly

Low-carbon hydrogen is expected to play a key role in realizing net-zero and sustainable development ***,there is a gap between the cost of producing low-carbon hydrogen and its potential users’willingness to pay for such *** implement support for the development of the industry,we propose using low-carbon hydrogen long-term agreements allocated through auction *** objectives are 2-fold:(i)matching supply and demand volumes considering the time horizon and geographical delivery point specification and(ii)allocating the *** perspective article innovates by proposing a reference price indexed to liquid to natural-gas prices,which is the main product that low-carbon hydrogen aims to *** premium and the production cost are defined through a double-sided *** aims to minimize the public policy funds required to incentivize the low-carbon hydrogen market while facilitating long-term agreements and mitigating price risks that may hinder investment.

关键词： hydrogen auctions Renewable Eenergy Systems support mechanisms natural gas

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A flexible lag definition for experimental variogram calculation

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Mining Science and Technology 2011年第2期21卷 207-211页

作者： Cuba miguel Centre of Computational Geostatistics School of Petroleum and Mining EngineeringUniversity of Alberta

Inferring the experimental variogram used in geostatistics commonly relies on the method-of-moments ***,the available data-set used for calculating the experimental variogram should be drawn from a regular ***,in practice the available data-set is typically sampled over a sparse pattern at irregularly spaced ***,some binning of the variogram cloud is required to obtain fair estimates of the experimental *** of the variogram data pairs as a result of conventional binning depends on parameters such as the main anisotropic directions and a regular definition of the lag *** parameters are not based on the configuration of the variogram data pairs in the variogram cloud but on a segment of it that is arbitrarily ***,the conventional experimental variogram estimation approach is biased because of the strict configuration of the bins over the variogram *** this paper,a new method of estimating experimental variograms is *** vectors and their tolerances are decided in the proposed method from information in the variogram cloud：they are not influenced by any predefined *** proposed methodology is a well-founded,practicable and easy-to-automate approach for experimental variogram calculation using an irregularly sampled *** of results from the new method to those from the traditional approach is very encouraging.

关键词： Geostatistics Variogram cloud Experimental variogram Variogram modeling Self-organizing-map

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Characterization of the Topography and Wettability of English Weed Leaves and Biomimetic Replicas

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Journal of Bionic Engineering 2014年第3期11卷 346-359页

作者： Pedro miguel Matos Pereira Ana Sofia Moita Gabriel Amaro Monteiro Duarte miguel Franca Prazeres IBB - Institute for Biotechnology and Bioengineering Centre for Biological and Chemical Engineering Department of Bioengineering Instituto Superior Tecnico Universidade de Lisboa Av. Rovisco Pals 1049-001 Lisboa Portugal IN+ - Center for Innovation Technology and Policy Research Instituto Superior T~cnico Universidade de Lisboa Av. Rovisco Pais 1049-001 Lisboa Portugal

The topography and wettability of the underside of English weed （Oxalis pes-caprae） leaves and of their biomimetic replicas are investigated. Polyvinyl siloxane molds were cast from the leaves and then filled with an epoxy pre-polymer to produce replicas. The particular topographical structures of leaves and replicas were evaluated by optical microscopy and Scanning Electron Microscopy （SEM） analysis. The static wettability of leaves and replicas was assessed by contact angle measurements, while the dynamic wettability was characterized by estimating contact angle hysteresis and studying the dynamic behavior of impacting water droplets. A smooth glass slip and its replica were used as control surfaces. The replica moulding method used was able to transfer the characteristic pattern of irregular 100 μm - 200 μm × 60 μm convex papillae interspersed with stomata of the original leaf to the epoxy replicas. The static contact angle of 143°± 3° and the contact angle hysteresis of 2~ indicate that the underside of the English weed leaf is close to superhydrophobic. The lower contact angles （130° ± 4°） and higher hysteresis （31°） observed for the replica when compared with the original leaves were associated to an inaccurate replication of the chemistry and structures of the three-dimensional wax projections covering the plant surface. Also, trichomes in the original leaves could not be accurately reproduced due to their flexibility and fragility. Differences in wetting behavior were also evident from droplet impact experiments, with rebound regimes prevailing in the original leaves and regimes characterized by higher adhesion and larger dissipation predominating in the replicas. Nevertheless, the morphological features of the leaf transferred to the replica were sufficient to promote a clear hydrophobic behavior of the replica when compared with the smooth epoxy reference surface.

关键词： biomimetic surfaces oxalis pes-caprae English weed replica molding wettability micro-topography

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Science Letters:Blind spot detection using vision for automotive applications

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第10期9卷 1369-1372页

作者： miguel ngel SOTELO José BARRIGA Department of Electronics University of Alcalá Alcalá de Henares 28871 Spain

This paper describes a vision-based system for blind spot detection (BSD) in intelligent vehicle applications. A camera is mounted in the lateral mirror of a car with the intention of visually detecting cars that are located in the so-called blind spot and cannot be perceived by the vehicle driver. The detection of cars in the blind spot is carried out using computer vision techniques, based on optical flow and a double-stage data clustering technique for robust vehicle detection.

关键词： Computer vision Optical flow Blind spot detection (BSD) Intelligent vehicles

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Plumbing System of Hunga Tonga Hunga Ha'apai Volcano

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Journal of Earth Science 2023年第3期34卷 706-716页

作者： Román Alvarez miguel Camacho Instituto de Investigaciones en Matemáticas Aplicadas y en Sistemas(IIMAS) Universidad Nacional Autónoma de MéxicoCoyoacán CDMX 04510Mexico Posgrado en Ciencias de la Tierra Universidad Nacional Autónoma de MéxicoCoyoacán CDMX 04510Mexico

The Hunga Tonga Hunga Ha’apai submarine volcano has experienced repeated eruptions in the latest *** recent one,in January 2022,released an enormous amount of energy inducing global perturbations,as tsunamis and atmospheric *** structure of the volcano is poorly understood,especially its internal ***-seated magmatic connections are difficult to define or *** use a high-resolution gravity data set obtained via satellite to calculate the Bouguer anomaly over its structure,to perform a preliminary exploration of its *** 3D gravity inversions,we find a complex plumbing system with various exhaust trajectories and multiple surface pockets of low-density material within the volcanic edifice;some appear to be associated with ring *** is in line with the report of the 2009 eruption,described as beginning from multiple *** found no signs of a magma chamber within 6 km depth,although several volcanic conduits are identified from such depth to the *** variations occur within a plumbing conduit or may vary from one conduit to another in the same *** models yield quantitative estimates for areas of magma-water interaction,constituting a baseline to compare with structural changes to be induced in future eruptions.

关键词： Hunga Tonga Hunga Ha'apai satellite gravity data 3D inversions volcano Tofua Island

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Natural variation of ncHLAII molecules:challenges and perspectives

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Cellular & Molecular Immunology 2022年第12期19卷 1432-1434页

作者： miguelÁlvaro-Benito Protein Biochemistry Institute for BiochemistryFreie Universität BerlinBerlinGermany

Identifying causal genetic variants for a given phenotype improves diagnosis and provides insights for designing ***,defining the link and/or contribution to a phenotype of rare variants or those with an indirect cont... 详细信息

关键词： diagnosis insight designing

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Role of gene polymorphisms in gastric cancer and its precursor lesions:Current knowledge and perspectives in Latin American countries

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World Journal of Gastroenterology 2014年第16期20卷 4503-4515页

作者： miguel Angel Chiurillo Laboratorio de Genética Molecular "Dr.Jorge Yunis-Turbay" Decanato de Ciencias de la SaludUniversidad Centroccidental Lisandro AlvaradoBarquisimeto 3001Venezuela

Latin America shows one of the highest incidence rates of gastric cancer in the world,with variations in mortality rates among nations or even within countries belonging to this *** cancer is the result of a multifactorial complex process,for which a multistep model of carcinogenesis is currently *** to the infection with Helicobacter pylori,that plays a major role,environmental factors as well as genetic susceptibility factors are significant players at different stages in the gastric cancer *** differences in population origin,demographic structure,socio-economic development,and the impact of globalization lifestyles experienced in Latin America in the last decades,all together offer opportunities for studying in this context the influence of genetic polymorphisms in the susceptibility to gastric *** aim of this article is to discuss current trends on gastric cancer in Latin American countries and to review the available published information about studies of association of gene polymorphisms involved in gastric cancer susceptibility from this region of the world.A total of 40 genes or genomic regions and69 genetic variants,58%representing markers involved in inflammatory response,have been used in a number of studies in which predominates a low number of individuals(cases and controls)*** of IL-1B(-511 C/T,14 studies;-31 T/C,10 studies)and IL-1RN(variable number of tandem repeats,17 studies)are the most represented ones in the reviewed *** genetic variants recently evaluated in large metaanalyses and associated with gastric cancer risk were also analyzed in a few studies[e.g.,prostate stem cell antigen(PSCA),CDH1,Survivin].Further and better analysis centered in gene polymorphisms linked to other covariates,epidemiological studies and the information provided by meta-analyses and genome-wide association studies should help to improve our understanding of gastric cancer etiology in order to d

关键词： Latin America Gastric cancer Precancerous lesions Gene polymorphisms Single nucleotide polymorphisms

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An integrated assessment of a group with complex systematics: the Iberomaghrebian lizard genus Podarcis (Squamata, Lacertidae)

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Integrative Zoology 2008年第4期3卷 247-266页

作者： miguel A.CARRETERO CIBIO Reseach Center in Biodiversity and Genetic ResourcesCampus Agrário de Vair鉶4485-661VairaoPortugal

A critical review of the evolutionary biology of Iberian and North African lizard members of the genus Podarcis(Lacertidae)based on phylogeny,phylogeography,morphometrics,behavior,ecology and physiology is *** Iberomaghrebian region is inhabited by at least 12 different evolutionary lineages that group into a monophyl-etic clade(except Podarcis muralis).In contrast to the current taxonomy,the saxicolous‘Podarcis hispanica’is paraphyletic with respect to Podarcis bocagei and Podarcis carbonelli,two currently recognized *** in the phylogenetic tree are deep,resulting from old divergences,clearly preceding the ***,more recent range changes as a result of glaciations are also *** most plausible evolutionary scenario for this group indicates both vicariant and dispersal *** parapatry between lineages is the rule,sympatry and even syntopy are frequent,but usually between ground-dwelling and saxicolous *** between forms with similar habitat use are rare and *** distinctiveness between lineages has been demonstrated,indicating historical ***,other characters have repeatedly evolved under similar environmental pressures independently of the evolutionary *** sexual dimorphism derives from sexual selection and is attained before sexual maturity,although developmental restrictions *** between popu-lations is also important and derives from local variation in both natural(habitat,climate)and sexual(density)selective *** for short-term changes has already been found,particularly in insular *** isolation between syntopic forms and partner recognition are based on male–male competition and on visual and chemical recognition of females by conspecific *** this ancient diversification,most forms maintain a degree of reproductive *** may occur,but is limited,and there is evidence of selection

关键词： Morphometrics Mediterranean basin phylogeny Podarcis reproductive isolation speciation.

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