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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： Danko Jeremic Lydia Jiménez-Díaz Juan D.navarro-López Neurophysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(AD)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in AD,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

phase separating Rho:a widespread regulatory function of disordered regions in proteins revealed in bacteria

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3203-3205页

作者： Eric Schumbera pablo Mier miguel A.Andrade-navarro Institute of Organismic and Molecular Evolution Faculty of BiologyJohannes Gutenberg University of Mainz55128 MainzGermany

A recent study published in Science by Krypotou et *** the role of an intrinsically disordered region(IDR)in the transcription termination Rho protein from Bacteroides thetaiotaomicron:in response to starvation Rho phase separated,which triggered an increase in Rho activity and expression changes.1 These results demonstrate that a highly conserved protein can acquire new regulatory properties in evolution by gaining an IDR that leads to protein phase separation.

关键词： al. disordered separating

Intestinal pseudo-obstruction caused by herpes zoster:Case report and pathophysiology

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World Journal of Clinical Cases 2018年第6期6卷 132-138页

作者： Roberto Anaya-prado José V pérez-navarro Ana Corona-Nakamura Michelle M Anaya-Fernández Roberto Anaya-Fernández Marian Eliza Izaguirre-pérez Department of Surgery at Western Medical Center the Mexican Institute of Social Security Division of Research at Autonomous University of Guadalajara Department of Infectious Diseases at Western Medical Center the Mexican Institute of Social Security Division of Research at University of Guadalajara

Herpes zoster(HZ) infection occurs in approximately 10% to 30% of individuals. Visceral neuropathies secondary to HZ can cause cystitis and urinary retention. But colonic pseudo-obstruction can also occur. peripheral neuropathy may reveal segmental motor paresis of either upper or lower limbs, the abdominal muscles or the diaphragm. We report the case of a 62-year-old male patient who presented with abdominal distention and cutaneous vesicular eruption on the left side of the abdominal wall. plain X-rays and computed tomography scan showed distended small bowel. A diagnosis of intestinal pseudo-obstruction was made secondary to segmental paresis of the small intestine and visceral neuropathy. Conservative management was successful and the patient was discharged uneventfully. Intestinal pseudo-obstruction ought to be consideredwhen dealing with non-obstructive(adynamic) conditions of the digestive tract associated with HZ infection; since early recognition may help to avoid unnecessary surgery.

关键词： Ogilvie’s symdrome Herpes zoster virus Neuropathies Intestinal pseudo-obstruction

Comparative analysis of two nonlethal methods for the study of the gut bacterial communities in wild lizards

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Integrative Zoology 2023年第6期18卷 1056-1071页

作者： Mauricio HERNÁNDEZ Sergio ANCONA Stephanie HEREIRA-pACHECO Aníbal HDÍAZ DE LA VEGA-pÉrez Yendi E.navarro-NOYA Doctorado en Ciencias Biológicas Centro de Tlaxcala de Biología de la ConductaUniversidad Autónoma de TlaxcalaTlaxcalaMexico Departamento de Ecología Evolutiva Instituto de EcologíaUniversidad Nacional Autónoma de MéxicoMexico CityMexico Estación Científica la Malinche Centro de Tlaxcala de Biología de la ConductaUniversidad Autónoma de TlaxcalaTlaxcalaMexico Consejo Nacional de Ciencia y Tecnología—Centro Tlaxcala de Biología de la Conducta Universidad Autónoma de TlaxcalaTlaxcalaMexico Laboratorio de Interacciones Bióticas Centro de Investigación en Ciencias BiológicasUniversidad Autónoma de TlaxcalaTlaxcalaMexico

Fecal samples or cloacal swabs are preferred over lethal dissections to study vertebrate gut microbiota for ethical reasons,but it remains unclear which nonlethal methods provide more accurate information about gut *** compared the bacterial communities of three gastrointestinal tract(GIT)segments,that is,stomach,small intestine(midgut),and rectum(hindgut)with the bacterial communities of the cloaca and feces in the mesquite lizard Sceloporus *** hindgut had the highest taxonomic and functional alpha diversity,followed by midgut and feces,whereas the stomach and cloaca showed the lowest *** taxonomic assemblages of the GIT segments at the phylum level were strongly correlated with those retrieved from feces and cloacal swabs(rs>0.84 in all cases).The turnover ratio of Amplicon Sequence Variants(ASVs)between midgut and hindgut and the feces was lower than the ratio between these segments and the *** than half of the core-ASVs in the midgut(24 of 32)and hindgut(58 of 97)were also found in feces,while less than 5 were found in the *** the ASVs level,however,the structure of the bacterial communities of the midgut and hindgut were similar to those detected in feces and *** findings suggest that fecal samples and cloacal swabs of spiny lizards provide a good approximation of the taxonomic assemblages and beta diversity of midgut and hindgut microbiota,while feces better represent the bacterial communities of the intestinal segments at a single nucleotide variation level than cloacal swabs.

关键词： animal microbiome cloacal swabs fecal samples intestinal tract reptile gut microbiome

Effect of Nd3+doping on structure,microstructure,lattice distortion and electronic properties of TiO_2 nanoparticles

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Journal of Rare Earths 2017年第3期35卷 259-270页

作者： Balter Trujillo-Navarrete María del pilar Haro-Vázquez Rosa María Félix-navarro Francisco paraguay-Delgado Henry Alvarez-Huerta Sergio pérez-Sicairos Edgar Alonso Reynoso-Soto institute technology of tijuana(itt) blvd.alberto limón padillaP.O.B 1166.Tijuana B.C.Mexico university autonomous of baja california(uabc) roadway university14418P.O.B 22390Tijuana B.C.Mexico investigations center of advanced materials(cimav).miguel de cervantes 120.P.O.B31109ChihuahuaMexico

Doped and undoped TiCh nanoparticles were prepared by Stober method and thermally treated at 600 ℃.The effect of Nd^（3＋） ion on the structure and micro structure of anatase-phase TiCh nanocrystals was studied by Rietveld refinement method using X-ray powder diffraction *** lengths,bond angles,and edges distances were *** phase formation was confirmed by high-resolution transmission electron *** adjustment of Ti-0 bond length induced by the addition of Nd^（3＋） ions,reduced the octahedral distortion and altered the octahedral array in the anatase-phase TiCh *** changes of structure and microstructure were mainly observed for TiCh nanoparticles doped with 0.1 at.%of Nd^（3＋） ions and attributed to the cationic substitution of Ti^（4＋） ions which promoted changes in the density of states and gap band of *** dopant insertion resulted in a better structural stability of the nanocrystals that enhanced their charge transference and photocatalytic efficiency.

关键词： neodymium TiO_2 nanoparticles microstructure lattice distortion photocatalytic activity optical properties Rietveld refinement rare earths

Maternal Behavior Their Adjustments and Implicated Factors

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Journal of Behavioral and Brain Science 2015年第2期5卷 40-55页

作者： Esther pérez-Torrero Lorena Rubio-navarro División de Investigación y posgrado Facultad de Ingeniería Universidad Autónoma de Querétaro Querétaro Mexico

The maternal behavior in mammals is one of the most stable and highly conserved motivated species-specific behaviors and crucial for reproductive functions. During maternal behavior nursing and feeding are associated factors with survival of mammalian offspring, mammals nurse their newborn in a wide diversity in the behavioral. In the mother relationship the suckling is the behavioral patterns that identified and unified mammals and showed several selected evolutionary conserved behavior. The milk is an important reward for the pups, it ensure the surviving. The quality of maternal behavior is transmitted between generations;the inadequate maternal care has harmful effects in the adulthood individual. The specific maternal pattern modalities differ greatly between species;the human bonding has underlying biological mechanisms similar in mammals. Maternal brain is modified in order to prepare the mother-pup relationship, being crucial for the adequate behavioral display in the mother-pup relationship. A bulk of surrounding factor such as sensorial stimulus, temperature, ultrasonic communication, and reinforcing stimulus determines the quality of the nursing and care of the progeny. Mother care and nursing quality have long lasting effects in adulthood, determining cognitive and behavioral development and some specific psychiatric and psychological condition in human populations.

关键词： Maternal Behavior Lactation Mother-pup Relationship Offspring Brain Suckling

DNA metabarcoding reveals seasonal changes in diet composition across four arthropod-eating lizard species(phrynosomatidae:Sceloporus)

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Integrative Zoology 2024年第3期19卷 480-495页

作者： Mauricio HERNÁNDEZ Stephanie HEREIRA-pACHECO Antton ALBERDI Aníbal H.DÍAZ DE LA VEGA-pÉrez Arturo ESTRADA-TORRES Sergio ANCONA Yendi E.navarro-NOYA Doctorado en Ciencias Biológicas Centro Tlaxcala de Biología de la ConductaUniversidad Autónoma de TlaxcalaTlaxcalaMexico Estación Científica La Malinche Centro Tlaxcala de Biología de la ConductaUniversidad Autónoma de TlaxcalaTlaxcalaMexico Center for Evolutionary Hologenomics The Globe InstituteUniversity of CopenhagenCopenhagenDenmark Consejo Nacional de Ciencia y Tecnología-Centro Tlaxcala de Biología de la Conducta Universidad Autónoma de TlaxcalaTlaxcalaMexico Departamento de Ecología Evolutiva Instituto de EcologíaUniversidad Nacional Autónoma de MéxicoMexico CityMexico Laboratorio de Interacciones Bióticas Centro de Investigación en Ciencias BiológicasUniversidad Autónoma de TlaxcalaSan Felipe IxtacuixtlaTlaxcalaMexico

Diet composition and its ecological drivers are rarely investigated in coexisting closely related *** used a molecular approach to characterize the seasonal variation in diet composition in four spiny lizard species inhabiting a mountainous *** metabarcoding revealed that the lizards Sceloporus aeneus,***,***,and *** mostly consumed arthropods of the orders Hemiptera,Araneae,Hymenoptera,and *** terrestrial lizards *** and *** mostly predated ants and spiders,whereas the arboreal–saxicolous *** and saxicolous *** largely consumed grasshoppers and *** taxonomic and phylogenetic diversity of the prey was higher during the dry season than the rainy season,likely because reduced prey availability in the dry season forced lizards to diversify their diets to meet their nutritional *** and phylogenetic composition varied seasonally depending on the species,but only dietary composition varied with *** dietary turnover was greater in *** than in ***,suggesting site-specific seasonal variability in prey availability;no other differences among species were ***,which lives at the highest altitude in our study site,displayed interseasonal variation in diet *** differences were correlated with the species’feeding strategies and elevational distribution,which likely contributed to the coexistence of these lizard species in the studied geographic area and beyond.

关键词： arthropod-eating lizards diet breadth environmental barcoding mountainous ecosystem seasonal dietary shifts

Revealing the underlying mechanisms behind TE extraordinary THz transmission

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photonics Research 2020年第4期8卷 430-439页

作者： SUZANNA FREER miguel CAMACHO SERGEI A.KUZNETSOV RAFAEL R.BOIX miguel BERUETE miguel navarro-CíA School of physics and Astronomy University of BirminghamBirmingham B152TTUK Department of physics and Astronomy University of ExeterExeter EX44QDUK Rzhanov Institute of Semiconductor physics SB RAS Novosibirsk Branch TDIAM Novosibirsk 630090Russia physics Department Novosibirsk State UniversityNovosibirsk 630090Russia Department of Electronics and Electromagnetism Faculty of PhysicsUniversity of Seville41012 SevilleSpain Antennas Group-TERALAB Universidad Pública de Navarra31006 PamplonaSpain Institute of Smart Cities Universidad Pública de Navarra31006 PamplonaSpain

Transmission through seemingly opaque surfaces,so-called extraordinary transmission,provides an exciting platform for strong light–matter interaction,spectroscopy,optical trapping,and color *** of the effort has been devoted to understanding and exploiting TM extraordinary transmission,while TE anomalous extraordinary transmission has been largely omitted in the *** is regrettable from a practical point of view since the stronger dependence of the TE anomalous extraordinary transmission on the array’s substrate provides additional design parameters for *** provide high-performance and cost-effective applications based on TE anomalous extraordinary transmission,a complete physical insight about the underlying mechanisms of the phenomenon must be first laid *** this end,resorting to a combined methodology including quasi-optical terahertz(THz)time-domain measurements,full-wave simulations,and method of moments analysis,subwavelength slit arrays under s-polarized illumination are studied here,filling the void in the current *** believe this work unequivocally reveals the leaky-wave role of the grounded-dielectric slab mode mediating in TE anomalous extraordinary transmission and provides the necessary framework to design practical high-performance THz components and systems.

关键词： Revealing the underlying mechanisms TE extraordinary transmission THz

Real-time fluorescence image-guided gastrointestinal oncologic surgery:Towards a new era

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World Journal of Gastrointestinal Oncology 2021年第9期13卷 1029-1042页

作者： Elías Martínez-López Aleix Martínez-pérez Sergio navarro-Martínez Juan Carlos Sebastián-Tomás Nicola de'Angelis Eduardo García-Granero Department of Surgery University of ValenciaValencia 46010Spain Department of General and Digestive Surgery Hospital Universitario Doctor PesetValencia 46017Spain Faculty of Health Sciences Valencian International UniversityValencia 46002Spain Minimally Invasive and Robotic Digestive Surgery Unit Miulli HospitalAcquaviva delle Fonti 70021Italy Department of General and Digestive Surgery Hospital Universitario y Politécnico La FeValencia 46026Spain

Technological improvements are crucial in the evolution of ***-time fluorescence-guided surgery(FGS)has spread worldwide,mainly because of its usefulness during the intraoperative decision-making *** success of any gastrointestinal oncologic resection is based on the anatomical identification of the primary tumor and its regional lymph *** allows also to evaluate the blood perfusion at the gastrointestinal stumps after colorectal or esophageal ***,a reduction on the anastomotic leak rates has been postulated as one of the foreseeable benefits provided by the use of FGS in these *** the use of fluorescence in lymph node detection was initially described in breast cancer surgery,the technique is currently applied in gastric or splenic flexure cancers,as they both present complex and variable lymphatic *** allows also to perform intraoperative lymphograms or sentinel lymph node *** applications of FGS are being developed to assist in the detection of peritoneal metastases or in the evaluation of the tumor resection *** present review aims to provide a general overview of the current status of real-time FGS in gastrointestinal oncologic *** put a special focus on the different applications of FGS,discussing the main findings and limitations found in the contemporary literature and also the promising near future applications.

关键词： Surgery Colorectal cancer Esophageal cancer Fluorescence Image-guided surgery Anastomotic leak Lymph node