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World Journal of Gastroenterology 2022年第39期28卷 5679-5690页

作者： Armando Rojas Cristian Lindner Iván Schneider Ileana Gonzàlez miguel Angel Morales Biomedical Research Laboratories Catholic University of MauleTalca 34600000MauleChile Medicine Faculty Catholic University of MauleTalca 34600000MauleChile Department of Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000SantiagoChile

Compelling evidence derived from clinical and experimental research has demonstrated the crucial contribution of chronic inflammation in the development of neoplasms,including gallbladder *** this regard,data derived from clinical and experimental studies have demonstrated that the receptor of advanced glycation end-products(RAGE)/AGEs axis plays an important role in the onset of a crucial and long-lasting inflammatory milieu,thus supporting tumor growth and *** are formed in biological systems or foods,and food-derived AGEs,also known as dietary AGEs are known to contribute to the systemic pool of *** they bind to RAGE,the activation of multiple and crucial signaling pathways are triggered,thus favoring the secretion of several proinflammatory cytokines also involved in the promotion of gallbladder cancer invasion and *** the present review,we aimed to highlight the relevance of the association between high dietary AGEs intakes and high risk for gallbladder cancer,and emerging data supporting that dietary intervention to reduce gallbladder cancer risk is a very attractive approach that deserves much more research efforts.

关键词： Gallbladder cancer Advanced glycation end-products Receptor of advanced glycation end-products Chronic inflammation Nutrition

Diabetic foot ulcer:A comprehensive review of pathophysiology and management modalities

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World Journal of Clinical Cases 2023年第8期11卷 1684-1693页

作者： Joel M Raja miguel A Maturana Sharif Kayali Amir Khouzam Nephertiti Efeovbokhan Department of Internal Medicine University of Tennessee Health Science CenterMemphisTN 38119United States Department of Cardiology NEA Baptist JonesboroJonesboroAR 72401United States

Diabetic foot ulcer (DFU) is a debilitating and severe manifestation ofuncontrolled and prolonged diabetes that presents as ulceration, usually locatedon the plantar aspect of the foot. Approximately 15% of individuals with diabeteswill eventually develop DFU, and 14%-24% of them will require amputation ofthe ulcerated foot due to bone infection or other ulcer-related complications. Thepathologic mechanisms underlying DFU are comprise a triad: Neuropathy,vascular insufficiency, and secondary infection due to trauma of the *** local and invasive care along with novel approaches like stem celltherapy pave the way to reduce morbidity, decrease amputations, and preventmortality from DFU. In this manuscript, we review the current literature withfocus on the pathophysiology, preventive options, and definitive management ofDFU.

关键词： Diabetes Ulcer Foot Antibiotics Revascularization Cell therapy

A rare cause of acute abdomen after a Good Friday

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World Journal of Clinical Cases 2022年第26期10卷 9539-9541页

作者： Leticia Pante Luísa Gailhard Brito miguel Franciscatto Eduardo Brambilla Jonathan Soldera School of Medicine Universidade de Caxias so SulCaxias do Sul 95070-560Brazil Proctology Hospital Geral de Caxias do SulCaxias do Sul 95070-560Brazil Clinical Gastroenterology Universidade de Caxias do SulCaxias do Sul 95070-560RSBrazil

Small bowel perforation caused by an ingested fish bone is rare but can involve the appendix or Meckel’s *** report the case of a 25-year-old man who presented to the emergency department with acute abdomen caused by... 详细信息

关键词： Fish bone Foreign body Small bowel perforation Meckel diverticulum

Contributions of the receptor for advanced glycation end products axis activation in gastric cancer

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World Journal of Gastroenterology 2023年第6期29卷 997-1010页

作者： Armando Rojas Cristian Lindner Iván Schneider Ileana González miguel Angel Morales Biomedical Research Laboratories Medicine FacultyCatholic University of MauleTalca 34600000Chile Medicine Faculty Catholic University of MauleTalca 34600000Chile Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000Chile

Compelling shreds of evidence derived from both clinical and experimental research have demonstrated the crucial contribution of receptor for advanced glycation end products(RAGE)axis activation in the development of neoplasms,including gastric cancer(GC).This new actor in tumor biology plays an important role in the onset of a crucial and long-lasting inflammatory milieu,not only by supporting phenotypic changes favoring growth and dissemination of tumor cells,but also by functioning as a pattern-recognition receptor in the inflammatory response to Helicobacter pylori *** the present review,we aim to highlight how the overexpression and activation of the RAGE axis contributes to the proliferation and survival of GC cells as and their acquisition of more invasive phenotypes that promote dissemination and ***,the contribution of some single nucleotide polymorphisms in the RAGE gene as susceptibility or poor prognosis factors is also discussed.

关键词： Gastric cancer Advanced glycation end-products Receptor of advanced glycation end-products Alarmins Helicobacter pylori Chronic inflammation

Kerr-Newman Black Holes and Negative Temperatures

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Journal of High Energy Physics, Gravitation and Cosmology 2022年第4期8卷 940-947页

作者： miguel Socolovsky Instituto de Ciencias Nucleares Universidad Nacional Autónoma de México Ciudad de México México

The application of the Unruh procedure to the Rindler approximation of the Kerr-Newman metric in the neighborhood of the event and Cauchy horizons leads, unambiguously, to the well-known positive Hawking (black hole) temperature at the outer horizon, but to a negative (white hole) temperature at the inner horizon. Some consequences for the heat capacities and the status of the third law of thermodynamics are also discussed.

关键词： Kerr-Newman Metric Cauchy Horizon Negative Temperature

Black Holes and the Third Law of Thermodynamics Revisited

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Journal of High Energy Physics, Gravitation and Cosmology 2023年第2期9卷 499-505页

作者： miguel Socolovsky Instituto de Ciencias Nucleares Universidad Nacional Aut&oacutenoma de M&eacutexico Ciudad de M&eacutexico M&eacutexico

Black holes contradict the Nernst-Planck (N/P) version of the 3rd law of thermodynamics, but agree with its unattainability (U) version. This happens without contradiction, because the N/P and U versions are not equivalent, namely, N/P implies U but U does not imply N/P. So, black holes obey the weaker version of the 3rd law, but not the stronger one.

关键词： Thermodynamics Third Law Black Holes

Null Geodesics, Raychaudhuri Equation, Trapped Surfaces, and Penrose Singularity Theorem

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Journal of High Energy Physics, Gravitation and Cosmology 2022年第3期8卷 536-557页

作者： miguel Socolovsky Instituto de Ciencias Nucleares Universidad Nacional Autónoma de México Cd. Universitaria Ciudad de México México

We review the concept of congruence of null geodesics, the Raychaudhuri equation for the expansion, its harmonic oscillator version and associated “quantum” propagator, the role of the equation in the derivation of ... 详细信息

关键词： Null Geodesics Trapped Surfaces Singularity Theorem

Lignocellulosic Micro and Nanofibrillated Cellulose Produced by Steam Explosion for Wood Adhesive Formulations

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Journal of Renewable Materials 2022年第2期10卷 263-271页

作者： Saad Nader Felipe Guzman Raphael Becar Cesar Segovia Cecilia Fuentealba miguel Peirera Evelyne Mauret Nicolas Brosse Laboratoire d’Etude et de Recherches sur le Materiau Bois-Green Process For Wood(LERMaB-GP4W) Facultedes Sciences et TechnologiesUniversitede LorraineVandœuvre-les-NancyFrance Laboratoire de Genie des Procedes Papetiers(LGP2) Saint Martin D’HèresFrance Unidad de Desarrollo Tecnologico(UDT) Universidad de ConcepcionCoronelChile Centre d’Essais TEchnique LORrain(CETELOR) EpinalFrance

The reinforcing impact of Lignocellulosic micro and nanofibrillated cellulose(L-MNFCs)obtained from Eucalyp-tus Globulus bark in Urea-Formaldehyde UF adhesive was tested.L-MNFCs were prepared by an environmentally friendly,low-cost process using a combination process involving steam explosion followed by refining and ultra-fine *** L-MNFCs showed a web-like morphology with some aggregates and lignin *** present a mixture of residual fibers and fine elements with a width varying between 5 nm to 20μm,*** effects of the addition of low amounts of L-MNFCs(1%wt.)on the properties of three different adhe-sives(Urea-Formaldehyde UF,Phenol-Formaldehyde PF,and Tannin-Hexamine TH)were studied by the evolution of the pH,the viscosity,and the mechanical *** showed that the viscosity of PF and UF adhesives increased with the addition of L-MNFCs,unlike ***,the addition led to better mechan-ical behavior for the three *** were then prepared using modified UF with L-MNFCs and *** showed that an amount of 1%*** L-MNFCs was sufficient to increase the internal bonding by≈67%,the modulus of elasticity by≈43%,and the modulus of rupture by≈29%.

关键词： Lignocellulosic microfibrils Eucalyptus globulus bark wood adhesives steam explosion wood panels

A Systematic Review of Forensic Approaches to Disasters: Gaps and Challenges

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International Journal of Disaster Risk Science 2023年第5期14卷 722-735页

作者： Adriano Mota Ferreira Victor Marchezini Tatiana Sussel Gonçalves Mendes miguel Angel Trejo-Rangel Allan Yu Iwama Graduate Program in Disasters Institute of Science and TechnologySão Paulo State University(Unesp)São Josédos CamposSP12247-004Brazil Cemaden–National Center for Monitoring and Early Warning of Natural Disasters São Josédos CamposSP12247-004Brazil Natural Hazards Center Institute of Behavioral ScienceUniversity of Colorado BoulderBoulderCO80309USA Department of Environmental Engineering Institute of Science and TechnologySão Paulo State University(Unesp)São Josédos CamposSP12247-004Brazil Irish Climate Analysis and Research UnitS(ICARUS) Department of GeographyMaynooth UniversityMaynoothW23 F2H6KildareIreland Graduate Program in Development and Environment Federal University of ParaíbaJoão PessoaPB58051-900Brazil

Disaster forensic approaches aim to identify the causes of disasters to support disaster risk ***,few studies have conducted a systematic literature review of scientific articles that labeled themselves as a forensic approach to *** article provides a qualitative analysis of these forensic studies,focusing on five main issues:(1)the methodologies applied;(2)the forensic approaches used in the disaster risk management phases;(3)the hazards addressed;(4)if the methodologies involve social participation,and using what types of participation;and(5)if there are references to urban planning in the scientific studies *** results showed a predominance of the Forensic Investigations of Disasters(FORIN)and Post-Event Review Capability(PERC)methodologies used in isolation or *** is a need for methodologies that engage people in participatory FORIN,fostering the co-production of knowledge and action research approaches.

关键词： Dynamic pressures Forensic investigation Participatory research Risk drivers Root causes

Revealing the underlying mechanisms behind TE extraordinary THz transmission

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Photonics Research 2020年第4期8卷 430-439页

作者： SUZANNA FREER miguel CAMACHO SERGEI A.KUZNETSOV RAFAEL R.BOIX miguel BERUETE miguel NAVARRO-CíA School of Physics and Astronomy University of BirminghamBirmingham B152TTUK Department of Physics and Astronomy University of ExeterExeter EX44QDUK Rzhanov Institute of Semiconductor Physics SB RAS Novosibirsk Branch TDIAM Novosibirsk 630090Russia Physics Department Novosibirsk State UniversityNovosibirsk 630090Russia Department of Electronics and Electromagnetism Faculty of PhysicsUniversity of Seville41012 SevilleSpain Antennas Group-TERALAB Universidad Pública de Navarra31006 PamplonaSpain Institute of Smart Cities Universidad Pública de Navarra31006 PamplonaSpain

Transmission through seemingly opaque surfaces,so-called extraordinary transmission,provides an exciting platform for strong light–matter interaction,spectroscopy,optical trapping,and color *** of the effort has been devoted to understanding and exploiting TM extraordinary transmission,while TE anomalous extraordinary transmission has been largely omitted in the *** is regrettable from a practical point of view since the stronger dependence of the TE anomalous extraordinary transmission on the array’s substrate provides additional design parameters for *** provide high-performance and cost-effective applications based on TE anomalous extraordinary transmission,a complete physical insight about the underlying mechanisms of the phenomenon must be first laid *** this end,resorting to a combined methodology including quasi-optical terahertz(THz)time-domain measurements,full-wave simulations,and method of moments analysis,subwavelength slit arrays under s-polarized illumination are studied here,filling the void in the current *** believe this work unequivocally reveals the leaky-wave role of the grounded-dielectric slab mode mediating in TE anomalous extraordinary transmission and provides the necessary framework to design practical high-performance THz components and systems.

关键词： Revealing the underlying mechanisms TE extraordinary transmission THz