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World Journal of Cardiology 2016年第10期8卷 615-622页

作者： Amir S Lotfi Hossein Eftekhari Auras R Atreya Ananth Kashikar Senthil K Sivalingam miguel giannoni Paul Visintainer Daniel Engelman Department of Cardiology Baystate Medical Center Tufts University School of Medicine Department of Anesthesiology Baystate Medical Center Tufts University School of Medicine Department of Epidemiology and Biostatistics Baystate Medical Center Tufts University School of Medicine Department of Cardiac Surgery Baystate Medical Center Tufts University School of Medicine

AIM To study whether remote ischemic preconditioning(RIPC) has an impact on clinical outcomes, such as post-operative atrial fibrillation(POAF).METHODS This was a prospective, single-center, single-blinded,randomized controlled study. One hundred and two patients were randomized to receive RIPC(3 cycles of 5 min ischemia and 5 min reperfusion in the upper arm after induction of anesthesia) or no RIPC(control). Primary outcome was POAF lasting for five minutes or longer during the first seven days after surgery. Secondary outcomes included length of hospital stay, incidence of inpatient mortality, myocardial infarction, and stroke. RESULTS POAF occurred at a rate of 54% in the RIPC group and 41.2% in the control group(P = 0.23). No statistically significant differences were noted in secondary outcomes between the two groups. CONCLUSION This is the first study in the United States to suggest that RIPC does not reduce POAF in patients with elective or urgent cardiac surgery. There were no differences in adverse effects in either group. Further studies are required to assess the relationship between RIPC and POAF.

关键词： Chronic ischemic heart disease Cardiac surgery Coronary artery disease Other treatment Remote ischemic preconditioning Post-operative atrial fibrillation

Cerebellopontine Angle Epidermoid Cyst: Case Report

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International Journal of Otolaryngology and Head & Neck Surgery 2013年第1期2卷 5-7页

作者： Fabio Di Giustino Rudi Pecci Beatrice giannoni Paolo Vannucchi Department of Surgical Sciences Oto-Neuro-Ophthalmology—Service of Audiology University of Florence Florence Italy

Epidermoid cysts are rare congenital tumors of the central nervous system (CNS), histologically benign and slow- growing lesions. Their frequency among primitive intracranial tumors is about 1% and they account for 40% of all intracranial epidermoid of the cerebellopontine angle (CPA);there they constitute the third most frequent neoplasm (5%), after acoustic neuromas and meningiomas. We report the case of a patient with a paucisymptomatic epidermoid cyst of the CPA.

关键词： Primary Brain Tumor Epidermoid Cyst Cerebellopontine Angle Stapedius Reflex Gaze-Evoked

Peripheral reflex feedbacks in chronic heart failure:Is it time for a direct treatment?

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World Journal of Cardiology 2015年第12期7卷 824-828页

作者： Alberto giannoni Gianluca Mirizzi Alberto Aimo Michele Emdin Claudio Passino Division of Cardiology and Cardiovascular Medicine Fondazione Toscana Gabriele Monasterio Institute of Life Sciences Scuola Superiore Sant’Anna

Despite repeated attempts to develop a unifying hypothesis that explains the clinical syndrome of heart failure(HF),no single conceptual paradigm for HF has withstood the test of time. The last model that has been developed,the neurohormonal model,has the great virtue of highlighting the role of the heart as an endocrine organ,as well as to shed some light on the key role on HF progression of neurohormones and peripheral organs and tissues beyond the heart itself. However,while survival in clinical trials based on neurohormonal antagonist drugs has improved,HF currently remains a lethal condition. At the borders of the neurohormonal model of HF,a partially unexplored path trough the maze of HF pathophysiology is represented by the feedback systems. There are several evidences,from both animal studies and humans reports,that the deregulation of baro-,ergo- and chemo-reflexes in HF patients elicits autonomic imbalance associated with parasympathetic withdrawal and increased adrenergic drive to the heart,thus fundamentally contributing to the evolution of the disease. Hence,on top of guidelinerecommended medical therapy,mainly based on neurohormonal antagonisms,all visceral feedbacks have been recently considered in HF patients as additional potential therapeutic targets.

关键词： Baroreflex Chemoreflex Ergoreflex Heart failure Sympathetic system Neurohormones

Use of Continuous Venovenous Hemodiafiltration with a High Cutoff Membrane in a Patient with Severe Acute Pancreatitis

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Open Journal of Nephrology 2012年第4期2卷 78-81页

作者： Cosimo Chelazzi Dario Giugni Claudia giannoni Gianluca Villa Angelo Raffaele De Gaudio Department of Critical Care Anesthesiology and Intensive Care Section University of Florence Florence Italy

In patients with severe acute pancreatitis (SAP) early and persistent elevated circulating levels of interleukins (IL)-1, 2 and 6 and tumor necrosis factor (TNF)-α are linked to severity of disease and early multiple organ failure (MOF), while persistently elevated serum IL-10 is linked to immune paralysis and infectious complications. Although experimental and clinical evidence exists that continuous venovenous hemodiafiltration with high cutoff membranes (HCO-CVVHDF) efficiently removes inflammatory mediators from blood of patients with severe sepsis or septic shock, data are lacking on the subset of patients with SAP, particularly in cases with uninfected necrosis. We treated with HCO-CVVHDF a 59-year-old man admitted to our intensive care unit (ICU) with SAP inducing early-onset cardiovascular, respiratory and renal dysfunctions associated with high circulating levels of IL-6 and TNF-α and without overt clinical or laboratory signs of infection. During the treatment, cardiovascular, respiratory and renal functions rapidly normalized and circulating levels of IL-6 and TNF-α consistently decreased. The patient was discharged from ICU on day 20.

关键词： Acute Pancreatitis Multiple Organ Failure Blood Purification

Cardioprotection by remote ischemic conditioning: Mechanisms and clinical evidences

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World Journal of Cardiology 2015年第10期7卷 621-632页

作者： Alberto Aimo Chiara Borrelli Alberto giannoni Luigi Emilio Pastormerlo Andrea Barison Gianluca Mirizzi Michele Emdin Claudio Passino Institute of Life Sciences Scuola Superiore Sant’Anna Division of Cardiology and Cardiovascular Medicine Fondazione Toscana Gabriele Monasterio

In remote ischemic conditioning(RIC), several cycles of ischemia and reperfusion render distant organ and tissues more resistant to the ischemia-reperfusion injury. The intermittent ischemia can be applied before the ischemic insult in the target site(remote ischemic preconditioning), during the ischemic insult(remote ischemic perconditioning) or at the onset of reperfusion(remote ischemic postconditioning). The mechanisms of RIC have not been completely defined yet; however, these mechanisms must be represented by the release of humoral mediators and/or the activation of a neural reflex. RIC has been discovered in the heart, and has been arising great enthusiasm in the cardiovascular field. Its efficacy has been evaluated in many clinical trials, which provided controversial results. Our incomplete comprehension of the mechanisms underlying the RIC could be impairing the design of clinical trials and the interpretation of their results. In the present review we summarize current knowledge about RIC pathophysiology and the data about its cardioprotective efficacy.

关键词： Remote ischemic conditioning Ischemic heart diseas

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Pasta City

设计 2005年第10期21卷 139-145页

作者：果果禹程（图）朱丽娟（图） Alessandro ciampi（图） Francessco Guazzelli（图） giannoni Giovanni（图） Rene salle（图） Marlboro Classics（图）

放大，聚焦，视线落到佛罗伦萨，意大利。那里烙着pasta的气质——佛罗伦萨的魅力来自于一种混合的滋味美食、艺术、品味……当然，逃不了设计与时尚。

关键词：意大利城市文明设计艺术西方文化

即刻负载种植修复的合理化临床使用过程：病例报告

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中国口腔医学继续教育杂志 2012年第4期15卷 199-202页

作者： Santo Garocchio Emanuele Camaioni Roberto Di Felice Alessandro De Dominicis Maurizio D'Amario Camillo D'Arcangelo Mario giannoni 聂鹤鹏(译) 汤春波(审) 王国平(审) 南京医科大学口腔医学院种植修复科江苏省南京市汉中路 136号 210029

本研究报告了一种在即刻负载种植修复中辅助诊断、手术和修复的新临床方案。该方法的目的是简化正中关系的记录，而以往通常是在手术过程中取印模，并在术后即刻完成。本方法在满足精确印模的同时缩短了操作时间，因此是一种简单有效的... 详细信息

本研究报告了一种在即刻负载种植修复中辅助诊断、手术和修复的新临床方案。该方法的目的是简化正中关系的记录，而以往通常是在手术过程中取印模，并在术后即刻完成。本方法在满足精确印模的同时缩短了操作时间，因此是一种简单有效的方法。本病例通过一位45岁上颔无牙患者即刻负载种植修复展示该方法的临床操作过程，并证实了其具有可重复性。

关键词：种植修复病例报告临床使用即刻负载手术过程辅助诊断临床方案