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Cities and Methods from Complexity Science

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Journal of Systems Science & Complexity 2016年第5期29卷 1177-1186页

作者： BALMACEDA Beatriz fuentes miguel CIDES Corpotraining Av. Providencia 2370 Santiago Chile Santa Fe Institute 1399 Hyde Park Road Santa Fe New Mexico 87501 USA IIF-Sadaf/CONICET Bulnes 642 Buenos Aires 1176 Argentina Facultad de Ingenieria y Tecnologla Universidad San Sebastidn Lota 2465 Santiago 7510157 Chile

The dynamics of human society is now been studying in the context of the artificial environment created by cities. In this work, the authors describe some of the formal methods used in complexity science to study urban systems. The authors discuss some of the important quantitative approaches on cities paying attention to some of the deepest controversies in present scientific *** authors will stress the importance of a transdisciplinary approach when studying this type of cooperative social environments.

关键词： Cities complexity environment.

Determination of Radioactive Contaminant ¹³⁷Cs (Fission Product) and Comparison with Natural ⁴⁰K Present in Mexican Strawberries

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Journal of Geoscience and Environment Protection 2022年第7期10卷 257-265页

作者： Fridda Concepción fuentes Gama Juan Manuel Navarrete Tejero Alejandro Ramírez Chávez miguel Ángel Zúñiga Pérez Department of Inorganic and Nuclear Chemistry Faculty of Chemistry National Autonomous University of Mexico Mexico City Mexico

Several previous papers have been published about radioactive contamination in Mexican soil, marine sediments and foodstuffs. Ever since, results have been according to expectation, mainly consisting of natural isotopes in small concentration. Continuous research leads with the surprising finding of fission product 137Cs (t1/2 = 30 years) in strawberries produced in different states, about 2000 km away from each other. Never before, such contaminant has been observed in foodstuffs, produced in this country. The aim of this work is to report the presence of 137Cs in Mexican strawberries and compare the activity of such contaminant with the natural radioactivity of 40K (t1/2 = 1.28 × 109 years), through gamma spectrometry. Eventually, the specific activity of 137Cs observed in samples FM4, FM5 and FBC is respectively 0.7, 0.8 and 0.3 Bq/kg. The limits established in CODEX-STAN-193-1995 for 137Cs are 1000 Bq/kg, so all samples meet the recommendation. It’s presence now in vegetables result with enough interest to be known and considered in the near future to measure the possible effect that radioactive contamination could reach after nearly 80 years from second world war, where no nuclear test has been performed, nuclear accident occurred, neither nuclear weapon has ever been used.

关键词： Radioactive Contamination

Tenofovir vs lamivudine plus adefovir in chronic hepatitis B:TENOSIMP-B study

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World Journal of Gastroenterology 2017年第41期23卷 7459-7469页

作者： Manuel Rodríguez Juan Manuel Pascasio Enrique Fraga Javier fuentes Martín Prieto Gloria Sánchez-Antolín Jose Luis Calleja Esther Molina María Luisa García-Buey María Angeles Blanco Javier Salmerón María Lucía Bonet Jose Antonio Pons Jose Manuel González miguel Angel Casado Francisco Jorquera 无 Division of Gastroenterology and Hepatology.Hospital Universitario Central de Asturias Unit for the Clinical Management of Digestive Diseases IBISHospital Universitario Virgen del Rocío Liver Transplantation and Hepatology Unit Gastroenterology ServiceHospital Universitario Reina Sofía Digestive Medicine Service Hospital Universitario Miguel Servet Hepatology Unit Digestive Medicine ServiceHospital Universitari i Politècnic La Fe Hepatology Unit Hospital Universitario Rio Hortega Liver Unit Hospital Universitario Puerta de Hierro de MajadahondaUniversidad Autónoma de Madrid Digestive Medicine Service Hospital Clínico de Santiago de Compostela Liver Unit Hospital Universitario de La Princesa Digestive Medicine Service Hospital General Universitario Gregorio Maranon Digestive Medicine Unit Complejo Hospitalario de Granada Digestive Medicine Service Hospital Universitario Son Espases Hepatology Unit IMIB Hospital Universitario Virgen de la Arrixaca Digestive Medicine Service Hospital Clínico Universitario de Valladolid Pharmacoeconomics and Outcomes Research Iberia Division of Gastroenterology and Hepatology Complejo Asistencial Universitario de León the TENOSIMP-B Research Group

AIM To demonstrate the non-inferiority(15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate(TDF) vs the combination of lamivudine(LAM) plus adefovir dipivoxil(ADV) in the maintenance of virologic response in patients with chronic hepatitis B(CHB) and prior failure with *** This study was a Phase IV prospective, randomized, open, controlled study with 2 parallel groups(TDF and LAM+ADV) of adult patients with hepatitis B e antigen(HBe Ag)-negative CHB, prior failure with LAM, on treatment with LAM+ADV for at least 6 mo, without prior resistance to ADV and with an undetectable viral load at the start of the study, in 14 Spanish hospitals. The follow-up time for each patient was 48 wk after randomization, with quarterly visits in which the viral load, biochemical and serological parameters, adverse effects, adherence to treatment and consumption of hospital resources were *** Forty-six patients were evaluated [median age: 55.4 years(30.2-75.2); 84.8% male], including 22 patients with TDF and 24 with LAM+ADV. During study development, hepatitis B virus DNA(HBV-DNA) remained undetectable, all patients remained HBe Ag negative, and hepatitis B surface antigen(HBs Ag) positive. Alanine aminotransferase(ALT) values at the end of the study were similar in the 2 groups(25.1± 7.65, TDF vs 24.22 ± 8.38, LAM+ADV, P = 0.646). No significant changes were observed in creatinine or serum phosphorus values in either group. No significant differences between the 2 groups were noted in the identification of adverse effects(AEs)(53.8%, TDF vs 37.5%, LAM+ADV, P = 0.170), and none of the AEs which occurred were serious. Treatment adherence was 95.5% and 83.3% in the TDF and the LAM+ADV groups, respectively(P = 0.488). The costs associated with hospital resource consumption were significantly lower with the TDF treatment than the LAM+ADV treatment(€4943 ± 1059 vs €5811 ± 1538, respectively, P < 0.001).CONCLUSION TDF monotherapy proved to be safe

关键词： Tenofovir Lamivudine+Adefovir Efficacy Safety Adherence Costs Hepatitis B

Systemic epigallocatechin gallate protects against retinal degeneration and hepatic oxidative stress in the P23H-1 rat

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Neural Regeneration Research 2022年第3期17卷 625-631页

作者： Lorena Perdices Lorena fuentes-Broto Francisco Segura Ana Cavero Elvira Orduna-Hospital Gema Insa-Sánchez Ana Isabel Sánchez-Cano Laura Fernández-Sánchez Nicolás Cuenca Isabel Pinilla Aragón Institute for Health Research(IIS Aragón) ZaragozaSpain Pharmacology Physiology&Legal and Forensic MedicineUniversity of ZaragozaZaragozaSpain Department of Applied Physics University of ZaragozaZaragozaSpain Health Sciences Faculty San Jorge UniversityVillanueva de GállegoSpain Department of Ophthalmology Miguel Servet University HospitalZaragozaSpain Department of Physiology Genetics and MicrobiologyUniversity of AlicanteAlicanteSpain Department of Surgery Gynecology and ObstetricsUniversity of ZaragozaZaragozaSpain/Department of OphthalmologyLozano Blesa University HospitalZaragozaSpain

Retinitis pigmentosa(RP) is a group of inherited retinal disorders that lead to photoreceptor *** has been reported to be related to oxidative stress,autophagy,and inflammation.(-)-Epigallocatechin gallate(EGCG),the most abundant catechin-based flavonoid in green tea leaves,has significant antioxidant,anti-carcinogenic,antimicrobial,and neuroprotective ***,given its low molecular weight and hydrophilic properties,can cross the blood-retinal barrier and is able to reach different ocular tissues such as the lens,cornea,and *** has been shown to provide retinal protection against ischemia;sodium nitroprusside-,N-methyl-D-aspartate-,lipopolysaccharide-,light-,sodium iodate-,or H2 O2-induced damage and diabetic *** suggests that systemic EGCG administration has the potential to protect against retinal degenerative or neurodegenerative diseases such as *** aim of this work was to investigate whether EGCG can protect against RP progression in the animal P23 H line 1,the model of *** P23 H rats were crossed with pigmented Long Evans rats to produce offspring exhibiting the clinical features of *** P23 H rats were treated via intraperitoneal injection with saline or EGCG at a dose of 25 mg/kg every week from P100 to P160 and then compared to wild-type Long Evans *** treated with EGCG showed better visual and retinal electrical function with increased contrast sensitivity and b-wave values compared with those observed in P23 H rats treated with *** reduced lipid peroxidation and increased total antioxidant capacity and catalase and superoxide dismutase *** differences were observed in visual acuity,nitrate levels,nitrite levels or glutathione S-transferase *** conclusion,EGCG not only reduced the loss of visual function in P23 H rats but also improved the levels of antioxidant enzymes and reduced oxidative *** study was approved by the Institutional Animal Care and Use Committee(CE

关键词： antioxidants contrast sensitivity electroretinogram green tea neurodegeneration oxidative stress retinal degeneration retinitis pigmentosa systemic visual acuity

Assessing radiation dose for postoperative radiotherapy in prostate cancer: Real world data

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World Journal of Clinical Oncology 2022年第7期13卷 652-662页

作者： Asunción Hervás-Morón Jose Domínguez-Rullán Victor Duque Santana Mireia Valero Carmen Vallejo Sonsoles Sancho Juan David García fuentes miguel Cámara Gallego Fernando López-Campos Department of Radiation Oncology Hospital Universitario Ramón Y CajalMadrid 28034Spain Department of Medical Physics Hospital Universitario Ramón Y CajalMadrid 28034Spain

BACKGROUND Approximately 30%of patients with localized prostate cancer(PCa)who undergo radical prostatectomy will develop biochemical *** these patients,the only potentially curative treatment is postoperative radiotherapy(PORT)with or without hormone ***,the optimal radiotherapy dose is unknown due to the limited data *** To determine whether the postoperative radiotherapy dose influences biochemical failure-free survival(BFFS)in patients with *** Retrospective analysis of patients who underwent radical prostatectomy for PCa followed by PORT-either adjuvant radiotherapy(ART)or salvage radiotherapy(SRT)-between April 2002 and July *** 2002 to 2010,the prescribed radiation dose to the surgical bed was 66-70 Gy in fractions of 2 Gy;from 2010 until July 2015,the prescribed dose was 70-72 *** were grouped into three categories according to the total dose administered:66-68 Gy,70 Gy,and 72 *** primary endpoint was BFFS,defined as the post-radiotherapy prostatespecific antigen(PSA)nadir+0.2 ng/*** endpoints were overall survival(OS),cancer-specific survival(CSS),and metastasis-free survival(MFS;based on conventional imaging tests).Treatment-related genitourinary(GU)and gastrointestinal(GI)toxicity was evaluated according to Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer ***,we aimed to identify potential prognostic ***,OS,CSS,and MFS were calculated with the Kaplan-Meier method and the log-rank *** and multivariate Cox regression models were performed to explore between-group differences in survival outcome *** A total of 301 consecutive patients were *** these,93(33.6%)received ART and 186(66.4%)SRT;22 patients were excluded due to residual macroscopic disease or local recurrence in the surgical *** this subgroup(n=93),43 patients(46.2%)were Gleason score(GS)≤6,44(47.3%)GS 7,and 6(6.5%)GS≥8;clinical stage

关键词： Prostate cancer Postoperative radiotherapy Dose intensified Radiation dose Biochemical relapse free survival

A biomarker study in Peruvian males with breast cancer

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World Journal of Clinical Oncology 2021年第10期12卷 926-934页

作者： Carlos A Castaneda Miluska Castillo Luis A Bernabe Joselyn Sanchez Ebert Torres Nancy Suarez Katherine Tello Hugo fuentes Jorge Dunstan miguel De La Cruz Jose Manuel Cotrina Julio Abugattas Henry Guerra Henry L Gomez Faculty of Health Sciences Universidad Cientifica del SurLima 15067Peru Department of Medical Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Research Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Breast Cancer Surgery Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru

BACKGROUND Breast cancer(BC)frequency in males is extremely low and tumor features vary from its female *** cancer clinical and pathological features differ by race in *** infiltrating lymphocyte(TIL)levels,mismatch repair(MMR)protein loss,androgen receptor(AR)expression,and PIK3CA gene mutations are predictive biomarkers of response to biological therapy in female *** is limited information about clinical and pathological features as well as predictive biomarkers in males of non-Caucasian races with *** To investigate clinicopathological features and biomarkers of BC tumors in males and their prognostic value in Peruvian *** This study looked at a single-institution series of 54 Peruvian males with invasive BC who were diagnosed from Jan 2004 to June *** pathological features,TIL levels,MMR proteins,AR immunohistochemistry staining,and PIK3CA gene mutations were prospectively evaluated in cases with available paraffin *** of AR and estrogen receptor(ER)positive cells was additionally calculated by software after slide *** analyses included association tests,intraclass correlation test and Kaplan Meier overall survival *** The median age was 63 years and most cases were ER-positive(85.7%),HER2 negative(87.2%),Luminal-A phenotype(60%)and clinical stage II(41.5%)among our male breast *** TIL was 10%and higher levels tended to be associated with Luminal-B phenotype and higher ***-positive was found in 85.3%and was correlated with ER(intraclass index of 0.835,P<0.001).Loss of MMR proteins was found in 15.4%and PIK3CA mutation(H1047R)in 14.3%(belonged to the Luminal-A phenotype).Loss of MMR proteins was associated with AR-negative(P=0.018)but not with ER(P=0.43)or TIL(P=0.84).Early stages(P<0.001)and lower grade(P=0.006)were associated with longer overall *** status,phenotype,AR status,TIL level,MMR protein loss nor PIK3CA mutation was not associated

关键词： Male breast neoplasm Androgen receptor Tumor-infiltrating lymphocyte Mismatch repair protein PIK3CA mutation

Acceptance of living liver donation among medical students: A multicenter stratified study from Spain

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World Journal of Gastroenterology 2016年第25期22卷 5800-5813页

作者： Antonio Ríos Ana Isabel López-Navas Ana Isabel López-López Francisco Javier Gómez Jorge Iriarte Rafael Herruzo Gerardo Blanco Francisco Javier Llorca Angel Asunsolo Pilar Sánchez-Gallegos Pedro Ramón Gutiérrez Ana Fernández María Teresa de Jesús Laura Martínez-Alarcón Alberto Lana Lorena fuentes Juan Ramón Hernández Julio Virseda José Yelamos José Antonio Bondía Antonio miguel Hernández Marco Antonio Ayala Pablo Ramírez Pascual Parrilla International Collaborative Donor Project ('Proyecto Colaborativo Internacional Donante' 30007 Casillas Murcia Spain Department of Surgery Paediatrics Obstetrics and Gynaecology University of Murcia Avenida de las Fuerzas Armadas 30800 Espinardo Murcia Spain Transplant Unit Surgery Service IMIB - Virgen de la Arrixaca University Hospital Carretera Madrid-Cartagena s/n 30120 El Palmar Murcia Spain Regional Transplant Centre Consejeria de Sanidad y Consumo de la Region de Murcia 30008 Ronda de Levante Murcia Spain Hospital Clinico Universitario Virgen de la Arrixaca Departamento de Cirugia General y del Aparato Digestivo Unidad de Trasplantes 30007 Casillas Murcia Spain Department of Psychology Universidad Catolica San Antonio (UCAM) Avenida de los Jeronimos 30107 Guadalupe Murcia Spain Department of Urology San Juan University Hospital of Alicante 03010 Calle Pintor Baeza Alicante Spain Universidad de Granada Avenida del Hospicio s/n 18010 Granada Spain Universidad de Navarra Campus Universitario 31080 Pamplona Navarra Spain Universidad Autonoma de Madrid Ciudad Universitaria de cantoblanco 28049 Madrid Spain Servicio de Cirugia HBP y Trasplante Hepatico Complejo Hospitalario Universitario de Badajoz Hospital Infanta Cristina Avenida Elvas s/n 06006 Badajoz Spain Universidad de Cantabria Avenida los Castros s/n 39005 Santander Cantabria Spain Departamento de Cirugia Ciencias Medicas y Sociales Facultad de Medicina y Ciencias de la Salud Universidad de Alcala Campus Cientifico-Tecnologico Plaza de San Diego s/n 28801 Alcala de Henares Madrid Spain Facultad de Medicina Universidad de Malaga 29071 Avenida de Cervantes Malaga Spain Servicio de Urologia (Complejo Hospitalario Universitario de Canarias CHUC) y Departamento de Cirugia (Universidad de La Laguna ULL) Calle Molinos de Agua s/n 38207 San Cristobal de La Laguna Santa Cruz de Tenerife Spain Departamento de Ciencias Biomedicas Basicas Facultad de Ciencias Biomedicas Universidad Europea de

AIM: To analyze the attitude of Spanish medical students toward living liver donation (LLD) and to establish which factors have an influence on this ***: Study type: A sociological, interdisciplinary, multicenter and observational study. Study population: Medical students enrolled in Spain (n = 34000) in the university academic year 2010-2011. Sample size: A sample of 9598 students stratified by geographical area and academic year. Instrument used to measure attitude: A validated questionnaire (PCID-DVH RIOS) was self-administered and completed anonymously. Data collection procedure: Randomly selected medical schools. The questionnaire was applied to each academic year at compulsory sessions. Statistical analysis: Student´s t test, χ2 test and logistic regression ***: The completion rate was 95.7% (n = 9275). 89% (n = 8258) were in favor of related LLD, and 32% (n = 2937) supported unrelated LLD. The following variables were associated with having a more favorable attitude: (1) age (P = 0.008); (2) sex (P < 0.001); (3) academic year (P < 0.001); (4) geographical area (P = 0.013); (5) believing in the possibility of needing a transplant oneself in the future (P < 0.001); (6) attitude toward deceased donation (P < 0.001); (7) attitude toward living kidney donation (P < 0.001); (8) acceptance of a donated liver segment from a family member if one were needed (P < 0.001); (9) having discussed the subject with one’s family (P < 0.001) and friends (P < 0.001); (10) a partner’s opinion about the subject (P < 0.001); (11) carrying out activities of an altruistic nature; and (12) fear of the possible mutilation of the body after donation (P < 0.001).CONCLUSION: Spanish medical students have a favorable attitude toward LLD.

关键词： Attitude Living liver donation Medical students Transplantation Organ donation Psychosocial variables Spain

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城市环境设计 2016年第5期 372-373页

作者： Sandra González álvarez miguel Comesa?a Alonso Alberto fuentes Valcárcel Ramón López González Maite Fraga Lamas

瓦尔特·本雅明《拱廊街计划》一书中对19世纪的中心——巴黎的技术、商业、社会和艺术空间发展的描述让我们有这样的疑问:什么是购物广场?它的现状如何?未来会怎样?这些问题让我们不再满足于已有知识体系对于商业广场的认知,从而踏入... 详细信息

瓦尔特·本雅明《拱廊街计划》一书中对19世纪的中心——巴黎的技术、商业、社会和艺术空间发展的描述让我们有这样的疑问:什么是购物广场?它的现状如何?未来会怎样?这些问题让我们不再满足于已有知识体系对于商业广场的认知,从而踏入寻求未来商业模式的旅程。"回归历史就意味着引用历史。"因此我们展望未来:21世纪的商业广场赋予我们怎样的想象?如何缝合多种功能板块?建筑如何作为公共花园存在于城市?这些问题不断碰撞、摩擦,使我们得到拓展视野、超乎想象的惊喜结果。

关键词：商业广场

Occupational determinants of continued smoking during pregnancy. INMA Valencia cohort study

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Open Journal of Preventive Medicine 2012年第4期2卷 436-443页

作者： Virginia fuentes-Leonarte Mario Murcia-Hinarejos Ma Carmen González-Galarzo Ana Ma García Marisa Rebagliato miguel Hernández University Alicante Spain Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP) Barcelona Spain The Center for Research in Occupational Health (CiSAL) Valencia Spain Unit of Addictive Disorders of San Marcelino Valencia Spain

To describe the smoking habits of the mothers participating in the INMA (INfancia y Medio Ambiente or Childhood and the Environment) cohort of Valencia and to determine which occupational factors are associated with smoking cessation during pregnancy. Cohort study comprising 855 pregnant women from Health Service Areas 6 and 7 was set up in the Autonomous Region of Valencia, Spain. Data on smoking and smoking cessation during pregnancy, and on sociodemographic and work related variables were collected through structured questionnaires at the first and third trimester of pregnancy. Multivariate logistic regression models were constructed to assess factors related to smoking at the beginning of the pregnancy and to continued smoking. 787 women followed in the project and completed all the data. Among them 40.9% smoked at the beginning of pregnancy and 56.2% continued until gestational week 32. Time and effort spent on housework was associated with smoking at the beginning of pregnancy while stress in the workplace related variables contributed to both the prevalence of smoking at the beginning of the pregnancy and the persistence in the habit throughout pregnancy. We found a high prevalence of smoking among the pregnant mothers. Both, conditions in the workplace, as well as the burden of housework were found to be risk factors for smoking and not quitting during pregnancy. These factors should be taken into account when developing health programs designed to encourage the incorporation of healthy habits into the lives of pregnant women.

关键词： Pregnancy Cohort Studies Smoking Working Women Smoking Cessation