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Don Quijote

作者： miguel de cervantes translated by Burton Raffel edited by Diana de Armas Wilson.

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堂·吉诃德

Effect of the Melatonin on Morning Blood Pressure Surge and Norepinephrine Endovenous Infusion in Healthy Volunteers

作者： (西)塞万提斯(miguel de cervantes)

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International Journal of Clinical Medicine 2015年第7期6卷 458-464页

作者： Jaime Carranza-Madrigal José miguel cervantes-Alfaro Sonia María López-Correa Escuela de Enfermería y Salud Pública Universidad Michoacana de San Nicolás de Hidalgo Morelia México División de Estudios de Postgrado Facultad de Ciencias Médicas y Biológicas “Dr. Ignacio Chávez” Universidad Michoacana de San Nicolás de Hidalgo Morelia México

Melatonin, the pineal gland hormone, has been considered as a central hypotension factor. However their roles in the regulation of the human blood pressure and its possible use as antihyper-tensive drug have not been fully determined. The objective of this trial was to determine the effect of melatonin on blood pressure morning increase and a peripheral vasoconstriction challenge in healthy volunteers. Twelve healthy male volunteers were included in a prospective, comparative, randomized, crossover trial in which changes on blood pressure (BP) and heart rate (HR) after the first morning orthostatism and endovenous norepinephrine (NE) infusion were measured one hour after the administration of placebo (PL) or 10 mg of melatonin in double blind conditions. Melatonin blunted the effects of the first orthostatism on BP and HR. Melatonin also reduces the pressor effect of NA. One concludes that melatonin has central and peripheral hypotensive effects that support a potential role of this hormone in cardiovascular therapeutics.

关键词： Blood Pressure Hypertension Melatonin Norepinephrine Orthostatism

Excess Levels of ILysine and Threonine in Low Protein, Wheat-based Diets on Serum Amino Acid Concentrations and Performance of Growing Pigs

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Journal of Agricultural Science and Technology(A) 2012年第5期2卷 619-627页

作者： Adriana Morales JoseLuis Landero Alfonso Araiza Hugo Bernal Willem C. Sauer Antonio Rosas miguel cervantes Instituto de Ciencias Agrlcolas Universidad Aut6noma de Baja California Mexicali Baja California 21100 Mexico Facultad de Agronomla Universidad Autonoma de Nuevo Leon Monterrey Mexico IlAF Universidad Michoacana de San Nicolas de Hidalgo Morelia Mich Mexico

Two experiments were conducted to evaluate the growth response and serum concentrations （SC） of amino acids （AA） in pigs fed wheat-based diets with either deficient, adequate or excess Lys and Thr. Previously, the standardized ileal digestibilities of AA in a basal diet were determined with five ileal cannulated pigs in a digestion trial. In experiment 1, 21 pigs （12.5±0.91 kg） were used to evaluate the effect of adding 0%, 0.69%, and 1.38% free L-Lys. The best growth response was obtained with 0.69% added L-Lys, equivalent to 1.05% total in the diet. The SC of Arg, Thr, and Val were lower （P 〈 0.05） in pigs fed the Lys adequate diet, compared to the deficient, but no further change occurred with excess Lys （P 〉 0.10）. Lys SC increased with each increment in the dietary Lys content （P 〈 0.05）. In experiment 2, 20 pigs （14.3 ± 1.57 kg） were used, and the addition of 0%, 0.14%, 0.28%, and 0.42% crystalline Thr, to the 0.69% L-Lys-supplemented basal diet, was evaluated. The best response was obtained with added 0.28% L-Thr, （0.66% total Thr）, but excess Thr reduced feed intake and growth rate. Moderate and excess levels of Yhr increased the SC of Thr, but excess reduced those of Va[ and Lys. These data show that excess Thr, but not Lys, affect the performance of growing pigs. Also, these data indicate that Val may become limiting in low protein diets with excess Lys or Thr.

关键词： Pigs lysine threonine low-wotein wheat.

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堂·吉诃德 1

Common and distinct regulation of human and mouse brown and beige adipose tissues： a promising therapeutic target for obesity

丛书名：最经典英语文库

2016年

作者：（西）塞万提斯（miguel de cervantes）

本书讲述了故事发生在四五百年前，那时欧洲的骑士时代已经结束了，但是本书的主人公堂吉诃德先生却读骑士小说入了迷，走火入魔，找出他的曾祖父曾经用过的盔甲、长矛和盾牌，打扮成骑士模样，骑上马出去周游世界……

ISBN: (纸本)9787205086121

关键词：语言、文字

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Protein & Cell 2017年第6期8卷 446-454页

作者： Xuejiao Liu Christopher cervantes Feng Liu Department of Metabolism and Endocrinology Metabolic Syndrome Research Center of Central South University The Second Xianqya Hospital Central South University Changsha 410011 China Department of Pharmacology University of Texas Health Science Center at San Antonio San Antonio TX 78229 USA

Obesity, which underlies various metabolic and cardio- vascular diseases, is a growing public health challenge for which established therapies are inadequate. Given the current obesity epidemic, there is a pressing need for more novel therapeutic strategies that will help adult individuals to manage their weight. One promising therapeutic intervention for reducing obesity is to enhance energy expenditure. Investigations into human brown fat and the recently discovered beige/brite fat have galvanized intense research efforts during the past decade because of their pivotal roles in energy dissi- pation. In this review, we summarize the evolution of human brown adipose tissue （hBAT） research and dis- cuss new in vivo methodologies for evaluating energy expenditure in patients. We highlight the differences between human and mouse BAT by integrating and comparing their cellular morphology, function, and gene expression profiles. Although great advances in hBAT biology have been achieved in the past decade, more cellular models are needed to acquire a better under- standing of adipose-specific processes and molecular mechanisms. Thus, this review also describes the development of a human brown fat cell line, which could provide promising mechanistic insights into hBAT function, signal transduction, and development. Finally, we focus on the therapeutic potential and current limi- tations of hBAT as an anti-glycemic, anti-lipidemic, and weight loss-inducing ＇metabolic panacea＇.

关键词： human brown adipose tissue energymetabolism obesity

Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1584-1606页

作者： Rodolfo Daniel cervantes-Villagrana Damaris Albores-García Alberto Rafael cervantes-Villagrana Sara Judit García-Acevez Department of Pharmacology Center for Research and Advanced Studies of the National Polytechnic Institute(CINVESTAV-IPN)07360 Mexico CityMexico Department of Environmental Health Sciences Florida International University(FIU)MiamiFlorida 33199USA Laboratorio de investigación en Terapéutica Experimental Unidad Académica de Ciencias QuímicasÁrea de Ciencias de la SaludUniversidad Autónoma de Zacatecas(UAZ)ZacatecasMéxico Dirección de Proyectos e Investigación Grupo Diagnóstico Médico Proa06400 CDMX CuauhtémocMéxico

Normal cells are hijacked by cancer cells forming together heterogeneous tumor masses immersed in aberrant communication circuits that facilitate tumor growth and *** the well characterized angiogenic effect of some tumor-derived factors;others,such as BDNF,recruit peripheral nerves and *** neurogenic switch,activated by tumor-derived neurotrophins and extracellular vesicles,attracts adjacent peripheral fibers(autonomic/sensorial)and neural progenitor ***,tumor-associated nerve fibers can guide cancer cell ***,IL-1β,CCL2,PGE2,among other chemotactic factors,attract natural immunosuppressive cells,including T regulatory(Tregs),myeloid-derived suppressor cells(MDSCs),and M2 macrophages,to the tumor *** leukocytes further exacerbate the aberrant communication circuit releasing factors with neurogenic ***,cancer cells directly evade immune surveillance and the antitumoral actions of natural killer cells by activating immunosuppressive mechanisms elicited by heterophilic complexes,joining cancer and immune cells,formed by PD-L1/PD1 and CD80/CTLA-4 plasma membrane ***,nervous and immune cells,together with fibroblasts,endothelial,and bone-marrow-derived cells,promote tumor growth and enhance the metastatic properties of cancer *** by the demonstrated,but restricted,power of anti-angiogenic and immune cell-based therapies,preclinical studies are focusing on strategies aimed to inhibit tumor-induced *** we discuss the potential of anti-neurogenesis and,considering the interplay between nervous and immune systems,we also focus on anti-immunosuppression-based *** molecules,antibodies and immune cells are being considered as therapeutic agents,aimed to prevent cancer cell communication with neurons and leukocytes,targeting chemotactic and neurotransmitter signaling pathways linked to perineural invasion and metastasis.

关键词： PD1 therapies invasion

Effect of Senescence Retardants on the Quality of Persian Lime Fruits

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Phyton-International Journal of Experimental Botany 2024年第8期93卷 1805-1818页

作者： Rafael Ariza-Flores Rafael Ambriz-cervantes Pedro Cadena-Iñiguez Luis A.Gálvez-Marroquín miguel A.Cano-García National Institute of Forestry Agriculture and Livestock Research(INIFAP)South Pacific Regional CenterSanto Domingo Barrio BajoVilla de EtlaOaxaca68200México National Institute of Forestry Agriculture and Livestock Research(INIFAP)Zacatepec Research StationZacatepecMorelos62780México National Institute of Forestry Agriculture and Livestock Research(INIFAP)Central Chiapas Research StationOcozocoautlaChis29140México National Institute of Forestry Agriculture and Livestock Research(INIFAP)Oaxaca Central Valley Research StationSanto Domingo Barrio BajoVilla de EtlaOaxaca68200México

The objective of this study consisted of evaluating the effect of the application of chitosan(Q),1-methylcyclopropene(1-MCP)under two controlled temperatures on some physical,physiological,and chemical parameters contributing to the quality of Persian lime Citrus latifolia *** treatments were evaluated,resulting from the combination of four senescence retardant applications(Q,1-MCP,1-MCP+Q,and without application)on fruits stored at two temperatures(12/20℃.Epidermis color(luminosity,chromaticity,and hue),fruit appearance,respiration,weight loss,total juice content,total soluble solids,and titratable acidity were registered during the *** results indicate that the 1-MCP and Q combination favored fruit postharvest quality conditions such as reducing respiration rate;maintaining fruit good appearance,turgidity,and brighter fruit chromaticity;fruits treated with chitosan and stored at 12℃,favored total soluble *** the other hand,Variables such as weight loss,juice content,acidity,phenols,flavonoids,antioxidant activity,and hue values were favored by a 12℃ storing temperature regardless of the *** general,the use of modified atmospheres,senescence retardants,and refrigeration as postharvest methods,can increase Persian lime shelf life.

关键词： Citrus latifolia quality conservation organic alternatives

Glycemic control in tuberculosis: Lessons learned from Taiwan

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Asian Pacific Journal of Tropical Medicine 2019年第10期12卷 438-441页

作者： Min-Chih Wang Jorge cervantes Paul L.Foster School of Medicine Texas Tech University Health Science Center LubbockTXUSA

The global epidemic of diabetes and tuberculosis poses challenges to the control of both *** with tuberculosis and diabetes experience worse clinical manifestations,increased risk of treatment failure,recurrence,and *** is also associated with risk for latent tuberculosis *** of hyperglycemia reduces the risk and improves the outcome of tuberculosis in diabetic *** epidemiological studies from Taiwan have provided new and important information on the benefits of metformin in *** addressing the issue of multidrug-resistant tuberculosis,a shortened anti-tuberculous therapeutic regime seems a feasible approach for better cure rates,with less loss-to-follow.

关键词： Diabetes Tuberculosis Taiwan