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Involvement of substance P and the NK-1 receptor in pancreatic cancer

World Journal of Gastroenterology 2014年第9期20卷 2321-2334页

作者： miguel Muoz Rafael Coveas Virgen del Rocío University Hospital Research Laboratory on Neuropeptides (IBIS) 41013 Seville Spain Institute of Neurosciences of Castilla y León (INCYL) Laboratory of Neuroanatomy of the Peptidergic Systems (Lab 14) University of Salamanca 37007 Salamanca Spain

Pancreatic cancer is the fourth leading cause of cancer related-death for both men and women and the 1-and5-year relative survival rates are 25%and 6%,***,it is urgent to investigate new antitumor drugs to improve the survival of pancreatic cancer *** peptide substance P(SP)has a widespread distribution throughout the *** binding to the neurokinin-1(NK-1)receptor,SP regulates biological functions related to cancer,such as tumor cell proliferation,neoangiogenesis,the migration of tumor cells for invasion,infiltration and metastasis,and it exerts an antiapoptotic effects on tumor *** is known that the SP/NK-1 receptor system is involved in pancreatic cancer progression:(1)pancreatic cancer cells and samples express NK-1 receptors;(2)the NK-1 receptor is overexpressed in pancreatic cancer cells in comparison with non-tumor cells;(3)nanomolar concentrations of SP induce pancreatic cancer cell proliferation;(4)NK-1 receptor antagonists inhibit pancreatic cell proliferation in a concentration-dependent manner,at a certain concentration,these antagonists inhibit100%of tumor cells;(5)this antitumor action is medi-ated through the NK-1 receptor,and tumor cells die by apoptosis;and(6)NK-1 receptor antagonists inhibit angiogenesis in pancreatic cancer *** these data suggest that the SP/NK-1 receptor system could play an important role in the development of pancreatic cancer;that the NK-1 receptor could be a new promising therapeutic target in pancreatic cancer,and that NK-1 receptor antagonists could improve the treatment of pancreatic cancer.

关键词： Pancreas Substance P Neurokinin-1 receptor antagonists Apoptosis Antitumor Angiogenesis Metastasis Pancreatic cancer

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Constructing Hopf Insulator from Geometric Perspective of Hopf Invariant

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Chinese Physics Letters 2024年第3期41卷 121-126页

作者：常治文郝维昌 miguel Bustamante 刘鑫 Institute of Theoretical Physics School of Physics and Optoelectronic EngineeringBeijing University of TechnologyBeijing 100124China School of Physics Beihang UniversityBeijing 100191China Complex and Adaptive Systems Laboratory School of Mathematics and StatisticsUniversity College DublinBelfield4DublinIreland

We propose a method to construct Hopf insulators based on the study of topological defects from the geometric perspective of Hopf invariant ***,we prove two types of topological defects naturally inhering in the inner... 详细信息

关键词： Hopf topological invariant

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Magnetofection as a new tool to study microglia biology

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Neural Regeneration Research 2019年第5期14卷 767-768页

作者： Jose Luis Venero miguel Angel Burguillos Instituto de Biomedicina de Sevilla (IBiS)/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla and Departamento de Bioquímica y Biología Molecular Facultad de Farmacia Universidad de Sevilla Department of Biochemistry University of Cambridge

Microglia are the resident macrophages of the brain,originally described by Pio del Rio-Hortega(a student of Santiago Ramon y Cajal)in a series of studies in *** those pioneering studies,many others have followed to describe microglia as complex and multitasking cells with many diverse roles under physiological(*** key role in synapse pruning during development)or diseased *** exist as sentinels or surveyors of the environment that surround neurons,becoming reactive upon a wide array of stimuli and consequently developing an appropriate inflammatory *** fact,a neuroinflammatory response driven by microglia is found in virtually every disease process that occurs within the central nervous ***,a better understanding of the mechanisms governing the microglia response is the key to improving the outcome of neurodegenerative conditions.

关键词： Magnetofection new tool study microglia biology

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Green ionic metal-organic frameworks as nanocatalysts for CO_(2)fixation

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Nano Research 2025年第1期18卷 260-269页

作者： Nuria Martín miguel Maireles-Porcar Julián Sánchez Velandia Belén Altava Francisco G.Cirujano Eduardo García-Verdugo Departamento de Química Inorgánica y Orgánica Universidad Jaume IAv.Sos Baynats/nCastellóde la PlanaCastellón 12071Spain

Co,Ni,and Zn iso-reticular coordination polymers of 2,5-dihydroxyterphthalic acid(H_(2)dot)can be rapidly obtained under room temperature and aqueous conditions using either sodium or ammonium hydroxide as the bases to deprotonate the *** use of metal bromides and tetrabutylammonium hydroxide(TBAOH)as the base allows the green synthesis of ionic metal-organic frameworks(MOFs),characterized by X-ray diffraction(XRD),Fourier transform infrared(FTIR),scanning electron microscopy(SEM),thermo gravimetric analysis(TGA),H-nuclear magnetic resonance(NMR),elemental analysis,and X-ray photoelectron spectroscopy(XPS),and employed in the pressure,solvent,and additive-free CO_(2)fixation to epoxides by its cycloaddition to epichlorohydrin,exhibiting a cooperative behavior between the MOF and the ionic liquid formed within the framework,achieving TONs of the confined tetrabutylammonium bromide(TBABr)up to 700.

关键词： metal-organic frameworks(MOFs) ionic liquids heterogeneous catalysis CO_(2)conversion

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Normozoospermic versus teratozoospermic domestic cats： differential testicular volume, sperm morphometry, and subpopulation structure during epididymal maturation

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Asian Journal of Andrology 2016年第6期18卷 871-878页

作者： miguel Angel Gutierrez-Reinoso Manuel Garcia-Herreros National Secretariat of Higher Education Science Technology and Innovation (SENESCYT) Quito Ecuador

Teratozoospermia （〈40% morphologically normal spermatozoa/ejaculate） is a frequent phenomenon in feline species. This research was carried out to study the possible differences in testicular volume, differential sperm morphometric traits, and potential differences regarding the sperm subpopulational structure during epididymal sperm maturation in teratozoospermic feline donors. Epididymal sperm samples were collected from the caput （R1）, corpus （R2）, and cauda （R3） epididymidis in two donor groups （N： normozoospermic; T： teratozoospermic）. Aliquots were assessed for concentration, viability, motility, and acrosomal integrity. Sperm morphometric descriptors from CASA-Morph analysis were analyzed by the Principal Component Analysis （PCA） and clustering analyses. Irrespective of the group analyzed, PCA revealed two Principal Components （PCs） for each epididymal region explaining more than the 93% of the variance. Surprisingly, the number of subpopulations remained constant in regions R1-R2-R3 irrespective of the donor group analyzed. However, the distribution of these subpopulations was found to be structurally different and strongly influenced by the epididymal region and the donor group. In conclusion, testicular morphometry and the sperm subpopulation structure were different in N and T donors. The alterations in subpopulations during epididymal maturation could be used as a potential clinical indicator of teratozoospermic individuals since an important influence of teratozoospermia on sperm subpopulation structure has been demonstrated.

关键词： epididymis feline sperm morphometry sperm subpopulations teratozoospermia testicular volume

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Science Letters:Visual odometry for road vehicles—feasibility analysis

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第12期8卷 2017-2020页

作者： SOTELO miguel-angel GARCíA Roberto PARRA Ignacio FERNNDEZ David GAVILN miguel LVAREZ Sergio NARANJO José-eugenio Department of Electronics University of Alcalá Alcalá de Henares 28871 Spain Department of Informatics Industrial Automation Institute CSIC Madrid Spain

Estimating the global position of a road vehicle without using GPS is a challenge that many scientists look forward to solving in the near future. Normally, inertial and odometry sensors are used to complement GPS measures in an attempt to provide a means for maintaining vehicle odometry during GPS outage. Nonetheless, recent experiments have demonstrated that computer vision can also be used as a valuable source to provide what can be denoted as visual odometry. For this purpose, vehicle motion can be estimated using a non-linear, photogrametric approach based on RAndom SAmple Consensus (RANSAC). The results prove that the detection and selection of relevant feature points is a crucial factor in the global performance of the visual odometry algorithm. The key issues for further improvement are discussed in this letter.

关键词： 3D visual odometry Ego-motion estimation RAndom SAmple Consensus (RANSAC) Photogrametric approach

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Exploring spatial relationships between stream channel features,water depths and flow velocities during flash floods using HEC-GeoRAS and Geographic Information Systems

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Journal of Geographical Sciences 2022年第4期32卷 757-782页

作者： miguel LEAL Eusébio REIS Pedro Pinto SANTOS Centre of Geographical Studies and Associated Laboratory TERRA Institute of Geography and Spatial PlanningUniversidade de Lisboa1600-276 LisbonPortugal Forest Research Centre and Associated Laboratory TERRA School of AgricultureUniversidade de LisboaTapada da Ajuda1349-017 LisbonPortugal

Water depths and flow velocities decisively influence the damage caused by flash *** Information System(GIS)is a powerful and useful tool,allowing the spatial analysis of results obtained by hydraulic modelling,namely from the HEC-RAS/HEC-GeoRAS *** GIS spatial analysis performed in this study seeks to explain and quantify the spatial relationships between the stream channel features and flow components during flash flood *** these relationships are generically known,there are few studies exploring this subject in different geographic contexts.A 1D hydraulic model was applied in a small watershed in Portugal,providing good results in the definition of floodable areas,water depths and longitudinal *** direct relationship was found between water depths and velocities in the floodable areas;however,negative strong correlations were found between the two flow components along the stream *** slope,channel and flood width,and roughness prove to be highly relevant on the longitudinal variations of water depths and velocities and on the location of maximum *** peak discharges and return periods(R;)can change the relationships between water depths and velocities at the same *** can be improved with more accurate elevation data for stream channels and floodplains.

关键词： flash floods water depth flow velocity geographic information systems(GIS) spatial analysis

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GBP-WAHSN:A Group-Based Protocol for Large Wireless Ad Hoc and Sensor Networks

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Journal of Computer Science & Technology 2008年第3期23卷 461-480页

作者： Jaime Lloret miguel Garcia Jesus Tomás Fernando Boronat Department of Communications Polytechnic University of ValenciaCamino Vera s/n46022ValenciaSpain

Grouping nodes gives better performance to the whole network by diminishing the average network delay and avoiding unnecessary message forwarding and additional overhead. Many routing protocols for ad-hoc and sensor networks have been designed but none of them are based on groups. In this paper, we will start defining group-based topologies, and then we will show how some wireless ad hoc sensor networks （WAHSN） routing protocols perform when the nodes are arranged in groups. In our proposal connections between groups are established as a function of the proximity of the nodes and the neighbor＇s available capacity （based on the node＇s energy）. We describe the architecture proposal, the messages that are needed for the proper operation and its mathematical description. We have also simulated how much time is needed to propagate information between groups. Finally, we will show a comparison with other architectures.

关键词： group-based protocol group-based architecture group-based routing algorithm large networks

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Perception of Disasters and Land Reclamation in an Informal Settlement on Reclaimed Land:Case of the BASECO Compound,Manila,the Philippines

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International Journal of Disaster Risk Science 2020年第5期11卷 640-654页

作者： Ven Paolo Bruno Valenzuela miguel Esteban Onuki Motoharu Graduate Program in Sustainability Science-Global Leadership Initiative The University of TokyoKashiwaChiba 277-8563Japan Department of Civil and Environmental Engineering Waseda UniversityTokyo 169-8555Japan

Southeast Asia's coastal urban areas continue to grow,with land reclamation fast becoming an important option for megacities to address issues of economic growth and increasing population *** are divided over the advantages and disadvantages of land reclamation,though this process continues unabated,exposing settlements to coastal *** Bataan Shipping and Engineering Company(BASECO)compound is an informal settlement on reclaimed land in Manila,the *** informal coastal settlements view disaster risk and their more pressing socioeconomic needs is crucial to understanding the potentials and repercussions of land *** a topographic survey,a questionnaire survey,and the protective action decision model,this study explored the perception of disasters and land reclamation of informal settlers who are living on reclaimed *** study found that people are aware of disaster risks,but are more concerned with everyday *** are divided on the issue of further land *** on the original non-reclaimed land view it as a coastal defense,while those on reclaimed land fear potential *** this,all locations in the community are concerned with the loss of jobs,economic opportunities,and eviction,rather than potential disasters.

关键词： Coastal hazards Flooding Informal settlements Land reclamation Philippines Risk perception Urbanization

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Assessing trends in wildland-urban interface fire research through text mining: a comprehensive analysis of published literature

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Journal of Forestry Research 2024年第4期35卷 102-114页

作者： Hafsae Lamsaf Asmae Lamsaf Mounir A.Kerroum miguel Almeida ADAI–Associação para o Desenvolvimento da Aerodinâmica Industrial Rua Pedro Hispano n.º123030‑289 CoimbraPortugal Laboratory of Research in Computer Science Faculty of SciencesIbn Tofail UniversityKenitraMorocco

Research on fires at the wildland-urban inter-face(WUI)has generated significant insights and advance-ments across various fields of ***,agri-culture,and social sciences have played prominent roles in understanding the impacts of fires in the environment,in protecting communities,and addressing management *** study aimed to create a database using a text mining technique for global researchers interested in WUI-projects and highlighting the interest of countries in this ***’s-Keywords analysis emphasized the dominance of fire science-related terms,especially related to WUI,and identified keyword clusters related to the WUI fire-risk-assessment-system-“exposure”,“danger”,and“vulnerability”within wildfire *** over the past decade showcase shifting research interests with a growing focus on WUI fires,while regional variations highlighted that the“exposure”keyword cluster received greater atten-tion in the southern Europe and South ***,vulnerability keywords have relatively a lower representation across all *** analysis underscores the interdisci-plinary nature of WUI research and emphasizes the need for targeted approaches to address the unique challenges of the wildland-urban ***,this study provides valu-able insights for researchers and serves as a foundation for further collaboration in this field through the understanding of the trends over recent years and in different regions.

关键词： WUI Text mining Wildfires Fire science State of the art Scientific publications

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