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Topical Applications of Thiosulfinate-Enriched Allium sativum Extract Accelerates Acute Cutaneous Wound Healing in Murine Model

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Chinese Journal of Integrative Medicine 2020年第11期26卷 812-818页

作者： Juan Luis Santiago Eva Maria Galan-Moya Jose Ramon Munoz-Rodriguez miguel angel de la Cruz-Morcillo Francisco Javier Redondo-Calvo Ignacio Gracia-Fernandez Peter M.Elias Jose Manuel Perez-ortiz Mao-Qiang Man Dermatology Service Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Research Unit Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Oncology Laboratory Centro Regional de Investigaciones BiomedicasUniversidad de Castilla-La ManchaAlbacete(02008)Spain Instituto de Tecnologia Quimica y Medioambiental Universidad de Castilla-La ManchaCiudad Real(13004)Spain Dermatology Service Vetera ns Affairs Medical Centerand Department of DermatologyUniversity of CaliforniaSan FranciscoCA(94121)USA Dermatology Hospital Southern Medical UniversityGuangzhou(510091)China

Objective To determine whether topical applications of thiosulfinate-enriched Allium sativum extract(TASE)can accelerate acute cutaneous wound healing(WH)in a murine *** Keratinocyte viability and in vitro wound closure were assessed in keratinocyte *** of topical TASE(0.5μg/mL of allicin in 97%ethanol)on acute cutaneous WH were determined in a murine model of acute cutaneous *** mice were alternately assigned to the vehicle-and TASE-treated groups(n=6 per group).Expression levels of mRNA for keratinocyte differentiation marker-related proteins(filaggrin,loricrin and involucrin)and lipid synthetic enzymes(elongation of very long chain fatty acids protein 4(ELOVL4),fatty acid synthase(FA2H),3-hydroxy-3-methyl-glutaryl-coenzyme A reductase(HMGCoA),and serine palmitoyltransferase(SPT))were assessed using real-time quantitative polymerase chain reaction on day 3 and 8 after wounding,while transepidermal water loss(TEWL)rates were measured in wounded *** TASE accelerated WH both in vivo(40%vs.22%reduction in wound area,P<0.01)and in vitro(90%vs.65%reduction in wound area,P<0.01).Moreover,topical applications of TASE upregulated the expression levels of epidermal mRNA for ELOVL4,HMGCoA,SPT,filaggrin,loricrin and involucrin(P<0.05 ***-treated controls)on day 3 after ***,TASE significantly lowered TEWL rates in comparison with vehicle alone on day 8(33.06±2.09 g/(m^2·h)vs.24.60±2.04 g/(m^2·h),P<0.01).Conclusions Topical applications of TASE stimulated keratinocyte proliferation and formation of epidermal permeability barrier function,leading to acceleration of acute cutaneous *** products containing TASE could be used to manage acute cutaneous WH.

关键词： Allium sativum thiosulfinate wound healing permeability barrier keratinocytes proliferation

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Arrhythmias in Common Arterial Trunk(CAT):Uncommon Atrial Tachycardia in CAT with Anomalous Pulmonary Venous Connection and Re-entry Atrial Tachycardia in CAT with HIV Seropositive Mother

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Congenital Heart Disease 2021年第4期16卷 417-425页

作者： Elio Caruso Silvia Farruggio Davide Calvaruso Corrado Di Mambro David angel ortiz Ruiz Salvatore Agati Rafie Khoargami Mediterranean Pediatric Cardiology Center“Bambino Gesù” San Vincenzo HospitalTaorminaItaly Cardiac Electrophysiology Research Center RajaieUniversity of Medical SciencesTehranIran

We show a brief report of two common arterial trunk cases(CAT)with different arrhythmias and discuss anatomy,clinical and diagnostic *** burden of volume and pressure overload of this cardiac malformation may predispose to different types of arrhythmia before and after surgical *** of labile hemodynamic state in this group of patients,prompt diagnosis of any arrhythmia is mandatory as the devastating factor on *** first patient with a diagnosis of CAT Type II Collett and Edwards(CE)had a particular history with HIV seropositive mother assuming antiretroviral therapy during pregnancy,who presented hyperbilirubinemia and liver dysfunction at birth,and re-entry atrial tachycardia after *** second patient had CAT Type I CE with a partial anomalous venous connection of left superior pulmonary vein and uncommon type of atrial tachycardia with dual AV nodal physiology.

关键词： Common arterial trunk arrhythmia anomalous pulmonary venous connection HIV

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Friction-based riveting technique for AZ31 magnesium alloy

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Journal of Magnesium and Alloys 2022年第1期10卷 122-130页

作者： Tianhao Wang Scott Whalen Xiaolong Ma Joshua Silverstein Hrishikesh Das Madhusudhan R.Pallaka angel ortiz Timothy Roosendaal Piyush Upadhyay Keerti S Kappagantula Pacific Northwest National Laboratory MSIN:K2-03902 Battelle Blvd.RichlandWA 99352United States

A new friction-based riveting technique, Rotating Hammer Riveting(RHR), is demonstrated to fully form AZ31 Mg rivet heads in a mere 0.23 s. Heat and pressure generated through severe plastic deformation during the process was sufficient to form the Mg rivet head without the need for a pre-heating operation. Due to preliminary twinning and followed by dynamic recrystallization, AZ31 Mg grains in the rivet head were refined during RHR, which enhance the formability of Mg rivets by triggering grain boundary sliding and reducing plastic anisotropy of Mg. In addition, RHR joints showed a metallurgical bond between the rivet head and top AZ31 Mg sheet, which eliminates a significant pathway for corrosion.

关键词： Rivet Magnesium Dissimilar joining

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Management of“Wall to Wall Heart”in a Transient Neonatal Tricuspid Regurgitation

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Congenital Heart Disease 2021年第3期16卷 205-210页

作者： Elio Caruso Silvia Farruggio Davide Calvaruso David Fabio Petruccelli David angel ortiz Ruiz Corrado Di Mambro Salvatore Agati Mediterranean Pediatric Cardiology Center“Bambino Gesù” San Vincenzo HospitalTaorminaItaly

We present a case of a one-day-old newborn,without prenatal diagnosis,referred to our cardiologic intensive care unit in critical condition presenting sub-cyanosis and peripheral oxygen saturation of 80%.Echocardiography diagnosis was tricuspid valve dysplasia with severe regurgitation,functional pulmonary valve atresia with intact ventricular septum and reversal flow in the large patent ductus arteriosus(PDA).Chest X-ray showed severe cardiomegaly and wall to wall *** E1 infusion was started once after *** few days,clinical conditions progressively worsened because of right heart failure;a first pharmacological approach to close PDA failed and surgery ligation of PDA was necessary to restore anterograde pulmonary flow and heart size.

关键词： Wall to wall heart tricuspid regurgitation pulmonary atresia arterial duct

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Dynamics of the ruminal microbial ecosystem, and inhibition of methanogenesis and propiogenesis in response to nitrate feeding to Holstein calves

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Animal Nutrition 2021年第4期7卷 1205-1218页

作者： Abimael ortiz-Chura Jose Gere Gisela Marcoppido Gustavo Depetris Silvio Cravero Claudia Faverin Cesar Pinares-Patino angel Cataldi d Maria E.Ceron-Cucchi Institute of Pathobiology CICVyA National Institute of Agricultural TechnologyIPVetUEDD INTA-CONICETHurlinghamC1686Argentina Engineering Research and Development Division National Technological University(UTN)National Scientific and Technical Research Council(CONICET)Buenos AiresC1179Argentina Agricultural Experimental Station of Balcarce National Institute of Agricultural Technology(INTA)BalcarceB7620Argentina Institute of Agrobiotechnology and Molecular Biology IABIMONational Institute of Agricultural Technology(INTA)National Scientific and Technical Research Council(CONICET)HurlinghamC1686Argentina The Agribusiness Group Lincoln UniversityPO Box 85016Lincoln7674New Zealand

It is known that nitrate inhibits ruminal methanogenesis,mainly through competition with hydrogenotrophic methanogens for available hydrogen(H2)and also through toxic effects on the ***,there is limited knowledge about its effects on the others members of ruminal microbiota and their *** this study,we investigated the effects of dietary nitrate inclusion on enteric methane(CH4)emission,temporal changes in ruminal microbiota,and fermentation in Holstein *** animals were maintained in individual pens for 45 *** were randomly allocated to either a control(CTR)or nitrate(NIT,containing 15 g of calcium nitrate/kg dry matter)*** emissions were estimated using the sulfur hexafluoride(SF6)tracer *** microbiota changes and ruminal fermentation were evaluated at 0,4,and 8 h *** this study,feed dry matter intake(DMI)did not differ between dietary treatments(P>0.05).Diets containing NIT reduced CH4 emissions by 27%(g/d)and yield by 21%(g/kg DMI)compared to the CTR(P0.05)but differed with time,and post-feeding(P<0.05).Increases in the concentrations of ruminal ammonia nitrogen(NH3-N)and acetate were observed,whereas propionate decreased at 4 h post-feeding with the NIT diet(P<0.05).Feeding the NIT diet reduced the populations of total bacteria,total methanogens,Ruminococcus albus and Ruminococcus flavefaciens,and the abundance of Succiniclasticum,Coprococcus,Treponema,Shuttlewortia,Succinivibrio,Sharpea,Pseudobutyrivibrio,and Selenomona(P<0.05);whereas,the population of total fungi,protozoa,Fibrobacter succinogenes,Atopobium and Erysipelotrichaceae L7 AE11 increased(P<0.05).In conclusion,feeding nitrate reduces enteric CH4 emissions and the methanogens population,whereas it decreases the propionate concentration and the abundance of bacteria involved in the succinate and acrylate pathways.D

关键词： Methane emission Nitrate Microbiota Ruminal fermentation

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Phenotypic Variation among and within Three Peppers Species(Capsicum)from Mexico

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Phyton-International Journal of Experimental Botany 2021年第1期90卷 259-275页

作者： Carlos Eduardo Ornelas-Ramírez Sergio Hernández-Verdugo Jesús Enrique Retes-Manjarrez angel Valdez-ortiz Antonio Pacheco-Olvera Tomás Osuna-Enciso Flor Porras Facultad de Agronomía Universidad Autónoma de SinaloaCuliacánSinaloa80000México Programa Regional de Posgrado en Biotecnología Facultad de Ciencias Químico-BiológicasUniversidad Autónoma de SinaloaCuliacánSinaloa80030México Centro de Investigación en Alimentación y Desarrollo A.C.Unidad Culiacán CuliacánSinaloa80110México

The phenotypic variation and its distribution among species,morphotypes,and among and within populations was estimated in 71 populations pertaining to 15 morphotypes of three domesticated species of Capsicum from *** were made in the states of Sinaloa,Nayarit,Oaxaca,Tabasco,and Yucatán in two agroecosystems:Backyard-garden and *** phenotypic characteristics were analyzed through one-way variance analysis and multivariate analyses of principal components analysis(PCA)and hierarchical clustering using Ward’s *** study was performed in a uniform greenhouse experiment.A high variation was found among and within populations in all the measured *** the total variation,13.0%was distributed among species,27.9%among morphotypes,8.1%among populations,and 51.0%within *** plants grew in a uniform environment,these results indicate that the differences observed among and within species,morphotypes,and populations have a genetic *** and multivariate analyses clearly differentiated morphotypes,suggesting that the category of morphotypes must be used to nominate the infraspecific variation in the domesticated *** principal components analysis identified a total of 15 principal components that contributed to explain the total *** first two components explained 59.64%of the total variation and seven components explained more than 90%of the total *** the measured characteristics,number of seed per fruit,weight of the fruit,width of the fruit,length of the fruit,stem diameter,days to flowering,and height of the plant contributed to component 1 variation,whereas width of the leaf,length of the leaf,and number of locules,number of fruits and number of seeds per plant contributed to component *** hierarchical clustering separated the populations and the morphotypes in two large different *** group consisted of populations collected in monoculture conditions and the oth

关键词： Phenotypic variation Capsicum annuum Capsicum chinense Capsicum frutescens morphotype

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Comparative study of breast cancer in Mexican and Mexican-American women

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Health（健康） 2010年第9期

作者： María Elena martínez Luis Enrique Gutiérrez-Millan Melissa Bondy Adrian Daneri-Navarro María Mercedes Meza-Montenegro Ivan Anduro-Corona Ma Isabel Aramburo-Rubio Luz María Adriana Balderas-Pe？a José Adelfo Barragan-Ruiz Abenaa Brewster Graciela Caire-Juvera Juan Manuel Castro-Cervantes Mario Alberto Chávez Zamudio Giovanna Cruz Alicia Del Toro-Arreola Mary E. Edgerton María Rosa Flores-Marquez Ramon Antonio Franco-Topete Helga Garcia Susan Andrea Gutierrez-Rubio Karin Hahn Luz Margarita Jimenez-Perez Ian K. Komenaka Zoila Arelí López Bujanda Dihui Lu Gilberto Morgan-Villela James L. Murray Jesse N. Nodora Antonio Oceguera-Villanueva miguel angel ortiz martínez Laura Pérez Michel Antonio Quintero-Ramos Aysegul Sahin Jeong Yun Shim Maureen Stewart Gonzalo Vazquez-Camacho Betsy Wertheim Rachel Zenuk Patricia Thompson

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从iPad的传播模式与功能解读传播技术的发展

从iPad的传播模式与功能解读传播技术的发展

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作者：天使（angel ortiz）南京大学

学位级别：硕士

本文以“传播技术与人的关系”为切入点,将iPad作为个案,通过深度访谈和焦点小组的方法,研究iPad对用户产生的影响,以此作为推论探讨传播技术的发展在个人和社会层面的影响。本文共分为四个部分：第一部分为绪论,交代了研究的缘起、研... 详细信息

本文以“传播技术与人的关系”为切入点,将iPad作为个案,通过深度访谈和焦点小组的方法,研究iPad对用户产生的影响,以此作为推论探讨传播技术的发展在个人和社会层面的影响。本文共分为四个部分：第一部分为绪论,交代了研究的缘起、研究问题和方法,以及对相关的理论和文献作出阐述;第二部分是在宏观层面回顾了人类传播技术的发展历史,在此基础上研究iPad作为传播新技术的代表,对技术的演变和发展具有什么意义;第三部分从微观层面分析iPad对个人的影响,研究在使用iPad后,用户的媒介使用、人际交往、阅读习惯分别发生了什么改变。由于iPad对儿童的影响区别于成人,所以在论文的第三部分单独对儿童用户进行了分析;第四部分则提出了笔者对未来人类传播技术发展趋势的预测,认为“人工智能”是传播技术发展的方向。通过具体的研究,本文得出了以下结论：首先,传播技术的进化趋势是总体向前的,可能传播技术刚出现的时候会有一些缺陷,但这些缺陷总会被新的技术所弥补,传播技术的发展将会越来越人性化。其次,通过调查发现iPad的传播模式和功能对用户的媒介使用、人际交往和阅读习惯确实产生了不同程度的影响,对于儿童的影响更为明显。iPad充当了现代儿童现实中的“伙伴”,给予儿童使用媒介极大的主动权,还是一种革命性的教育工具。通过对iPad的系统研究,笔者在论文的结尾提出了一些乐观的预测,认为随着传播技术的不断发展,人类社会将会进入“人工智能”时代,技术的进步将给人类带来更多便利与自由。

关键词：人性化趋势补偿性媒介人工智能

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Synergic Effect of Mucuna pruriens ***(Fabaceae)and Pontoscolex corethrurus(Oligochaeta,Glossoscolecidae)on the Growth of Quercus insignis(Fagaceae)Seedlings,a Native Species of the Mexican Cloud Forest

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Open Journal of Forestry 2014年第1期4卷 1-7页

作者： Maria L.Avendano-Yánez angel I.ortiz-Ceballos Lázaro R.Sánchez-Velásquez María R.Pineda-López Jorge A.Meave Instituto de Biotecnología y Ecología Aplicada(INBIOTECA) Universidad VeracruzanaVeracruzMéxico Departamento de Ecología y Recursos Naturales Facultad de CienciasUniversidad Nacional Autonoma de MéxicoMexico D.F.México

Propagation of native species in local nurseries is an important activity in reforestation and forest restoration programs. A requisite for successful plantation is that nursery produced plants are of a size and quality that allows optimal establishment under field conditions. Manipulation of edaphic processes through the combined use of the earthworm Pontoscolex corethrurus, Mucuna pruriens and inorganic fertilizers may promote faster biomass gain. This study assessed the activity of P. corethrurus, its association with M. pruriens (green manure) and inorganic fertilizers, on the growth of Quercus insignis seedlings under greenhouse conditions. Measured variables were basal diameter, height, biomass and foliar nitrogen content. Growth rates of basal diameter (F = 5.33;P F = 2.84;P P. corethrurus-M. pruriens-inorganic fertilizer, relative to the control. Also, leaf biomass and total biomass of the seedlings were greater in the treatment of P. corethrurus-fertilizer (F = 2.32;P F = 3.71;P Foliar nitrogen content

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A Case Report of Lymphocytic Hypophysitis Related to Pregnancy

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Open Journal of Endocrine and Metabolic Diseases 2015年第12期5卷 171-176页

作者： Estrella Diego Andreea Ciudin Olga Simo-Servat angel ortiz Liliana Gutierrez-Carrasquilla Jordi Mesa Hospital Universitario Valle de Hebron Barcelona Spain Hospital Arnau de Vilanova Lleida Spain

A 39-year-old woman consulted in the postpartum period because of agalactia, polyuria, polydipsia, and headache and decreased visual acuity. The initial analysis was compatible with a panhypopituitarism. The magnetic resonance (MRI) showed an expansive sellar and suprasellar lesion of high density in the basal study and enhancement after contrast administration, in contact with the optic chiasm, so urgent surgery was indicated. While waiting for the surgery, intravenous corticosteroids were initiated and the symptoms rapidly resolved. Most of the pituitary axes were recovered, except the diabetes insipidus. The control MRI showed complete resolution of the sellar mass. The surgery was canceled and the diagnosis of lymphocyte hypohpyisitis was made. Lymphocyte hypophysitis is an uncommon disease in which inflammation of the pituitary gland occurs. This results in a permanent or transient hormonal insufficiency. Lymphocyte hypophysitis is a very rare condition that occurs preferentially in women in the peripartum period. Early initiation of high doses of systemic corticosteroids may avoid unnecessary surgery in some cases.

关键词： Hypophysitis Pregnancy Panhypopituitarism Lymphocytic Hypophysitis

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