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World Journal of Gastroenterology 2022年第39期28卷 5679-5690页

作者： Armando Rojas Cristian Lindner Iván Schneider Ileana Gonzàlez miguel angel Morales Biomedical Research Laboratories Catholic University of MauleTalca 34600000MauleChile Medicine Faculty Catholic University of MauleTalca 34600000MauleChile Department of Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000SantiagoChile

Compelling evidence derived from clinical and experimental research has demonstrated the crucial contribution of chronic inflammation in the development of neoplasms,including gallbladder *** this regard,data derived from clinical and experimental studies have demonstrated that the receptor of advanced glycation end-products(RAGE)/AGEs axis plays an important role in the onset of a crucial and long-lasting inflammatory milieu,thus supporting tumor growth and *** are formed in biological systems or foods,and food-derived AGEs,also known as dietary AGEs are known to contribute to the systemic pool of *** they bind to RAGE,the activation of multiple and crucial signaling pathways are triggered,thus favoring the secretion of several proinflammatory cytokines also involved in the promotion of gallbladder cancer invasion and *** the present review,we aimed to highlight the relevance of the association between high dietary AGEs intakes and high risk for gallbladder cancer,and emerging data supporting that dietary intervention to reduce gallbladder cancer risk is a very attractive approach that deserves much more research efforts.

关键词： Gallbladder cancer Advanced glycation end-products Receptor of advanced glycation end-products Chronic inflammation Nutrition

Contributions of the receptor for advanced glycation end products axis activation in gastric cancer

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World Journal of Gastroenterology 2023年第6期29卷 997-1010页

作者： Armando Rojas Cristian Lindner Iván Schneider Ileana González miguel angel Morales Biomedical Research Laboratories Medicine FacultyCatholic University of MauleTalca 34600000Chile Medicine Faculty Catholic University of MauleTalca 34600000Chile Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000Chile

Compelling shreds of evidence derived from both clinical and experimental research have demonstrated the crucial contribution of receptor for advanced glycation end products(RAGE)axis activation in the development of neoplasms,including gastric cancer(GC).This new actor in tumor biology plays an important role in the onset of a crucial and long-lasting inflammatory milieu,not only by supporting phenotypic changes favoring growth and dissemination of tumor cells,but also by functioning as a pattern-recognition receptor in the inflammatory response to Helicobacter pylori *** the present review,we aim to highlight how the overexpression and activation of the RAGE axis contributes to the proliferation and survival of GC cells as and their acquisition of more invasive phenotypes that promote dissemination and ***,the contribution of some single nucleotide polymorphisms in the RAGE gene as susceptibility or poor prognosis factors is also discussed.

关键词： Gastric cancer Advanced glycation end-products Receptor of advanced glycation end-products Alarmins Helicobacter pylori Chronic inflammation

A Systematic Review of Forensic Approaches to Disasters: Gaps and Challenges

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International Journal of Disaster Risk Science 2023年第5期14卷 722-735页

作者： Adriano Mota Ferreira Victor Marchezini Tatiana Sussel Gonçalves Mendes miguel angel Trejo-Rangel Allan Yu Iwama Graduate Program in Disasters Institute of Science and TechnologySão Paulo State University(Unesp)São Josédos CamposSP12247-004Brazil Cemaden–National Center for Monitoring and Early Warning of Natural Disasters São Josédos CamposSP12247-004Brazil Natural Hazards Center Institute of Behavioral ScienceUniversity of Colorado BoulderBoulderCO80309USA Department of Environmental Engineering Institute of Science and TechnologySão Paulo State University(Unesp)São Josédos CamposSP12247-004Brazil Irish Climate Analysis and Research UnitS(ICARUS) Department of GeographyMaynooth UniversityMaynoothW23 F2H6KildareIreland Graduate Program in Development and Environment Federal University of ParaíbaJoão PessoaPB58051-900Brazil

Disaster forensic approaches aim to identify the causes of disasters to support disaster risk ***,few studies have conducted a systematic literature review of scientific articles that labeled themselves as a forensic approach to *** article provides a qualitative analysis of these forensic studies,focusing on five main issues:(1)the methodologies applied;(2)the forensic approaches used in the disaster risk management phases;(3)the hazards addressed;(4)if the methodologies involve social participation,and using what types of participation;and(5)if there are references to urban planning in the scientific studies *** results showed a predominance of the Forensic Investigations of Disasters(FORIN)and Post-Event Review Capability(PERC)methodologies used in isolation or *** is a need for methodologies that engage people in participatory FORIN,fostering the co-production of knowledge and action research approaches.

关键词： Dynamic pressures Forensic investigation Participatory research Risk drivers Root causes

Prevalence of meeting 24-Hour Movement Guidelines from pre-school to adolescence: A systematic review and meta-analysis including 387,437 participants and 23 countries

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Journal of Sport and Health Science 2022年第4期11卷 427-437页

作者： miguel angel Tapia-Serrano Javier Sevil-Serrano Pedro Antonio Sanchez-miguel Jose Francisco Lopez-Gil Mark STremblay Antonio Garcıa-Hermoso Department of Didactics of Musical Plastic and Body ExpressionFaculty of Teaching TrainingUniversity of ExtremaduraAvenida de la UniversidadS/NCaceres 10071Spain Department of Physical Activity and Sport Faculty of Sport ScienceUniversity of Murcia(UM)San Javier 30720Spain Healthy Active Living and Obesity Research Group Children’s Hospital of Eastern Ontario(CHEO)Research InstituteOttawaON K1H 8L1Canada Navarrabiomed Public University of Navarra(UPNA)Health Research Institute of Navarra(IdiSNA)Navarra Hospital Complex(CHN)Pamplona 310008Spaia

Background:Meeting the 24-Hour Movement Guidelines(physical activity,screen time,and sleep duration) has been associated with positive health ***,there are no previous meta-analyses that have examined the overall adherence to the 24-Hour Movement Guidelines from pre-school to adolescence across the ***,the main purpose of this systematic review and meta-analysis was to examine the overall(non)adherence to the 24-Hour Movement Guidelines among preschoolers,children,and adolescents ***:Four electronic databases(MEDLINE,Scopus,Web of Science,and Cochrane Database of Systematic Reviews) were searched for quantitative studies published in Spanish and English between January 2016 and May *** that were conducted with apparently healthy participants and reported the overall(non)adherence to the 24-Hour Movement Guidelines in preschoolers and/or children and/or adolescents were ***:Sixty-three studies comprising 387,437 individuals(51% girls) aged 3-18 years from 23 countries were ***,7.12%(95%confidence interval(95%CI):6.45%-7.78%) of youth met all three 24-Hour Movement Guidelines,and 19.21%(95%CI:16.73%-21.69%)met none of the 3 *** sex,adherence to all recommendations was significantly lower in girls(3.75%,95%CI:3.23%-4.27%) than in boys(6.89%,95%CI:5.89%-7.89%)(p <0.001).However,there were no sex differences regarding adherence to any of the 3 individual recommendations(girls,15.66%,95%CI:8.40%-22.92%;boys,12.95%,95%CI:6.57%-19.33%).In terms of age group,adherence to the 3 recommendations was 11.26%(95%CI:8.68%-13.84%),10.31%(95%CI:7.49%-13.12%),and 2.68%(95%CI:1.78%-3.58%) in preschoolers,children,and adolescents,***,8.81%(95%CI:5.97%-11.64%) of preschoolers,15.57%(95%CI:11.60%-19.54%) of children,and 28.59%(95%CI:22.42%-34.75%) of adolescents did not meet any of the *** America was the region with the lowest adherence(all:2.93%;none:3

关键词： Exercise Lifestyle Movement behaviors Sedentary behaviors Youth

Innovation in pathogenesis and management of aortic aneurysm

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World Journal of Experimental Medicine 2024年第2期14卷 35-45页

作者： Maryam Barkhordarian Hadrian Hoang-Vu Tran Aiswarya Menon Sai Priyanka Pulipaka Izage Kianifar Aguilar Axel Fuertes Shraboni Dey angel Ann Chacko Tanni Sethi Ayrton Bangolo Simcha Weissman Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States

Aortic aneurysm(AA)refers to the persistent dilatation of the aorta,exceeding three *** the pathophysiology of this condition is important for its prevention and management,given its responsibility for more than 25000 deaths in the United *** are classified based on their location or *** pathophysiologic pathways including inflammation,the immune system and atherosclerosis have been implicated in its *** markers such as transforming growth factorβ,interleukin-1β,tumor necrosis factor-α,matrix metalloproteinase-2 and many more may contribute to this *** genetic disorders such as Marfan syndrome,Ehler-Danlos syndrome and Loeys-Dietz syndrome have also been associated with this *** years has seen the investigation of novel management of AA,exploring the implication of different immune suppressors,the role of radiation in shrinkage and prevention,as well as minimally invasive and newly hypothesized surgical *** this narrative review,we aim to present the new contributing factors involved in pathophysiology of *** also highlighted the novel management methods that have demonstrated promising benefits in clinical outcomes of the AA.

关键词： Aortic aneurysm Abdominal aneurysm Thoracic aneurysm Immunotherapy Surgical management Pathophysiology Inflammation and molecular pathways

Bronchiectasis and COVID-19 infection:a two-way street

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Chinese Medical Journal 2022年第20期135卷 2398-2404页

作者： Grace Oscullo Jose DanieGómez-Olivas Thais Beauperthuy AminaBekki Alberto Garcia-Ortega Maria Gabriella Matera Mario Cazzola miguel angel Martinez-Garcia Department of Pneumology Hospital Universitario y Politécnico la Fe de ValenciaValencia 46012Spain Department of Experimental Medicine University of Campania“Luigi Vanvitelli”Naples 80121Italy Department of Experimental Medicine University of Rome Tor VergataRome 00185Italy CIBERES de enfermedades respiratorias Instituto de Salud Carlos IIIMadrid 41263Spain

Bronchiectasis(BE)has been linked to past viral infections such as influenza,measles,or *** years ago,a new pandemic viral infection severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)broke out and it still persists today,and a significant proportion of surviving patients have radiological and clinical sequelae,including *** aim was to thoroughly review the information available in the literature on the bidirectional relationship between SARS-CoV-2 infection and the development of BE,as well as the impact of this infection on patients already suffering from *** information indicates that only a small percentage of patients in the acute phase of coronavirus disease 2019(COVID-19)pneumonia develop BE,although the latter is recognized as one of the radiological sequelae of COVID-19 pneumonia,especially when it is caused by *** severity of the initial pneumonia is the main risk factor for the development of future BE,but during the COVID-19 pandemic,exacerbations in BE patients were reduced by approximately 50%.Finally,the impact of BE on the prognosis of patients with COVID-19 pneumonia is not yet known.

关键词： Bronchiectasis Coronavirus COVID-19 SARS-CoV-2

Investigate the Wake Flow on Houseflies with Particle-Tracking-Velocimetry and Schlieren Photography

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Journal of Bionic Engineering 2023年第2期20卷 656-667页

作者： Yun Liu angel David Lozano Department of Mechanical and Civil Engineering Purdue University NorthwestWestvilleIN46323USA

Utilizing high-speed schlieren photography and particle-tracking-velocimetry,the wake flow of tethered houseflies is *** high-speed schlieren photography is implemented on tethered houseflies inside an air container with a stable vertical temperature gradient to visualize the disturbed wake flow from the *** resulting photography images were then processed with the physics based optical flow method to derive the light-path averaged flow ***,the state of the art:Shake-the-Box system is implemented on a tethered housefly to measure the volumetric flow field in the wake of the insect,revealing interesting flow behavior and structures that can also be observed and correlated to the schlieren photography *** the dimensionless velocity magnitude of the wake flow from the two experiments,a good qualitative agreement is reached,suggesting the viability of high-speed schlieren photography in investigating the wake flow of small ***,the high-speed schlieren photography is successfully applied on a housefly that is taking off from the ground,visualizing the disturbed wake flow on the freely flying insect that is challenging to visualize with other methods.

关键词： Insect flight Schlieren photography Shake-the-Box Wake flow

Software Project Effort Estimation Based on Multiple Parametric Models Generated Through Data Clustering

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Journal of Computer Science & Technology 2007年第3期22卷 371-378页

作者： Juan J.Cuadrado Gallego Daniel Rodríguez miguel angel Sicilia miguel Garre Rubio angel García Crespo Department of Computer Science The University of Alcalá AlcaláSpain Department of Computer Science Carlos Ⅲ University.Madrid Spain

Parametric software effort estimation models usually consists of only a single mathematical relationship. With the advent of software repositories containing data from heterogeneous projects, these types of models suffer from poor adjustment and predictive accuracy. One possible way to alleviate this problem is the use of a set of mathematical equations obtained through dividing of the historical project datasets according to different parameters into subdatasets called partitions. In turn, partitions are divided into clusters that serve as a tool for more accurate models. In this paper, we describe the process, tool and results of such approach through a case study using a publicly available repository, ISBSG. Results suggest the adequacy of the technique as an extension of existing single-expression models without making the estimation process much more complex that uses a single estimation model. A tool to support the process is also presented. Keywords software engineering, software measurement, effort estimation, clustering

关键词： software engineering software measurement effort estimation clustering

Prevalence of the terrain reversal effect in satellite imagery

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International Journal of Digital Earth 2015年第8期8卷 640-655页

作者： miguel-angel Bernabé-Poveda Arzu Çöltekin Universidad de las Fuerzas Armadas–ESPE Departamento de Ciencias de la Tierra y de la ConstrucciónSangolquíPichinchaEcuador Geographic Information Visualization and Analysis Group Department of GeographyUniversity of ZurichSwitzerland

The terrain reversal effect is a perceptual phenomenon which causes an illusion in various 3D geographic visualizations where landforms appear inverted,*** perceive valleys as ridges and vice *** that such displays are important for spatio-visual analysis,this illusion can lead to critical mistakes in interpreting the ***,it is currently undocumented how commonly this effect is *** this paper,we study the prevalence of the terrain reversal effect in satellite imagery through a two-stage online user *** experiment was conducted with the participation of a diverse and relatively large population(n=535).Participants were asked to identify landforms(valley or ridge?)or judge a 3D spatial relationship(is A higher than B?).When the images were rotated by 180°,the results were *** a control task with‘illusion-free’original images,people were successful in identifying landforms,yet a very strong illusion occurred when these images were rotated 180°.Our findings demonstrate that the illusion is acutely present;thus,we need a better understanding of the problem and its ***,the results caution us that in an interactive environment where people can rotate the display,we might be introducing a severe perceptual problem.

关键词： terrain reversal relief inversion false topographic perception phenomenon photo interpretation visual illusion user study

Parental perception of child's weight,their attitudes towards child's dietary habits and the risk of obesity

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World Journal of Pediatrics 2022年第7期18卷 482-489页

作者： Lorena Garcia-Blancol Arantxa Berasaluce Andrea Romanos-Nanclares miguel angel Martinez-Gonzalez Laura Moreno-Galaraga Nerea Martin-Calvo San Juan Primary Care Health Center.Servicio Navarro de Salud-Osasunbidea PamplonaSpain IdisNA.Instituto de Investigacion Sanitaria de Navrra.Pamplona Spain Department of Preventive Medicine and Public Health School of Medicine.University of NavarraC/Irunlarrea l.31080 Pamplona.Spain Biomedical Research Centre Network On Obesity and Nutrition(CIBERobn).Physiopathology of Obesity and NutritionInstituteof Health Carlos Ⅲ.Av.Monforte de Lemos.3-528029 MadridSpain Department of Nutrition.Harvard T.H.Chan School of Public Health Boston.MA 02115.USA Department of Pediatrices.Complejo Hospialario de Navarra B.Pamplona.Spain

Background The association between parental perception of child's weight and their attitudes towards his/her dietary habits has not been reported *** study aimed to assess the association between parental underestimation of child's weight and parental attitudes towards child's dietary *** We conducted a cross-sectional analysis of SENDO cohort participants recruited between January 2015 and June *** information was collected through online questionnaires completed by *** calculated crude and multivariable-adjusted odds ratio(OR)and 95%confidence intervals(CI)for unhealthy attitudes towards child's dietary habits associated with parental underestimation of child's *** Sixteen percent of children in the SENDO project had parents who underestimated their *** who under-estimated their child's weight status were more likely to have unhealthy attitudes toward his/her dietary habits[OR 3.35;95%CI(1.71-6.53)].Conclusions Parental underestimation of child's weight was associated with unhealthy attitudes towards child's dietary *** and public health practitioners should pay attention to the parental perception of child's weight to identify parents who underestimate it as an at-risk group in which to inquire about lifestyle and dietary habits.

关键词： Childhood obesity Dietary atitudes Eating habits Overweight Weight perception