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Reconstruction of lateral root formation through single-cell RNA sequencing reveals order of tissue in itiation

Molecular Plant 2021年第8期14卷 1362-1378页

作者： Laura Serrano-Ron Pablo Perez-Garcia Alvaro Sanchez-Corrionero Inmaculada Gude Javier Cabrera Pui-Leng Ip Kenneth D.Birnbaum miguel a.moreno-risueno Centro de Biotecnologia y Genomica de Plantas Universidad Politecnica de Madrid(UPM)-lnstituto Naci on al de Investigacion y Tec no logia Agraria y Alimentaria(INIA)Pozuelo de Alarcon28223 MadridSpain Departamento de Biotecnologia-Biologia Vegetal Escuela Tecnica Superior de Ingenieria AgronomicaAlimentaria y de BiosistemasUniversidad Politecnica de Madrid(UPM)28040 MadridSpain Center for Genomics and Systems Biology Department of BiologyNew York UniversityNew YorkNYUSA

Postembryonic organogenesis is critical for plant ***,lateral roots(LRs)form the bulk of mature root systems,yet the ontogeny of the LR primordium(LRP)is not *** this study,we performed the single-cell RNA sequencing through the first four stages of LR formation in *** analysis led to a model in which a single group of precursor cells,with a cell identity different from their pericycle origins,rapidly reprograms and splits into a mixed ground tissue/stem cell niche fate and a vascular precursor *** ground tissue and stem cell niche fates soon separate and a subset of more specialized vascular cells form sucrose transporting phloem cells that appear to connect to the primary *** did not detect cells resembling epidermis or root cap,suggesting that outer tissues may form later,preceding LR *** this stage,some remaining initial precursor cells form the primordium flanks,while the rest create a reservoir of pluripotent cells that are able to replace the LR if *** ablation of the central and lateral LRP regions showed that remaining cells restart the sequence of tissue initiation to form a ***,our study reveals an ontological hierarchy for LR formation with an early and sequential split of main root tissues and stem cells.

关键词： organogenesis patterning stem cells single-cell RNA-seq cell fate regeneration

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The cold-induced factor CBF3 mediates root stem cell activity,regeneration,and developmental responses to cold

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Plant Communications 2023年第6期4卷 197-211页

作者： Pablo Perez-Garcia Ornella Pucciariello Alvaro Sanchez-Corrionero Javier Cabrera Cristina del Barrio Juan Carlos del Pozo Mariano Perales Krzysztof Wabnik miguel a.moreno-risueno Centro de Biotecnologíay Genómica de Plantas(Universidad Politécnica de Madrid(UPM)–Instituto Nacional de Investigacióny Tecnología Agraria y Alimentaria–CSIC(INIA-CSIC)) MadridSpain

Plant growth and development involve the specification and regeneration of stem cell niches(SCNs).Although plants are exposed to disparate environmental conditions,how environmental cues affect developmental programs and stem cells is not well *** stem cells are accommodated in meristems in SCNs around the quiescent center(QC),which maintains their *** a combination of genetics and confocal microscopy to trace morphological defects and correlate them with changes in gene expression and protein levels,we show that the cold-induced transcription factor(TF)C-REPEAT BINDING FACTOR 3(CBF3),which has previously been associated with cold acclimation,regulates root development,stem cell activity,and ***3 is integrated into the SHORT-ROOT(SHR)regulatory network,forming a feedback loop that maintains SHR ***3 is primarily expressed in the root endodermis,whereas the CBF3 protein is localized to other meristematic tissues,including root *** of cbf3-1 using a wild-type CBF3 gene and a CBF3 fusion with reduced mobility show that CBF3 movement capacity is required for SCN patterning and regulates root ***,cold induces CBF3,affecting QC ***,exposure to moderate cold around 10℃–12℃promotes root regeneration and QC respecification in a CBF3-dependent manner during the recuperation *** contrast,CBF3 does not appear to regulate stem cell survival,which has been associated with recuperation from more acute cold(-4℃).We propose a role for CBF3 in mediating the molecular interrelationships among the cold response,stem cell activity,and development.

关键词： stem cells regeneration organ patterning protein movement cell fate low temperature

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Brain scarring in infants:immunological insights from a neonatal hypoxic-ischemic encephalopathy model

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Neural Regeneration Research 2025年第10期20卷 2909-2910页

作者： Pedro moreno Pimentel-Coelho Carlos Chagas Filho Biophysics Institute Federal University of Rio de JaneiroRio de JaneiroBrazil

Neonatal hypoxic-ischemic encephalopathy(HIE)is a significant cause of disability in *** brain function and accelerating neurological recovery may require a combination of neuroprotective and pro-regenerative treatments at different stages of *** the first hours after the neonatal insult are the most critical period for neuroprotection,the existence of secondary and tertiary mechanisms of brain injury offers the possibility of preventing delayed neurodegeneration in the subsequent days,weeks,or months(Levison et al.,2022).

关键词： neonatal protective hypoxic

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Input signal design to estimate interwell connectivities in mature fields from the capacitance-resistance model

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Petroleum Science 2014年第4期11卷 563-568页

作者： Gustavo a.moreno Larry W.Lake YPF-Tecnología Baradero S/N (1925) EnsenadaBuenos AiresArgentina YPF Macacha Guemes 515CABAArgentina CPARM University of Texas at AustinAustinTXUSA

Interwell connectivities are fundamental parameters required to manage waterfloods in oil reservoirs. Data-driven models, such as the capacitance-resistance model （CRM）, are fast tools to estimate these parameters from time-correlations of input （injection rates） and output （production rates） signals. Noise and structure of the input time-series impose limits on the information that can be extracted from a given data-set. This work uses the CRM to study general prescriptions for the design of input signals that enhance the information content of injection/production data in the estimation of well-to-well interactions. Numerical schemes and general features of the optimal input signal strategy are derived for this problem.

关键词： Intervell connectivity capacitance-resistance model mature field experiment design

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Empirical mode decomposition of multiphase flows in porous media:characteristic scales and speed of convergence

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Petroleum Science 2020年第1期17卷 153-167页

作者： Nicolás Echebarrena Pablo D.Mininni Gustavo a.moreno YPF-Technology EnsenadaBuenos AiresArgentina CONICET Buenos AiresArgentina Physics Department IFIBASchool of Exact and Natural SciencesUniversity of Buenos AiresCONICETUniversity Campus1428 Buenos AiresArgentina

We apply a proper orthogonal decomposition(POD)to data stemming from numerical simulations of a fingering instability in a multiphase flow passing through obstacles in a porous medium,to study water injection processes in the production of hydrocarbon *** show that the time evolution of a properly defined flow correlation length can be used to identify the onset of the fingering *** of characteristic lengths for each of the modes resulting from the POD provides further information on the dynamics of the ***,using numerical simulations with different viscosity ratios,we show that the convergence of the POD depends non-trivially on whether the fingering instability develops or *** result has implications on proposed methods to decrease the dimensionality of the problem by deriving reduced dynamical systems after truncating the system’s governing equations to a few POD modes.

关键词： Two-phase flow Empirical mode decomposition Viscous fingering Porous media

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Generalized algorithms for particle motion and collision with streambeds

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International Journal of Sediment Research 2019年第4期34卷 295-306页

作者： Patricio a.moreno-Casas Fabián A.Bombardelli Juan Pablo Toro Department of Civil and Environmental Engineering University of CaliforniaDavis Facultad de Ingeniería y Ciencias Aplicadas Universidad de los AndesMonse?or Alvaro del Portillo Department of Civil Engineering Universidad Andres Bello

Recent theoretical and numerical models for the motion of saltating particles close to stream beds are constituted of three sub-models: a) a set of equations describing the particle "free flight", b) a sub-model to calculate the post-collision particle velocity, and c) a mathematical representation of the bed roughness. In this paper, a comprehensive three-dimensional(3-D), theoretical/numerical model for bedload motion at large Reynolds numbers is presented. By using geometric considerations and stochastic parameters to characterize collisions with the wall, five new sub-models for representation of bed roughness are, for the first time to the best of our knowledge, proposed and implemented. The emphasis of this paper is on the particle model, for which Basset, Magnus, drag, submerged weight, virtual mass,and lift forces are included. For the range of particle sizes(sands) analyzed herein, it is found that the stream-wise contribution of the Basset force, compared to other forces, may be as large as 60%. Whereas in the wall-normal direction, the Basset force is equally important as the drag force, and it is exceeded only by the submerged weight. It is also found that the best agreement between numerical and experimental results in terms of jump length, jump height, and stream-wise particle velocity is achieved for restitution and friction coefficients of 0.65 and 0.1, respectively. Important conclusions are obtained regarding the lack of realistic prediction with available "roughness" models with small ranges of angles.

关键词： Particle saltation Particle collision Particle rotation Bed-load transport Basset force

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Piling up multidecker pyrgos[n]cages as antibacterial materials

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Science China Materials 2025年第01期 314-316页

作者： miguel A.Liuzzi-Vaamonde Jackson B.Lancaster Samantha A.Mason Yuanning Feng Department of Chemistry and Biochemistry The University of Oklahoma

The development of antibiotics is regarded as one of the most significant scientific advances in modern medicine. Before the commercialization of antibiotics, infectious diseases were catastrophic throughout history [1]. Penicillin was used to treat serious infections in the 1940s, but unfortunately, with the introduction of antibiotics came the emergence of antibiotic resistance [2,3]. Evolved and adapted methicillin-resistant Staphylococcus aureus (MRSA) strains are presently impacting community and healthcare systems across the globe [4].

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The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： Susana Mellado María JoséMorillo-Bargues Carla Perpiñá-Clérigues Francisco García-García Victoria.moreno-Manzano Consuelo Guerri María Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MSC-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and C–X3–C motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MSC-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

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Hybrid magnetorheological elastomers enable versatile soft actuators

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npj Computational Materials 2022年第1期8卷 1546-1559页

作者： miguel Angel moreno-Mateos Mokarram Hossain Paul Steinmann Daniel Garcia-Gonzalez Department of Continuum Mechanics and Structural Analysis Universidad Carlos III de MadridAvda.de la Universidad 3028911LeganésMadridSpain Zienkiewicz Centre for Computational Engineering Faculty of Science and EngineeringSwansea UniversitySA18ENSwanseaUK Institute of Applied Mechanics University of Erlangen-NurembergEgerland Str.5ErlangenGermany Glasgow Computational Engineering Centre School of EngineeringUniversity of GlasgowG128QQGlasgowUK

Recent advances in magnetorheological elastomers(MREs)have posed the question on whether the combination of both soft-and hard-magnetic particles may open new routes to design versatile multifunctional ***,we conceptualise ultra-soft hybrid MREs(≈1–10 kPa stiffness)combining experimental and computational ***,a comprehensive experimental characterisation is *** results unravel that the magneto-mechanical performance of hybrid MREs can be optimised by selecting an adequate mixing ratio between ***,a multi-physics computational framework provides insights into the synergistic magneto-mechanical interactions at the *** particles amplify the magnetisation and hard particles contribute to torsional *** numerical results suggest that the effective response of hybrid MREs emerges from these intricate ***,we uncover exciting possibilities to push the frontiers of MRE *** are demonstrated by simulating a bimorph beam that provides actuation flexibility either enhancing mechanical bending or material stiffening,depending on the magnetic stimulation.

关键词： versatile magneto enable

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The glutamate metabotropic receptor 5(GRM5)gene is associated with beef cattle home range and movement tortuosity

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Journal of Animal Science and Biotechnology 2023年第1期14卷 72-87页

作者： Cristian a.moreno Garcia Huitong Zhou David Altimira Robyn Dynes Pablo Gregorini Sadeepa Jayathunga Thomas M.R.Maxwell Jonathan Hickford Department of Agricultural Sciences Faculty of Agriculture and Life SciencesLincoln UniversityPO Box 85084Lincoln 7647New Zealand. Exertion Games Lab 8 Scenic BoulevardClaytonVictoria 3800Australia. AgResearch Limited Lincoln Research CentreCnr Springs Road and Gerald StreetLincoln 7674New Zealand. Scion Tītokorangi Drive(formerly Long Mile Rd)Rotorua 3010New Zealand.

Background:The grazing behaviour of herbivores and their grazing personalities might in part be determined genetically,but there are few studies in beef cattle illustrating *** this study,we investigated for first time the genetic variation within a candidate‘grazing gene',the glutamate metabotropic receptor 5 gene(GRM5),and tested associations between variation in that gene and variation in grazing personality behaviours(GP-behaviours)displayed by free-ranging cows during winter grazing in the steep and rugged rangelands of New *** beef cows(n=303,from 3 to 10 years of age)were tracked with global positioning system(GPS)and,with 5-minutes(min)relocation frequency,various GP-behaviours were *** included horizontal and vertical distances travelled,mean elevation,elevation range,elevation gain,slope,home range and movement tortuosity,variously calculated using daily relocation trajectories with repeated measurements(i.e.,7 to 24 days(d))and satellite-derived digital elevation models(DEM).The different GP-behaviours were fitted into mixed models to ascertain their associations with variant sequences and genotypes of ***:We discovered three GRM5 variants(A,B and C)and identified the six possible genotypes in the cattle *** mixed models revealed that A was significantly associated with elevation range,home range and movement ***,GRM5 genotypes were associated(P<0.05)to home range and movement tortuosity,while trends suggesting association(P<0.1)were also revealed for elevation range and horizontal distance *** GP-behaviour models were improved by correcting for cow age-class as a fixed *** analysis of GP-behaviours averaged per cow age-class suggests that grazing personality is fully established as beef cows reached 4 years of *** range and movement tortuosity were not only associated with GRM5 variation,but also negatively correlated with each other(r=-0.27,P<0.001).Conclusions:There se

关键词： Animal personality Breeding programmes Genetic associations Grazing distribution Grazing patterns Steep and rugged terrain

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