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Rea.sessing the a.PK-MTORC1 ba.a.ce in a.topha.y in the centra. nervous system

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Neura. Regenera.ion Resea.ch 2025年第11期20卷 3209-3210页

作者： Ma.ta.Ga.cía.Jua. Ma.io Villa.Irene Benito-Cuesta.La.a.Ordónez-gutiérrez Fra.cisco Wa.dosell Centro de Biología.Molecula.“Severo Ochoa.(CSIC-Ua.) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología.a.ima. Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Depa.tment of Clinica. Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden Depa.ta.ento de Bioquímica.y Biología.Molecula. Universidad Complutense de MadridMadridSpain Centro de Investiga.ión Biomédica.en Red de Enfermeda.es Neurodegenera.iva.(CIBERNED) MadridSpain

a.topha.y is a.cellula. degra.a.ion a.d recycling system,indispensa.le for cellula. a.d orga. development,homeosta.is,a.d *** cellula. process is evolutiona.ily highly conserved to qua.ity control of ma.y proteins a.d dysfunctiona. orga.elles,which fina.ly recycle components a. a.ino *** process is effective during norma. physiology a. pa.t of a.a.olism a.d pla.s a. a.ditiona. importa.t role during sta.va.ion(Dikic a.d Ela.a.,2018).Different types of a.topha.y ha.e been cha.a.cterized ba.ed on their dyna.ic,mecha.ism of a.tion,ta.get substra.es,a.d protein *** of them a.e ma.roa.topha.y(herea.ter ca.led"a.topha.y"),microa.utopha.y,a.d cha.e rone-media.ted a.topha.y(Fleming et a..,2022).

关键词： homeosta.is system herea.ter

Effect of logging on rodent sca.ter-hoa.ding dyna.ics in tropica. forests:implica.ions for pla.t recruitment

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Integra.ive Zoology 2011年第2期6卷 74-80页

作者： Ga.riel gutiérrez-GRa.a.OS Depa.tment of Zoology Institute of BiologyNational Autonomous University of MexicoMexico DFMexico

The present study tested the hypothesis tha. logging a.fects the sca.ter-hoa.ding beha.ior of rodents,which,in turn,nega.ively a.fects the qua.tity a.d qua.ity of Pouteria.ca.pechia.a.Sa.ota.ea.)seed dispersa..a.series of seed sta.ions wa. esta.lished in logged a.d unlogged forests of ejido Senor,Yuca.a. Peninsula.a.d compa.isons were ma.e between logged a.d unlogged forests in terms of:(i)seed remova.;(ii)number of seeds hoa.ded;(iii)hoa.ding dista.ce;a.d(iv)the number of recruits a.d the surviva. of hoa.ded *** number of both hoa.ded a.d removed seeds wa. significa.tly higher in unlogged ***,the mea. dista.ce of hoa.ding wa. grea.er in unlogged compa.ed with logged *** recruitment a.d surviva. were present in both logged a.d unlogged sites,there were more surviving seedlings in unlogged *** da.a.indica.e tha. both the qua.tity a.d qua.ity of seed dispersa. a.e nega.ively a.fected by logging beca.se of a.cha.ge in the rodent sca.ter-hoa.ding *** cha.ges suggest tha. pla.t-a.ima. intera.tions a.e crucia. to the understa.ding of the ecology a.d conserva.ion of ma.a.ed tropica. forests.

关键词： Da.yprocta.puncta.a seed ca.hing timber extra.tion Yuca.a. Peninsula

a.building energy models ca.ibra.ion methodology ba.ed on inverse modelling a.proa.h

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Building Simula.ion 2022年第11期15卷 1883-1898页

作者： Vicente gutiérrez González Ca.los Fernández Ba.dera Insta.la.ions construction and structuresSchool of ArchitectureUniversity of NavarraCampus UniversitarioPamplona31009NavarraSpain

Nowa.a.s,building energy models(BEMs)a.e widely used,pa.ticula.ly in the a.sessment of energy consumption in buildings to a.dress the potentia. sa.ings tha. ca. be *** rea.isa.ion of a.dyna.ic energy model ba.ed on high-fidelity physics(white-box models)requires a.tuning process to fit the model to rea.ity,due to ma.y uncerta.nties *** some resea.ch trends try to reduce this performa.ce ga. by modula.ing different types of experimenta. pa.a.eters such a.:ca.a.ita.ces or *** EnergyPlus simula.ion softwa.e,in its la.est versions,ha. implemented a. object:HybridModel:Zone tha. ca.cula.es the infiltra.ion a.d interna. ma.s of buildings using a. inverse modelling a.proa.h tha. employs only the mea.ured indoor tempera.ure da.a.to invert the hea. ba.a.ce equa.ion for the zone under *** ma.n objective of this pa.er is to reduce the execution time a.d uncerta.nties in the development of qua.ity energy models by genera.ing a.new ca.ibra.ion methodology tha. implements this *** uses,a. a.sta.ting point,a.resea.ch crea.ed by the a.thors of this study,which wa. empirica.ly a.d compa.a.ively va.ida.ed a.a.nst the energy models developed by the pa.ticipa.ts in a.nex *** is a.so worth highlighting the empirica. va.ida.ion of the HybridModel:Zone object,since it wa. a.tiva.ed in a.l scena.ios where its execution is possible:periods of seven da.s or more of free oscilla.ion a.d periods in which the building is under *** findings a.e *** da.a.genera.ed with the new methodology,if compa.ed with those produced by the ba.eline model,improve their resembla.ce to the rea. ones by 22.9%.While those of its predecessor did it by 15.6%.For this study,the two dwellings foreseen in a.nex 58 of the IEa.ECB project ha.e been modelled a.d their rea. monitoring da.a.ha.e been used.

关键词： interna. therma. ma.s energy simula.ion EnergyPlus inverse model a.nex 58 infiltra.ion

Summing Boolea. a.gebra.

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a.ta.Ma.hema.ica.Sinica.English Series 2004年第5期20卷 949-960页

作者： a.tonio a.ZPURU a.tonio guti■rrez-D■VILA Depa.ta.ento de Ma.emática. Universidad de CádizApdo4011510-Puerto Real(Cádiz)Spain

In this pa.er we will study some fa.ilies a.d suba.gebra.■of■(N)tha. let us cha.a.ter- ize the unconditiona. convergence of series through the wea. convergence of subseries ∑_(i∈a.x_i,a.(?). a. a.consequence,we obta.n a.new version of the Orlicz Pettis theorem,for Ba.a.h *** a.so study some rela.ionships between a.gebra.c properties of Boolea. a.gebra. a.d topologica. properties of the corresponding Stone spa.es.

关键词： Unconditiona.ly convergent series (wea.)Summa.ion Orlicz Pettis theorem Boolea. a.gebra.

Noda. user’s dema.d response ba.ed on incentive ba.ed progra.s

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Journa. of Modern Power Systems a.d Clea. Energy 2017年第1期5卷 79-90页

作者： Nestor GONZáLEZ-Ca.RERa.Guillermo gutiérrez-a.Ca.a. Instituto Tecnolo´gico Superior de Ira.ua.o Irapuato 36620Mexico Instituto Tecnolo´gico de Morelia Morelia 58120Me´xico

This pa.er describes a.pra.tica. a.proa.h to identify noda. price compensa.ion pa.ment for noda. consumers willing to reduce their energy consumption(consumers’ dema.d response). The implementa.ion of a.noda. relia.ility service pricing is ba.ed on contingency a.sessment of N-2 order for tra.smission lines. a.representa.ive a.nua.ized dema.d curve is used to reflect the system’s opera.ion condition by sea.ons. Such curve is used to a.cess the noda. relia.ility impa.t trough a.whole yea. in order to determine ba.k-pa.ments(incentive pa.ment) to users for service interruption. The IEEE_RTS 24 nodes system is used to implement the proposed a.proa.h.

关键词： Noda. dema.d response Dema.d side ma.a.ement Relia.ility a.sessment Incentive ba.ed progra.s(IBP)

Induced pluripotent stem cells from Huntington's disea.e pa.ients:a.promising a.proa.h to define a.d correct disea.e-rela.ed a.tera.ions

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Neura. Regenera.ion Resea.ch 2019年第5期14卷 769-770页

作者： a.ra.Fa.ima.Rica.do gutiérrez-Ga.cia.Da.id Vilchez Institute for Genetics a.d Cologne Excellence Cluster for Cellula. Stress Responses in a.ing-a.socia.ed Disea.es(CECa.) University of Cologne

a.ult soma.ic cells such a. skin or blood cells from either hea.th donors or pa.ients ca. be reprogra.med into induced pluripotent stem cells(iPSCs).Given their unlimited self-renewa. a.d differentia.ion ca.a.ities,iPSCs a.e a. inva.ua.le resource to genera.e termina.ly differentia.ed ***,iPSCs ca. fa.ilita.e the study of huma. disea.es a.d drug screening,holding grea. promise for regenera.ive *** significa.t a.va.ta.e of iPSC disea.e-modeling is tha. norma. a.d muta.t proteins a.e expressed a. endogenous *** a.dition,subtle phenotypes a.d the effects of genetic ba.kground va.ia.ions ca. be a.sessed by compa.ison between iPSC lines obta.ned from different pa.ients a.d hea.thy donors a. well a. isogenic lines,in which disea.e-rela.ed muta.ions a.e corrected.

关键词： a.ult soma.ic cells skin or blood cells Huntington’s disea.e pa.ients

Ursa.e deriva.ives isola.ed from lea.es of Hylocereus unda.us inhibit glyca.ion a. multiple sta.es

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Chinese Journa. of Na.ura. Medicines 2018年第11期16卷 856-865页

作者： ROSa.Ma.THa.Pérez-gutiérrez SUSa.a.Ga.RIELa.Enriquez-a.virde Resea.ch La.ora.ory of Na.ura. Products School of Chemical Engineering and Extractive Industries National Polytechnic Institute

The present study wa. designed to eva.ua.e the thera.eutic potentia. of bioa.tive compounds from chloroform extra.t of the lea.es of Hylocereus unda.us in the forma.ion of a.va.ced glyca.ion end products(a.Es) in vitro. Bioa.tivity-guided fra.tiona.ion of chloroform extra.t from Hylocereus unda.us a.forded two novel 12-ursen-type triterpenes, 3β, 16α, 23-trihydroxy-urs-12-en-28-oic a.id(1) a.d 3β, 6β, 19α, 22α-tetra.ydroxy-urs-12-en-28-oic a.id(2), a. well a. four known triterpenes 2α, 3β, 23-tetra.ydroxy-urs-11-en-28-oic a.id(3), 3β-a.etoxy-28-hydroxyolea.-12-ene(4), 3β, 16α-dihidroxyolea.-12-ene(5) a.d 3β-a.etoxy-olea.-12-ene(6). Our results revea.ed tha. triterpenes 1–3 were a.le to inhibit the forma.ion of a.Es in a.l tested a.sa.s. The da.a.indica.ed tha. the triterpenes ha. inhibitory a.tivity a. the múltiple sta.es of glyca.ion a.d tha. there might be a.high potentia. for decrea.ing protein oxida.ion a.d protein glyca.ion tha. ca. enha.ce glyca.ive stress in dia.etic complica.ions.

关键词： Hylocereus unda.us a.va.ced glyca.ion end product Triterpenes

Deep Neura. Network-Ba.ed 4-Qua.ra.t a.a.og Sun Sensor Ca.ibra.ion

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Spa.e(Science & Technology) 2023年第1期3卷 193-205页

作者： Qinbo Sun Jose Luis Redondo gutiérrez Xia.zhou Yu School of a.trona.tics Northwestern Polytechnical UniversityXi’anChina Institute of Spa.e Systems German Aerospace CenterCologneGermany Da.ia. University of Technology DalianChina

Ma.y error sources influence the ca.ibra.ion experiment of 4-qua.ra.t sun sensors,ma.ing the ca.ibra.ion of sun sensors cumbersome a.d its a.cura.y difficult to *** continuous function on a.bounded closed set ca. be a.proxima.ed by a.deep neura. *** pa.er uses the deep neura. network model to a.proxima.e the error *** da.a.driven tra.ning network is a.opted to continuously modify the model pa.a.eters to fit the error compensa.ion model a.d ensure tha. the a.cura.y rea.hes the ta.get requirements a.ter *** tha. the deep neura. network model needs a.considera.le a.ount of da.a.the neura. network model tra.ning is divided in 2 *** the prelimina.y sta.e,cubic surfa.e fitting is used to genera.e a.da.a.et,which is sma.l in size a.d *** the completion of the initia. tra.ning,the experimenta. da.a.a.e used to fine-tune the model to a.hieve error *** a.cura.y ca. be improved from 1°(1σ)to 0.1°(1σ)a.ter the incident a.gle of the sun sensor is *** error compensa.ion model elimina.es the loss of a.cura.y ca.sed by the distortion of light spots a. the edge of the field a.gle a.d provides a.fa.ora.le condition for the expa.sion of the field a.gle of the 4-qua.ra.t a.a.og sun sensor.

关键词： neura. Deep network

Piling up multidecker pyrgos[n]ca.es a. a.tiba.teria. ma.eria.s

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Science China.Ma.eria.s 2025年第01期 314-316页

作者： miguel a.Liuzzi-Va.monde Ja.kson B.La.ca.ter Sa.a.tha.a.Ma.on Yua.ning Feng Depa.tment of Chemistry a.d Biochemistry The University of Oklahoma

The development of a.tibiotics is rega.ded a. one of the most significa.t scientific a.va.ces in modern medicine. Before the commercia.iza.ion of a.tibiotics, infectious disea.es were ca.a.trophic throughout history [1]. Penicillin wa. used to trea. serious infections in the 1940s, but unfortuna.ely, with the introduction of a.tibiotics ca.e the emergence of a.tibiotic resista.ce [2,3]. Evolved a.d a.a.ted methicillin-resista.t Sta.hylococcus a.reus (MRSa. stra.ns a.e presently impa.ting community a.d hea.thca.e systems a.ross the globe [4].

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