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Compa.ing Fine-Tuning, Zero a.d Few-Shot Stra.egies with La.ge La.gua.e Models in Ha.e Speech detection in English

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2849-2868页

作者： Rongha. Pa. Joséa.tonio garcía.día. Ra.a.l Va.encia.garcía depa.ta.ento de Informática.y Sistema. Universidad de MurciaCampus de EspinardoMurcia30100Spain

La.ge La.gua.e Models(LLMs)a.e increa.ingly demonstra.ing their a.ility to understa.d na.ura. la.gua.e a.d solve complex ta.ks,especia.ly through text *** of the releva.t ca.a.ilities is contextua. lea.ning,which involves the a.ility to receive instructions in na.ura. la.gua.e or ta.k demonstra.ions to genera.e expected outputs for test insta.ces without the need for a.ditiona. tra.ning or gra.ient *** recent yea.s,the popula.ity of socia. networking ha. provided a.medium through which some users ca. enga.e in offensive a.d ha.mful online *** this study,we investiga.e the a.ility of different LLMs,ra.ging from zero-shot a.d few-shot lea.ning to *** experiments show tha. LLMs ca. identify sexist a.d ha.eful online texts using zero-shot a.d few-shot a.proa.hes through informa.ion ***,it is found tha. the encoder-decoder model ca.led Zephyr a.hieves the best results with the fine-tuning a.proa.h,scoring 86.811%on the Expla.na.le detection of Online Sexism(EdOS)test-set a.d 57.453%on the Multilingua. detection of Ha.e Speech a.a.nst Immigra.ts a.d Women in Twitter(Ha.Eva.)***,it is confirmed tha. the eva.ua.ed models perform well in ha.e text detection,a. they bea. the best result in the Ha.Eva. ta.k *** error a.a.ysis shows tha. contextua. lea.ning ha. difficulty distinguishing between types of ha.e speech a.d figura.ive ***,the fine-tuned a.proa.h tends to produce ma.y fa.se positives.

关键词： Ha.e speech detection zero-shot few-shot fine-tuning na.ura. la.gua.e processing

Oligodendroctyes:the forgotten pla.ers of dia.etes pa.hophysiology

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Neura. Regenera.ion Resea.ch 2024年第11期19卷 2349-2350页

作者： Jua. a.tonio López-Villodres Bea.riz garcía.día. depa.ta.ento Fisiología.Huma.a Histología HumanaAnatomía Patológica y Educación Física y DeportivaFacultad de MedicinaUniversidad de MálagaMálagaSpain UGC Neurociencia.Instituto de Investiga.ión Biomédica.de Mála.a.y Pla.a.orma.en Na.omedicina.IBIMa.Pla.a.orma.Biona.d) MálagaSpain

Oligodendrocytes(OLs),glia. cells tha. provide myelin shea.hs to a.ons in the centra. nervous system(CNS),ha.e a.dua. ***,this myelin fa.ty cover a.ound the a.ons protects the nerves a.d is crucia. for the sa.ta.ory propa.a.ion of a.tion *** a.d not less importa.t,OLs provide trophic support to neurons a.d ***,OL meta.olism is importa.t for OL well-being a.d the proper a.complishment of their functions,a.d OL meta.olism energetics directly a.fect the energy meta.olism of neighboring neurons.

关键词： meta.olism nerves myelin

a.comprehensive look a. the psychoneuroimmunoendocrinology of spina. cord injury a.d its progression: mecha.isms a.d clinica. opportunities

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Milita.y Medica. Resea.ch 2024年第2期11卷 228-267页

作者： miguel a.Ortega.Osca. Fra.le-Ma.tinez Cielo garcía.Montero Sergio Ha.o miguel Ángel Álva.ez-Mon diego de Leon-Oliva.a.a.M.Gomez-La.oz Jorge Monserra. Ma. a.ienza.Pérez da.id día. Elisa.Lopez-dola.o Melchor Álva.ez-Mon depa.tment of Medicine a.d Medica. Specia.ities University of Alcala28801 Alcala de HenaresSpain Ra.ón y Ca.a. Institute of Sa.ita.y Resea.ch(IRYCIS) 28034 MadridSpain depa.tment of Psychia.ry a.d Menta. Hea.th Hospital Universitario Infanta Leonor28031 MadridSpain Service of Reha.ilita.ion National Hospital for Paraplegic PatientsCarr.de la PeraledaS/N45004 ToledoSpain Immune System disea.es‑Rheuma.ology Service a.d Interna. Medicine University Hospital Príncipe de Asturias(CIBEREHD)28806 Alcala de HenaresSpain

Spina. cord injury(SCI)is a.deva.ta.ing a.d disa.ling medica. condition genera.ly ca.sed by a.tra.ma.ic event(prima.y injury).This initia. tra.ma.is a.compa.ied by a.set of biologica. mecha.isms directed to a.eliora.e neura. da.a.e but a.so exa.erba.e initia. da.a.e(seconda.y injury).The a.tera.ions tha. occur in the spina. cord ha.e not only loca. but a.so systemic consequences a.d virtua.ly a.l orga.s a.d tissues of the body incur importa.t cha.ges a.ter SCI,expla.ning the progression a.d detrimenta. consequences rela.ed to this ***(PNIE)is a.growing a.ea.of resea.ch a.ming to integra.e a.d explore the intera.tions a.ong the different systems tha. compose the huma. orga.ism,considering the mind a.d the body a. a.*** initia. tra.ma.ic event a.d the consequent neurologica. disruption trigger immune,endocrine,a.d multisystem dysfunction,which in turn a.fect the pa.ient's psyche a.d *** the present review,we will explore the most importa.t loca. a.d systemic consequences of SCI from a.PNIE perspective,defining the cha.ges occurring in ea.h system a.d how a.l these mecha.isms a.e ***,potentia. clinica. a.proa.hes derived from this knowledge will a.so be collectively presented with the a.m to develop integra.ive thera.ies to ma.imize the clinica. ma.a.ement of these pa.ients.

关键词： Spina. cord injury(SCI) Psychoneuroimmunoendocrinology(PNIE) Seconda.y injury Immunoinfla.ma.ory dysfunction Gut microbiota Tra.sla.iona. opportunities

The dorsa. root ga.glion a. a.ta.get for neurorestora.ion in neuropa.hic pa.n

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Neura. Regenera.ion Resea.ch 2024年第2期19卷 296-301页

作者： Guillermo Estivill-Torrús a.a.Belen Ma.tínez-Pa.illa.Lourdes Sánchez-Sa.ido a.ne Ba.on-Va. Evercooren Bea.riz garcía.día. Instituto de Investiga.ión Biomédica.de Mála.a.y Pla.a.orma.en Na.omedicina.IBIMa.Pla.a.orma.BIONa.d) MálagaSpain Unida. Clínica.de Neurociencia. Hospital Regional Universitario de MálagaMálagaSpain depa.ta.ento de Biología.Molecula. y Bioquímica Universidad de MálagaSpain Sorbonne Université Institut du Cerveau-Paris Brain Institute-ICMINSERMCNRSAP-HPHôpital Pitié-SalpêtrièreParisFrance

Neuropa.hic pa.n is a.severe a.d chronic condition widely found in the genera. *** rea.on for this is the extensive va.iety of da.a.e or disea.es tha. ca. spa.k this unplea.a.t consta.t feeling in *** the processing of pa.n,the dorsa. root ga.glia.constitute a. importa.t region where dorsa. root ga.glion neurons pla. a.crucia. role in the tra.smission a.d propa.a.ion of sensory electrica. ***,the dorsa. root ga.glia.ha.e recently exhibited a.regenera.ive ca.a.ity tha. should not be neglected in the understa.ding of the development a.d resolution of neuropa.hic pa.n a.d in the elucida.ion of innova.ive ***,we will review the complex interpla. between cells(sa.ellite glia. cells a.d infla.ma.ory cells)a.d fa.tors(cytokines,neurotrophic fa.tors a.d genetic fa.tors)tha. ta.es pla.e within the dorsa. root ga.glia.a.d a.counts for the genera.ion of the a.erra.t excita.ion of prima.y sensory neurons occurring in neuropa.hic *** importa.tly,we will summa.ize a. upda.ed view of the current pha.ma.ologic a.d nonpha.ma.ologic thera.ies ta.geting the dorsa. root ga.glia.for the trea.ment of neuropa.hic pa.n.

关键词： cytokines dorsa. root ga.glia genetic fa.tors neuropa.hic pa.n neurotrophic fa.tors pha.ma.ologic a.d nonpha.ma.ologic thera.ies sa.ellite glia. cells sensory neurons

Identifica.ion a.d functiona. cha.a.teriza.ion of fish IL‑17 receptors suggest importa.t roles in the response to noda.irus infection

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Ma.ine Life Science & Technology 2024年第2期6卷 252-265页

作者： Ca.men González‑Fernández miguel a.garcía.Álva.ez a.berto Cuesta depa.tment of Cell Biology a.d Histology Faculty of BiologyUniversity of Murcia30100 MurciaSpain La.ora.oire d’écotoxicologie Centre de Lyon-VilleurbanneINRAEUR RiverLy69625 VilleurbanneFrance

Th17 is a.lymphocyte T helper(Th)subpopula.ion releva.t in the control a.d regula.ion of the immune response cha.a.terized by the production of interleukin(IL)-*** crucia. cytokine fa.ily a.ts through their binding to the IL-17 receptors(IL-17R),ha.ing up to six *** the biology of fish Th17 is well-recognized,the molecula. a.d functiona. cha.a.teriza.ion of IL-17 a.d IL-17R ha. been ***,our a.m wa. to identify a.d cha.a.terize the IL-17R repertory a.d regula.ion in the two ma.n Mediterra.ea. cultured fish species,the gilthea. sea.rea.(Spa.us a.ra.a.a.d the Europea. sea.ba.s(dicentra.chus la.ra.).Our in silico results showed the clea. identifica.ion of six members in ea.h fish species,from IL-17Ra.to IL-17RE-like,with well-conserved gene structure a.d protein doma.ns with their huma. *** of them showed wide a.d constitutive tra.scription in na.ve tissues but with highest levels in mucosa. tissues,na.ely skin,gill or *** leucocytes,T mitogens showed the strongest up-regula.ion in most of the il17 receptors though il17ra.resulted in inhibition by most ***,in vivo noda.irus infection resulted in a.tera.ions on the tra.scription of il17 *** noda.irus infection led to some increments in the il17ra.il17rb,il17rc a.d il17rd tra.scripts in the susceptible Europea. sea.ba.s,ma.y down-regula.ions were observed in the resista.t gilthea. *** da.a.identify the presence a.d conserva.ion of six coding IL-17R in gilthea. sea.rea. a.d Europea. sea.ba.s a. well a. their differentia. regula.ion in vitro a.d upon noda.irus infection.

关键词： Th17 cells IL-17 receptors Immunity Teleost fish Noda.irus(NNV) a.ua.ulture

Mixed neuroendocrine non-neuroendocrine neopla.ms in ga.troenteropa.crea.ic tra.t

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World Journa. of Ga.trointestina. Oncology 2024年第4期16卷 1166-1179页

作者： Seba.tián día.-López Jerónimo Jiménez-Ca.tro Ca.los Enrique Robles-Ba.ra.a.Ca.los a.a.a.de miguel Ma.uel Cha.es-Conde Medica. Oncology depa.tment Hospital Universitario ValmeSeville 41014AndalucíaSpain

Mixed neuroendocrine non-neuroendocrine neopla.ms(MiNENs)a.e a.hetero-geneous group of ma.igna.t neopla.ms tha. ca. settle in the ga.troenteropa.-crea.ic *** a.e composed of a.neuroendocrine(NE)a.d a.non-NE compo-nent in a. lea.t 30%of ea.h *** non-NE component ca. include different histologica. combina.ions of gla.dula.,squa.ous,mucinous a.d sa.coma.oid phenotypes,a.d one or both of the components ca. be low-or high gra.e *** cha.ges in the nomencla.ure of these neopla.ms might lea. to grea. dea. of confusion,a.d the la.k of specific clinica. tria.s is the ma.n rea.on why their ma.a.ement is *** review a.ms to cla.ify the definition of MiNEN a.d a.a.yze a.a.la.le evidence a.out their dia.nosis a.d trea.ment options a.cording to their loca.ion a.d extension through ca.eful a.a.ysis of the a.a.la.le *** would be importa.t to rea.h a.genera. consensus on their dia.nosis in order to construct a.cla.sifica.ion tha. rema.ns sta.le over time a.d fa.ilita.es the design of clinica. tria.s tha.,due to their low incidence,will require long recruitment periods.

关键词： Mixed neuroendocrine non-neuroendocrine neopla.ms Mixed a.enoneuroendocrine ca.cinoma. Mixed tumours Ga.troenteropa.crea.ic Trea.ment Etiology dia.nosis

Sma.l molecules to ta.get ta. a.yloid a.grega.ion

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Neura. Regenera.ion Resea.ch 2024年第3期19卷 509-511页

作者： Zoe Ma.gla.o-a.tuñedo Sa.uel Peña.día. Sa.va.or Ventura Institut de Biotecnologia.i Biomedicina Universitat Autònoma de BarcelonaBellaterraSpain

Protein a.grega.ion ha. been linked with ma.y neurodegenera.ive disea.es,such a. a.zheimer’s disea.e(a.)or Pa.kinson’s *** belongs to a.group of heterogeneous a.d incura.le neurodegenera.ive disorders collectively known a. *** comprise frontotempora. dementia.Pick’s disea.e,or corticoba.a. degenera.ion,a.ong *** symptoma.ology va.ies with the specific ta. protein va.ia.t involved a.d the a.fected bra.n region or cell ***,they sha.e a.common neuropa.hologica. ha.lma.k-the forma.ion of proteina.eous deposits na.ed neurofibrilla.y *** ta.gles,prima.ily composed of a.grega.ed ta.(Zha.g et a..,2022),disrupt norma. neurona. functions,lea.ing to cell dea.h a.d cognitive decline.

关键词： ta. degenera.ion a.grega.ion

Refra.tive outcomes a.ter V4c Toric colla.er lens impla.ta.ion over 1y of follow-up

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Interna.iona. Journa. of Ophtha.mology(English edition) 2024年第7期17卷 1322-1330页

作者： Humberto Ca.rera.-día. Josefina.Reñones de a.a.o Ma.ía.del Rosa.io Ca.rera.-día. a.a.ia.Lorente-Velázquez Vitha. Euroca.a.ia. Las Palmas de Gran Canaria 35004Spain University Hospita. of Girona.doctor Josep Trueta Gerona 17007Spain depa.ta.ent of Optometry a.d Vision Faculty of Optics and OptometryComplutense University of MadridMadrid 28040Spain

a.M:To eva.ua.e refra.tive outcomes a.d cornea. a.tigma.ism cha.ges a.ter Toric impla.ta.le colla.er lens with a.centra. port(V4c T-ICL)impla.ta.ion over 1y of ***:a.retrospective study wa. performed including 50 eyes of 50 pa.ients tha. underwent V4c T-ICL ***(UdVa.a.d corrected(CdVa.dista.ce visua. a.uities,refra.tion,refra.tive a.d cornea. a.tigma.ism cha.ges a.d cornea. coupling correction were eva.ua.ed preopera.ively,1 a.d 12mo *** a.a.ysis wa. used for a.tigma.ism *** of a.justment(Ca.j)wa. ca.cula.ed for cornea. coupling ***:The mea. UdVa.a.hieved wa. 0.03 logMa. a. 1mo a.d rema.ned uncha.ged throughout the whole follow-up(P=0.193).a. the la.t visit,84%of the eyes a.hieved a.CdVa.of 0.00 logMa. or *** spherica. equiva.ent refra.tion(SEQ),96%of eyes were ra.ges of±1.00 d a.d 84%of them within±0.50 ***,94%of eyes ha. a.rema.ning refra.tive cylinder within±1.00 d a.d 78%of them within±0.50 ***,SEQ a.d refra.tive cylinder,rema.n sta.le over the postopera.ive follow-up(P=1.000 a.d P=0.660,respectively).In terms of surgica.ly induced a.tigma.ism(SIa.,no sta.istica.ly significa.t differences were found over the follow-up(P=0.102)a.d under correction wa. found with a.correction index lower tha. the unit a. ea.h visit.a.kera.ometric a.tigma.ism induced of 0.59±0.53(vector mea.:0.26×73º)d wa. rea.hed a. the la.t *** significa.t cha.ges in terms of cornea. a.tigma.ism orienta.ion were reported over post-surgery visits(P=0.129 a.d P=0.097 a. 1 a.d 12mo respectively).No clinica. significa.ce wa. found for Ca.j on with-the-rule *** postopera.ive complica.ions resulting from the surgery were ***:Refra.tive outcomes suggest tha. the V4c T-ICL impla.ta.ion for correction of myopic a.tigma.ism wa. sa.isfa.tory in terms of effectiveness,sa.ety,a.d sta.ility during 1y of *** a.tigma.ism induced by the incision a.ound 0.5 d is a.hieved

关键词： V4c Toric colla.er lens cornea. a.tigma.ism surgica.ly induced a.tigma.ism cornea. coupling

a.sessment of Inta.gible Losses in Ea.thqua.e Engineering

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Open Journa. of Civil Engineering 2024年第3期14卷 469-485页

作者： Ja.me garcía.Pérez Orla.do día.-López Eric garcía.López Instituto de Ingeniera Ingeniera Estructural Edif 2 Universidad Nacional Autnoma de Mxico Ciudad Universitaria Mexico City Mxico Cobertizo Sa. Pedro Mrtir s/n Facultad de Ciencias Jurdicas y Sociales Universidad de Castilla-La Mancha Toledo Espaa

In order to find optimum design pa.a.eters in ea.thqua.e engineering, a. objective function is optimized. This function comprises the initia. cost of a.structure a.d the cost due to the da.a.e of ea.thqua.es. Inta.gible losses ma. be included in the la.ter, such a. how much society is willing to invest to preserve a.huma. life. In this pa.er, the expression of the objective function is developed in terms of the seismic design coefficient, a.d the a.orementioned inta.gible loss is ca.cula.ed from both the individua. point of view a.d tha. of society. The ca.cula.ion of the inta.gible is ba.ed on utility curves. Fina.ly, optimum seismic design coefficients a.e ca.cula.ed for a.firm ground site.

关键词： Seismic Risk Optimum Coefficients Structura. Relia.ility Inta.gible Losses Utility