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Current surgical treatment of diverticular disease in the Netherlands

World Journal of Gastroenterology 2010年第14期16卷 1742-1746页

作者： Annelien N Morks Bastiaan R Klarenbeek Elvira R Flikweert Donald L van der Peet Thomas M Karsten Eric H Eddes miguel a cuesta Peter W de Graaf Department of Surgery Reinier de Graaf Gasthuis PO Box 5011 2600 GA Delft The Netherlands Department of Surgery VU University Medical Center PO Box 7057 1007 MB Amsterdam The Netherlands Department of Surgery Deventer Ziekenhuis PO Box 5001 7400 GC Deventer The Netherlands

AIM: To evaluate the development of diagnostic tools, indications for surgery and treatment modalities concerning diverticular disease (DD) in the Netherlands. METHODS: Data were collected from 100 patients who underwent surgery for DD in three Dutch hospitals. All hospitals used the same standardized data base. The collected data included patient demographics, patient history, type of surgery and complications. Patients were divided into two groups, one undergoing elective surgery (elective group) and the other undergoing acute surgery (acute group). RESULTS: Two hundred and ninety-nine patients were admitted between 2000 and 2007. One hundred and seventy-eight patients underwent acute surgery and 121 patients received elective operations. The median age of the 121 patients was 69 years (range: 28-94 years), significantly higher in acute patients (P = 0.010). Laparoscopic resection was performed in 31% of elective patients. In the acute setting, 61% underwent a Hartmann procedure. The overall morbidity and mortality were 51% and 10%, and 60% and 16% in the acute group, which were significantly higher than in the elective group (36% and 1%). Only 35% of the temporary ostomies were restored. CONCLUSION: This study gives a picture of current surgical practice for DD in the Netherlands. New developments are implemented in daily practice, resulting in acceptable morbidity and mortality rates.

关键词： Diverticulitis Surgery Diverticular disease

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Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： Marta García-Juan Mario Villa Irene Benito-cuesta Lara Ordónez-Gutiérrez Francisco Wandosell Centro de Biología Molecular“Severo Ochoa”(CSIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden Departamento de Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

关键词： homeostasis system hereafter

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Piling up multidecker pyrgos[n]cages as antibacterial materials

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Science China Materials 2025年第01期 314-316页

作者： miguel A.Liuzzi-Vaamonde Jackson B.Lancaster Samantha A.Mason Yuanning Feng Department of Chemistry and Biochemistry The University of Oklahoma

The development of antibiotics is regarded as one of the most significant scientific advances in modern medicine. Before the commercialization of antibiotics, infectious diseases were catastrophic throughout history [1]. Penicillin was used to treat serious infections in the 1940s, but unfortunately, with the introduction of antibiotics came the emergence of antibiotic resistance [2,3]. Evolved and adapted methicillin-resistant Staphylococcus aureus (MRSA) strains are presently impacting community and healthcare systems across the globe [4].

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Identification and functional characterization of fish IL‑17 receptors suggest important roles in the response to nodavirus infection

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Marine Life Science & Technology 2024年第2期6卷 252-265页

作者： Carmen González‑Fernández miguel A.García‑Álvarez Alberto cuesta Department of Cell Biology and Histology Faculty of BiologyUniversity of Murcia30100 MurciaSpain Laboratoire d’écotoxicologie Centre de Lyon-VilleurbanneINRAEUR RiverLy69625 VilleurbanneFrance

Th17 is a lymphocyte T helper(Th)subpopulation relevant in the control and regulation of the immune response characterized by the production of interleukin(IL)-*** crucial cytokine family acts through their binding to the IL-17 receptors(IL-17R),having up to six *** the biology of fish Th17 is well-recognized,the molecular and functional characterization of IL-17 and IL-17R has been ***,our aim was to identify and characterize the IL-17R repertory and regulation in the two main Mediterranean cultured fish species,the gilthead seabream(Sparus aurata)and the European sea bass(Dicentrarchus labrax).Our in silico results showed the clear identification of six members in each fish species,from IL-17RA to IL-17RE-like,with well-conserved gene structure and protein domains with their human *** of them showed wide and constitutive transcription in naïve tissues but with highest levels in mucosal tissues,namely skin,gill or *** leucocytes,T mitogens showed the strongest up-regulation in most of the il17 receptors though il17ra resulted in inhibition by most ***,in vivo nodavirus infection resulted in alterations on the transcription of il17 *** nodavirus infection led to some increments in the il17ra,il17rb,il17rc and il17rd transcripts in the susceptible European sea bass,many down-regulations were observed in the resistant gilthead *** data identify the presence and conservation of six coding IL-17R in gilthead seabream and European sea bass as well as their differential regulation in vitro and upon nodavirus infection.

关键词： Th17 cells IL-17 receptors Immunity Teleost fish Nodavirus(NNV) Aquaculture

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Isotopic niche provides an insight into the ecology of a symbiont during its geographic expansion

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Current Zoology 2022年第2期68卷 185-197页

作者： Enrique GONZALEZ-ORTEGON Marta PEREZ-miguel Jose I.NAVAS Pilar DRAKE Jose A.cuesta Instituto de Ciencias Marinas de Andalucia(ICMAN-CSIC) Campus Universitario Rio San PedroAvda.Republica Saharaui211519CadizPuerto RealSpain Unidad Asociada Crecimiento Azul CSIC-IFAPA El Puerto de Santa Maria SpainSpain Instituto de Investigacion y Formacion Agraria y Pesquera IFAPA-Centro Agua del PinoCtra.EI Rompido-Punta Umbriakm 3.821459 EI RompidoHuelvaSpain

The study of the recent colonization of a symbiont and its interaction with host communities in new locations is an opportunity to understand how they *** use of isotopic ratios in trophic ecology can provide measurements of a species'isotopic niche,as well as knowledge about how the isotopic niches between symbiont and host species *** isotope measurements were used to assess the sources of carbon assimilated by the host species(the bivalves Mytilus galloprovincialis and Scrobicularia plana)and their associated symbiont pea crab Afropinnotheres monodi,which occurs within these bivalves'mantle *** mixing model estimates suggest that all of them assimilate carbon from similar sources,particularly from pseudofaeces and particulate organic matter in this symbiotic system based on filter *** symbiotic species occupy comparable trophic levels and its association seems to be commensal or parasitic depending on the duration of such *** pea crab *** reflects a sex-specific diet,where males are more generalist than the soft females because the latter's habitat is restricted to the host *** high isotopic overlap between soft females and *** may reflect a good commensal relationship with the host.

关键词： bivalves commensal kleptoparasitism parasitism stable isotope trophic position

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A prototype for on-site generation of chlorinated disinfectant for use in rural aqueducts

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Water Science and Engineering 2024年第1期17卷 33-40页

作者： Diana Marcela cuesta Parra Felipe Correa Mahecha Andrés Felipe Rubio Pinzon Davidcamilo Ramirez Bustos Leonel Alveyro Teran Llorente miguel Fernando Jimenez Jimenez Chemical and Environmental Engineering Department Fundacion Universidad de AmericaBogota 117111Colombia Chemical Engineering Department Fundacion Universidad de AmericaBogota 117111Colombia Mecanical Engineering Department Fundacion Universidad de AmericaBogota 117111Colombia

Sodium hypochlorite has significant potential as a sanitation solution in hard-to-reach *** studies have investigated the optimal electrolysis parameters for its production with volumes greater than 1o *** study evaluated sodium hypochlorite production through electrolysis in a 22-L prototype and identified the optimal operating *** were performed using graphite electrodes with areas of 68.4 cm^(2) at the laboratory scale and 1865.0 cm^(2) at the prototype scale.A design for experiments with different operating times,chloride concentrations,and electric current intensities was *** optimal operating time,sodium chloride concentration,and current intensity at the laboratory scale were 120 min,150 g of chloride per liter,and 3 A,respectively,leading to the production of 5.02 g/L of the disinfectant with an energy efficiency of 12.21 mg of Cl_(2) per *** the prototype scale,the maximum sodium hypochlorite concentration of 3.99 g of chloride per liter was achieved with an operating time of 120 min,a sodium chloride concentration of 100 g of chloride per liter,and a current intensity of 70 A,reaching an energy efficiency of 42.56 mg of Cl_(2) per *** addition,this study evaluated the influences of the chloride concentration,current intensity,and operating time on the production of sodium hypochlorite at the two scales,and formulated the equations showing the trends of sodium hypochlorite production and energy efficiency in the electrochemical *** 22-L prototype model for production of this oxidizing substance is promising for disinfection of large volumes of water in areas that are difficult to access.

关键词： Disinfection Electrolysis Energy efficiency Optimization Sodium hypochlorite

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Enriched Acoustic Environment as a customized treatment for tinnitus: A non-controlled longitudinal study

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Journal of Otology 2024年第2期19卷 63-71页

作者： María cuesta Pedro Cobo Institute of Physical and Information Technologies(ITEFI) CSICSerrano 14428006MadridSpain

Tinnitus is a heterogeneous hearing disorder with no cure at present,but some treatments,such as a combination of counselling and sound therapy,can alleviate the discomfort it *** sound therapy efficiency depends on both the type of sound stimulus and the time of *** study describes the fundamentals of a personalized sound therapy that stimulates the auditory system with either continuous or sequential sounds whose spectra are adjusted to the hearing levels of the *** sound therapy is called Enriched Acoustic Environment and is assessed in a sample of 137 participants with ***-related distress relief was clinically relevant and statistically significant for 90%of these *** was quantified as a mean decrease of 24.3 points on the Tinnitus Handicap Inventory.31%of participants were treated with sequential stimuli and achieved greater relief of distress(29.4 points on their Tinnitus Handicap Inventory score)compared to those treated with continuous sound(69%).According to these results,sequential sound seems to be optimal compared to continuous sound.

关键词： Tinnitus Sound therapy Enriched acoustic environment Tinnitus handicap inventory

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Social Isolation in Male Rats During Adolescence Inhibits the Wnt/β-Catenin Pathway in the Prefrontal Cortex and Enhances Anxiety and Cocaine-Induced Plasticity in Adulthood

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Neuroscience Bulletin 2020年第6期36卷 611-624页

作者： Santiago cuesta Alejandrina Funes Alejandra M.Pacchioni Area Toxicologia Departamento de Ciencias de los Alimentos y del MedioambienteFacultad de Ciencias Bioquimicas y FarmaceuticasUniversidad Nacional de RosarioSuipacha 5312000 RosarioSanta FeArgentina Consejo Nacional de Investigaciones Cientificas y Tecnicas RosarioArgentina Present Address:Department of Microbiology University of Texas Southwestern Medical CenterDallasTX 75390USA

In adult animals,it is well established that stress has a proactive effect on psychostimulant ***,whether only a short period of stress during adolescence can also affect cocaine responses later in life and what mechanisms are involved are ***,we showed that 5 days of social isolation during rat adolescence had a long-term impact on anxiety-like behaviors,cocaine-induced conditioned place preference,and the expression of sensitization during *** the molecular level,social isolation decreased the activity of the Wnt/β-catenin pathway in the prefrontal cortex(PFC).Furthermore,after the expression of cocaine sensitization,isolated rats showed an increase in this pathway in the nucleus ***,these findings suggest that,adolescent social isolation by altering the Wnt/β-catenin pathway in the developing PFC might increase the cocaine responses during adulthood,introducing this pathway as a novel neuroadaptation in the cortical-accumbens connection that may mediate a stress-induced increase in vulnerability to drugs.

关键词： Social isolation Adolescence Cocaine vulnerability Wnt/(i-catenin pathway

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European legal framework related to underground mining and tunnelling concerning commission directive (EU) 2017/164, 31 January establishing a fourth list of indicative occupational exposure limit values

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International Journal of Mining Science and Technology 2020年第4期30卷 541-545页

作者： miguel Tato Diogo Department of Mining Engineering Faculty of EngineeringUniversity of PortoPorto 4200-465Portugal

Directive(EU)2017/164 establishes a fourth list of indicative occupational exposure limit values(IOELVs)to protect workers from risks of exposure to hazardous *** states that in underground mining and tunnelling,Member States may benefit from a transitional period regarding IOELVs for nitrogen monoxide,nitrogen dioxide,and carbon monoxide,during which the existing established IOELVs may be *** European Advisory Committee on Health and Safety at Work questions the technical feasibility of the proposed IOELVs in underground mining(CO,NO and NO2)and tunnelling(NO and NO2).Challenges arise concerning the availability of measurement methodologies for compliance with proposed IOELVs(NO2)in underground mining and tunnelling environments.

关键词： Nitrogen monoxide Nitrogen dioxide Carbon monoxide IOELVs European Directive 2017/164 Underground mining Tunnelling

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Improving surface integrity when drilling CFRPs and Ti-6Al-4V using sustainable lubricated liquid carbon dioxide

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Chinese Journal of Aeronautics 2023年第7期36卷 129-146页

作者： In˜igo RODRIGUEZ Pedro Jose´ARRAZOLA Mikel cuesta Luka STERLE Franci PUSˇAVEC Faculty of Engineering Mondragon UnibertsitateaArrasate-Mondragon 20500Spain Faculty of Mechanical Engineering University of LjubljanaLjubljana 1000Slovenia

In the quest for decreasing fuel consumption and resulting gas emissions in the aeronautic sector,lightweight materials such as Carbon Fiber Reinforced Polymers(CFRPs)and Ti-6Al-4V alloys are being *** materials,with excellent weight-to-strength ratios,are widely used for structural applications in aircraft *** date,several studies have been published showing that the use of metalworking fluids(MWFs),special tool geometries,or advanced machining techniques is required to ensure a surface quality that meets aerospace component *** MWFs pose a number of environmental and worker health hazards and also degrade the mechanical properties of CFRPs due to water absorption in the ***,a transition to more environmentally friendly cooling/lubrication techniques that prevent moisture problems in the composite is *** research shows that lubricated LCO_(2) is a viable option to improve the quality of drilled CFRP and titanium aerospace components compared to dry machining,while maintaining clean work *** results show that the best combination of tool geometry and cooling conditions for machining both materials is drilling with Brad point drills and lubricated LCO_(2).Drilling under these conditions resulted in a 90%improvement in fiber pullout volume compared to dry machined CFRP *** addition,a 33% reduction in burr height and a 15% improvement in surface roughness were observed compared to dry drilling of titanium.

关键词： Carbon fibers Cryogenics Green manufacturing Machining Solid lubricants Surface morphology Titanium alloys

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