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Effect of magnetic field orientation on fluidized beds of magnetic particles:Theory and experiment

Particuology 2014年第1期12卷 54-63页

作者： miguel ángel sánchez quintanilla Manuel Jesús Espin José Manuel Valverde Department of Electronics and Electromagnetism University of Seville Department of Applied PhysicsⅡ University of Seville

Geldart-A fluidized beds of fine particles experience a jamming transition between a fluid-like state and a solid-like state at a certain superficial gas velocity, that depends on the relative strength of interparticle attractive forces with respect to particle weight, lnterparticle forces provide the bed with a certain tensile strength in the jammed state. In the work presented here we analyze the behavior of a fluidized bed of magnetic particles subjected to an externally applied magnetic field, which contributes to enhance interparticle forces. The importance of the magnetic contribution to interparticle forces is measured by the changes in the tensile strength and the superficial gas velocity at the jamming transition. The link of the field orientation with the microstructure of the bed is discussed,

关键词： Magneto-fluidization Jamming transition Fluidization Fine powders Cohesion Magnetization

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Long-term effects of gestational diabetes mellitus on the pancreas of female mouse offspring

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World Journal of Diabetes 2024年第4期15卷 758-768页

作者： Enriqueta Muñoz-Islas Edgar David santiago-sanMartin Eduardo Mendoza-sánchez Héctor Fabián Torres-Rodríguez Laura Yanneth Ramírez-quintanilla Christopher Michael Peters Juan miguel Jiménez-Andrade Unidad Académica Multidisciplinaria Reynosa-Aztlán Universidad Autónoma de TamaulipasReynosa 88740TamaulipasMexico Department of Anesthesiology Wake Forest University School of MedicineWinston SalemNC 27101United States

BACKGROUND Prolonged fetal exposure to hyperglycemia may increase the risk of developing abnormal glucose metabolism and type-2 diabetes during childhood,adolescence,and adulthood;however,the mechanisms by which gestational diabetes mellitus(GDM)predisposes offspring to metabolic disorders remain *** To quantify the nerve axons,macrophages,and vasculature in the pancreas from adult offspring born from mouse dams with *** GDM was induced by *** of streptozotocin(sTZ)in ICR mouse *** 12 wk old,fasting blood glucose levels were determined in *** 15 wk old,female offspring born from dams with and without GDM were sacrificed and pancreata were processed for *** quantified the density of sensory[calcitonin gene-related peptide(CGRP)]and tyrosine hydroxylase(TH)axons,blood vessels(endomucin),and macro-phages(CD68)in the splenic pancreas using confocal *** Offspring mice born from sTZ-treated dams had similar body weight and blood glucose values compared to offspring born from vehicle-treated ***,the density of CGRP+and TH+axons,endomucin+blood vessels,and CD68+macrophages in the exocrine pancreas was significantly greater in offspring from mothers with GDM vs control ***,the microvasculature in the islets was significantly greater,but not the number of macrophages within the islets of offspring born from dams with GDM compared to control *** GDM induces neuronal,vascular,and inflammatory changes in the pancreas of adult progeny,which may partially explain the higher propensity for offspring of mothers with GDM to develop metabolic diseases.

关键词： Gestational diabetes mellitus Immunohistochemistry Confocal microscopy Pancreas Offspring

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A role for the Tgf-β/Bmp co-receptor Endoglin in the molecular oscillator that regulates the hair follicle cycle

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Journal of Molecular Cell Biology 2019年第1期11卷 39-52页

作者： Maria I.Calvo-sanchez sandra Fernandez-Martos Elisa Carrasco Gema Moreno-Bueno Carmelo Bernabeu miguel quintanilla Jesus Espada Instituto de Investigaciones Biomedicas'Alberto sols' Consejo Superior de Investigaciones Cientificas(CSIC)-Departamento de BioqufmicaUniversidad Autonoma de Madrid(UAM)Madrid 28029Spain Instituto de Investigaciones Biosanitarias Facultad de Ciencias ExperimentalesUniversidad Francisco de Vitoria(UFV)Pozuelo de Alarcon 28223Spain Centro de Investigacion Biomedica en Red de Cancer(CIBERONC) Spain Centro de Investigaciones Biologicas Consejo Superior de Investigaciones Cientificas(CSIC)and Centro de Investigacion Biomedica en Red de Enfermedades Raras(CIBERER)Madrid 28040Spain Centro Integrativo de Biologfa y Quimica Aplicada Universidad Bernardo O'HigginsSantiago 8370854Chile Instituto Ramon y Cajal de Investigacion sanitaria(IRYCIs) Hospital Universitario Ramon y CajalMadridSpain

The hair follicle is a biological oscillator that alternates growth,regression,and rest phases driven by the sequential activation of the proliferation differentiation programs of resident stem cell *** activation of hair follicle stem cell niches and subsequent entry into the growing phase is mainly regulated by Wnt/β-catenin signalling,while regression and resting phases are mainly regulated by Tgf-β/Bmp/smad activity.A major question still unresolved is the nature of the molecular switch that dictates the coordinated transition between both signalling *** we have focused on the role of Endoglin(Eng),a key co-receptor for members of the Tgf-β/Bmp family of growth *** an Eng haploinsufficient mouse model,we report that Eng is required to maintain a correct follicle cycling pattern and for an adequate stimulation of hair follicle stem cell *** further report thatβ-catenin binds to the Eng promoter depending on Bmp ***,we show thatβ-catenin interacts with smad4 in a Bmp/Eng-dependent context and both proteins act synergistically to activate Eng promoter *** observations point to the existence of a growth/rest switching mechanism in the hair follicle that is based on an Eng-dependent feedback cross-talk between Wnt/β-catenin and Bmp/smad signals.

关键词： Endoglin hair follicle skin stem cells Wnt/β-catenin Tgf-β/Bmp/smad

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