检索结果-南通市图书馆

World Journal of Acupuncture-Moxibustion 1992年第4期2卷 40-45,30页

作者： Kazu mori Meiji College of Oriental Medicine Kyoto Japan

Effects of acupuncture on the brain function of 80 healthy adults and patientswere analyzed using EEG topography and possitron CT (PET). Though changes in EEG topogramcaused by acupuncture stimulation were seen all over the cortex, they were prominent in the area fromthe frontal lobe to the parietal lobe. Positron CT image revealed that acupuncture stimulation tem-porarily activated from the paleocoretx to the neocortex, affecting wide range of the cranial nerve cellsincluding A10 nerve. These results suggest that comfortable stimulations by acupuncture have sucheffects as to remove the friction between the neocortex and the paleocortex, regulate the autonomicnervous system, and activate the Healer (the healing force of nature) at the brain stem level includingthe hypothalamus.

关键词： acupuncture stimulation cortex hypothalamus frontal comfortable regulate activate remove affecting

Serial changes in expression of functionally clustered genes in progression of liver fibrosis in hepatitis C patients

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第13期14卷 2010-2022页

作者： Yoshiyuki Takahara Mitsuo Takahashi Qing-Wei Zhang Hirotaka Wagatsuma Maiko mori Akihiro Tamori Susumu Shiomi Shuhei Nishiguchi Exploratory & Applied Pharmaceutical Research Department Pharmaceutical Company Ajinomoto Co. Inc. 1-1 Suzuki-cho Kawasaki-ku Kawasaki 210-8681 Japan Department of Nuclear Medicine Graduate School of Medicine Osaka City University Osaka Japan Division of Hepatobiliary and Pancreatic Diseases Department of Internal Medicine Hyogo College of Medicine Nishinomiya Japan

AIM: To investigate the relationship of changes in expression of marker genes in functional categories or molecular networks comprising one functional category or multiple categories in progression of hepatic fibrosis in hepatitis C (HCV) patients. METHODS: Marker genes were initially identified using DNA microarray data from a rat liver fibrosis model. The expression level of each fibrosis associated marker gene was analyzed using reverse transcription-polymerase chain reaction (RT-PCR) in clinical biopsy specimens from HCV-positive patients (n = 61). Analysis of changes in expression patterns and interactions of marker genes in functional categories was used to assess the biological mechanism of fibrosis. RESULTS: The profile data showed several biological changes associated with progression of hepatic fibrosis. Clustered genes in functional categories showed sequential changes in expression. Several sets of clustered genes, including those related to the extracellular matrix (ECM), inflammation, lipid metabolism, steroid metabolism, and some transcription factors important for hepatic biology showed expression changes in the immediate early phase (F1/F2) of fibrosis. Genes associated with aromatic amino acid (AA) metabolism, sulfur-containing AA metabolism and insulin/ Wnt signaling showed expression changes in the middle phase (F2/F3), and some genes related to glucose metabolism showed altered expression in the late phase of fibrosis (F3/F4). Therefore, molecular networks showing serial changes in gene expression are present in liver fibrosis progression in hepatitis C patients. CONCLUSION: Analysis of gene expression profiles from a perspective of functional categories or molecular networks provides an understanding of disease and suggests new diagnostic methods. Selected marker genes have potential utility for biological identification of advanced fibrosis.

关键词： Hepatitis C Liver fibrosis Marker gene Gene expression RT-PCR Molecular network Metabolism Transcription factor Diagnosis

Japanese herbal medicine, Saiko-keishi-to, prevents gut ischemia/reperfusion-induced liver injury in rats via nitric oxide

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2004年第15期10卷 2241-2244页

作者： Yoshinori Horie Mikio Kajihara Shuka.mori Yoshiyuki Yamagishi Hiroyuki Kimura Hironao Tamai Shinzo Kato Hiromasa Ishii Department of Internal Medicine School of MedicineKeio UniversityTokyo 160-8582Japan

AIM:To determine whether Saiko-keishi-to(TJ-10),a Japanese herbal medicine,could protect liver injury induced by gut ischemia/reperfusion(I/R),and to investigate the role of NO. METHODS:Male Wistar rats were exposed to 30-min gut isohemia followed by 60 min of *** microscopy was used to monitor leukocyte *** tumor necrosis factor(TNF)levels and alanine aminotransferase (ALT)activities were ***-10 1 g/(kg.d)was intragastrically administered to rats for 7 d.A NO synthase inhibitor was administered. RESULTS:In control rats,gut I/R elicited increases in the number of stationary leukocytes,and plasma TNF levels and ALT activities were mitigated by pretreatment with *** with the NO synthase inhibitor diminished the protective effects of TJ-10 on leukostasis in the liver,and the increase of plasma TNF levels and ALT *** with TJ-10 increased plasma nitrite/nitrate levels. CONCLUSION:TJ-10 attenuates the gut I/R-induced hepatic microvascular dysfunction and sequential hepatocellular injury via enhancement of NO production.

关键词： Liver Circulation Animals Drugs, Chinese Herbal Liver Diseases control Male Nitric Oxide Rats Rats, Wistar Reperfusion Injury Research Support, Non-U.S. Gov't

Rectal perforations and fistulae secondary to a glycerin enema:Closure by over-the-scope-clip

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第24期18卷 3177-3180页

作者： Hirohito mori Hideki Kobara Shintaro Fujihara Noriko Nishiyama Mitsuyoshi Kobayashi Tsutomu Masaki Kunihiko Izuishi Yasuyuki Suzuki Department of Gastroenterology and Neurology Kagawa Medical University School of MedicineKagawa 761-0793Japan Department of Gastroenterological Surgery Kagawa Medical University School of MedicineKagawa 761-0793Japan

Rectal perforations due to glycerin enemas(GE) typically occur when the patient is in a seated or lordotic standing *** the perforation occurs and peritonitis results,death is usually *** describe two cases of rectal perforation and fistula caused by a *** 88-year-old woman presented with a large rectal perforation and a fistula just after receiving a *** case was further complicated by an abscess in the right rectal *** second patient was a 78-year-old woman who suffered from a rectovesical fistula after a *** both cases,we performed direct endoscopic abscess lavage with a saline solution and closed the fistula using an over-the-scope-clip(OTSC) *** procedures resulted in dramatic improvement in both *** endoscopic lavage and OTSC closure are very useful for pararectal abscess lavage and fistula closure,respectively,in elderly patients who are in poor general *** two cases are the first reports of the successful endoscopic closure of fistulae using double OTSCs after endoscopic lavage of the debris and an abscess of the rectum secondary to a GE.

关键词： Rectal perforation Glycerin enema Abscesslavage Fistula closure Over-the-scope-clip

Case of pediatric traditional serrated adenoma resected via endoscopic submucosal dissection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第24期23卷 4462-4466页

作者： Sonoko Kondo Hirohito mori Noriko Nishiyama Takeo Kondo Ryuichi Shimono Hitoshi Okada Takashi Kusaka Department of Pediatrics Faculty of MedicineKagawa University Department of Gastroenterology and Neurology Faculty of MedicineKagawa University Department of Pediatric Surgery Faculty of MedicineKagawa University

Traditional serrated adenoma(TSA)is a type of serrated polyp of the colorectum and is thought to be a precancerous *** are three types of serrated polyps,namely,hyperplastic polyps,sessile serrated adenomas/polyps,and *** is the least common of the three types and accounts for about 5% of serrated *** we report a pediatric case of TSA that was successfully resected by endoscopic submucosal dissection(ESD).This rare case report describes a pediatric patient with no family history of colonic polyp who was admitted to our hospital with *** colonoscopy,we found a polypoid lesion measuring 10 mm in diameter in the lower *** selected ESD as a surgical option for en bloc resection,and histopathological examination revealed *** findings in this case suggest that TSA with precancerous potential can occur in children,and that ESD is useful for treating this lesion.

关键词： Pediatric colonic polyp Hematochezia Colorectal serrated lesions Traditional serrated adenoma Endoscopic mucosal resection Endoscopic submucosal dissection

A novel large deletion(exons 12,13)and a missense mutation(p.G46R)in the PAH in a Japanese patient with phenylketonuria

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2015年第2期11卷 181-184页

作者： Yoshihiro Maruo Masafumi Suzaki Katsuyuki Matsui Yu Mimura Asami mori Haruo Shintaku Yoshihiro Takeuchi Department of Pediatrics Shiga University of Medical ScienceTsukinowaSetaOtsuShiga 520-2192Japan Central Research Laboratory Shiga University of Medical ScienceTsukinowaSetaOtsuShiga 520-2192Japan Department of Pediatrics Osaka City University Graduate School of MedicineOsakaJapan

Background:Phenylketonuria(PKU)is caused by a defect in phenylalanine hydroxylase(PAH).More than 500 mutations have been reported for the gene encoding ***,approximately l%-5%of these include large deletions and large duplications that cannot be detected by conventional ***:In this report we tried to fully characterize a PAH-deficient *** patient was a 2-year-old Japanese boy who was diagnosed with classical PKU at the time of neonatal screening,which was confirmed by the tetrahydrobiopterin-loading ***-related direct sequencing and multiplex ligation-dependent probe amplification(MLPA)were used to analyze of the PAH of the ***:Using PCR-related direct sequencing method,we could detect only a heterozygous novel missense mutation:p.136G>C(p.G46R).A second mutation was detected by *** patient was heterozygous for a novel large deletion of exons 12 and 13:c.1200-?_1359+?del(EX12_13del).For genetic counseling,an accurate genetic diagnosis is often ***:Through a combination of MLPA and conventional methods,the success rate of PAH mutation identification can be close to 100%.

关键词： large deletion multiplex ligation-dependent probe amplification phenylalanine hydroxylase phenylketonuria

Intussusception due to rectal adenocarcinoma in a young adult:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第35期20卷 12678-12681页

作者： Ryo Inada Takeshi Nagasaka Toshiaki Toshima Yoshiko mori Yoshitaka Kondo Hiroyuki Kishimoto Toshiyoshi Fujiwara Department of Gastroenterological Surgery Okayama University Graduate School of MedicineDentistry and Pharmaceutical Sciences

An intussusception due to colonic adenocarcinoma has sometimes been reported. However, to the best of our knowledge, reports of intussusception due to rectal adenocarcinoma are extremely rare. In this report, the case of a young man with rectal adenocarcinoma causing intussusception is described. A 24-year-old man visited a hospital complaining of abdominal pain, and an upper rectal cancer was diagnosed by colonoscopy. Computed tomography showed intussusception caused by a large tumor in the pelvis and absence of distant metastases. Locally advanced rectal cancer causing intussusception was diagnosed, and a low anterior resection was performed. Intraoperatively, repair of the invagination could not be accomplished easily; therefore, the repair was abandoned. Instead, the tumor was removed en bloc to avoid dissemination of the cancer. Histopathologically, the tumor was diagnosed as a poorly differentiated adenocarcinoma, pStage IIA. The patient has no evidence of recurrence at 10 mo after the operation.

关键词： Adult intussusception En bloc resection Low anterior resection Rectal adenocarcinoma Young cancer

Impact of obesity on the surgical outcome following repeat hepatic resection in Japanese patients with recurrent hepatocellular carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第10期14卷 1553-1558页

作者： Tohru Utsunomiya Masahiro Okamoto Toshihumi Kameyama Ayumi Matsuyama Manabu Yamamoto Megumu Fujiwara Masaki mori Shiomi Aimitsu Teruyoshi Ishida Department of Surgery Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital Hiroshima Japan Department of Pathology Hiroshima RedCross Hospital and Atomic Bomb Survivors Hospital Hiroshima730-8619 Japan Department of Radiology Hiroshima Red CrossHospital and Atomic Bomb Survivors Hospital Hiroshima730-8619 Japan Department of Internal Medicine of the Liver Hiroshima Red Cross Hospital and Atomic Bomb SurvivorsHospital Hiroshima 730-8619 Japan

AIM: To evaluate the impact of obesity on the posto- perative outcome after hepatic resection in patients with hepatocellular carcinoma (HCC). METHODS: Data from 328 consecutive patients with primary HCC and 60 patients with recurrent HCC were studied. We compared the surgical outcomes between the non-obese group (body mass index: BMI < 25 kg/m2) and the obese group (BMI ≥ 25 kg/m2). RESULTS: Following curative hepatectomy in patients with primary HCC, the incidence of postoperative complications and the long-term prognosis in the non- obese group (n = 240) were comparable to those in the obese group (n = 88). Among patients with recurrent HCC, the incidence of postoperative complications after repeat hepatectomy was not significantly different between the non-obese group (n = 44) and the obese group (n = 16). However, patients in the obese group showed a significantly poorer long-term prognosis than those in the non-obese group (P < 0.05, five-yearsurvival rate; 51.9% and 92.0%, respectively). CONCLUSION: Obesity alone may not have an adverse effect on the surgical outcomes of patients with primary HCC. However, greater caution seems to be required when planning a repeat hepatectomy for obese patients with recurrent HCC.

关键词： Body mass index Hepatocellular carcinoma Hepatectomy Prognosis

Does laparoscopic liver resection for colorectal liver metastases provide a true survival benefit compared with open liver resection?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2020年第5期9卷 657-660页

作者： Shinichi Akahoshi Toru Beppu Yasuhisa.mori Koichi Kinoshita Nobutaka Sato Ken Kikuchi Department of Surgery Yamaga City Medical CenterKumamotoJapan Department of Surgery and Oncology Graduate School of Medical SciencesKyushu UniversityFukuokaJapan Adviser Sakurajuji HospitalKumamotoJapan

The recent Southampton consensus guideline and two previous international consensus meetings held in Louisville and morioka in 2008 and 2014,respectively have recommended laparoscopic liver resection(LLR)as a standard procedure for selected patients with colorectal liver metastases(CRLM)(1-3).The Oslo-CoMet and LapOpHuva studies are the only two randomized controlled trials(RCTs)that have provided solid evidence showing that LLR is a safer,less invasive,and more cost-effective approach with higher health-related quality of life and oncological outcomes equivalent to those of open liver resection(OLR)for patients with CRLM(4-6).

关键词： resection colorectal metastases

Real-time in situ three-dimensional integral videography and surgical navigation using augmented reality: a pilot study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Oral Science 2013年第2期5卷 98-102页

作者： Hideyuki Suenaga Huy Hoang Tran Hongen Liao Ken Masamune Takeyoshi Dohi Kazuto Hoshi Yoshiyuki mori Tsuyoshi Takato Department of Oral-Maxillofacial Surgery Dentistry and OrthodonticsThe University of Tokyo Hospital Department of Mechano-Informatics Graduate School of Information Science and TechnologyThe University of Tokyo Department of Bioengineering Graduate School of EngineeringThe University of Tokyo

To evaluate the feasibility and accuracy of a three-dimensional augmented reality system incorporating integral videography for imaging oral and maxillofacial regions, based on preoperative computed tomography data. Three-dimensional surface models of the jawbones, based on the computed tomography data, were used to create the integral videography images of a subject＇s maxillofacial area. The three-dimensional augmented reality system （integral videography display, computed tomography, a position tracker and a computer） was used to generate a three-dimensional overlay that was projected on the surgical site via a half-silvered mirror. Thereafter, a feasibility study was performed on a volunteer. The accuracy of this system was verified on a solid model while simulating bone resection. Positional registration was attained by identifying and tracking the patient/surgical instrument＇s position. Thus, integral videography images of jawbones, teeth and the surgical tool were superimposed in the correct position. Stereoscopic images viewed from various angles were accurately displayed. Change in the viewing angle did not negatively affect the surgeon＇s ability to simultaneously observe the three-dimensional images and the patient, without special glasses. The difference in three-dimensional position of each measuring point on the solid model and augmented reality navigation was almost negligible （〈1 mm）; this indicates that the system was highly accurate. This augmented reality system was highly accurate and effective for surgical navigation and for overlaying a three-dimensional computed tomography image on a patient＇s surgical area, enabling the surgeon to understand the positional relationship between the preoperative image and the actual surgical site, with the naked eye.

关键词： augmented reality computed tomography integral videography three-dimensional image