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World Journal of Gastroenterology 2018年第2期24卷 211-215页

作者： Hirohito mori Hideki Kobara Noriko Nishiyama Tsutomu Masaki Departments of Gastroenterology and Neurology Kagawa University

AIM To evaluate appropriate and rapid polyglycolic acid sheet(PGAs) covering time using device delivery station system(DDSS).METHODS This pilot basic study was conducted to evaluate the potential of accurate and rapid PGAs delivery using DDSS. Three 11-month-old female Beagle dogs were used in this study. Two endoscopic submucosal dissections(ESDs) 4 cm in diameter were performed in lesser curvature of middle gastric body and greater curvature of antrum(total 6 ESDs performed). DDSS(3 cm length, 12 mm in outer diameter) has 2 chambers which 16 cm^2 large 2 PGAs were stored, and DDSS was attached post ESD ulcers, respectively. Beriplast P?(CSL Behring K.K., Tokyo, Japan)(combination of fibringlue and thrombin) was applied equally to the artificial ulcer, and tight attachment of 2 PGAs with DDSS were completed. The evaluation items were covering times, post ESD bleeding and perforation during *** The covering time of PGAs(defined as the duration from the beginning of endoscope insertion into the mouth to the end of the fibrin glue coating process) was 6.07(4.86-8.29) min. There was no postESD bleeding(1-7 d after ESD), and there was no perforation during *** DDSS was very useful for rapid delivering and tight attachment of PGAs, and has potentials of multipurpose delivery station system.

关键词： Post-endoscopic submucosal dissection ulcers Bleeding Polyglycolic acid sheet Rapidly delivery Tightly attachment

Dynamics of canopy-dwelling arthropods under different weed management options,including glyphosate,in conventional and genetically modified insect-resistant maize

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Insect Science 2021年第4期28卷 1121-1138页

作者： Esteban García-Ruiz Guillermo Cobos Ismael Sánchez-Ramos Susana Pascual María-Cristina Chueca María-Concepción Escorial Inés Santín-Montanyá Íñigo Loureiro Manuel González-Núñez Plant Protection Department Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria(INIA)MadridSpain

The use of genetically modified varieties tolerant to herbicides(HT varieties)and resistant to insects(Bt varieties)in combination with application of a broad-spectrum herbicide such as glyphosate could be an effective option for the simultaneous control of weeds and pests in ***,the possible impact of these tools on nontarget arthropods still needs to be *** a field study in central Spain,potential changes in populations of canopy-dwelling arthropods in Bt maize under different weed management options,including glyphosate application,were ***-dwelling arthropods were sampled by visual inspection and yellow sticky *** Bt variety had no effect on any group of studied arthropods,except for the expected case of corn borers—the target pests of Bt *** the effects of herbicide regimes,the only observed difference was a lower abundance of Cicadellidae and Mymaridae on yellow sticky traps in plots not treated with pre-emergence *** effect was especially pronounced in a treatment involving two glyphosate *** decrease in Cicadellidae and Mymaridae populations was associated with a higher density of weeds in plots,which may have hindered colonization of the crop by *** differences,however,were only significant in the last year of the *** low likelihood of the use of glyphosate-and herbicide-tolerant varieties for weed control triggering important effects on the nontarget arthropod fauna of the maize canopy is discussed.

关键词： Bt maize canopy-dwelling arthropods GMHT maize glyphosate herbicide management parasitoids

Factors predicting upstaging from clinical N0 to pN2a/N3a in breast cancer patients

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World Journal of Clinical Oncology 2022年第9期13卷 748-757页

作者： Goshi Oda Tsuyoshi Nakagawa Hiroki mori Iichiro Onishi Tomoyuki Fujioka Mio mori Kazunori Kubota Ryoichi Hanazawa Akihiro Hirakawa Toshiaki Ishikawa Kentaro Okamoto Hiroyuki Uetakesszsz Department of Breast Surgery Tokyo Medical and Dental UniversityTokyo 1138519Japan Department of Plastic and Reconstructive Surgery Tokyo Medical and Dental UniversityTokyo 1138519Japan Department of Pathology Tokyo Medical and Dental UniversityTokyo 1138519Japan Department of Radiology Tokyo Medical and Dental UniversityTokyo 1138519Japan Department of Clinical Biostatistics Tokyo Medical and Dental UniversityTokyo 1138519Japan Department of Specialized Surgeries Tokyo Medical and Dental UniversityTokyo 1138519Japan

BACKGROUND With sentinel node metastasis in breast cancer(BC)patients,axillary lymph node(ALN)dissection is often omitted from cases with breast-conserving *** of lymph node dissection reduces the invasiveness of surgery to the patient,but it also obscures the number of metastases to non-sentinel *** possibility of finding≥4 lymph nodes(pN2a/pN3a)preoperatively is important given the ramifications for postoperative *** To search for clinicopathological factors that predicts upstaging from N0 to pN2a/*** Patients who were sentinel lymph node(SLN)-positive and underwent ALN dissection between September 2007 and August 2018 were selected by retrospective chart *** patients had BC diagnosed preoperatively as N0 with axillary evaluation by fluorodeoxyglucose(FDG) positron emission tomography/computed tomography and ultrasound (US)examination. When suspicious FDG accumulation was found in ALN, the presence of metastasiswas reevaluated by second US. We examined predictors of upstaging from N0 to pN2a/*** 135 patients, we identified 1-3 ALNs (pN1) in 113 patients and ³4 ALNs (pN2a/pN3a) in22 patients. Multivariate analysis identified the total number of SLN metastasis, the maximaldiameter of metastasis in the SLN (SLNDmax), and FDG accumulation of ALN as predictors ofupstaging to pN2a/*** identified factors involved in upstaging from N0 to pN2a/pN3a. The SLNDmax and numberof SLN metastasis are predictors of ≥ 4 ALNs (pN2a/pN3a) and predictors of metastasis to nonsentinelnodes, which have been reported in the past. Attention should be given to axillaryaccumulations of FDG, even when faint.

关键词： Breast cancer Axillary lymph node metastasis Positron emission tomography/computed tomography Sentinel lymph node Predictive factors of lymphnode metastasis Standardized uptake value max Diameter of sentinel lyphonode metastasis

Wetting of Au and Ag particles on monocrystalline graphite substrates

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Rare Metals 2006年第5期25卷 469-472页

作者： Joonho Lee Toshihiro Tanaka Kazufumi Seo Nobumitsu Hirai Jung-Goo Lee Hirotaro mori Department of Materials Science & Engineering Korea University5-1 Anam-dongSeongbuk-kuSeoul 136-713Republic of Korea Div.of Materials and Manufacturing Science Osaka University2-1 YamadaokaSuitaOsaka 565-0871Japan Research Center for Ultra High Voltage Electron Microscopy Osaka University7-1 MihogaokaIbarakiOsaka 567-0047Japan

The wetting behavior of Au and Ag particles on a monocrystalline graphite substrate was investigated using the microscopic sessile drop method under a purified Ar atmosphere at 1300 K. The measured contact angles of the liquid Au and Ag on monocrystalline graphite substrates of （0001） face were 129° and 124°, respectively. It is believed that the interaction at the interface is dominated by the physical bonding （van der Waal＇s interaction）.

关键词： graphite microscopic sessile drop method surface structure wetting

Adenomyoepithelioma of the breast with malignant transformation and repeated local recurrence:A case report

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World Journal of Clinical Cases 2021年第29期9卷 8864-8870页

作者： Goshi Oda Tsuyoshi Nakagawa Mio mori Tomoyuki Fujioka Iichiro Onishi Department of Breast Surgery Tokyo Medical and Dental UniversityTokyo 113-8519Japan Department of Radiology Tokyo Medical and Dental UniversityTokyo 113-8519Japan Department of Pathology Tokyo Medical and Dental UniversityTokyo 113-8519Japan

BACKGROUND Adenomyoepithelioma(AME)of the breast is a rare type of benign breast *** AMEs show benign behavior,but reports of the malignant type are *** present the case of a patient with AME with repeated local recurrences and further malignant *** SUMMARY A 53-year-old woman visited our hospital with a 16-mm palpable mass in the right breast.A core needle biopsy was *** pathological diagnosis was *** with a safety margin was performed without axillary lymph node dissection(ALND).Two years later,local recurrence developed,and the patient again underwent lumpectomy with a safety *** pathology showed malignant AME,and the margin was *** months later,local recurrence developed again in the same location,and a total mastectomy was performed without *** pathological diagnosis was malignant *** patient was disease-free for three years *** The treatment of AME requires caution,as it may exhibit repeated recurrences after local excision as well as malignant transformation.

关键词： Breast tumor Adenomyoepithelioma Malignant adenomyoepithelioma Local recurrence Malignant transformation Case report

Determination of symptoms associated with hiesho among young females using hie rating surveys

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Journal of Integrative Medicine 2018年第1期16卷 34-38页

作者： Hidetoshi mori Hiroshi Kuge Shunji Sakaguchi Tim Hideaki Tanaka Junji Miyazaki Faculty of Health Sciences Course of Acupuncture and Moxibustion Tsukuba University of Technology Tsukuba 305-8521 Japan Department of Anesthesiology Osaka Medical College Hospital Osaka 569-8686 Japan Research Division of Acupuncture and Moxibustion Kansai University of Health Sciences Osaka 590-0482 Japan Takarazuka University of Medical and Health Care Takarazuka 666-0162 Japan

Objective： Hie （cold sensation） is one of the most well-known health complaints in Japan and elsewhere in East Asia. Those who suffer from severe hie are considered to have hiesho （cold disorder）. This study was conducted to determine symptoms associated with hie in young females using a survey consisting of the hie scale and hie diary. Methods： Two hundred and seventy-one participants were included for the analysis. Survey forms were distributed to the participants. Diagnosis of hiesho was determined by using the hie scale. A discriminant score of over -0.38 was considered hiesho. The Short Form-8 Health Survey Standard Version （SF-8） was used to measure health-related quality of life （QOL）. The participants were also asked to respond to the questionnaire evaluating 14 physical and emotional symptoms, utilizing a six-level Likert scale item. Results： The 1st factor （hie factor） was correlated with hie （r= 0.546）, dry mouth （r= 0.332）, lower- extremity edema （r = 0.450）, headrushes （r=0.470）, shoulder stiffness （r = 0.311 ）, headrushes with chills （r = 0.726）, and fatigue （r= 0.359）. Cronbach＇s α of the 1st factor was 0.748, which indicated reliability between the items. When hie factor was the dependent variable, standardized partial regression coefficient was β=-0.387 for physical component score （P 〈 0.001） and β=-0.243 for mental component score （P 〈 0.001 ）. Conclusion： This study indicated that hiesho symptoms among young female adults were associated with bodily pain and general health perceptions of the SF-8 QOL survey.

关键词： Cold l:ypersensitivity Questionnaires Health surveys Quality of life Regression analysis Reproducibility of results

A Case of Low-Grade Appendiceal Mucinous Neoplasm of Its Difficultly to Distinguish from a Right Ovarian Tumor Due to Postmenopause

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Open Journal of Obstetrics and Gynecology 2022年第11期12卷 1140-1146页

作者： Tsutomu Muramoto Kyosuke Kamijo Megumi Sano Yuki Ibuki Atushi mori Yaeko Kobayashi Nagano Municipal Hospital Department of Obstetrics and Gynecology Nagano Japan

We here present a rare case of appendiceal tumor mimicking ovarian tumor in menopause woman. The patient was a 56-year-old woman, G1P1, who presented to our hospital with a right adnexal cyst diagnosed at another hospital. Transvaginal echocardiography showed a cyst in the right adnexal region, and pelvic contrast-enhanced MRI revealed a small cyst in the same region. The left ovary was atrophic and identifiable. It was unclear whether the cyst was contiguous with the gastrointestinal tract. Blood tests showed no elevation of tumor markers. We considered its possibility of a gastrointestinal origin, but since right normal ovary was not found, we thought the tumor was of ovarian origin and decided on a laparoscopic resection of the right adnexa. Intraoperatively, we observed atrophied bilateral normal ovaries, and the pelvic tumor was contiguous to the appendix. Surgeons performed a laparoscopic appendectomy after consultation with us. After resection we searched the abdominal and pelvic cavities, but found no obvious disseminated lesions. The histological diagnosis was low-grade appendiceal mucinous neoplasm (LAMN), a rare benign tumor of the appendix. Appendiceal tumors can be difficult to differentiate from right ovarian tumors due to their close anatomic location in the pelvis. It is possible to determine whether the tumor is of ovarian or appendiceal origin by identifying normal ovaries and the location of the feeding vessels into the tumors. In our case, there were no lesions other than the appendix, but LAMN can metastasize to the ovary, cause pseudomyoxoma peritonei, or be an overlapping tumor with an ovarian tumor. If an appendiceal tumor is diagnosed after surgery for ovarian tumor, the intra-abdominal cavity should be searched for metastasis or dissemination, and a thorough search for ovarian lesions should be performed with the possibility of an overlapping tumor in mind.

关键词： Low-Grade Appendiceal Mucinous Neoplasm Ovarian Tumor Menopause Woman

Effect of polyvinyl butyrate nanoparticles incorporated with immune suppressing vitamins on alteration of population of intestinal immune cells

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Progress in Natural Science:Materials International 2020年第5期30卷 707-710页

作者： Yunmei Mu Yusuke Kinashi Akihiro Kishimura Takeshi mori Koji Hase Yoshiki Katayama Graduate School of Systems Life Sciences Kyushu University Division of Biochemistry Faculty of Pharmacy Keio University Department of Applied Chemistry Faculty of Engineering Kyushu University Center for Future Chemistry Kyushu University International Research Center for Molecular System Kyushu University Division of Mucosal Barrierology International Research and Development Center for Mucosal Vaccines The Institute of Medical Science the University of Tokyo Department of Biomedical Engineering Chung Yuan Christian University

The nanoparticles(NPs) from polyvinyl butyrate(PVBu) which can work as an orally applicable donor of butyrate for intestine were prepared. Immunotolerance inducing molecules such as vitamin D3and all-trans retinoic acid(ATRA) were incorporated into PVBu NPs. The alteration in populations and numbers of DC103+dendritic cells(DC) and regulatory T(Treg) cells in intestinal immune tissues were examined after oral administration of NPs. It was found that NPs reduced the population of CD103+DC and Treg cells in Peyer’s patched in lower part of the intestine and inversely increased the population of CD103+DC in mesenteric lymph node(MLN), while the population of Treg cells in MLN was unchanged. These observations indicate that NPs may enhance the immunotolerance at MLN and lamina propria toward luminal antigens, indicating the promising features of PVBu NPs as therapeutics of allergy and autoimmune diseases.

关键词： Butyrate Polyvinyl butyrate Retinoic acid Vitamin D 3 Tolerogenic dendritic cells Regulatory T cells

Metagenomic analysis reveals changes of the Drosophila suzukii microbiota in the newly colonized regions

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Insect Science 2018年第5期25卷 833-846页

作者： Isabel Martinez-Sanudo Mauro Simonato Andrea Squartini Nicola.mori Laura Marri Luca Mazzon Department of Agronomy Food Natural resources Animals and Environment (DAFNAE) University of Padova Legnaro (PD) Italy Dipartimento di Scienze della Vita Universit& di Siena Siena Italy

The spotted wing drosophila, Drosophila suzula＇i （Matsumura）（Diptera： Drosophilidae） is a highly polyphagous pest of a wide variety of wild or cultivated berry and stone fruit. Originating from Southeast Asia, it has recently invaded a wide range of regions in Europe and North America. It is well known that insect microbiotas may significantly influence several aspects of the host biology and play an important role in invasive species introduction into new areas. However, in spite of the great economic im- portance of D. suzukii, a limited attention has been given so far to its microbiota. In this study, we present the first in-depth characterization of gut bacterial diversity from field （native and invasive range） and lab-reared populations of this insect. The gut bacterial communities of field insects were dominated, regardless of their origin, by 2 families of the phylum Proteobacteria： Acetobacteraceae and Enterobacteriaceae, while Firmicutes, mainly represented by the family Staphylococcaceae, prevailed in lab-reared population. Locality was the most significant factor in shaping the microbiota of wild flies. More- over, a negative correlation between diversity and abundance of Enterobacteriaceae and the time elapsed since the establishment of D. suzukii in a new region was observed. Altogether our results indicate that habitat, food resources as well as the colonization phase of a new region contribute to shape the bacterial communities of the invasive species which, in turn, by evolving more quickly, could influence host adaptation in a new environment.

关键词： 16S rRNA Enterobacteriaceae illumina invasive insects microbiota spot-ted wing drosophila

Anterior proliferative vitreoretinopathy in a patient with Coats disease

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International Journal of Ophthalmology(English edition) 2018年第2期11卷 343-345页

作者： Satoru Kase Shohei mori Kousuke Noda Susumu Ishida Department of Ophthalmology Faculty of Medicine and Graduate School of Medicine Hokkaido University

Dear Editor,I am Satoru Kase,from the Department of Ophthalmology,Faculty of Medicine and Graduate School of Medicine,Hokkaido University,Sapporo,Japan.I write to present a case of Coats disease showing anterior proli... 详细信息

关键词： PVR NVG Anterior proliferative vitreoretinopathy in a patient with Coats disease