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Umbilical cord-derived mesenchymal stem cells preconditioned with isorhamnetin:potential therapy for burn wounds

World Journal of Stem Cells 2020年第12期12卷 1652-1666页

作者： Shazmeen Aslam Irfan Khan Fatima Jameel midhat batool zaidi Asmat Salim Stem Cell Laboratory Dr.Panjwani Center for Molecular Medicine and Drug ResearchInternational Center for Chemical and Biological SciencesUniversity of KarachiKarachi 74700SindhPakistan

BACKGROUND Impaired wound healing can be associated with different pathological *** wounds are the most common and detrimental injuries and remain a major health issue *** stem cells(MSCs)possess the ability to regenerate tissues by secreting factors involved in promoting cell migration,proliferation and differentiation,while suppressing immune *** of MSCs with small molecules having cytoprotective properties can enhance the potential of these cells for their use in cell-based *** To enhance the therapeutic potential of MSCs by preconditioning them with isorhamnetin for second degree burn wounds in *** Human umbilical cord MSCs(hU-MSCs)were isolated and characterized by surface markers,CD105,vimentin and *** preconditioning,hU-MSCs were treated with isorhamnetin after selection of the optimized concentration(5μmol/L)by cytotoxicity *** migration potential of these MSCs was analyzed by the in vitro scratch *** healing potential of normal,and preconditioned hU-MSCs was compared by transplanting these MSCs in a rat model of a second degree burn ***,and preconditioned MSCs(IH+MSCs)were transplanted after 72 h of burn injury and observed for 2 *** and gene expression analyses were performed on day 7 and 14 after cell transplantation to determine complete wound *** The scratch assay analysis showed a significant reduction in the scratch area in the case of IH+MSCs compared to the normal untreated MSCs at 24 h,while complete closure of the scratch area was observed at 48 *** analysis showed reduced inflammation,completely remodeled epidermis and dermis without scar formation and regeneration of hair follicles in the group that received IH+*** expression analysis was time dependent and more pronounced in the case of IH+***(IL)-1β,IL-6 and Bcl-2 associated X genes showed significant downregulation,while transforming growth f

关键词： Burn wound Isorhamnetin Mesenchymal stem cells Preconditioning Wound healing Small molecule

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