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Electrocatalytic evolution of oxygen on NiCu particles modifying conductive alumina/nano-carbon network composite electrode

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Science China(Technological Sciences) 2012年第12期55卷 3388-3394页

作者： FUJI Masayoshi SHIRAI Takashi WATANABE Hideo takahashi Minoru Ceramics Research Laboratory Nagoya Institute of Technology

In this paper, a novel electrically conductive alumina/nano-carbon network (NCN) composite material was used as an electro- catalyst carrier. A NiCu/Al2O3 /NCN composite electrode was prepared by electrodepositing NiCu particles onto the surface of the conductive alumina/NCN composite. Morphology, composition, crystalline structure and electrochemical properties of the NiCu/Al2O3 /NCN composite electrode were investigated. The results showed that NiCu particles can be deposited onto the surface of the alumina/NCN composite by a coelectrodeposition method. NiCu particles in the form of solid solution with face-centered cubic (fcc) structure were relatively uniformly distributed over the carbon layer of the conductive ceramic between alumina grains. As-resulted NiCu/Al2O3 /NCN composite electrode had a remarkably enhanced electrochemical activity and high stabilization for oxygen evolution reaction, which indicated its potential application with enhanced performance to oxygen evolution reaction (OER). Moreover, based on the electrochemical measurement, the mechanism of the OER on the NiCu/Al2O3 /NCN composite electrode was discussed.

关键词：导电复合材料氧化铝颗粒复合电极析氧反应纳米碳碳网络铜镍硫化物电化学性能

Current advances in humanized mouse models

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Cellular & Molecular Immunology 2012年第3期9卷 208-214页

作者： Ryoji Ito Takeshi takahashi Ikumi Katano Mamoru Ito Central Institute for Experimental Animals Kawasaki Japan

Humanized mouse models that have received human cells or tissue transplants are extremely useful in basic and applied human disease research. Highly immunodeficient mice, which do not reject xenografts and support cell and tissue differentiation and growth, are indispensable for generating additional appropriate models. Since the early 2000s, a series of immunodeficient mice appropriate for generating humanized mice has been successively developed by introducing the IL-2Rynull gene （e.g., NOD/SCID/7c＂uu and Rag2nu＂ycnun mice）. These strains show not only a high rate of human cell engraftment, but also generate well-differentiated multilineage human hematopoietic cells after human hematopoietic stem cell （HSC） transplantation. These humanized mice facilitate the analysis of human hematology and immunology in vivo. However, human hematopoietic cells developed from HSCs are not always phenotypically and functionally identical to those in humans. More recently, a new series of immunodeficient mice compensates for these disadvantages. These mice were generated by genetically introducing human cytokine genes into NODISCIDI？cn＂u and Rag2nulITcnUll mice. In this review, we describe the current knowledge of human hematopoietic cells developed in these mice. Various human disease mouse models using these humanized mice are summarized.

关键词： animal model immunodeficient mice immunology hematology humanized mice

A Breast Density Classification System for Mammography Considering Reliability Issues in Deep Learning

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Open Journal of Medical Imaging 2023年第3期13卷 63-83页

作者： Eri Matsuyama Megumi Takehara Noriyuki takahashi Haruyuki Watanabe Faculty of Informatics University of Fukuchiyama Kyoto Japan Breast Center Dokkyo Medical University Hospital Tochigi Japan School of Hearth Sciences Fukushima Medical University Fukushima Japan School of Radiological Technology Gunma Prefectural College of Health Sciences Gunma Japan

In a convolutional neural network (CNN) classification model for diagnosing medical images, transparency and interpretability of the model’s behavior are crucial in addition to high classification accuracy, and it is highly important to explicitly demonstrate them. In this study, we constructed an interpretable CNN-based model for breast density classification using spectral information from mammograms. We evaluated whether the model’s prediction scores provided reliable probability values using a reliability diagram and visualized the basis for the final prediction. In constructing the classification model, we modified ResNet50 and introduced algorithms for extracting and inputting image spectra, visualizing network behavior, and quantifying prediction ambiguity. From the experimental results, our proposed model demonstrated not only high classification accuracy but also higher reliability and interpretability compared to the conventional CNN models that use pixel information from images. Furthermore, our proposed model can detect misclassified data and indicate explicit basis for prediction. The results demonstrated the effectiveness and usefulness of our proposed model from the perspective of credibility and transparency.

关键词： Explainable AI t-SNE Entropy Wavelet Transform Mammogram

Clinical Trial Protocol: Randomized Controlled Trial of Cancer Pain Monitoring System (CAPAMOS) in Patients with Advanced Cancer

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Open Journal of Nursing 2022年第2期12卷 113-124页

作者： Shiori Yoshida Fumiko Sato Keita Tagami Shin takahashi Department of Oncology Nursing Tohoku University Graduate School of Medicine Sendai Japan Department of Palliative Medicine Tohoku University Graduate School of Medicine Sendai Japan Department of Medical Oncology Tohoku University Hospital Sendai Japan

Purpose: This randomized controlled trial (RCT) protocol was designed to evaluate the effectiveness of the Cancer Pain Monitoring System (CAPAMOS), a telenursing system designed to alleviate pain in ambulatory patients with advanced cancer. Methods: The study design involved a randomized controlled trial consisting of an intervention group using CAPAMOS and a control group that received usual care. At the time of enrollment, both groups will be given a questionnaire regarding issues, such as concerns related to cancer pain and self-management of opioid medication. Patients will then receive pain relief education based on the results of the questionnaire. Subjects in the control group will receive a pain diary and pain-relief pamphlet that acts as an educational tool. They could also call the outpatient clinic if they wanted to ask for a nursing consultation. The intervention group will be able to use CAPAMOS to manage their pain and receive video consultation with a telenurse, who is an oncology nursing specialist. Educational tools will be built into CAPAMOS. The study will be conducted for one month. The primary endpoint of this study was to calculate the Japanese Brief Pain Inventory score. The secondary endpoints were to assess the opioid medication self-management, Barriers Questionnaire, Japanese EuroQol 5-dimensions 5-level, and economic evaluation. Assessment items will be evaluated at registration and 2 and 4 weeks after registration. Conclusions: A RCT based on this protocol is expected to validate the efficacy of telenursing using CAPAMOS in patients with advanced cancer and pain.

关键词： Telenursing Cancer Pain Advanced Cancer Patients Symptom Management Patient Care Randomized Controlled Trial

Fabrication of MoSi_2-SiC Composites by a Spark Plasma Sintering Method

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International Journal of Minerals,Metallurgy and Materials 1999年第2期13卷 116-118页

作者： Kurokawa K. Ube M. takahashi H. Division of Molecular Chemistry Graduate School of Engineering Hokkaido University Kita-13 Nishi-8 Kita-ku Sapporo 060-8628 Japan Center for Advanced Research of Energy Technology Hokkaido University Japan

MolybdenUmdisilicidepeoSi,)hashighmeltingpoint（2293K）,relativelylowdensity（6.249/cm3）,abrittle-to-ductiletemper;tabout1173K[l]andoutstandingoxidationresistance[2M].Forthisreason,thedisilicidematrixcompositesarebei... 详细信息

关键词： MoSi2-SiC composite spark plasma sintering in-siam Synthesis sintering behavior

Characterization of chlorine and heavy metals for the potential recycling of bottom ash from municipal solid waste incinerators as cement additives

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Frontiers of Environmental Science & Engineering 2016年第4期10卷 43-51页

作者： Boran WU Dongyang WANG Xiaoli CHAI Fumitake takahashi Takayuki SHIMAOKA State Key Laboratory of Pollution Control and Resources Reuse Tongji University Shanghai 200092 China Department of Environmental Science and Technology Interdisciplinary Graduate School of Science and Engineering Tokyo Institute of Technology Yokohama 226-8502 Japan Department of Urban and Environmental Engineering Graduate School of Engineering Kyushu University Fukuoka 819-0395 Japan

Bottom ash is an inevitable by-product fi＇om municipal solid waste （MSW） incineration plants. Recycling it as additives for cement production is a promising disposal method. However, the heavy metals and chlorine are the main limiting factors because of the potential environmental risks and corrosion of cement kilns. Therefore ,investigating heavy metal and chlorine characteristics of bottom ash is the significant prerequisite of its reuse in cement industries. In this study, a correlative analysis was conducted to evaluate the effect of the MSW components and collection mode on the heavy metal and chlorine characteristics in bottom ash. The chemical speciation of insoluble chlorine was also investigated by synchrotron X-ray diffraction analysis. The results showed that industrial waste was the main source of heavy metals, especially Cr and Pb, in bottom ash. The higher contents of plastics and kitchen waste lead to the higher chlorine level （0.6 wt.%-0.7 wt.%） of the bottom ash. The insoluble chlorine in the MSW incineration bottom ash existed primarily as AlOCl, which was produced under the high temperature （1250℃） in incinerators.

关键词： Bottom ash ChlorineHeavy metals Waste inputs Synchrotron X-ray diffraction AlOCl

Atomic force microscopy analysis of orientation and bending of oligodeoxynucleotides in polypod-like structured DNA

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Nano Research 2015年第12期8卷 3764-3771页

作者： Tomoki Shiomi Mengmeng Tan Natsuki takahashi Masayuki Endo Tomoko Emura Kumi Hidaka Hiroshi Sugiyama Yuki takahashi Yoshinobu Takakura Makiya Nishikawa Department of Biopharmaceutics and Drug Metabolism Graduate School of Pharmaceutical Sciences Kyoto University Sakyo-ku Kyoto 606-8501 Japan Institute for Integrated Cell-Material Sciences (WPI-iCeMS) Kyoto University Sakyo-ku Kyoto 606-8501 Japan Department of Chemistry Graduate School of Science Kyoto University Sakyo-ku Kyoto 606-8502 Japan

我们以前证明象多足一样组织了 DNA，或 polypodna，与三或更构造了 oligodeoxynucleotides (ODN ) ，被象树枝状的房间和巨噬细胞那样的有免疫力的房间高效地收起，取决于它的结构的复杂性。包括 polypodna 的 ODN 应该弯曲形成象多足... 详细信息

我们以前证明象多足一样组织了 DNA，或 polypodna，与三或更构造了 oligodeoxynucleotides (ODN ) ，被象树枝状的房间和巨噬细胞那样的有免疫力的房间高效地收起，取决于它的结构的复杂性。包括 polypodna 的 ODN 应该弯曲形成象多足一样结构，并且可以那么由采用 bendtype 符合构造或跨类型的符合构造做。这里，我们试着阐明取向并且用原子力量显微镜学(AFM ) 在 polypodnas ODN 弯曲。我们设计了 pentapodnas 的二种类型(即，有五个豆荚的 polypodna ) 使用 60- 到 88 底 ODN，它然后在 DNA origami 上被使不能调动装裱。AFM 成像证明在 pentapodna 的 ODN 采用了拐弯类型符合构造。当他们在非强迫的条件下面在框架上被使不能调动时， Tetrapodna 和 hexapodna 也采用了拐弯类型符合构造。这些调查结果提供向协调设计的有用信息，和 structureactivity 关系为，许多 DNA nanostructures。

关键词：原子力显微镜分析反义寡核苷酸弯曲型结构 DNA 取向树突状细胞免疫细胞巨噬细胞

Hemorrhagic ovarian cyst without peritoneal bleeding in a patient with ovarian hyperstimulation syndrome: case report

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Chinese Medical Journal 2005年第18期118卷 1577-1581页

作者： Hiroko Kurioka Kentaro takahashi Nobuyuki Kita Yoichi Noda Department of General Medicine Shimane Prefectural Central Hospital Izumo JapanDepartment of Obstetrics and Gynecology Shiga University of Medical Science Ohtsu Japan Department of Obstetrics and Gynecology Shiga University of Medical Science Ohtsu Japan Department of Obstetrics and Gynecology Shiga University of Medical Science Ohtsu Japan

Gynecologic and obstetric disorders presenting with abdominal pain are ectopic pregnancy,rupture of endometrial cysts, mature cystic teratoma and torsion of the adnexae. Hemorrhagic ovarian cysts, which included among... 详细信息

关键词： hemorrhagic ovarian cyst·ovarian hyperstimulation syndrome·human menopausal gonadotropin·human chorionic gonadotropin

Diffusion-weighted MRI in abdominal oncology:Clinical applications

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World Journal of Gastroenterology 2010年第7期16卷 832-836页

作者： Reiji Sugita Kei Ito Naotaka Fujita Shoki takahashi Department of Radiology Sendai City Medical CenterSendai 983-0824Japan Department of Gastroenterology Sendai City Medical CenterSendai 983-0824Japan Department of Diagnostic Radiology Graduate School of MedicineTohoku UniversitySendai 980-8574Japan

Diffusion-weighted magnetic resonance imaging(DWI) provides image contrast that is different from that obtained by conventional magnetic resonance *** previously,DWI has been used to evaluate various diseases of the central nervous system,several technical advances have expanded the clinical applications of DWI beyond the central nervous *** a result,many reports have been published on the use of DWI in abdominal ***,abdominal DWI has now being focused on evaluation of patients with abdominal *** can be used for pretreatment tumor detection,characterization including predicting tumor response to therapy,monitoring tumor response during therapy,and follow-up study after treatment to detect possible tumor recurrence.

关键词： Diffusion weighted magnetic resonance imaging Abdominal neoplasms