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Open Journal of Orthopedics 2017年第11期7卷 369-374页

作者： Hiroshi Yonezu Hiroshi Mikami Koichi Oba Katsutoshi Miyatake michihiro takai Akihiro Nitta Department of Orthopedics Yoshinogawa Medical Center Tokushima Japan

An abnormality of femoral anteversion (FA) is often recognized in patients with osteoarthritis of the hip joint (hip OA). And it is considered that rotation abnormality in the knee and the lower leg occurs as compensation, in cases of FA abnormality. The purpose of this study was to assess the magnitude and variability of FA and femoral condyle rotation (FCR) in order to identify the association between FA and FCR in female patients with hip OA who require total hip arthroplasty. A total of 174 hips from 174 hip OA patients undergoing THA were included in this study. All patients were Asian women (average age: 71.1 years). An equilateral correlation was accepted in FA and FCR. It was thought that FA abnormality might be accompanied by morphological rotation abnormalities of the knee joint. Caution is needed in considering femoral anteversion using the posterior condylar line. We must consider FA in patients undergoing THA after having considered the whole leg rotation.

关键词： Femoral Anteversion Femoral Condyle Rotation Osteoarthritis of the Hip Posterior Condylar Line Epicondylar Line Total Hip Arthroplasty (THA)

Successful Treatment with a Weekly Injection of Teriparatide for the Nonunion of a Distal Humerus Fracture

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Open Journal of Orthopedics 2017年第7期7卷 173-179页

作者： Hiroshi Yonezu Hiroshi Mikami Koichi Oba Katsutoshi Miyatake michihiro takai Akihiro Nitta Department of Orthopedics Yoshinogawa Medical Center Yoshinogawa Tokushima Japan

A distal humerus fracture nonunion is one of the complications with which we should be vigilant. It requires an open reduction and rigid internal fixation. However, treatment with an operative procedure is difficult because the small bones involved in distal humerus fracture nonunion or if osteoporosis is present. And an improvement in the function of the elbow joint is not satisfied because of a postoperative elbow joint contracture. Furthermore, the risk of anesthesia to elderly patients restricts the use of an operation for treatment. A weekly injection of teriparatide has the ability to stimulate bone formation. We present a case of an 87-year-old woman treated with a weekly injection of teriparatide for the nonunion of a distal humerus fracture.

关键词： Distal Humerus Fracture Nonunion Teriparatide

The Relationship of Serum Calcium, Phosphorus, and Parathyroid Hormone with Renal Function in Elderly Osteoporotic Patients with No History of Chronic Kidney Disease

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Advances in Aging Research 2017年第4期6卷 55-60页

作者： Hiroshi Yonezu Hiroshi Mikami Koichi Oba Katsutoshi Miyatake michihiro takai Akihiro Nitta Department of Orthopedics Yoshinogawa Medical Center Yoshinogawa Japan

The prevalence of osteoporosis and decline in renal function increases with age. Therefore, the coexistence rate of both these conditions rises in the elderly population. Abnormalities in mineral bone metabolism are major complications in chronic kidney disease (CKD). However, in elderly osteoporotic patients without a history of CKD, there are few reports on the relationship between calcium (Ca), phosphorus (P), and parathyroid hormone (PTH), and renal function. The purpose of this study was to investigate the relationship between Ca, P, and PTH, and renal function in elderly osteoporosis patients with no history of CKD. We evaluated 169 patients who had been treated for osteoporosis. The eGFR decreased with age resulting in a negative correlation (r = -0.514, p p p p p < 0.01, respectively). Even if Ca and P are in the normal range, in case of a poor effect of an osteoporotic therapeutic drug, it is necessary to consider the measurement of intact PTH in elderly osteoporosis patients with no history of CKD.

关键词： Calcium Phosphorus Parathyroid Hormone Renal Function Elderly Osteoporotic Patients

Natural Convection Melting in a Rectangular Heat Storage Tank of Carbon Nanotube Dispersed Latent Heat Storage Material

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Journal of Thermal Science 2024年第3期33卷 847-855页

作者： Shin-ichi MORITA Tomoya SAITO Kazunori takai Yasutaka HAYAMIZU Naoto HARUKI Division of Mechanical and Electrical Engineering Kitami Institute of Technology165 Koen-choKitami-shiHokkaido090-8507Japan National Institute of Technology Yonago College4448 Hikona-cyoYonago-shiTottori683-8502Japan Okayama Prefectural University 111 KubokiSoja-shiOkayama719-1197Japan

A dispersion system fluid can convect even if the dispersoid is a solid phase.Therefore,heat exchange performance can be improved while maintaining fluidity using a material with high thermal conductivity as the dispersoid.This study presents the melting performance evaluation results of a latent heat storage material with a carbon nanotube(CNT)dispersion system with high thermal conductivity,which enhances the thermal conductivity of the latent heat storage material and does not limit free convection.Increasing the thermal conductivity and enhancing the melting convection of the heat storage material result in increased latent heat storage speed.In this study,the thermal conductivity of the latent heat storage material was successfully increased by dispersing CNTs in the material.When 0.1%(in mass)of multi-wall CNT(MWCNT)was dispersed in a paraffin-based latent heat storage material,the shear stress increased by 1.5 times at a shear rate of 500 s^(-1),while taking into account the potential effects of convective inhibition.Therefore,a latent heat storage experiment was conducted in a rectangular heat storage tank using the CNT dispersion composition ratio as a parameter.A rectangular vessel with a heated vertical surface was used for the latent heat storage experiment.The melting speed was determined by comparing the amount of latent heat stored in a CNT-dispersed latent heat storage material and a single-phase latent heat storage material sample.The experimental results show that the time required for the latent heat storage material to completely melt in the heat storage tank was the shortest for the single-phase latent heat storage material sample.However,the fastest melting progress was observed for the sample with 0.02%(in mass)MWCNT content in the melting rate range of up to approximately 40%in the tank.The results indicate that this phenomenon is caused by the difference in the melting rates in the upper part of the tank.The generated data are useful for determining the shape and heat transfer surface arr

关键词： latent heat storage phase change carbon nano tube free convection heat transfer

Risk factors and diagnostic biomarkers for nonalcoholic fatty liver disease-associated hepatocellular carcinoma:Current evidence and future perspectives

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World Journal of Gastroenterology 2022年第27期28卷 3410-3421页

作者： Masayuki Ueno Haruhiko Takeda Atsushi takai Hiroshi Seno Department of Gastroenterology and Hepatology Kyoto University Graduate School of MedicineKyoto 6068507Japan

High rates of excessive calorie intake diets and sedentary lifestyles have led to a global increase in nonalcoholic fatty liver disease(NAFLD).As a result,this condition has recently become one of the leading causes of hepatocellular carcinoma(HCC).Furthermore,the incidence of NAFLD-associated HCC(NAFLD-HCC)is expected to increase in the near future.Advanced liver fibrosis is the most common risk factor for NAFLD-HCC.However,up to 50%of NAFLDHCC cases develop without underlying liver cirrhosis.Epidemiological studies have revealed many other risk factors for this condition;including diabetes,other metabolic traits,obesity,old age,male sex,Hispanic ethnicity,mild alcohol intake,and elevated liver enzymes.Specific gene variants,such as single-nucleotide polymorphisms of patatin-like phospholipase domain 3,transmembrane 6 superfamily member 2,and membrane-bound O-acyl-transferase domaincontaining 7,are also associated with an increased risk of HCC in patients with NAFLD.This clinical and genetic information should be interpreted together for accurate risk prediction.Alpha-fetoprotein(AFP)is the only biomarker currently recommended for HCC screening.However,it is not sufficiently sensitive in addressing this diagnostic challenge.The GALAD score can be calculated based on sex,age,lectin-bound AFP,AFP,and des-carboxyprothrombin and is reported to show better diagnostic performance for HCC.In addition,emerging studies on genetic and epigenetic biomarkers have also yielded promising diagnostic potential.However,further research is needed to establish an effective surveillance program for the early diagnosis of NAFLD-HCC.

关键词： Nonalcoholic fatty liver disease Hepatocellular carcinoma Risk factors Biomarkers Tumor markers Genetics

Artificial neural network-based determination of denoised optical properties in double integrating spheres measurement

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Journal of Innovative Optical Health Sciences 2023年第6期16卷 105-116页

作者： Yusaku takai Takahiro Nishimura Yu Shimojo Kunio Awazu Graduate School of Engineering Osaka University Yamadaoka 2-1SuitaOsaka 565-0871Japan Global Center for Medical Engineering and Informatics Osaka University Yamadaoka 2-2SuitaOsaka 565-0871Japan

Accurate determination of the optical properties of biological tissues enables quantitative understanding of light propagation in these tissues for optical diagnosis and treatment applications.The absorption(μa)and scattering(μs)coe±cients of biological tissues are inversely analyzed from their diffuse re°ectance(R)and total transmittance(T),which are measured using a double integrating spheres(DIS)system.The inversion algorithms,for example,inverse adding doubling method and inverse Monte Carlo method,are sensitive to noise signals during the DIS measurements,resulting in reduced accuracy during determination.In this study,we propose an arti ficial neural network(ANN)to estimateμa andμs at a target wavelength from the R and T spectra measured via the DIS to reduce noise in the optical properties.Approximate models of the optical properties and Monte Carlo calculations that simulated the DIS measurements were used to generate spectral datasets comprisingμa,μs,R and T.Measurement noise signals were added to R and T,and the ANN model was then trained using the noise-added datasets.Numerical results showed that the trained ANN model reduced the effects of noise inμa andμs estimation.Experimental veri fication indicated noise-reduced estimation from the R and T values measured by the DIS with a small number of scans on average,resulting in measurement time reduction.The results demonstrated the noise robustness of the proposed ANN-based method for optical properties determination and will contribute to shorter DIS measurement times,thus reducing changes in the optical properties due to desiccation of the samples.

关键词： Absorption coefficient scattering coe±cient bio-tissue tissue spectroscopy noise reduction.

An old uterine rupture repaired 2 months postpartum using laparoscopy aided by hysteroscopy: A case report

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Laparoscopic, Endoscopic and Robotic Surgery 2022年第4期5卷 153-157页

作者： Yuichiro Kizaki Kouki Samejima Shigetaka Matsunaga Tomonori Nagai Yasushi takai Department of Obstetrics and Gynecology Saitama Medical CenterSaitama Medical UniversitySaitama Ken 350-8550Japan

With an incidence of 0.005%,unscarred uterine rupture is extremely rare.It is difficult to diagnose uterine rupture because of the absence of characteristic clinical symptoms.Here,we report a rare case of a 31-year-old woman with a uterine rupture that was accurately diagnosed and repaired by laparoscopy and hysteroscopy on postpartum day 69.The patient recovered uneventfully and was discharged on postoperative day 4.Three months after surgery,pelvic magnetic resonance imaging was performed,which confirmed wound repair.In women with a stable condition,laparoscopy with hysteroscopy could be an alternative choice for the diagnosis and treatment of suspected uterine rupture;however,more substantial studies are needed to confirm this surgical approach.

关键词： Hysteroscopy Laparoscopic surgery Uterine rupture Postpartum hemorrhage Uterine preservation

Body composition changes following chemotherapy for testicular germ cell tumor:obesity is the long-term problem

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Asian Journal of Andrology 2022年第5期24卷 458-462页

作者： Yuki takai Sei Naito Hidenori Kanno Atsushi Yamagishi Mayu Yagi Toshihiko Sakurai Hayato Nishida Takuya Yamanobe Tomoyuki Kato Norihiko Tsuchiya Department of Urology Yamagata University Faculty of MedicineYamagata 990-9585Japan

Metabolic syndrome is a long-term complication of systemic chemotherapy for testicular germ cell tumor(TGCT).It is believed to be caused by secondary hypogonadism or toxic medicines because of orchidectomy followed by systemic chemotherapy.In this study,changes in the body composition of patients over time were quantitatively analyzed up to 24 months after chemotherapy.This study retrospectively analyzed 44 patients with TGCT who underwent chemotherapy at our institution from January 2008 to December 2016.Subcutaneous and visceral fat areas and psoas and skeletal muscle areas were measured by computed tomography before and immediately after chemotherapy as well as 3 months,6 months,12 months,and 24 months after chemotherapy.The subcutaneous and visceral fat indices and psoas and skeletal muscle indices were calculated as each area divided by body height squared.The total fat area had already significantly increased 3 months after the initiation of chemotherapy(P=0.004).However,it did not return to prechemotherapeutic levels even at 24 months after chemotherapy.The skeletal muscle area was significantly decreased at the end of chemotherapy(P<0.001);however,the value returned to baseline within 12 months.In multivariable analysis,the prechemotherapeutic skeletal muscle index and number of chemotherapy cycles were independently associated with the reduction of skeletal muscle at the end of chemotherapy(P=0.001 and P=0.027,respectively).In patients with TGCT,skeletal muscle mass decreased during chemotherapy and recovered within 12 months,whereas fat mass progressively increased from the initiation of chemotherapy until 24 months after chemotherapy.

关键词： body composition chemotherapy obesity sarcopenia secondary hypogonadism testicular cancer

Circulating tumor DNA as a liquid biopsy target for detection of pancreatic cancer

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World Journal of Gastroenterology 2016年第38期22卷 8480-8488页

作者： Erina takai Shinichi Yachida Division of Cancer Genomics National Cancer Center Research InstituteTokyo

Most pancreatic cancer patients present with advanced metastatic disease, resulting in extremely poor 5-year survival, mainly because of the lack of a reliable modality for early detection and limited therapeutic options for advanced disease. Therefore, there is a need for minimally-invasive diagnostic tools for detecting pancreatic cancer at an early stage, when curative surgery and also novel therapeutic approaches including precision medicine may be feasible. The "liquid biopsy" addresses these unmet clinical needs based on the concept that simple peripheral blood sampling and detection of circulating tumor DNA(ct DNA) could provide diagnostic information. In this review, we provide an overview of the current status of bloodbased tests for diagnosis of pancreatic cancer and the potential utility of ct DNA for precision medicine. We also discuss challenges that remain to be addressed in developing practical ct DNA-based liquid biopsy approaches for early diagnosis of pancreatic cancer.

关键词： Circulating tumor DNA Pancreatic cancer Biomarker Precision medicine Liquid biopsy

Factors associated with surgical-site infection after total laparoscopic hysterectomy

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Laparoscopic, Endoscopic and Robotic Surgery 2022年第4期5卷 131-135页

作者： Kosuke Shigematsu Koki Samejima Yuichirou Kizaki Shigetaka Matsunaga Tomonori Nagai Yasushi takai Department of Obstetrics and Gynecology Saitama Medical CenterSaitama Medical UniversitySaitama 350-8550Japan

Objective:In recent years,minimally invasive surgery has been emphasized in gynecological surgery,and total laparoscopic hysterectomy has been increasingly reported.In this retrospective single-center study,the main objective was to identify risk factors for the development of surgical-site infection(SSI)after total laparoscopic hysterectomy.The secondary objective was to investigate the efficacy of transvaginal drainage as a treatment for SSI.Methods:This retrospective study investigated 377 patients who underwent total laparoscopic hysterectomy in the Department of Obstetrics and Gynecology at the Saitama Medical Center,Saitama Medical University,Japan between January 1,2015 and December 31,2019.Patients were divided into the SSI group and non-SSI group based on whether they suffered from SSI.The data of preoperative,intraoperative,and postoperative risk factors for SSI were collected and analyzed.Results:Of the 377 patients who underwent total laparoscopic hysterectomy,21 patients were in the SSI group and 356 patients were in the non-SSI group.After the comparison between the two groups and the multivariate analysis,only the C-reactive protein level on postoperative day 3(OR¼1.556,95%CI:1.233 e1.964,p7.6 mg/dL on postoperative day 3 could detect the SSI onset early.In the SSI group,the hospital stay was longer for patients with transvaginal drainage than for patients without(17.40±3.21 d vs.10.90±2.39 d,p¼0.0027).However,none required reoperation.Conclusions:Patients with a high postoperative C-reactive protein level may be experiencing SSI,and ultrasonography and other imaging procedures should be performed immediately.If a vaginal abscess is confirmed on imaging,transvaginal drainage should be performed early,which may prevent reoperation.

关键词： Hysterectomy Laparoscopic surgery Surgical-site infection