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Python Server Page Perf.rmance Analysis and Modeling

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Communications and Network 2024年第1期16卷 1-30页

作者： Razaf.ndraibe Marolahy Alix Randrianomenjanahary Lala f.rdinand Raf.mantanantsoa f.ntaine Mahatody Thomas f. Angelo Raherinirina University of.f.anarantsoa Fianarantsoa Madagascar

Today, in the f.eld of.computer networks, new services have been developed on the Internet or intranets, including the mail server, database management, sounds, videos and the web server itself.Apache. The number of.solutions f.r this server is theref.re growing continuously, these services are becoming more and more complex and expensive, without being able to f.lf.ll the needs of.the users. The absence of.benchmarks f.r websites with dynamic content is the major obstacle to research in this area. These users place high demands on the speed of.access to inf.rmation on the Internet. This is why the perf.rmance of.the web server is critically important. Several f.ctors inf.uence perf.rmance, such as server execution speed, network saturation on the internet or intranet, increased response time, and throughputs. By measuring these f.ctors, we propose a perf.rmance evaluation strategy f.r servers that allows us to determine the actual perf.rmance of.dif.erent servers in terms of.user satisf.ction. f.rthermore, we identif.ed perf.rmance characteristics such as throughput, resource utilization, and response time of.a system through measurement and modeling by simulation. f.nally, we present a simple queue model of.an Apache web server, which reasonably represents the behavior of.a saturated web server using the Simulink model in Matlab (Matrix Laboratory) and also incorporates sporadic incoming traf.ic. We obtain server perf.rmance metrics such as average response time and throughput through simulations. Compared to other models, our model is conceptually straightf.rward. The model has been validated through measurements and simulations during the tests that we conducted.

关键词： Perf.rmance Analysis Queue Perf.rmance Model Web Server Internet World Wide Web Web Server Perf.rmance

Endoplasmic reticulum stress,autophagy,neuroinf.ammation,and sigma 1 receptors as contributors to depression and its treatment

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Neural Regeneration Research 2024年第10期19卷 2202-2211页

作者： Chika f.jii Charles f.Zorumski Yukitoshi Izumi Department of.Psychiatry Washington University School of MedicineSt.LouisMOUSA Taylor f.mily Institute f.r Innovative Psychiatric Research Washington University School of MedicineSt.LouisMOUSA

The etiological f.ctors contributing to depression and other neuropsychiatric disorders are largely undef.ned. Endoplasmic reticulum stress pathways and autophagy are well-def.ned mechanisms that play critical f.nctions in recognizing and resolving cellular stress and are possible targets f.r the pathophysiology and treatment of.psychiatric and neurologic illnesses. An increasing number of.studies indicate the involvement of.endoplasmic reticulum stress and autophagy in the control of.neuroinf.ammation, a contributing f.ctor to multiple neuropsychiatric illnesses. Initial inf.ammatory triggers induce endoplasmic reticulum stress, leading to neuroinf.ammatory responses. Subsequently, induction of.autophagy by neurosteroids and other signaling pathways that converge on autophagy induction are thought to participate in resolving neuroinf.ammation. The aim of.this review is to summarize our current understanding of.the molecular mechanisms governing the induction of.endoplasmic reticulum stress, autophagy, and neuroinf.ammation in the central nervous system. Studies f.cused on innate immune f.ctors, including neurosteroids with anti-inf.ammatory roles will be reviewed. In the context of.depression, animal models that led to our current understanding of.molecular mechanisms underlying depression will be highlighted, including the roles of.sigma 1 receptors and pharmacological agents that dampen endoplasmic reticulum stress and associated neuroinf.ammation.

关键词： allopregnanolone f.uvoxamine ketamine neurosteroids postpartum depression quercetin

Item-Level Analysis of.the Revised Occupational Therapy f.eldwork Perf.rmance Evaluation Applied in Practice

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Open Journal of.Therapy and Rehabilitation 2024年第2期12卷 145-159页

作者： Cynthia L. Sears Brad E. Egan Patricia f. Tomsic Craig A. Velozo Graduate College of.Health Prof.ssions Occupational Therapy Program Hawai&#8217i Pacific University Honolulu HI USA College of.Science and Health Occupational Therapy Program DePaul University Chicago IL USA Department of.Occupational Therapy Wingate University Wingate NC USA College of.Health Prof.ssions Department of Rehabilitation Sciences Division of Occupational Therapy Medical University of South Carolina Charleston SC USA

Competency-based assessments f.r healthcare prof.ssionals are critical f.r saf. and ef.ective client outcomes. Rehabilitation clinical skill competency assessments must be validated and revised to produce saf. and skilled practitioners. The revised American Occupational Therapy Association (AOTA) f.eldwork Perf.rmance Evaluation (f.PE) instrument measures occupational therapy student perf.rmance to determine readiness f.r practice. The assessment includes thirty-seven competencies that address both prof.ssion specif.c clinical skills and general prof.ssional behavior skills. The objective of.this study was to use Rasch methods to explore the use of.the revised f.PE in actual f.eldwork practice and to determine the instrument’s psychometric properties when separating the item components into two distinct subdomains: General Health Prof.ssions Competences and Occupational Therapy-Specif.c Competencies. Internal construct validity and test reliability were analyzed using data f.om 149 occupational therapy students af.er completing their initial Level II A f.eldwork clinical internship. This study examined the item dif.iculty hierarchy, item f.t, person-f.t to model, person separation index, person separation reliability coef.icient, strata, ceiling and f.oor ef.ect, and unidimensionality of.the f.PE instrument as a whole and as two separate domains. With the exception of.not meeting the criteria f.r unidimensionality, the f.ll f.PE instrument and the Occupational Therapy-Specif.c Competencies subdomain showed acceptable item-level psychometrics f.r reliability and precision. While the General Health Prof.ssions Competencies subdomain showed good item-level psychometrics, it was below the criterion f.r reliability and only separated the sample into two strata. Results support the validity, reliability, and clinical use of.the revised f.PE f.ll instrument and the Occupational Therapy-Specif.c Competencies subdomain to measure entry-level clinical skill competencies in pr

关键词： Rehabilitation Competency-Based Assessments Occupational Therapy Measurement Rasch Analysis

The ef.ects of.local variations in conditions on carbon storage and release in the continental mantle

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National Science Review 2024年第6期11卷 22-36页

作者： Stephen f.f.ley Chunf.i Chen Dorrit E.Jacob School of.Natural Sciences Macquarie University Research School of.Earth Sciences Australian National University State Key Laboratory of.Geological Processes and Mineral Resources School of Earth Sciences China University of Geosciences

Recent advances indicate that the amount of.carbon released by gradual degassing f.om the mantle needs to be revised upwards, whereas the carbon supplied by plumes may have been overestimated in the *** in rock types and oxidation state may be very local and exert strong inf.uences on carbon storage and release mechanisms. Deep subduction may be prevented by diapirism in thick sedimentary packages,whereas carbonates in thinner sequences may be subducted. Carbonates stored in the mantle transition zone will melt when they heat up, recognized by coupled stable isotope systems(e.g. Mg, Zn, Ca). There is no single ‘mantle oxygen f.gacity’, particularly in the thermal boundary layer(TBL) and lowermost lithosphere, where very local mixtures of.rock types coexist. Carbonate-rich melts f.om either subduction or melting of.the uppermost asthenosphere trap carbon by redox f.eezing or as carbonate-rich dykes in this zone. Deeply derived, reduced melts may f.rm f.rther diamond reservoirs, recognized as polycrystalline diamonds associated with websteritic silicate minerals. Carbon is released by either edge-driven convection,which tears sections of.the TBL and lower lithosphere down so that they melt by a mixture of.heating and oxidation, or by lateral advection of.solids beneath rif.s. Both mechanisms operate at steps in lithosphere thickness and result in carbonate-rich melts, explaining the spatial association of.craton edges and carbonate-rich magmatism. High-pressure experiments on individual rock types, and increasingly on reactions between rocks and melts, are f.ne-tuning our understanding of.processes and turning up unexpected results that are not seen in studies of.single rocks. f.ture research should concentrate on elucidating local variations and integrating these with the interpretation of.geophysical signals. Global concepts such as average sediment compositions and a unif.rm mantle oxidation state are not appropriate f.r small-scale processes; an increa

关键词： lithospheric mantle carbonate melts deep carbon cycle craton destruction continental rif.s

Understanding the neighborhoods’in-between spaces on spatial perception,social interaction,and security

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f.ontiers of.Architectural Research 2024年第1期13卷 21-36页

作者： Lizeth f.lix Mariel Organista Autonomous University of.Baja Calif.rnia Ensenada 22860Mexico

This study ref.ects on the impact that the neighborhoods’in-between spaces have on:spatial perception,social interaction,and *** sites,characterized by their abandonment and deterioration,can also be seen as crucial spaces of.opportunity f.r cities,in the architectural,urban and landscape *** paper aims to analyze the sociospatial relationships in the neighborhoods’in-between spaces and examine the impact of.inbetween space conf.guration on urban *** investigation draws on a survey of.perception to residents about the requirements f.r a suitable social interaction in these *** study was developed in a neighborhood in the city periphery,characterized by their social dynamics and location in a nature conservation *** f.ndings indicate that the appropriation process,activities,and collective practices are dependent on the spatial legibility,in this case when this increases,gives rise to improve the habitability and the rehabilitation of.the in-between ***,the lack of.design on in-between spaces substantially af.ects the use of.these spaces and the social interaction among residents.

关键词： In-between spaces Socio-spatial relationships Habitability Neighborhoods Security

Clinical studies in COVID-related olf.ctory disorders:Review of.an institutional experience

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World Journal of.Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 129-136页

作者： Theresa Tharakan Dorina Kallogjeri Jay f.Piccirillo Department of.Otolaryngology-Head and Neck Surgery Clinical Outcomes Research OfficeSchool of MedicineWashington University in St LouisSt LouisMissouriUSA

Objective:To share a single institutional experience with clinical research on COVID-related olf.ctory dysf.nction(OD).Data Source/Method:Narrative review of.published original data and ongoing clinical trials on COVID-related OD at Washington University f.om 2020 to ***:There were three new diagnostic-/patient-reported outcome measures developed and *** report f.ve clinical trials of.interventions f.r COVID-related olf.ctory disorders:combined Visual-Olf.ctory Training(VOLT)with patient-pref.rred scents versus standard olf.ctory training(VOLT trial),oral gabapentin versus placebo(Gabapentin f.r the Relief.of.Acquired Chemosensory Experience trial),nasal theophylline irrigations versus placebo(Smell Changes and Ef.icacy of.Nasal Theophylline trial),stellate ganglion block(single-arm),and mindf.lness-based stress reduction(MBSR)versus lif.style intervention(MBSR trial).Conclusions:Initial intervention trials f.r COVID-related OD have shown potential f.r improving subjective and objective olf.ctory ***,there remains no gold standard treatment that def.nitively outperf.rms placebo in controlled ***,continued investigation of.novel therapeutic strategies f.r COVID-related OD is necessary to maximize olf.ctory outcomes f.r af.ected patients.

关键词： chemosensory disorders COVID olf.ctory dysf.nction

Standaertsite公园,根特,比利时

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世界建筑 2024年第6期 60-65页

作者：无 michiel De Cleene(摄影) Jef.Geldof.摄影) Joshua Delissen(摄影) Murmuur建筑事务所 Carton123建筑事务所 AE-建筑事务所不详

前身为自助商店“Standaert”的旧址与莱德贝格两条人口稠密的中心街道相连。除此以外,该场地还深入内部区域,被花园围墙和附属建筑所环绕。通过移除一部分场地周边的环境,设计师在城市中打开了一个开口,使其突然出现了一个景观。设计... 详细信息

前身为自助商店“Standaert”的旧址与莱德贝格两条人口稠密的中心街道相连。除此以外,该场地还深入内部区域,被花园围墙和附属建筑所环绕。通过移除一部分场地周边的环境,设计师在城市中打开了一个开口,使其突然出现了一个景观。设计师的主要意图是尽可能保持公园的规模,同时也对这个密集城市结构中的两条街道产生影响。有限的建筑空间被合理利用。

关键词：附属建筑内部区域主要意图人口稠密公园街道比利时

Morphological traits explain the individual position within resource-consumer networks of.a Neotropical marsupial

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Current Zoology 2024年第4期70卷 453-464页

作者： Nicholas f.de Camargo Hernani f.M.de Oliveira Juliana f.Ribeiro Amabilio J.A.de Camargo Emerson M.Vieira Laboratorio de Ecologia de Vertebrados Departamento de EcologiaInstituto de Ciencias BiologicasUniversidade de BrasiliaCP 04457BrasiliaDF70910-900Brazil Departamento de Zoologia Setor de Ciencias BiologicasUniversidade Federal do ParanaAvenida Coronel Francisco Heraclito dos Santos100CuritibaPR81531980Brazil Embrapa Cerrados Rodovia BR020km 18CP 08223PlanaltinaDE73310-970Brazil

Knowledge regarding the inf.uence of.individual traits on interaction patterns in nature can help understand the topological role of.individuals within a network of.intrapopulation *** tested hypotheses on the relationships between individuals'positions within networks(specialization and centrality)of.4 populations of.the mouse opossum Gracilinanus agilis and their traits(i.e.,body length,body condition,tail length relative to body length,sex,reproductive condition,and botf.y parasitism)and also seasonal ef.ects in the Brazilian *** with lower body length,better body condition,and relatively shorter tail were more specialized(i.e.,less connected within the network).Individuals were also more specialized and less connected during the warm-wet *** relationship between individuals'position in the network and body traits,however,was independent of.*** propose that specialization may arise not only as a result of.pref.rred f.ed-ing strategies by more capable individuals(i.e.,those with better body condition and potentially prone to def.nd and access high-quality f.od resources)but alsobecause of.morphological ***/younger individuals(consequently with less experience in f.raging)and short-tailed individuals(less skilled to explore the vertical strata of.the vegetation)would f.ed only on a subset of.the available f.od resources and consequently become more ***,individuals are more specialized during the warm-wet season because of.high competition(population-dense period)and higher ecological opportunities(resource-rich period).Theref.re,our study reveals the relevance of.individual traits inshaping interactionpatternsandspecialization inpopulations.

关键词： bodytraits centrality Cerrado Gracilinanus agilis seasonality specialization.

Radiative capture of.proton through the ^(14)N(p,γ)^(15)O reaction at low energy

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Chinese Physics C 2024年第4期48卷 183-192页

作者： B.f.Irgaziev Abdul Kabir Jameel-Un Nabi National University of.Uzbekistan Tashkent 100174Uzbekistan Space and Astrophysics Research lab National Centre of GIS and Space ApplicationsDepartment of Space ScienceInstitute of Space TechnologyIslamabad 44000Pakistan University of.Wah Quaid AvenueWah Cantt 47040PunjabPakistan

The CNO cycle is the main source of.energy in stars more massive than our *** process def.nes the energy production,the duration of.which can be used to determine the lif.time of.massive *** cycle is an important tool f.r determining the age of.globular *** proton capture via p+^(14)N→^(15)O+γ,at energies of.astrophysical interest,is an important process in the CNO *** this project,we apply a potential model to describe both non-resonant and resonant reactions in the channels where radiative capture occurs through electric E1 *** employed the R-matrix method to describe the ongoing reactions via M1 resonant transitions,when it was not possible to correctly reproduce the experimental data using the potential *** partial components of.the astrophysical S-f.ctor are calculated f.r all possible electric and magnetic dipole transitions in ^(15)*** linear extrapolated S-f.ctor at zero energy(S(0))agrees well with earlier reported values f.r all transition types considered in this *** on the value of.the total astrophysical S-f.ctor,depending on the collision energy,we calculate the nuclear reaction rates f.r p+^(14)N→^(15)O+γ.The computed rates agree well with the results reported in the NACRE II Collaboration and most recent existing measurements.

关键词： CNO cycle potential model R-matrix method cross-section astrophysical S-f.ctor nuclear rates.