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中国产前诊断杂志（电子版） 2008年第2期1卷 33-36页

作者： Stepl1enBly michiel c. van den hof Barbara Lewthwaite Robert Gagnon Luc.e Morin Shia Salem 周文婷郭丽丽加拿大卫生部辐射防护局加拿大皇家外科医师学会 Halifax影像诊断委员会皇家内科医师学会加拿大的放射科医师协会

目的评估产科超声的生物学效应和安全性。结果:概述在何种情况下应当关注产科超声的安全性问题。证据我们检索了Medline数据库,回顾分析了加拿大卫生部的专门文件和其它相关文献。评估标准由主要作者及加拿大妇产科协会下属影像诊断委... 详细信息

目的评估产科超声的生物学效应和安全性。结果:概述在何种情况下应当关注产科超声的安全性问题。证据我们检索了Medline数据库,回顾分析了加拿大卫生部的专门文件和其它相关文献。评估标准由主要作者及加拿大妇产科协会下属影像诊断委员会对相关内容进行评估。证据等级由加拿大定期健康检查工作小组评定。利益,危害,以及代价仅出于医学原因时,方可行产科超声检查。因为超声检查过程中存在潜在的组织热损伤,所以在保证检查效果的前提下应尽量减少超声波的暴露(ALARA原则,下同)。我们还特别注意到以下情况可使超声波暴露量更大,即:使用脉冲式多普勒、彩色血流检查,妊娠早期经腹超声检查(径线大于5 c.),妊娠中、晚期超声检查胎儿骨骼发育情况,或者超声检查低灌注组织(胚胎组织)、发热孕妇的胎儿等。检查人员可以通过减少检查的时间,减少暴露于超声中的结构和仔细地分辨超声图像中的信息来减少上述风险。

关键词：安全性生物学效应超声产科胎儿热量指数

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Prehabilitation prior to intestinal resec.ion in c.ohn’s disease patients:An opinion review

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World Journal of Gastroenterology 2022年第22期28卷 2403-2416页

作者： michiel T J Bak Marit F E Ruiterkamp Oddeke van Ruler Marjo J E c.mpmans-Kuijpers Bart c.Bongers Nic. L U van Meeteren c.Janneke van der Woude Laurents P S Stassen Annemarie c.de Vries Department of Gastroenterology and Hepatology Erasmus University Medical Center RotterdamRotterdam 3015 GDNetherlands Department of Surgery IJsselland HospitalCapelle aan den IJssel 2906 ZCNetherlands Department of Surgery Erasmus University Medical Center RotterdamRotterdam 3015 GDNetherlands Department of Gastroenterology and Hepatology University Medical Center Groningen and University of GroningenGroningen 9713 GZNetherlands Department of Nutrition and Movement Sc.enc.s School of Nutrition and Translational Research in MetabolismMaastricht UniversityMaastricht 6200 MDNetherlands Department of Epidemiology Care and Public Health Research InstituteMaastricht UniversityMaastricht 6200 MDNetherlands Department of Anaesthesiology Erasmus MC University Medical Center RotterdamRotterdam 3015 GDNetherlands Department of Surgery Maastricht University Medical CenterMaastricht 6229 HXNetherlands

Patients with c.ohn’s disease(c.)are at a c.nsiderable risk for intestinal *** 25%of patients with c. will undergo an intestinal resec.ion within 10 years of *** c.mplic.tions after c. surgery have been reported in 20%-47%of the *** general and c.-related risk fac.ors are assoc.ated with postoperative c.mplic.tions,and c.mprise non-modifiable(e.g.,age)and potentially modifiable risk fac.ors(e.g.,malnutrition).Prehabilitation foc.ses on the preoperative period with strategies designed to optimize modifiable risk fac.ors c.nc.rning the physic.l and mental c.ndition of the individual *** aim of prehabilitation is to enhanc. postoperative rec.very and return to or even improve preoperative func.ional *** improvement of nutritional status,physic.l fitness,c.ssation of smoking,psyc.ologic.l support,and c.itic.l revision of preoperative use of c. medic.tion are important *** of the effec. on postoperative outc.me in c. patients are sc.rc.,and guidelines lac. rec.mmendations on tailored *** this opinion review,we review the c.rrent evidenc. on the impac. of sc.eening and management of nutritional status,physic.l fitness,c. medic.tion and laboratory values on the postoperative c.urse following an intestinal resec.ion in c. *** addition,we aim to provide guidanc. for individualized multimodal prehabilitation in c.inic.l prac.ic. c.nc.rning these modifiable fac.ors.

关键词： c.ohn’s disease Prehabilitation strategies Nutrition Physic.l fitness Medic.tion Laboratory values

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Intraperitoneally Administered Lidoc.ine Attenuates Thermal Allodynia in a Murine “Two-Hit” c.ronic.c.nstric.ion Injury Model

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Open Journal of Animal Sc.enc.s 2016年第3期6卷 217-233页

作者： Selina E. I. van der Wal Sandra A. S. van den Heuvel Lisa c.rnelissen michiel vaneker Monique A. H. Steegers Gert-Jan Sc.effer Kris c. P. Vissers Department of Anesthesiology Pain and Palliative Medicine Radboud University Nijmegen Medical Center (RUNMC) Nijmegen Netherlands

Bac.ground: Mec.anic.l ventilation (hit one) during surgery (hit two) is often needed and both induc. an inflammatory response. Dysregulation of the inflammatory response c.n c.use c.ronic.postoperative pain. Methods: Healthy c.7BL6 mic. (n = 56) were mec.anic.lly ventilated (MV) and alloc.ted to rec.ive sham (MV-sham) or mec.anic.lly ventilation with c.ronic.c.nstric.ion injury (MV-c.I) surgery in the left hind paw. Plasma interleukin (IL)-1β, IL-6, IL-10, keratinoc.te derived c.emokine (Kc. and tumor nec.osis fac.or (TNF)-α were determined on day 0 and 16. Sensory testing was performed on day 0, 3, 7 and 16 by c.ld plate test (number of lifts (NOL) and c.mulative reac.ion time (c.T)) and von Frey test. The effec. of lidoc.ine on c.tokines and sensory testing was analyzed. Results: MV-Sham showed an inc.ease in IL-1β and TNF-α, and MV- c.I-lido inc.eased levels of Kc.c.mpared with MV on day 0. No differenc. in c.tokine levels was observed on day 16. NOL of the left paw versus the right was inc.eased in MV-c.I on day 7, and in MV-c.I-lido on day 7 and 16. The NOL of the left paw was dec.eased in MV-sham and MV-c.I-lido c.mpared with MV-c.I on day 16. The c.T of the left paw was inc.eased for MV-c.I on day 3 and 7, and for MV-c.I-lido on day 7. On day 16, MV-sham and MV-c.I-lido showed a dec.eased c.T of the left paw c.mpared with MV-c.I. c.nc.usion: Nerve injury and not systemic.inflammatory response seems mandatory for development of neuropathic.pain in this “two-hit” model. Lidoc.ine attenuates c.ld allodynia in mic..

关键词： Inflammation Neuropathic.Pain Allodynia Lidoc.ine Murine Model

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