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Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade

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World Journal of Gastrointestinal Oncology 2017年第9期9卷 354-362页

作者： Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros michelle W Taggart Keith Francis Fournier Department of Surgical Oncology at the University of Texas MD Anderson Cancer Center Department of Medical Oncology at the University of Texas MD Anderson Cancer Center Department of Radiology at the University of Texas MD Anderson Cancer Center Department of Pathology at the University of Texas MD Anderson Cancer Center Department of SurgicalOncology at the University of Texas MD Anderson Cancer Center

AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards *** There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms.

关键词： Hyperthermic intraperitoneal chemotherapy Pseudomyxoma peritonei Histology Grade Prognostic Outcomes

Investigation of extracted Sclerocarya birrea seed oil as a bioenergy resource for compression ignition engines

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International Journal of Agricultural and Biological Engineering 2012年第3期5卷 59-67页

作者： Ejilah robinson Abdulkadir Lukman Adisa Bello Department of Mechanical Engineering Technology Federal PolytechnicBauchiNigeria Mechanical Engineering Programme Abubakar Tafawa Balewa UniversityBauchiNigeria

Sclerocarya birrea(Marula)seed oil was extracted and characterized for its physico-chemical properties and fatty acid compositions,respectively,by using standardized laboratory methods of the Association of Official and Analytical Chemist(AOAC).The fuel and lubrication properties of marula oil were also determined by using the ASTM methods,and the oil was evaluated in terms of its antiwear,viscometrics,volatility,stability,environmental compatibility properties and energy *** was found that the high percentage of mono-unsaturated oleic acid(73.6%)provided the oiliness that makes marula oil a natural alternative to genetically modify high oleic acid sunflower oil used in biodiesel *** aggregate properties of seed oiliness as exemplified by the high oleic acid content,high saponification value(178.6 mg/KOH)and viscosity(41 mm2/s)makes marula oil to be prospective based oil for engine crank case biolubricants with antiwear and friction reduction ***,the higher oil viscosity exhibited by marula seed oil in comparison to diesel could pose some durability problems to compression ignition engines,when used directly as ***,the reduction of oil viscosity would be required by heating,blending with diesel fuel,or by transesterification to forestall the risk of engine failure resulting from the use of unmodified marula *** flash point of marula oil(235℃)is somewhat close to that of monograde SAE 40 mineral oil(240℃),and appreciably higher than that of diesel fuel(52℃).The high flash point makes the seed oil less flammable and ensures safer handling and ***,the low pour point(-13.7℃)ensures the oil usability for engines at cold start and under low load *** oxidation stability of marula oil is ascribed to the traces of natural antioxidants presented in the oil and improves the oil’s shelf life,notwithstanding the high peroxide value(4.58 mequiv/kg),and linolenic acid content(0.3%),which ought to have be

关键词： marula seed oil high oleic acid oxidation stability cetane number heating value bioenergy resource compression ignition engine

Inducible competitors and adaptive diversification

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Current Zoology 2013年第4期59卷 537-552页

作者： Beren W. robinson David W. PFENNIG Department of Integrative Biology University of Guelph Guelph Ontario N 1G 2W 1 Canada Department of Biology University of North Carolina Chapel Hill NC 27599 USA

Identifying the causes of diversification is central to evolutionary biology. The ecological theory of adaptive diversi- fication holds that the evolution of phenotypic differences between populations and species--and the formation of new spe- cies-stems from divergent natural selection, often arising from competitive interactions. Although increasing evidence suggests that phenotypic plasticity can facilitate this process, it is not generally appreciated that competitively mediated selection often also provides ideal conditions for phenotypic plasticity to evolve in the first place. Here, we discuss how competition plays at least two key roles in adaptive diversification depending on its pattern. First, heterogenous competition initially generates heterogeneity in resource use that favors adaptive plasticity in the form of ＂inducible competitors＂. Second, once such competitively induced plas- ticity evolves, its capacity to rapidly generate phenotypic variation and expose phenotypes to alternate selective regimes allows populations to respond readily to selection favoring diversification, as may occur when competition generates steady diversifying selection that permanently drives the evolutionary divergence of populations that use different resources. Thus, competition plays two important roles in adaptive diversification---one well-known and the other only now emerging--mediated through its effect on the evolution ofphenotypic plasticity

关键词： Phenotypic plasticity Competition Adaptive radiation Character displacement Genetic assimilation Resourcepolymorphism

Key elements required to publish a good article:consensus among executive editors of Traditional Chinese Medicine and integrative medicine journals——a Delphi study

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Journal of Traditional Chinese Medicine 2015年第3期35卷 335-342页

作者： Hu Xiaoyang robinson Nicola Yu He Liu Jianping School of Health and Social Care London South Bank University School of Basic Medicine Beijing University of Chinese Medicine Centre for Evidence-Based Chinese Medicine Beijing University of Chinese Medicine

OBJECTIVE:To explore consensus among Traditional Chinese Medicine(TCM)/ integrative medicine(IM) journal executive editors in China regarding:(a)Their perceptions about the differences between papers published in Chinese/English journals;(b)the key elements required for publishing a good quality paper;(c) how editors manage and decide on the manuscripts submitted to their ***:A three classic round Delphi was conducted with a purposive sample of TCIWIM Chinese journal executive *** key themes and items generated from six open ended questions in the first round were redistributed to the editors in two subsequent questionnaire rounds and scored on a five-point Likert ***,reliability and stability of responses were assessed between the editors in the same round and between ***:All ten editors initially agreeing to participate completed the three rounds,provided 60 comments in the first round,relating to 6 themes on:elements of publishing good quality article;differences between Chinese and English published articles;reasons for low quality of Chinese studies;maintaining the journal's good reputation;initiatives and strategies;and differences between Chinese and English versions of the same *** levels of consensus were reached for 97%***-class correlation(ICC) coefficient for agreement among editors was high in both second and third round and there was a good stability between the two ***:High inter/intra-editor agreement was identified in the differences between TCM/IM research papers published in English and *** standards and probity are keys in elevating the reputation of ***' perspectives in maintaining and improving quality journal can be viewed as fundamental for editors and researchers in publishing any articles.

关键词： Medicine,Chinese Traditional Integrative medicine Delphi Publication quality Editors' perspectives

Determining the mechanism behind yoga’s effects on preventing the symptoms of Alzheimer’s disease

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Neural Regeneration Research 2020年第2期15卷 261-262页

作者： Adithy Hassan Meghan robinson Stephanie M. Willerth Division of Medical Sciences 3800 Finnerty RoadUniversity of VictoriaVictoriaBritish ColumbiaCanada The Vancouver Prostate Centre VancouverBritish ColumbiaCanada Department of Mechanical Engineering University of VictoriaVictoriaBritish ColumbiaCanadaCentre for Biomedical ResearchUniversity of VictoriaVictoriaBritish ColumbiaCanadaInternational Collaboration on Repair DiscoveriesUniversity of British ColumbiaVancouverBritish ColumbiaCanada

Background on the relationship between meditation/yoga practice and its effect on Alzheimer's disease (AD): Dementia refers to a variety of conditions that affect the normal function of the brain, leading to symptoms like memory loss, issues with problem solving, difficulty in processing thoughts and disordered language (McKhann et al., 2011).

关键词： effects yoga Alzheimer's disease

Ground of a Theory:The Language Codes of Roland Barthes and American Critical Structuralism

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Language and Semiotic Studies 2021年第1期7卷 79-106页

作者： John Timothy robinson The Woven Tale Press

This paper is an application of Johnathan Culler’s Structuralist Poetics from 1975 combined with the language codes of Roland Barthes which he developed in his study of S/Z to the close reading of ***’s main argument is that there must be another strategy combined with all major approaches in Structuralist thought in that time *** answer to this problem was to develop a set of strategies or concepts to compensate for the reader in the analysis of literary works.I outline in this essay my approach based on the language codes of Roland Barthes:semantic,symbolic,cultural-referential,actional and *** a brief discussion of my understanding and contextualization of Structuralism today for this particular genre application,I apply the concepts to a reading of the famous William Carlos Williams’poem,"The Red Wheelbarrow"as a test-case application of the concepts.

关键词： poetry literary theory Structuralism poetics

Exploration of channel width scaling and edge states in transition metal dichalcogenides

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Nano Research 2018年第4期11卷 1768-1774页

作者： Feng Zhang Chia-Hui Lee Joshua A. robinson Joerg Appenzeller Department of Electrical and Computer Engineering Brick Nanotechnology Center Purdue University West Lafayette IN 47907 USA Department of Materials Science and Engineering The Pennsylvania State University University Park PA 16802 USA

We explore the impact of edge states in three types of transition metal dichalcogenides （TMDs）, namely metallic Td-phase WTe2 and semiconducting 2H-phase MoTe2 and MoS2, by patterning thin flakes into ribbons with varying channel widths. No obvious charge depletion at the edges is observed for any of these three materials, in contrast to observations made for graphene nanoribbon devices. The semiconducting ribbons are characterized in a three-terminal field-effect transistor （FET） geometry. In addition, two ribbon array designs have been carefully investigated and found to exhibit current levels higher than those observed for conventional one-channel devices. Our results suggest that device structures incorporating a high number of edges can improve the performance of TMD FETs. This improvement is attributed to a higher local electric field, resulting from the edges, increasing the effective number of charge carriers, and the absence of any detrimental edge-related scattering.

关键词： two-dimensional (2D)-layered materials edge states WTe2 MoTe2 MoS2 channel width scaling

Hardy spaces on Lie groups of polynomial growth

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Science China Mathematics 2010年第1期53卷 23-40页

作者： ter ELST A F M robinson Derek W Department of Mathematics University of Auckland Center for Mathematics and its Applications Mathematical Science Institute

We give several characterizations of Hardy spaces associated with complex, second-order,subelliptic operators on Lie groups with polynomial growth.

关键词： Lie groups Hardy spaces heat kernel

Functional group resolved NMR relaxation of 3-carbon adsorbates in mesoporous alumina

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Magnetic Resonance Letters 2023年第3期3卷 248-255,I0004页

作者： Neil robinson Carmine D’Agostino Michael LJohns Department of Chemical Engineering The University of Western Australia35 Stirling HighwayPerthWA 6009Australia Department of Chemical Engineering The University of ManchesterOxford RoadManchesterM139PLUK Dipartimento di Ingegneria Civile ChimicaAmbientale e Dei Materiali(DICAM)Alma Mater Studiorum e Universita di BolognaVia Terracini28Bologna40131Italy

NMR relaxation analysis provides a unique and non-invasive probe of fluid dynamics within porous materials,and may be applied to the interpretation of a wide variety of material and interfacial ***,we report two-dimensional^(1)H T_(1)-T_(2)relaxation correlation measurements of a range of three-carbon adsorbates(1-propanol,2-propanol and propanoic acid)imbibed within the mesoporous metal oxide *** data,acquired across field strengths of 2 MHz,12.7 MHz and 43 MHz,clearly reveal two populations in each measurement,identified as the alkyl and hydroxyl moieties of each *** results expand the range of materials in which such functional group resolved relaxation is known to occur,and demonstrate the clear persistence of such phenomena using a range of typical benchtop NMR systems employed to study fluid-saturated porous media.

关键词： NMR relaxation Adsorption Porous media Low-field NMR