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Subcutaneous Model for the Study of dengue Virus Infection in Immune Competent Mice

Journal of Biosciences and Medicines 2018年第5期6卷 97-110页

作者： Beatriz Senra Santos Natalia Lima pessoa Natalia Lucinda Gustavo Cardoso de Oliveira Thais souza Silva Ketyllen Reis Andrade Ketyllen Reis Andrade Bruno Galv&atilde o Filho Marcele Neves Rocha Alexandre Vieira Machado Pedro Augusto Alves É rica Alessandra Rocha Alves Erna Geessien Kroon Marco Antô nio Campos Instituto René Rachou Funda&amp amp ccedil & amp atilde o Oswaldo Cruz Fiocruz Belo Horizonte Brazil departamento de Microbiologia Universidade Federal de Minas Gerais Belo Horizonte Brazil Empresa Brasileira de Pesquisa Agropecuá ria Laborat&amp amp oacute rio de Virologia Brasilia Brazil

Various mouse models to study dengue have been described by different authors, some of them using immunodeficient or some using humanized mice. Our group reported previously a deadly murine model, which used the intracranial inoculum of highly virulent dengue virus (deNV) in immune competent mouse. Here we present a model of immune competent mouse (C57BL/6), infected subcutaneously by the same highly virulent deNV (deNV3 genotype I). In this immunocompetent systemic mice model, the cytokine levels and hematological parameters such as total and differential leukocyte and platelets counts, together with weight loss, were considered important monitoring parameters, allowing a better understanding of the systemic human disease. Mice were inoculated subcutaneously and evaluated by the percentage weight variation as well as the clinical signs. Hematological parameters and cytokines levels were measured and viral titration in brain tissue or serum neutralization was performed to confirm mice infection. The subcutaneously deNV inoculated mice showed weight loss after infection, but they did not show any other clinical signs. The leukocytes and platelets decreased after subcutaneous inoculation. The cytokines TNF alpha and IFN gamma increased after infection in mice. The subcutaneous model provided scope for improved understanding of the dengue pathogenesis, as well as possible mechanism for protection to subsequent mouse infected by intracranial route in mice. This model could be used to study the vertebrate immune response and evaluation of drugs or vaccine against dengue virus.

关键词： Subcutaneous Murine Model dengue Disease Immune Competent Mouse Cytokines Innate Immune Response

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Energy Harvesting Based on Magnetic Dispersion for Three-Phase Power System

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Energy and Power Engineering 2013年第3期5卷 20-23页

作者： Tarcisio Oliveira de Moraes Júnior Yuri Percy Molina Rodriguez Ewerton Cleudson de Sousa Melo Maraiza Prescila dos Santos Cleonilson Protásio de souza Federal Institute of Paraíba-IFPB CajazeirasBrazil department of Electrical Engineering Federal University of Paraíba-UFPBJoao PessoaBrazil

This paper presents a comparative study on Magnetic-Dispersion based Energy Harvesting Systems (MD-EHS) on electrical conductors that supply power for a three-phase AC motor. It introduces two MD-EHS which are based on magnetic cores of different material, named, nanocrystalline, ferrite and iron powder. The first one consists of harvesting energy from magnetic flux through three symmetrical magnetic cores installed on each power conductors of a three-phase AC motor. The second one consists of a single magnetic core for harvesting energy from magnetic flux of only one of these conductors. Both ones have an AC/DC converter and a variable resistor based load. Experimental results have agreed with the theoretical analysis and show that the first proposed MD-EHS is capable of supplying 14 times more energy than the second MD-EHS, considering nanocrystalline cores and phase current of 3 A, and 7.5 times more energy, considering ferrite cores and phase current of 9 A. Such energy can be applied to various low-power devices, especially in wireless sensor network.

关键词： Energy Harvesting Magnetic Dispersion Magnetic Cores

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Pressure Ulcers in Institutionalized Elderly People:Association of Sociodemographic and Clinical Characteristics and Risk Factors

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Open Journal of Nursing 2017年第1期7卷 111-122页

作者： Suellen Duarte de Oliveira Matos Iraktania Vitorino Diniz Adriana Lira Rufino de Lucena Smalyanna Sgren da Costa Andrade Karen Krystine Goncalves de Brito Elizabeth souza Silva de Aguiar Emanuelle Malzac Freire de Santana Mailson Marques de Sousa Ana Paula Marques Andrade de souza Hemílio Fernandes Campos Coelho Mirian Alves da Silva Marta Miriam Lopes Costa Maria Julia Guimaraes Oliveira Soares Simone Helena dos Santos Oliveira Graduate Program in Nursing Universidade Federal da ParaíbaJoao PessoaBrazil departament of Statistics Universidade Federal da ParaíbaParaíbaBrazil

Objective: To evaluate the association of socio-demographic and clinical characteristics, and risk factors with occurrence of pressure ulcers in institutionalized elderly people. Method: This cross-sectional, analytical study, in quantitative approach, performed from the database analysis linked to the project “Pressure Ulcer in institutionalized elderly people: Association of incidence with the risk factors to functional and nutritional assessment” developed in six long-stay institutions for the elderly people in João pessoa. Data were analyzed using the Statistical Package for Social Sciences (SPSS) version 20.0. Associations were made through chi square test and Odds Ratio. Results: The clinical conditions of significant associations with the occurrence of pressure ulcers were the variables neurological disorders (p = 0.011) and visual impairment (p = 0.005). As for risk factors, the most important was fecal incontinence (p Conclusion: The analysis of the associations pointed out problems that require intervention in order to prevent health implications of the elderly people and to minimize the risk and occurrence of this injury.

关键词： Elderly People Institutions for the Elderly People Pressure Ulcer Health Profile Risk Factors

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Integration of Fogo Player and SAGE (Scalable Adaptive Graphics Environment) for 8K UHD Video Exhibition

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Journal of Computer and Communications 2014年第12期2卷 50-55页

作者： Jane de Almeida Guido Lemos de souza Filho Carlos Eduardo Coelho Freire Batista Lucenildo Lins de Aquino Junior Jose Ivan Vilarouca Filho Manoel Silva Neto Cicero Inacio da Silva Leandro Ciuffo Iara Machado Clayton Reis da Silva Laboratory of Cinematic Arts and Visualization (LabCine) Mackenzie Presbyterian University S&atildeo Paulo Brazil Laboratory of Digital Video Applications (LAVID) Federal University of Paraíba (UFPB) Jo&atildeo Pessoa Brazil Telehealth Program Federal University of S&atildeo Paulo (UNIFESP) S&atildeo Paulo Brazil The National Education and Research Network (RNP) Rio de Janeiro Brazil

After 4K, 8K UHD resolution can be considered the new challenge for film, visualization and television. Due to the dimension of 8K image, the remote micro and macro images are considered appropriate for visualization with scientific and educational purposes. This article describes the implementation of the 8K video plug-in to play UHD videos into the SAGE, a collaborative environment for the advancement of scientific research and education developed by EVL (Electronic Visualization Laboratory), upgrading its current resolution for video playing. It also presents the challenges of producing 8K content, the development of the code and introduces the features to view 8K ultra high definition videos in multiple tiles through the use of low cost computer clusters. The SAGE 8K video plug-in implementation was made possible because of the previous development of the Fogo Player, a system to run 4K and 8K content. The results were successfully presented at the CineGrid International Workshop 2013 in San Diego.

关键词： 8K Ultra High definition Fogo Player Visualization SAGE UHD CineGrid

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Enteroparasitoses in Patients with Rheumatoid Arthritis

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Advances in Infectious Diseases 2017年第4期7卷 143-152页

作者： Ana Paula Monteiro Gomides Alex Luiz de Oliveira Pires Cleandro Pires Albuquerque Talita Yokoy de souza Luciana Muniz Caliandra Maria Bezerra Luna Lima Leopoldo Luiz Santos-Neto Licia Maria Henrique da Mota Universidade de Brasília (UnB) Brasília Brazil Universidade Federal da Paraíba Jo&#227 o pessoa Brazil

Background: Patients with rheumatic diseases have profound alterations in the immune system as a result of underlying diseases and the treatments used, which increases the risk of occurrence and severity of infections, including enteroparasitosis. The current treatment for rheumatoid arthritis involves immunosuppressive therapies powerfully needed for screening infectious processes. The prevalence of parasitic infections in rheumatoid arthritis patients is not currently documented in literature. The objective of the current study was to determine the prevalence of parasitic diseases in a population with RA. Methods: We collected demographic and socioeconomic data from 67 patients at the Hospital Universitário de Brasília from July 2015 to April 2016. All patients underwent a parasitological examination of their stool and multiple variables were analyzed using Poisson regression method. Results: The mean age of patients was 53.9 years. They were predominantly in women (94%) and caucasian (47.8%). The mean disease duration was 9.2 years and most patients had the disease in remission or light activity. The prevalence of parasitic infections in these patients was 11.9%, all cases being that of protozoa of the following species: Endolimax nana, Entamoeba histolytica and Entamoeba coli. The final multivariate analysis indicated that the presence of disease had a significant statistical relationship between the presence of enteroparasitosis and rheumatoid arthritis with no fatigue by VAS (p = 0.0488) and best current health index by VAS (p = 0.0012). Conclusion: This study indicates that the prevalence of enteroparasitoses in a population with Rheumatoid Arthritis was 11.9% and all cases were found of protozoa.

关键词： Parasitic Infections Rheumatoid Arthritis Protozoosis Enteroparasitoses Intestinal Infection

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Motor speed estimation and failure detection of a small UAV using density of maxima

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Frontiers of Information Technology & Electronic Engineering 2021年第7期22卷 1002-1009页

作者： Jefferson S.souza Moises C.BEZERRIL Mateus A.SILVA Frank C.VERAS Abel LIMA-FILHO Jorge Gabriel RAMOS Alisson V.BRITO Laboratory of System Engineering and Robotics Federal University of ParaibaJoao PessoaBrazil department of Information Systems Federal University of PiauiPicosBrazil department of Mechanical Engineering Federal University of ParaibaJoao PessoaBrazil department of Physics Federal University of ParaibaJoao PessoaBrazil

This work presents the application of the technique named signal analysis based on chaos using density of maxima to analyze brushless direct current *** uses a correlation coefficient estimated from the density of maxima of the current *** study demonstrates in experiments the speed estimation of a brushless motor on a testbench and failure detection in a small flying *** experimental results demonstrate that it is possible to estimate the speed in 97.8%of the cases and to detect failure in 82.75%of the analyzed cases.

关键词： Unmanned aerial vehicle(UAV) Speed identification Failure detection Chaos

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DNA Vaccines Approach:From Concepts to Applications

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World Journal of Vaccines 2014年第2期4卷 50-71页

作者： Vanessa Bastos Pereira Meritxell Zurita-Turk Tessalia Diniz Luerce Saraiva Camila Prosperi de Castro Bianca Mendes souza Pamela Mancha Agresti Fernanda Alvarenga Lima Vanessa Nathalie Pfeiffer Marcela Santiago Pacheco Azevedo Clarissa Santos Rocha Daniela Santos Pontes Vasco Azevedo Anderson Miyoshi Laboratorio de Genetica Celular e Molecular Instituto de Ciencias BiologicasUniversidade Federal de Minas Gerais(UFMG)Belo HorizonteBrazil Universidade Estadual da Paraiba(UEPB) Joao PessoaBrazil

DNA vaccines are the third generation vaccines based on purified plasmid preparations containing transgenes that encode antigenic/therapeutic proteins or peptides capable of triggering an immune response against a wide range of diseases. This vaccine platform presents several attributes that confer distinct advantages over other vaccine technologies in terms of safety, ease of fabrication and stability. Many aspects, such as antigen expression and especially vector design, are under study because of their great influence on immunogenicity and efficacy of DNA vaccines. In this regard, with the attempt of improving the efficiency of DNA vaccines, co-expression of stimulatory sequences and diverse vector delivery systems are being optimized. With this in mind, this review aims to giving a conceptual approach of DNA vaccines, explaining their mechanisms of action and listing the already licensed veterinary DNA vaccines presented in the market.

关键词： DNA Vaccines Vector design delivery Systems Approved DNA Vaccines Bacterial delivery

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Unraveling oral psoriasis and its relationship with geographic tongue: A literature review

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World Journal of dermatology 2016年第2期5卷 84-92页

作者： Bruna Lavinas Sayed Picciani Thays Teixeira-souza áquila Almenara Curty Lívia Maria Santos Izahias Thiago Moreira pessoa Sueli Carneiro Heron Fernando Sousa Gonzaga Eliane Pedra Dias Postgraduate Program in Pathology School of MedicineFluminense Federal University Sector of dermatology Medical Clinic DepartmentFederal of Rio de Janeiro University department of dermatology Medical School

Differentiating between oral psoriasis and geographic tongue is difficult and controversial because some patients with geographic tongue do not necessarily have psoriasis. Furthermore, the number of clinical studies, reporting histopathological and genetic evidence for the definitive diagnosis of oral psoriasis, is limited. The aim of this literature review was to obtain data for supporting the diagnosis of oral psoriasis with particular emphasis on the relationship between psoriasis and geographic tongue. Based on the current data, it can be concluded that geographic tongue is the most common oral lesion in psoriasis, and histopathological, immunohistochemical, and genetic similarities have been observed between the two diseases. This review also emphasizes the importance of conducting oral examinations in patients with psoriasis and skin examinations in patients with geographic tongue.

关键词： Psoriasis Geographic tongue Oral psoriasis Benign migratory glossitis

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Punica granatum Leaf Lipophilic Fraction Favours Mortality by Attenuating Inflammation in Mice with Polymicrobial Sepsis

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Journal of Pharmacy and Pharmacology 2019年第7期7卷 355-367页

作者： Nagila Caroline Fialho Sousa Isabella Fernandes da Silva Figueiredo Mizael Calacio de Araujo Elaine Pereira de Andrade Thais Costa Alves Bruna Letícia Rosa da Silva Domingos Magno Santos Pereira Saulo JoseFigueiredo Mendes Joao Francisco Silva Rodrigues Jaqueline pessoa Pontes Simone Aparecida Teixeira AndreAlvares Marques Vale Marcus Vinicius Dias-souza Lidio Goncalves Lima-Neto Vera Lucia dos Santos Ana Paula Azevedo-Santos Marcelo Nicolas Muscara Valerio Monteiro-Neto Andrea de souza Monteiro Luis Claudio Nascimento da Silva Elizabeth Soares Fernandes Programa de Pos-graduacao Universidade CEUMARua JosueMontellon°1RenascencaSao LuisMA 65075-120Brazil departamento de Farmacologia Universidade de Sao PauloAv.Prof.Lineu Prestesn°1524Sala 326ButantanSao PauloSP 05508-900Brazil Programa de Pos-graduacao em Ciências em Saude Universidade Federal do MaranhaoAvenida dos Portuguesesn°1966BacangaSao LuisMA 65080-805Brazil departamento de Microbiologia Universidade Federal de Minas GeraisAv.Antonio Carlosn°6627PampulhaBelo HorizonteMG 31270-901Brazil departamento de Patologia Universidade Federal do MaranhaoAvenida dos Portuguesesn°1966BacangaSao LuísMA 65080-805Brazil

Punica granatum *** known antimicrobial and anti-inflammatory *** of different parts of this plant have been commonly used in the folk medicine to prevent and treat infections;and studies have supported the use of *** extracts for this ***,little is known of the effects of ***-derived fractions in severe infectious diseases such as ***,we investigated the actions of the hexane fraction(HF),rich in lipophilic compounds,obtained from the leaves of this plant,in a murine model of polymicrobial *** pre-treatment with HF increased mortality in septic *** same animals presented with lower levels of interleukin-6,nitric oxide and hydrogen peroxide in their peritoneal lavage samples than vehicle *** also increased polymorphonuclear cell accumulation in to the peritoneum of mice with ***-derived nitric oxide upon lipopolysaccharide stimuli was markedly reduced by incubation with ***,triterpenes,phytosterols,vitamin E and ascorbyl palmitate were detected in the *** results indicate that *** leaf lipophilic fractions may worsen sepsis *** effect may be associated with its bioactive compounds which act synergistically or not,increasing sepsis mortality in vivo.

关键词： P.granatum infection inflammation

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