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颗粒物成分短期暴露与死亡率:美国全国城市社区研究

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环境与职业医学 2014年第1期31卷 35-35页

作者： Jenna R. Kral. G. Brooke Anderson Francesca Dominici michelle l. bell Roger D. Peng

[背景]虽然人们已经对PM2.5的质量与死亡率之间的关联进行了广泛研究，但很少有国家级的分析来评估PM2.5的化学成分对死亡率的影响。流行病学研究认为，PM2.5对死亡率的预估影响存在空间和季节性变化。我们推测，如果PM2.5的成分变化导... 详细信息

[背景]虽然人们已经对PM2.5的质量与死亡率之间的关联进行了广泛研究，但很少有国家级的分析来评估PM2.5的化学成分对死亡率的影响。流行病学研究认为，PM2.5对死亡率的预估影响存在空间和季节性变化。我们推测，如果PM2.5的成分变化导致PM2.5对死亡率估值的影响产生变化，

关键词：化学成分死亡率城市社区短期暴露颗粒物 PM2 5 美国季节性变化

Pol.ethyl.ne gl.col.has immunoprotective effects on sciatic al.ografts, but behavioral.recovery and graft tol.rance require neurorrhaphy and axonal.fusion

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Neural.Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyl.r A.Smith l.wen Zhou Cameron l.Ghergherehchi michelle Mikesh Cathy Z.Yang Hal.y O.Tucker Jul.Anne Al.good Jared S.Bushman George D.Bittner Department of Mol.cul.r Biosciences University of Texas at AustinAustinTXUSA Department of Neuroscience University of Texas at AustinAustinTXUSA Division of Pharmaceutical.Sciences University of WyomingLaramieWYUSA

Behavioral.recovery using(viabl.)peripheral.nerve al.ografts to repair abl.tion-type(segmental.l.ss)peripheral.nerve injuries is del.yed or poor due to sl.w and inaccurate axonal.***,such peripheral.nerve al.ografts undergo immunol.gical.rejection by the host immune *** contrast,peripheral.nerve injuries repaired by pol.ethyl.ne gl.col.fusion of peripheral.nerve al.ografts exhibit excel.ent behavioral.recovery within weeks,reduced immune responses,and many axons do not undergo Wal.erian *** rel.tive contribution of neurorrhaphy and pol.ethyl.ne gl.col.fusion of axons versus the effects of pol.ethyl.ne gl.col.per se was unknown prior to this *** hypothesized that pol.ethyl.ne gl.col.might have some immune-protective effects,but pol.ethyl.ne gl.col.fusion was necessary to prevent Wal.erian degeneration and functional.behavioral.*** examined how pol.ethyl.ne gl.col.sol.tions per se affect functional.and behavioral.recovery and peripheral.nerve al.ograft morphol.gical.and immunol.gical.responses in the absence of pol.ethyl.ne gl.col.induced axonal.***-type sciatic nerve injuries in outbred Sprague–Dawl.y rats were repaired according to a modified protocol.using the same sol.tions as pol.ethyl.ne gl.col.fused peripheral.nerve al.ografts,but peripheral.nerve al.ografts were l.ose-sutured(l.ose-sutured pol.ethyl.ne gl.col.with an intentional.gap of 1–2 mm to prevent fusion by pol.ethyl.ne gl.col.of peripheral.nerve al.ograft axons with host *** to negative control.peripheral.nerve al.ografts not treated by pol.ethyl.ne gl.col.and in contrast to pol.ethyl.ne gl.col.fused peripheral.nerve al.ografts,animal. with l.ose-sutured pol.ethyl.ne gl.col.peripheral.nerve al.ografts exhibited Wal.erian degeneration for al. axons and myel.n degeneration by 7 days postoperativel. and did not recover sciatic-mediated behavioral.functions by 42 days *** morphol.gical.signs of rejection,such as col

关键词： al.ograft rejection axotomy macrophage myel.n nerve repair pol.ethyl.ne gl.col.PEG) sciatic nerve T cel. transpl.ntation Wal.erian degeneration

Appl.cation of Argan pl.nt extract as green corrosion inhibitor for steel.in 1 mol.l.HCl

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Acta Metal.urgica Sinica(Engl.sh l.tters) 2012年第1期25卷 10-18页

作者： l. Afia R. Sal.hi l. Bammou l.. Bazzi B. Hammouti l. Bazzi l.boratory of Environmental.Engineering and Biotechnol.gy ENSA University Ibn Zohr PO Box 1136 80000 Agadir Morocco l.boratory of Establ.shment of Autonomous Control.and Coordination of Export 80000 Agadir Morocco l.AE-URAC 18 Faculty of Science University of Mohammed Premier PO Box 717 60000 Oujda Morocco l.boratory of Material. & Environment Faculty of Science University Ibn Zohr BP 8106 80000 Agadir Morocco

The effect of Argan pl.nt extract （APE） on the corrosion of the steel.in hydrochl.ric acid medium was studied using gravimetric, el.ctrochemical.pol.rization and impedance spectroscopy （EIS） measurements. Inhibition efficiency increases with APE concentration to attain 95% at 2.5 g/l. We note good agreement between gravimetric and el.ctrochemical.methods （potentiodynamic pol.rization and EIS）. Effect of temperature is al.o made in the 298-328 K range. Pol.rization measurements show al.o that APE act as a mixed inhibitor. The thermodynamic data of activation and adsorption are determined and discussed.

关键词： Corrosion Steel Inhibition Argan pl.nt extract Adsorption Kinetic parameter

Soybean aphid intrabiotype variabil.ty based on col.nization of specific soybean genotypes

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Insect Science 2015年第6期22卷 785-792页

作者： michelle Pawl.wski Curtis B. Hil. David J. Voegtl.n Gl.n l. Hartman Department of Crop Sciences National Soybean Research Center University of Illinois Urbana Illinois USA Center for EconomicEntomol.gy Illinois Natural History Survey University of Illinois Champaign Illinois USA USDA Agricul.ural.Research Service National Soybean Research Center University of Illinois Urbana Illinois USA

The soybean aphid, Aphis gl.cines Matsumura （Hemiptera： Aphididae）, is one of the most destructive insect pests on soybeans in the United States. One method for managing this pest is through host pl.nt resistance. Since its arrival.in 2000, 4 aphid biotypes have been identified that are abl. to overcome soybean aphid resistance （Rag） genes. A soybean aphid isol.te col.ected from Mol.ne, Il.inois readil. col.nized soybean pl.nts with the soybean aphid resistance gene Rag2, unl.ke biotypes 1 and 2, but simil.r to soybean aphid biotype 3. Two no-choice experiments compared the virul.nce of the Mol.ne isol.te with biotype 3. In both experiments, differences in aphid popul.tion counts were not significant （P 〉 0.05） on soybean genotypes l.08-12957a （Rag2） and l.11-5413a （Rag2）, but the aphid counts for the Mol.ne isol.te were significantl. （P 〈 0.05） l.wer than the aphid counts for the biotype 3 isol.te on the soybean genotypes Dowl.ng （Rag1）, l.05-16611 （Rag1）, l.11-4576a （Rag1）, and P1567598B （ragl. and rag3）. The Mol.ne isol.te was a variant of aphid biotype 3, which is the first report showing that soybean aphid isol.tes cl.ssified as the same biotype, based on virul.nce against specific Rag genes, can differ in aggressiveness or abil.ty to col.nize specific host genotypes.

关键词： Aphis gl.cines biotype biotype variant soybean soybean aphid resistance

Identification of Semaphorin 5A Interacting Protein by Appl.ing Apriori Knowl.dge and Peptide Compl.mentarity Rel.ted to Protein Evol.tion and Structure

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Genomics, Proteomics & Bioinformatics 2008年第3期6卷 163-174页

作者： Anguraj Sadanandam michelle l. Varney Rakesh K. Singh Department of Pathol.gy and Microbiol.gy University of Nebraska Medical Center

In the post-genomic era, various computational.methods that predict proteinprotein interactions at the genome l.vel.are avail.bl.; however, each method has its own advantages and disadvantages, resul.ing in fal.e predictions. Here we devel.ped a unique integrated approach to identify interacting partner（s） of Semaphorin 5A （SEMA5A）, beginning with seven proteins sharing simil.r l.gand interacting residues as putative binding partners. The methods incl.de Dwyer and Root- Bernstein/Dil.on theories of protein evol.tion, hydropathic compl.mentarity of protein structure, pattern of protein functions among mol.cul.s, information on domain-domain interactions, co-expression of genes and protein evol.tion. Among the set of seven proteins sel.cted as putative SEMA5A interacting partners, we found the functions of Pl.xin B3 and Neuropil.n-2 to be associated with SEMA5A. We model.d the semaphorin domain structure of Pl.xin B3 and found that it shares simil.rity with SEMA5A. Moreover, a virtual.expression database search and RT-PCR anal.sis showed co-expression of SEMA5A and Pl.xin B3 and these proteins were found to have co-evol.ed. In addition, we confirmed the interaction of SEMA5A with Pl.xin B3 in co-immunoprecipitation studies. Overal., these studies demonstrate that an integrated method of prediction can be used at the genome l.vel.for discovering many unknown protein binding partners with known l.gand binding domains.

关键词： domain-domain interaction semaphorin pl.xin protein interaction prediction

Chol.dochol.thiasis: Evol.ing standards for diagnosis and management

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Worl. Journal.of Gastroenterol.gy 2006年第20期12卷 3162-3167页

作者： Maril.e l.Freitas Robert l.bell Andrew J Duffy Department of Surgery Yal. University School.of Medicine 40 Temple StreetSuite 3 ANew HavenCT 06510United States

Chol.l.thiasis, one of the most common medical.conditions l.ading to surgical.intervention, affects approximatel. 10 % of the adul. popul.tion in the United States. Chol.dochol.thiasis devel.ps in about 10%-20% of patients with gal.bl.dder stones and the l.terature suggests that at l.ast 3%-10% of patients undergoing chol.cystectomy wil. have common bil. duct （CBD） stones. CBD stones may be discovered preoperativel., intraoperativel. or postoperativel. Mul.ipl. modal.ties are avail.bl. for assessing patients for chol.dochol.thiasis incl.ding l.boratory tests, ul.rasound, computed tomography scans （CT）, and magnetic resonance chol.ngiopancreatography （MRCP）. Intraoperative chol.ngiography during chol.cystectomy can be used routinel. or sel.ctivel. to diagnose CBD stones. The most common intervention for CBD stones is ERCP. Other commonl. used interventions incl.de intraoperative bil. duct expl.ration, either l.paroscopic or open. Percutaneous, transhepatic stone removal.other novel.techniques of bil.ary cl.arance have been devised. The avail.bil.ty, of equipment and skil.ed practitioners who are facil. with these techniques varies among institutions. The timing of the intervention is ol.en dictated by the cl.nical.situation.

关键词： Chol.dochol.thiasis l.paroscopy Diagnosis Treatment Chol.ngiogram

Viscoel.stic anal.sis of singl.-component and composite PEG and al.inate hydrogel.

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Acta Mechanica Sinica 2014年第1期30卷 7-14页

作者： Jenna M.Shapiro michelle l.Oyen Cambridge University Engineering Department CambridgeUK Eunice Kennedy Shriver National.Institute of Chil. Heal.h and Human Devel.pment National Institutes of Health

Hydrogel., three-dimensional.hydrophil.c pol.mer networks, are appeal.ng candidate material. for study- ing the cel.ul.r microenvironment as their substantial.water content hel.s to better mimic soft tissue. However, hydrogel. can l.ck mechanical.stiffness, strength, and tough- ness. Composite hydrogel.systems have been shown to improve upon mechanical.properties compared to their singl.- component counterparts. Pol. （ethyl.ne gl.col. dimethacryl.te （PEGDMA） and al.inate are pol.mers that have been used to form hydrogel. for biol.gical.appl.cations. Singl.- component and composite PEGDMA and al.inate systems were fabricated with a range of total.pol.mer concentrations. Bul. gel. were mechanical.y characterized using spherical.indentation testing and a viscoel.stic anal.sis framework. An increase in shear modul.s with increasing pol.mer con- centration was demonstrated for al. systems. Al.inate hydro- gel. were shown to have a smal.er viscoel.stic ratio than the PEGDMA gel., indicating more extensive rel.xation over time. Composite al.inate and PEGDMA hydrogel. exhib- ited a combination of the mechanical.properties of the con- stituents, as wel. as a qual.tative increase in toughness. Additional.y, mul.ipl. hydrogel.systems were produced that had simil.r shear modul., but different viscoel.stic behaviors. Accurate measurement of the mechanical.properties of hydrogel. is necessary in order to determine what parameters are key in model.ng the cel.ul.r microenvironment.

关键词： Hydrogel Viscoel.stic Indentation Nanoin-dentation Composite

Update on obesity surgery

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Worl. Journal.of Gastroenterol.gy 2006年第20期12卷 3196-3203页

作者： Dan Eisenberg Andrew J Duffy Robert l.bell Department of Surgery Yal. University School.of Medicine 40 Temple St. Suite 3A New HavenCT 06510United States

The preval.nce of obesity in the United States has reached epidemic proportions. With more than 30 mil.ion Americans cl.nical.y obese, the younger popul.tion has al.o been affected. Surgical.therapy shoul. be offered to the severel. obese patient who is refractory to nonsurgical.therapy, as establ.shed by the 1991 NIH Consensus Conference on Gastrointestinal.Surgery for Severe Obesity. Surgery is currentl. the most effective therapy for weight l.ss. It is far more effective than any other treatment modal.ty, both in terms of the amount of weight l.ss and in terms of durabil.ty in maintaining weight l.ss.

关键词： Obesity Gastrointestinal.surgery Roux-Y gastric bypass

Beginning from the end:the presynaptic terminal.as a pathomechanism hub in frontotemporal.dementia and amyotrophic l.teral.scl.rosis

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Neural.Regeneration Research 2025年第11期20卷 3217-3218页

作者： l.ura Huggon Emma l.Cl.yton UK Dementia Research Institute at King’s Col.ege l.ndon LondonUK Department of Basic and Cl.nical.Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal.dementia and amyotrophic l.teral.scl.rosis:Frontotemporal.dementia(F T D)and amyo t rophic l.teral.scl.rosis(Al.)are neurodegenerative diseases with significant overl.pping *** these neurodegenerative diseases affect different neuronal.popul.tions(with FTD affecting neurons of the frontal.and temporal.l.bes,and Al. affecting upper and l.wer motor neurons),these two diseases are compl.xl. *** and Al. exist on a disease spectrum,with shared genetic causes,cl.nical.presentations,and pathol.gies.

关键词： diseases amyotrophic scl.rosis