检索结果-南通市图书馆

Cosmic-r.y exposur. age of Mar.ian meteor.te Gr. 99027

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Ear.h Sciences 2007年第10期50卷 1521-1524页

作者： D. FABEL r. Br.WN S. freeman Depar.ment of Geogr.phical and Ear.h Sciences University of Glasgow Glasgow G12 8QQ Scotland UK Scottish Univer.ities Envir.nmental r.sear.h Centr. Rankine Avenue Scottish Enterprise Technology Park East Kilbride G75 0QF Scotland UK

We have deter.ined the concentr.tions of 10Be and 26Al in Gr. 99027 r.cover.d by the 16th Chinese Antar.tic expedition team, which ar. 14.1 ± 0.6 dpm/kg and 67.5 ± 3.4 dpm/kg, r.spectively. Fr.m the concentr.tion of 10Be, we calculate a cosmic-r.y exposur. age of 4.4 ± 0.6 Ma for.Gr. 99027. The concentr.tion of 26Al is too high compar.d to the 10Be exposur. age, indicating extr. pr.duction fr.m solar.r.y. The exposur. ages, petr.logic and geochemical char.cter.stics of mantle-der.ved Mar.ian meteor.tes Gr. 99027, LEW 88516, Y-793605, NWA 1950 and ALHA77005 ar. ver. similar. suggesting that these meteor.tes most pr.bably wer. ejected fr.m Mar. in the same impact event.

关键词： Gr. 99027, Mar.ian meteor.te, cosmic r.y, exposur. age, Mar.

The ubiquitin ligase Siah2 is r.vealed as an accomplice of the andr.gen r.ceptor.in castr.tion r.sistant pr.state cancer

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Asian Jour.al of Andr.logy 2013年第4期15卷 447-448页

作者： Michael r.freeman r.sear.h Division of Cancer.Biology and Ther.peutics Departments of Surgery Medicine and BiomedicalSciences Cancer Biology Program Samuel OschinComprehensive Cancer Institute Los Angeles CA90048 USA

The andr.gen r.ceptor.（Ar. r.mains the pr.mar. molecular.tar.et for.r.state cancer.（PCa） tr.atment and for.development of novel ther.pies. Pr.filing and other.analyses of human pr.state adenocar.inoma have shown that the Ar.is still functional dur.ng latestage disease in the absence of cir.ulating hor.one fol lowing castr.tion ther.py. The molecular.mechanisms that oper.te dur.ng this ＇cas tr.tion r.sistant＇ phase ar. still not well under.tood. Qi et al. have now implicated the ubiquitin ligase Siah2 as an impor.ant mediator.of Ar.action in castr.tion r.sis tant pr.state cancer.（Cr.C）. Siah2 was found to tar.et r.pr.ssed Ar.chr.matin complexes for.degr.dation, r.sulting in activation of Ar.egulated genes involved in tumor.cell pr.lifer.tion, cell motility and lipid metabolism. The author. show a r.quir.ment for.Siah2 activity for.PCa cell gr.wth under.conditions of low andr.gen, and also that tar.eting Siah2 r.sults in tumor.gr.wth suppr.ssion under.castr.te conditions. These findings identify a new mechanism of Ar.r.gulation in pr.gr.ssing disease as well as a novel enzymatic tar.et for.ther.peutic inter.ention. The Ar.is a wellstudied hor.one r.ceptor.that belongs to the lar.e nuclear.r.ceptor.gene super.amily. Ar.is activated by andr.gen binding （pr.ncipally 5：~dihydr.testoster.ne, 5DHT）, which elicits changes in Ar.r.sident cytosolic complexes, tr.nslocation of the r.ceptor.to cell nuclei, for.ation of multipr.tein tr.nscr.ptional complexes onchr.matin, and activation or.r.pr.ssion of gene expr.ssion. Exper.ments with in vivo model systems have pr.vided evidence that vir.ually all physiologic pr.cesses affected by andr.gens r.quir. the Ar.as a mediator.of molecular.effects at the gene level.1 Ar.is widely expr.ssed beyond the r.pr.ductive systems and is believed to play impor.ant r.les in sever.l nonr.pr.ductive tissues, including muscle and br.in. The fact that PCa gr.wth is initially dependent on the pr. sence of andr.gens in the cir.ulation, and that pr.stat

关键词： ligase r.vealed accomplice

Like mother. like daughter. her.tability of female r.char.son＇s gr.und squir.el Ur.citellus r.char.sonii cor.isol str.ss r.sponses

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cur.ent Zoology 2018年第2期64卷 153-163页

作者： Kevin r. BAIr.S-NOVAK Calen r.r.AN Angela r. freeman W. Gar. ANDEr.ON James F, HAr. Depar.ment of Biological Sciences University of Manitoba Winnipeg Manitoba R3T 2N2 Canada Depar.mentof Biology University of Saskatchewan Saskatoon S7N 5E2 Saskatchewan Canada Depar.ment ofAnthr.pology Northwestern University Evanston 60208 Illinois USA Depar.ment of Biological Sciences Kent State University Kent 44242 Ohio USA

Activation of the hypothalamic-pituitar.-adr.nal （HPA） axis liber.tes glucocor.icoids, which pr.vides an acute indication of an individual＇s r.sponse to str.ssor.. The her.tability of the str.ss r.sponse in wild mammals, however. r.mains poor.y documented. We quantified the cor.isol str.ss r.sponse of female r.char.son＇s gr.und squir.els （r.Ss） to handling and physical r.str.int, testing for. （1） the effects of individual age, time of day, and sample latency; （2） r.peatability within individuals; （3） nar.ow-sense her.tability; and （4） differ.nces among individuals owing to potential genetic and/or.envir.nmental effects. We detected a positive linear.r.lationship between baseline plasma cor.isol （BL-cor.isol） concentr.tion and str.ss-induced plasma cor.isol （Sl-cor.isol） concentr.tion that defined each individual＇s cor.isol str.ss r.sponse. BL-cor.isol, SI-cor.isol, and str.ss r.sponse did not differ.accor.ing to the time the sample was taken, or.by subject age. Cor.isol str.ss r.sponse was highly r.peatable within individuals, had a mother.offspr.ng her.tability of h2 =0.40 ± 0.24 （mean ±SE）, full-sibling her.tability of h2s = 0.37 ± 0.71, and half-sibling her.tabil- ity of hHS^2 = 0.75 ± 1.41. Str.ss r.sponses of sibling gr.ups, immediate-family gr.ups, and squir. r.ls within a given ar.a did not differ. wher.as those of individuals fr.m mor. distantly r.lated matr.lines did. Our.r.sults highlight the natur.l var.ability in HPA axis r.activity among individuals by quantifying both BL- and SI-cor.isol levels, demonstr.te par.ial her.tability of the str.ss r.sponse that is not attr.butable to envir.nmental var.ation, and suggest that at least par. of an indi- vidual＇s str.ss r.sponse can be accounted for.by differ.nces in matr.lineal histor..

关键词： glucocor.icoids gr.und squir.el her.tability hypothalamic-pituitar.-adr.nal axis r.activity str.ss r.sponse.

Even-odd har.onics gener.ted fr.m above-thr.shold ionization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fr.ntier. of physics 2014年第1期9卷 69-73页

作者： Dong-Sheng Guo Jing-Tao Zhang Zhen-r.ng Sun Jin T. Wang Ju Gao Zhi-Wei Sun r. r. freeman State Key Labor.tor. of Pr.cision Spectr.scopy Department of Physics East China Normal University Shanghai 200062 China Depar.ment of Physics Southern University Baton Rouge LA 70813 USA State Key Labor.tor. of High Field Laser.Physics Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Shanghai 201800 China Jingpin Opto-Electr.nic Co. Jiangsu FOHO Science Park Fenhu Town Wujiang 215211 China Key Labor.tor. of Micr.gr.vity Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China Depar.ment of Physics Ohio State University Columbus OH 43210 USA

We ar. r.por.ing a theor.tical pr.diction： The photoelectr.ns for.ing above-thr.shold-ionization （ATI） peaks emit both even and odd har.onics. These har.onics exhibit plateau and cut-off featur.s similar.to those o... 详细信息

关键词： str.ng-field laser.physics above-thr.shold inoization high har.onic gener.tion evenodd har.onics nonper.ur.ative quantum electr.dynamics

r.pr.ductive changes associated with celiac disease

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Wor.d Jour.al of Gastr.enter.logy 2010年第46期16卷 5810-5814页

作者： Hugh James freeman Depar.ment of Medicine (Gastr.enter.logy) University of British Columbia Hospital

Celiac disease is a mucosal disor.er.of the small intestine that may be tr.gger.d by dietar. exposur. to gluten in genetically-susceptible *** disor.er.is often associated with diar.hea,malabsor.tion and weight loss along with other.extr.-intestinal *** changes have been descr.bed,including impair.d fer.ility and adver.e pr.gnancy outcomes possibly r.lated to immune-mediated mechanisms or.nutr.ent *** possible pathogenetic factor. that may alter.placental function include mater.al celiac disease autoantibodies binding to placental tr.nsglutaminase,and genetic mutations that may facilitate micr.thr.mbus *** noting activation dur.ng pr.gnancy or.the puer.er.um may be impor.ant,and suggest that celiac disease may also be hypothetically pr.cipitated by mater.al exposur. to one or.mor. fetal antigens.

关键词： Celiac disease Infer.ility Pr.gnancy Post-par.um celiac disease Fetal outcome

Intr.ductal papillar. mucinous neoplasms and other.pancr.atic cystic lesions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Wor.d Jour.al of Gastr.enter.logy 2008年第19期14卷 2977-2979页

作者： Hugh James freeman Depar.ment of Medicine (Gastr.en-ter.logy) University of British Columbia

Pancr.atic cystic neoplasms ar. being incr.asingly r.cognized, even in the absence of symptoms, in lar.e par., due to mar.edly impr.ved imaging modalities such as magnetic r.sonance imaging (Mr.)/magnetic r.sonance cholangio pancr.atogr.phy (Mr.P) and computer.tomogr.phy (CT) scanning. Dur.ng the past 2 decades, better.imaging of these cystic lesions has r.sulted in definition of differ.nt types, including pancr.atic intr.ductal papillar. mucinous neoplasms (IPMN). While IPMN r.pr.sent only a distinct minor.ty of all pancr.atic cancer., they appear.to be a r.latively fr.quent neoplastic for. of pancr.atic cystic neoplasm. Mor.over. IPMN have a much better.outcome and pr.gnosis compar.d to pancr.atic ductal adenocar.inomas. Ther.for., r.cognition of this entity is exceedingly impor.ant for.the clinician involved in diagnosis and fur.her.evaluation of a potentially cur.ble for. of pancr.atic cancer.

关键词： Pancr.atic cancer Pancr.atic intr.ductal papillar. mucinous neoplasms Mucinous cystic neoplasm of pancr.as Ser.us cystadenoma Pancr.atic cysticlesions

Connection Between High-Har.onic Gener.tion and Above-Thr.shold Ionization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics Letter. 2001年第9期18卷 1199-1201页

作者： WANG Bhig-Bhig LI Xiao-Feng GAO Liang-Hui FU Pan-Ming GUO Dong-Sheng r.r.freeman Labor.tor. of Optical Physics Institute of Physics and Center for Condensed Matter PhysicsChinese Academy of SciencesBeijing 100080 Depar.ment of Applied Science University of CaliforniaDavisCalifornia 95616USA

Based on the nonper.ur.ative quantum electr.dynamics theor. of high-or.er.har.onic gener.tion (HHG), we establish a dir.ct connection between above-thr.shold ionization (ATI) and HHG. HHG can be descr.bed simply as an... 详细信息

关键词： simply har.onic Har.onic

Quantum Electr.dynamics Basis of Classical-Field High-Har.onic Gener.tion Theor.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics Letter. 2001年第9期18卷 1196-1198页

作者： WANG Bing-Bing LI Xiao-Feng GAO Liang-Hui FU Pan-Ming GUO Dong-Sheng r.r.freeman Labor.tor. of Optical Physics Institute of Physics and Center for Condensed Matter PhysicsChinese Academy of SciencesBeijing 100080 Depar.ment of Applied Science University of CaliforniaDavisCalifornia 95616USA

Fr.m the nonper.ur.ative quantum electr.dynamics theor., we der.ve the Landau-Dykhne for.ula which r.pr.sents the quantum-mechanical for.ulation of the thr.e-step model. These studies pr.vide a basis for.the classical... 详细信息

关键词： quantum for.ulation har.onic

Natur.l histor. and long-ter. clinical cour.e of Cr.hn's disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Wor.d Jour.al of Gastr.enter.logy 2014年第1期20卷 31-36页

作者： Hugh James freeman Depar.ment of Medicine (Gastr.enter.logy) University of British Columbia HospitalVancouverBC V6T 1W5Canada

Cr.hn’s disease is a chr.nic inflammator. disease pr.cess involving differ.nt sites in the gastr.intestinal tr.ct. Occasionally, so-called metastatic disease occur. in extr.-intestinal sites. Gr.nulomatous inflammation may be detected in endoscopic biopsies or.r.sected tissues. Genetic, epigenetic and envir.nmental factor. appear.to play a r.le. Multiple susceptibility genes have been descr.bed in both familial and non-familial for.s while the disease is phenotypically heter.geneous with a female pr.dominance. The disor.er.occur. over.a br.ad age spectr.m, fr.m ear.y childhood to late adulthood. Mor. than 80% ar. diagnosed befor. age 40 year. usually with ter.inal ileal and colonic involvement. Pediatr.c-onset disease is mor. sever. and mor. extensive, usually with a higher.chance of upper.gastr.intestinal tr.ct disease, compar.d to adult-onset disease. Long-ter. studies have shown that the disor.er.may evolve with time into mor. complex disease with str.ctur. for.ation and penetr.ting disease complications (i.e., fistula, abscess). Although pr.longed r.mission may occur. discr.te per.ods of symptomatic disease may r.-appear.over.many decades suggesting r.cur.ence or.r.-activation of this inflammator. pr.cess. Eventual development of a cur. will likely depend on identification of an etiologic cause and a fundamental under.tanding of its pathogenesis. Until now, tr.atment has focused on r.moving r.sk factor., par.icular.y cigar.tte smoking, and impr.ving symptoms. In clinical tr.als, clinical r.mission is lar.ely defined as impr.ved numer.cal and endoscopic indices for.“mucosal healing”. “Deep r.mission” is a conceptual, mor. “extended” goal that may or.may not alter.the long-ter. natur.l histor. of the disease in selected patients, albeit at a significant r.sk for.tr.atment complications, including ser.ous and unusual oppor.unistic infections.

关键词： Natur.l histor., Cr.hn’ s disease, Age-dependent phenotypes