检索结果-南通市图书馆

Antifungal activity and antidiarrheal activity via antimotility mechanisms of (-)-fenchone in experimental models

World Journal of Gastroenterology 2020年第43期26卷 6795-6809页

作者： michelle liz de souza pessoa Leiliane Macena Oliveira Silva Maria Elaine Cristina Araruna Catarina Alves de Lima Serafim Edvaldo Balbino Alves Junior Alessa Oliveira Silva Matheus Marley Bezerra pessoa Hermes Diniz Neto Edeltrudes de Oliveira Lima Leonia Maria Batista department of Pharmaceutical Sciences IPeFarMFederal University of ParaibaJoao Pessoa 58051-970ParaibaBrazil Health Sciences Center Federal University of ParaibaJoaoPessoa 58051-970ParaibaBrazil Postgraduate Program in Natural and Synthetic Bioactive Products Universidade Federal da ParaibaJoão Pessoa 58051-900Brazil

BACKGROUND(-)-Fenchone is a bicyclic monoterpene present in essential oils of plant species,such as Foeniculum vulgare and Peumus boldus,used to treatment of gastrointestinal *** studies report its anti-inflammatory,antioxidant,and antinociceptive *** To investigate antidiarrheal activity related to gastrointestinal motility,intestinal secretion and antimicrobial *** A castor oil-induced diarrhea model was used to evaluate antidiarrheal *** transit and gastric emptying protocols were used to assess a possible antimotility *** receptors,presynaptic α2-adrenergic and tissue adrenergic receptors,KATP channels,nitric oxide were investigated to uncover antimotility mechanisms of action and castor oil-induced enteropooling to elucidate antisecretory *** antimicrobial activity was evaluated in the minimum inhibitory concentration model,the fractional inhibitory concentration index using the(-)-fenchone association method with standard antifungal ***(-)-Fenchone(75,150 and 300 mg/kg)showed antidiarrheal activity,with a significant decrease in the evacuation *** activity is possibly related to a percentage of reduced intestinal transit(75,150 and 300 mg/kg).The antimotility effect of(-)-fenchone decreased in the presence of pilocarpine,yohimbine,propranolol,L-NG-nitroarginine methyl ester or *** the enteropooling model,no reduction in intestinal fluid weight was observed.(-)-Fenchone did not show antibacterial activity;on the other hand,inhibits the growth of strains of fungi with a minimum fungicide concentration of 32μg/***,when it was associated with amphotericin B,no synergism was *** The antidiarrheal effect of(-)-fenchone in this study involves antimotility effect and not involve antisecretory mechanisms.(-)-Fenchone presents antifungal activity;however,it did not show antibacterial activity.

关键词： (-)-Fenchone Monoterpenes Diarrhea Motility Antifungal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Helicobacter pylori and EBV in gastric carcinomas:Methylation status and microsatellite instability

引用

World Journal of Gastroenterology 2010年第3期16卷 312-319页

作者： Adriana Camargo Ferrasi Nídia Alice Pinheiro Silvia Helena Barem Rabenhorst Otávia Luisa Caballero Maria Aparecida Marchesan Rodrigues Fabrício de Carvalho Celso Vieira de souza Leite Marcia Valéria Pitombeira Ferreira Marcos Aurélio pessoa Barros Maria Inês de Moura Campos Pardini Blood Transfusion Center Botucatu Medical SchoolUNESP-Sao Paulo State University department of Pathology-Federal University of Ceara Ludwig Institute of Cancer Research department of Pathology Medical SchoolUNESP-Sao Paulo State University department of Gastroenterology Surgery Medical SchoolUNESP-Sao Paulo State University

AIM:To verify the methylation status of CDH1, DAPK, COX2, hMLH1 and CDKN2A genes and to evaluate their association with Helicobacter pylori (H. pylori)-cagA+ and Epstein Barr virus (EBV) infections in gastric ***: Methylation-specific PCR (MSP) assay was performed in 89 primary gastric carcinomas (intestinal and diffuse types). Microsatellite instability (MSI) analysis was performed using the BAT26 primer set and PCR products were analyzed with the ABI PRISM 3100 Genetic Analyzer using Genescan 3.7 software (Applied Biosystems). detection of H. pylori and genotyping were performed by PCR, using specifi c primers for ureaseC and cagA genes. The presence of EBV was assessed by in situ hybridization. Statistical analyses were performed using the χ2 or Fisher's exact ***: The most frequent hypermethylated gene was COX-2 (63.5%) followed by DAPK (55.7%), CDH1 (51%), CDKN2A (36%) and hMLH1 (30.3%). Intestinal and diffuse adenocarcinomas showed different methylation profiles and there was an association between methylation of E-CDH1 and H. pylori-cagA+ in the intestinal adenocarcinoma type. MSI was correlated with hMLH1 methylation. There was an inverse correlation between DAPK hypermethylation and ***: We found a strong association between CDH1 methylation and H. pylori-cagA+ in intestinal-type gastric cancer, association of MSI and better prognosis and an heterogeneous COX-2 overexpression.

关键词： Gastric cancer Methylation Microsatellite instability Helicobacter pylori Epstein Barr virus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Active packaging for lipid foods and development challenges for marketing

引用

Food Bioscience 2022年第1期45卷 20-33页

作者： Erica da Costa Moncao Cristiani Viegas Brandao Grisi Janaína de Moura Fernandes Priscila Santos souza Antonia Lucia de souza Programa de Pos-Graduacao Em Ciencia e Tecnologia de Alimentos Universidade Federal da ParaíbaJoao PessoaPB58051Brazil Programa de Pos-Graduacao Em Tecnologia Agroalimentar Universidade Federal da ParaíbaBananeiras-PB58220-000Brazil Programa de Pos-Graduacao Em Química Universidade Federal da ParaíbaJoao PessoaPB58051Brazil

Consumer demand for natural products with low concentration of additives and controlled environmental impact has been a major challenge for the lipid food packaging *** of this fact,active packaging such as oxygen absorbers and antioxidant releasers are trends in the *** this work,research developed on oxygen absorbing packaging and antioxidant-releasing packaging will be *** work will also reveal the challenges to *** that slows down lipid oxidation in food presents satisfactory results and greater efficacy than vacuum *** challenges for the development of active packaging that consist of biopolymers and natural additives are related to the physical and mechanical properties of the *** research should develop biodegradable active packaging that are resistant to industrial ***,there are plenty of natural resources not yet studied and that may be applicable for the development of active oxygen-absorbing and antioxidant active packaging for food.

关键词： Oxygen absorbers Antioxidants Food packaging Lipids Oxidation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synthesis of Poly (Ether Ether) Ketone Sulfonated Membrane with Tin Dioxide Particles

引用

Journal of Materials Science and Chemical Engineering 2016年第2期4卷 49-60页

作者： liz Contino Vianna de Aguiar Florêncio Gomes de Ramos Filho Carla Akimi Kawaguti Ailton de souza Gomes Universidade Federal do Rio de Janeiro Instituto de Macromol&eacute culas Professora Eloisa Mano Rio de Janeiro Brazil Centro Universitá rio Estadual da Zona Oeste-UEZO Rio de Janeiro Brazil

The development of clean energy sources is a subject in focus and boosts fuel cells for research. In this context, studies on proton conductive membranes have an important role. In the present work two groups of membranes were synthetized: one contained SPEEK/SnO2 (varying the content of tin oxide from 2%, 4% and 6%) and the other with SPEEK/SnO2/HPW. The change in the membrane structure was characterized by X-ray diffraction, the swelling in water and ethanol solution uptake test, thermal stability using TGA, change in Tg in DSC, the selective permeability by pervaporation test in water and the solution ethanol and proton conductivity by impedance spectroscopy. Through these analyses, it is possible to verify some effects: the tin oxide particles reduced the Tg membranes, they also controlled the membranes swelling in water and kept it approximately 30% lower than the pure SPEEK swelling and finally, among the tin oxide quantities tested in the membranes, it was reached 67.8 mS/cm as maximum value of proton conductivity.

关键词： Membrane SPEEK Tin Oxide HPW Proton Conductivity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Inhibitory Effect of the Essential Oil from Hyptis suaveolens （L.） Poit on the Growth and Aflatoxins Synthesis of Aspergillus flavus

引用

Journal of Life Sciences 2013年第3期7卷 276-281页

作者： Ana Carolina pessoa Moreira Egberto Santos Carmo Paulo Alves Wanderley Evandro Leite de souza Edeltrudes de Oliveira Lima department of Pharmaceutical Sciences Federal University of Paraiba Joao Pessoa 58051-900 Brazil Academic Unit of Health Federal University of Campina Grande Cuitd 58175-000 Brazil department of Agriculture Federal University of Paraiba Bananeiras 58220-000 Brazil Laboratory of Food Microbiology Department of Nutrition Federal University of Paraiba Joao Pessoa 58051-900 Brazil

H. suaveolens （L.） Poit has been used in folk medicine revealing a wide pharmacological potential. This study aimed to evaluate the efficacy of the essential oil from 11. suaveolens leaves in inhibiting the growth of A. flavus LM257 and synthesis of aflatoxins Bl and B2. The essential oil at 20, 40 and 80 laL/mL strongly reduced the biomass and spore germination ofA. flavus. A 100% inhibition was found at 40 μL/mL and 80μL/mL, while at 20 μL/mL the growth depressed over 50% for both tested parameters. The essential oil at all assayed concentrations totally inhibited the production of aflatoxin B1 and B2. From these results, the essential oil from 11. suaveolens leaves may be considered as an alternative and effective inhibitor ofA. flavus, in addition to offer some protective effect to the production of aflatoxins.

关键词： Hyptis suaveolens essential oil Aspergillusflavus mycotoxins inhibitory effect.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of yeast fermented soursop and umbu-caja pulps on the colonic microbiota of middle-aged hypertensive adults

引用

Food Bioscience 2023年第1期51卷 1067-1075页

作者： Elvira de Lourdes Chaves Macedo Tatiana Colombo Pimentel Janne Santos de Morais Dirceu de Sousa Melo Angelica Cristina de souza Marcos dos Santos Lima Karoliny Brito Sampaio Noadia Priscila Araújo Rodrigues Disney Ribeiro DiasEvandro Leite de souza Rosane Freitas Schwan Marciane Magnani Laboratory of Microbial Processes in Foods Federal University of Paraiba58051-900Joao PessoaPBBrazil Federal Institute of Parana 87703-536ParanavaíPRBrazil Federal University of Lavras 37200-900LavrasMGBrazil Institute Federal of Sertao Pernambucano 56314-520PetrolinaPEBrazil Laboratory of Food Microbiology Federal University of Paraiba58058-600Joao PessoaPBBrazil

The effects of umbu-caja and soursop pulps fermented by the yeast Issatchenkia terricola 129 on the colonic microbiota of middle-aged hypertensive adults were evaluated in vitro fermentation during 48 *** relative abundance of distinct bacterial groups,pH values,and contents of organic acids,sugars,and phenolic compounds were determined at 0,24,and 48 h of *** boulardii CNCM I-745,a recognized probiotic yeast,was used for comparison *** colonic fermentation,maltose,glucose,and fructose were metabolized,resulting in reduced pH values and decreased relative abundance of Bacteroides spp./Prevotella *** soursop pulp with *** 129 improved the colonic microbiota by increasing the relative abundance of Bifidobacterium *** Lactobacillus *** reducing the relative abundance of Eubacterium rectale/Clostridium coccoides and Clostridium histolyticum,resulting in the highest prebiotic *** the same time,the consumption of rhamnose and gallic acid and higher contents of propionic and acetic acids and procyanidin B2 were *** effects on colonic microbiota were less pronounced for *** followed by umbu-caja pulp with *** *** results indicate that fermented soursop pulp with *** 129 may modulate the colonic microbiota of middle-aged hypertensive adults.

关键词： Colonic fermentation Microbiota Metabolism Spondias spp. Annona muricata L

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oxidative and storage stability in beef burgers from the use of bioactive compounds from the agro-industrial residues of passion fruit(Passiflora edulis)

引用

Food Bioscience 2022年第4期48卷 693-700页

作者： Marthyna pessoa de souza Francyide Davi de Amorim Magda Rhayanny Assunçao Ferreira Luiz Alberto Lira Soares Marcia Almeida de Melo Academic Unit of Veterinary Medicine Federal University of Campina Grande58700-970PatosParaíbaBrazil department of Pharmaceutical Sciences Federal University of Pernambuco50740520RecifePernanbucoBrazil

This work aims to evaluate the effect of extracts obtained from passion fruit residues on the oxidative,microbiological,and physicochemical quality of beef burgers during *** types of treatments were considered,including control(without addition of antioxidants),BHT(100 mg kg^(-1)of butylated hydroxytoluene),AE(1000 mg kg^(-1)of aqueous extract),and EE(500 mg kg^(-1)of ethanolic extract).The ethanolic and aqueous extracts showed a concentration of total phenolics of 39.94±1.52 mg GAE.g^(-1)and 11.91±0.39 mg GAE.g^(-1),*** have also shown antioxidant and antimicrobial in vitro *** the conditions tested,AE and EE have prevented lipid oxidation in beef burgers similar to *** well as inhibiting the growth of mesophilic and psychrophilic *** discoloration process was minimized up to the 9th day of storage with just ***,agro-industrial passion fruit residues are sources of natural additives,with antimicrobial and antioxidant properties,which can be used by the meat industry to improve the oxidative and microbiological stability of beef burgers during storage.

关键词： Antimicrobial Fruit by-product Lipid oxidation Natural antioxidant Shelf life

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Non-Polar Chemical Constituents of Atemoya and Evaluation of the Cytotoxic and Antimicrobial Activity

引用

Phyton-International Journal of Experimental Botany 2021年第3期90卷 921-931页

作者： Suzana Vieira Rabêlo Fernanda Granja da Silva Oliveira Michele Miriam Calixto de Lira Livia Macedo Dutra Adilson Sartoratto Marta Cristina Teixeira Duarte Maria Claudia dos Santos Luciano Maria Francilene souza Silva Cláudia doÓpessoa Manoel Odorico de Moraes Filho Emmanoel Vilaça Costa Jackson Roberto Guedes da Silva Almeida Post-Graduate Program in Biotechnology(RENORBIO) Federal Rural University of PernambucoRecifePernambuco52171-900Brazil Post-Graduate Program in Biotechnology State University of Feira de SantanaFeira de SantanaBahia44036-900Brazil Center for Studies and Research of Medicinal Plants(NEPLAME) Federal University of San Francisco ValleyPetrolinaPernambuco56304-205Brazil Multidisciplinary Center of Chemical Biological and Agricultural Research(CPQBA)Campinas State UniversityCampinasSão Paulo13083-970Brazil National Laboratory of Experimental Oncology(LabNOE) Federal University of CearáFortalezaCeará60020-181Brazil departament of Chemistry Federal University of AmazonasManausAmazonas69067-005Brazil

This study aimed to identify the chemical composition of essential oil from fruits(EOAF)and the hexanic crude extract from aerial parts(At-Hex)of atemoya(Annona cherimola x Annona squamosa),a hybrid belonging to the Annonaceae *** and antimicrobial activity was also *** was obtained by hydrodistillation using a Clevenger apparatus,and their composition was analyzed by gas chromatography-mass spectrometry(GC-MS)*** was tested against human tumor cell lines HCT-116(colon carcinoma),SF-295(glioblastoma),OVCAR-8(ovarian carcinoma)and HL60(leukemia)using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide(MTT)assay,while antimicrobial activity was conducted by bioauthography method against eleven microorganisms ***-four compounds were identified in the EOAF and twenty-nine in *** monoterpenes linalool(25.70%),α-pinene(10.38%),β-pinene(9.12%),transocimene(7.43%),and the sesquiterpene bicyclogermacrene(12.58%)were the major constituents of EOAF,whereas the sesquiterpene spathulenol(13.91%)was the main compound of ***-Hex showed a high cytotoxicity against SF-295(glioblastoma).These findings show an important chemotaxonomic contribution for the Annonaceae family,mainly for the Annona *** proved to be a promising source of substances with potential cytotoxic activity.

关键词： Annona GC-MS volatile compounds terpenoids biologic activities

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

On the Study of Autonomous Underwater Vehicles by Computational Fluid-Dynamics

引用

Open Journal of Fluid Dynamics 2020年第1期10卷 63-81页

作者： Joao Victor Nunes de Sousa Antonio Gilson Barbosa de Lima Francisco Alves Batista Edna Cordeiro de souza Daniel Cesar de Macedo Cavalcante Paulo de Morais pessoa Joao Evangelista Franco do Carmo department of Mechanical Engineering Federal University of Campina GrandeCampina GrandeBrazil department of Physics State University of ParaibaCampina GrandeBrazil department of Physics and Mathematical Federal University of Campina GrandeCampina GrandeBrazil Federal Institute of Education Science and Technology of the Sertao PernambucanoSerra TalhadaBrazil

Autonomous Underwater Vehicles (AUV’s) are considered as advanced classes of vehicles, capable of performing pre-established missions without physical communication with the ground or human assistance. The research and development of this type of vehicles have been motivated, due to its excellent characteristics, ideal to the military, scientific and industrial sectors. Thus, the objective of this paper is to study fluid flow behavior past over AUV’s, without and with control surfaces (rudders), by Computational Fluid-Dynamics (CFD), aiming to obtain information about the impact of the operating depth and control surfaces on the vehicle's hydrodynamics, in order to help researchers and designers of this class of vehicles. Results of the drag coefficient, pressure, velocity and streamlines distribution around the vehicles are presented and analyzed.

关键词： Autonomous Underwater Vehicle Fluid Flow Computational Fluid-Dynamics Drag Coefficient

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ingredients from integral valorization of Isabel grape to formulate goat yogurt with stimulatory effects on probiotics and beneficial impacts on human colonic microbiota in vitro

引用

Food Science and Human Wellness 2023年第4期12卷 1331-1342页

作者： Francyeli Araújo Silva Rita de Cássia Ramos do Egypto Queiroga Evandro Leite de souza Glenise Bierhalz Voss Maria Manuela Estevez Pintado Margarida Angélica da Silva Vasconcelos department of Nutrition Federal University of PernambucoRecife 50670-420Brazil department of Nutrition Health Sciences CenterFederal University of ParaíbaJoão Pessoa 58050-585Brazil Universidade Católica Portuguesa CBQF-Centro de Biotecnologia e Química Fina-Laboratório AssociadoEscola Superior de BiotecnologiaPorto 4169-005Portugal

Isabel grape(IG)products have high contents of phenolic compounds and fiber recognized for their positive impacts on microorganisms associated with health benefits to *** study evaluated the effects of goat yogurts formulated with ingredients from IG integral valorization on the growth and metabolism of different probiotic strains,as well as on the population of selected bacterial groups and metabolic activity of human colonic microbiota in *** yogurts with IG ingredients(IGI)stimulated the growth of tested Lactobacillus and Bifidobacterium probiotic strains during a 48-h cultivation,as well as decreased the pH values and enhanced the organic acid *** yogurts with IGI increased the population of Lactobacillus *** Bifidobacterium *** a 24-h in vitro colonic fermentation.A stable Firmicutes:Bacteroidetes ratio close to 1 was found in media with goat yogurt formulations during the colonic fermentation,being similar to the effect caused by *** yogurt formulations with IGI caused increased production of short-chain fatty acids and sugar consumption during colonic *** yogurts with IGI should be a valuable strategy for development of novel added-value foods with beneficial effects on gut microbiota and human health.

关键词： Goat dairy product Grape Beneficial microorganisms Gut microbiota Modulatory effects

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：