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Genes & Diseases 2024年第1期11卷 60-63页

作者： Goodwin G.Jinesh Marian T.Smallin Nino Mtchedlidze Isha Godwin Marco Napoli Nicole Hackel Manali S.Phadke Avani A.Deshpande Xiaobo Li John H.Lockhart Jaden R.Baldwin Suehelay Acevedo-Acevedo Yifeng Gao michelle a.reiser Keiran S.M.Smalley Elsa R.Flores Andrew S.Brohl Department of Molecular Oncology H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Molecular Medicine Program H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Saveetha Medical College ChennaiTamil Nadu 602105India Tumor Biology Department H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Sarcoma Department H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA

SP100 is an antiviral protein that restricts the productive stage of human papillomavirus(HPV)and multiple other viruses,and viruses in turn block sUMO-1-mediated stabilization of SP100 and promotes its degradation(Table S1).Interferon(IFN)signaling could still produce more SP100 through transcription to counteract viruses.1 Viruses also disable the transcriptional up-regulation of SP100 to achieve persistent infection in hosts.

关键词： SP100 melanoma stabilization

FAIR： A Call to Make Published Data More Findable, Accessible, Interoperable, and Reusable

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Molecular Plant 2018年第9期11卷 1105-1108页

作者： Leonore reiser Lisa Harper Michael Freeling Bin Han Sheng Luan The Arabidopsis Information Resource/Phoenix Bioinformatics Fremont CA 94538 USA Maize Genome Database/United States Department of Agriculture Albany CA 94710 USA Department of Plant Biology University of California Berkeley CA 94720 USA National Center for Gene Research CAS Center for Excellence in Molecular Plant Sciences Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200233 China These authors contributed equally to this article

Biology has become an information-dense, data-intensive enterprise that requires the ability to access, integrate, and compute on large amounts of data. To enable better use of data, stakeholders （scientists, curators, librarians, and journal publishers） have established standards to ensure that data are findable, accessible, interoperable.

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Bestimmung des regionalen Blutvolumens (rBV) in Meningeomen: Vergleich von Echoplanar-und Gradientenechosequenzen

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2004年第6期24卷 610-614页

作者：吴仁华 Roland Bruening Christian Berchtenbreiter Jügen Weber 郎志谨 Maximilian reiser Abteilung für Radiologie Medizinische Fakultt der Universitt ShantouShantou 515041ChinaInstitut für Diagnostische RadiologieKlinikum GrophadernLudwig-Maximilians-UniversittMünchen 81377Germany Institut für Diagnostische Radiologie Klinikum GrophadernLudwig-Maximilians-UniversittMünchen 81377Germany Abteilung für Radiologie Medizinische Universitt DalianDalian 116011

Summary: The purpose of this study was to evaluate relative regional blood volume (rCBV) in meningioma and compare the utility of reconstruction using both gradient-echo sequence and echo-planar-imaging (EPI) *** patients with meningiomas were studied on a Siemens 1.5-T scanner. During the gradient-echo sequence (n=12) and EPI sequence (n=6), a bolus ^(0.2 mmol/kg) of Gd-DTPA was injected mechanically with a flow rate of 5 ml/second. Image processing of dynamic data was performed on a pixel-by-pixel basis. The ratio of tumor rCBV/gray matter rCBV was 3.01±1.18 (3.07 ± 1.39 in gradient sequence and 2.84 ± 0.94 in EPI sequence). The ratio of gray matter/ white matter as the reference tissue had a mean of 2.79 ± 0.76 using the FLASH sequence, and a mean of 3.04 ± 1.31 using EPI. These differences were not statistically signifcant (P>0.5, t-test). According to the ratio of tumor rCBV/gray matter rCBV, a mean value, 14.5 ml/100 g, of rCBV in meningiomas was calculated. Compared with gray matter, increased inhomogeneous rCBV was observed in meningioma. Based on the two different sequences, no bias can be observed in our rCBV reconstruction.

关键词： magnetic resonance imaging meningioma blood volume

慢病毒介导GDNF对帕金森病的多巴胺能神经营养作用(英文)

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Acta Biochimica et Biophysica Sinica 2003年第10期35卷 937-940页

作者：孙兵,惠国桢,郭礼和,reiser Jakob 中国科学院上海生命科学研究院生物化学与细胞生物学研究所苏州大学附属第一医院神经外科中国科学院上海生命科学研究院生物化学与细胞生物学研究所路易斯安那健康研究中心上海20031 苏州大学附属第一医院神经外科苏州215006 苏州215006 上海20031 路易斯安那州70112

探讨慢病毒介导GDNF对帕金森病的治疗作用。将gdnf片段替代pNL lacZ CMV质粒中的LacZ编码区 ,构建pNL gdnf质粒。采用磷酸钙转染方法 ,将慢病毒系统中三个质粒瞬时共转染 2 93T细胞 ,并收集病毒粒子。用立体定位仪将高滴度病毒注射入PD... 详细信息

探讨慢病毒介导GDNF对帕金森病的治疗作用。将gdnf片段替代pNL lacZ CMV质粒中的LacZ编码区 ,构建pNL gdnf质粒。采用磷酸钙转染方法 ,将慢病毒系统中三个质粒瞬时共转染 2 93T细胞 ,并收集病毒粒子。用立体定位仪将高滴度病毒注射入PD大鼠的纹状体中。分别在治疗后 14 ,30 ,6 0天检测阿朴吗啡 (APO)诱导旋转反应的变化 ;用Western印迹方法测定蛋白质的表达 ;用免疫组织化学方法检测lacZ和TH的表达 ;移植治疗后PD鼠的行为学逐渐有了改善 ,尤以治疗后14天明显。GDNF蛋白在大鼠脑内至少表达了 6 0天 ,对多巴胺神经有一定的神经营养作用。因此 ,慢病毒介导GDNF能显著改善PD鼠的行为学表现 ,是治疗帕金森病的有效方法之一。

关键词：胶质细胞源性神经生长因子慢病毒(lentivirus)载体帕金森病基因治疗

Sperm banking before gonadotoxic treatment:is it worth the effort?

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Asian Journal of Andrology 2021年第5期23卷 490-494页

作者： Kilian Vomstein Elisabeth reiser Germar M Pinggera Peter Toerzsoek Susanne Deininger Thomas Kriesche Wolfgang Biasio Lukas Lusuardi Bettina Toth Department of Gynecological Endocrinology and Reproductive Medicine Medical University InnsbruckInnsbruck 6020Austria Department of Urology Medical University InnsbruckInnsbruck 6020Austria Department of Urology and Andrology University Hospital of SalzburgSalzburg 5020Austria

We aimed to compare the sperm quality in different cancer types and benign diseases before gonadotoxic treatment,and assess the usage rate of cryopreserved sperm for assisted reproductive treatment(ART).This retrospective study was conducted at two university clinics between January 2008 and July 2018.A total of 545 patients suffering from cancer or benign diseases were included in the *** pretreatment sperm analyses were based on the World Health Organization(WHO)*** with testicular malignancy(TM)showed a significantly lower sperm count(median[interquartile range]:18.7×10^(6)[5.3×10^(6)-43.0×10^(6)]ml^(-1);P=0.03)as well as total sperm count(42.4×10^(6)[13.3×10^(6)-108.5×10^(6)]per ejaculate;P=0.007)compared to other malignant and benign *** addition,patients with nonseminomatous TM showed the lowest sperm count(14.3×10^(6)[6.0×10^(6)-29.9×10^(6)]ml^(-1),vs seminomas:16.5 x 106[4.6×10^(6)-20.3×10^(6)]ml^(-1);P=0.001).With reference to the WHO 2010 guidelines,approximately 48.0%of the patients with TM and 23.0%with hematological malignancies(HM)had *** the observation period,only 29 patients(5.3%)used their frozen sperms for 48 ART cycles,resulting in 15 clinical pregnancies and 10 live *** sperm quality varies with the type of underlying disease,with TM and HM patients showing the lowest sperm *** to the observed low usage rate of cryopreserved sperm,further patient interviews and sperm analyses should be included in the routine oncologic protocols to avoid unnecessary storage ***,sperm banking is worth the effort as it provides hope for men who cannot reproduce naturally after gonadotoxic treatment.

关键词： cryopreservation fertility gonadotoxic treatment sperm count testicular disease

Gastrointestinal bleeding 30 years after a complicated cholecystectomy

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World Journal of Gastroenterology 2010年第37期16卷 4747-4750页

作者： Thorsten Brechmann Wolff Schmiegel Volkmar Nicolas Markus reiser Department of Gastroenterology and Hepatology Berufsgenossenschaftliche Kliniken Bergmannsheil University of Bochum Department of Diagnostic and Interventional Radiology Berufsgenossenschaftliche Kliniken Bergmannsheil University of Bochum

Gastrointestinal bleeding from small-bowel varices is a rare and difficult to treat complication of portal hypertension. We describe the case of a 79-year-old female patient with recurrent severe hemorrhage from smallbowel varices 30 years after a complicated cholecystectomy. When double balloon enteroscopy was unsuccessful to reach the site of bleeding, a rendezvous approach was favored with intraoperative endoscopy. Active bleeding from varices within a biliodigestive anastomosis was found and controlled by endoscopic injection of cyanoacrylate. Intraoperative endoscopy should be considered in the case of life-threatening gastrointestinal hemorrhage that is not accessible by conventional endoscopy.

关键词： Upper gastrointestinal bleeding Intestinal varices Intraoperative endoscopy Cyanoacrylate

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空间电荷主导电子束的纵向聚焦设计(英文)

高能物理与核物理 2003年第12期27卷 1119-1122页

作者：邓建军王建光 reiser Martin Godlove Terry 清华大学工程物理系北京100084 马里兰大学等离子体研究所 FM技术公司

在空间电荷主导电子束研究中 ,纵向聚焦非常重要 ,在输运过程中由于强空间电荷力的影响 ,束团将很快变长并崩溃 ,马里兰大学的电子环设计用于方形束团和抛物线形束团的研究 ,环中需要用三个感应腔对束团进行纵向聚焦 .文中首先介绍了方... 详细信息

在空间电荷主导电子束研究中 ,纵向聚焦非常重要 ,在输运过程中由于强空间电荷力的影响 ,束团将很快变长并崩溃 ,马里兰大学的电子环设计用于方形束团和抛物线形束团的研究 ,环中需要用三个感应腔对束团进行纵向聚焦 .文中首先介绍了方形束团和抛物线形束团的纵向束流动力学 ,推导了两种束团纵向聚焦所需要的 5MHz重复率高压脉冲波形 ,并给出了实现纵向聚焦的感应腔设计及其特殊要求 .

关键词：纵向聚焦空间电荷主导电子束高能物理学纵向束流动力学感应腔

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直线感应加速器间隙中的径向聚焦

原子能科学技术 1991年第2期25卷 19-28页

作者：陈银宝 M.reiser 中国原子能科学研究院美国马里兰大学等离子体研究实验室

在直线感应加速器间隙中的电场的聚焦特性与在双圆筒静电透镜中的电场的聚焦特性相同。在非相对论情况下,对双圆筒静电透镜的聚焦性质已有系统的研究。本文提出相对论情况下双圆筒静电透镜的聚焦性质,得出在薄透镜近似下的解析公式,并... 详细信息

在直线感应加速器间隙中的电场的聚焦特性与在双圆筒静电透镜中的电场的聚焦特性相同。在非相对论情况下,对双圆筒静电透镜的聚焦性质已有系统的研究。本文提出相对论情况下双圆筒静电透镜的聚焦性质,得出在薄透镜近似下的解析公式,并给出计算实例及与数值积分计算相比较。结果表明,在实际应用的范围内,解析公式具有足够的精确度。

关键词：直线感应加速器径向聚焦双圆筒静电透镜

Pilot Project on in Situ Aerobisation of Old Landfills： Results from Konstanz Dorfweiher Landfill

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Journal of Physical Science and Application 2014年第4期4卷 248-254页

作者： Daniel Laux Martin reiser Martin Kranert Ministry of the Environment Climate Protection and the Energy Sector Baden-Wuerttemberg Stuttgart 70029 Germany Institute of Sanitary Engineering Water Quality and Solid Waste Management (ISWA) University of Stuttgart Stuttgart 70569Germany

A new in situ treatment technique was being utilized on a part of the Dorfweiher landfill in Konstanz, Germany to reduce the aftercare period. From 2010 to 2012, the landfill was aerated intermittently with low pressure. Outgoing air was treated passively in an open biofilter which covers the landfill surface. The landfill was aerated by means of 80 air injection wells arranged area-wide in a 10 m grid. An elaborate measuring process and technological controls are being utilized in the pilot scheme. The data collected offer interesting insights about the processes during aeration, allowing optimization of the aeration strategy depending on changes of the conditions in the landfill. During the three-year aeration phase, conditions have changed inside the landfill section in various ways. In numerous zones of the landfill body, the aeration caused aerobic conditions with a decline of methane production. Accelerated settlings are measured up to 11%. The effects of the aerobic stabilization on the landfill are evaluated in a two-year monitoring phase started in 2013.

关键词： Landfill in situ aerobisation aftercare period stabilization methane

An orally-available monovalent SMAC mimetic compound as a broad-spectrum antiviral

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Protein & Cell 2024年第1期15卷 69-75页

作者： Miao Mei Maria_Antonietta Impagnatiello Jun Jiao Ulrich reiser Ulrike Tontsch-Grunt Ju Zhang Paul Nicklin Bingke Yu Yu Wang Yuan He Xu Tan Tsinghua-Peking Center for Life Sciences Beijing Advanced Innovation Center for Structural BiologyBeijing Frontier Research Center for Biological StructureMOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologySchool of Pharmaceutical SciencesTsinghua UniversityBeijing 100084China Chinese Institutes for Medical Research Beijing 100069China Boehringer Ingelheim RCV GmbH&Co KG ViennaAustria College of Life Sciences and Oceanography Shenzhen UniversityShenzhen 518060China Research Beyond Borders Boehringer IngelheimBiberach an der RissGermany Research Beyond Borders Boehringer IngelheimShanghai 200120China

DearEditor,The coronavirus disease 2019(COVID-19)pandemic caused great global morbidity and mortality concurrent with astronomical socioeconomic damages and *** now,the culpable pathogen,SARS-CoV-2,has infected over 6 hundred million people resulting in more than 6 million deaths worldwide(WHO SARSCoV-2 cases).There is an urgent need for rapid development of effective and affordable therapeutics for COVID-19 patients.

关键词： mortality spectrum compound