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Insect Science 2018年第6期25卷 1119-1127页

作者： Lachlan C.Jones Brodie J.Foster michelle a.rafter Gimme H.Walter School of Biological Sciences The University of QueenslandSt LuciaBrisbaneQueenslandAustrafia

To survive in nature,organisms may need to take direct action to mitigate specific dangers from their environmental *** flying insects are thought to be at particular risk from rainfall that would be of negligible concern to larger *** study species Frankliniella schultzei is a thrips that inhabits flowers and feeds mostly on petal tissue and *** found to respond in the laboratory to decreases in atmospheric pressure associated with cyclonic conditions (rather than merely heavy rainfall),their responses to conditions preceding rainfall have not been tested in the *** field sampling investigated the relationship between floral development and sites at which male,female,and larval thrips were generally present on sunny *** then designed a sampling strategy to test if these thrips can anticipate imminent rainfall or storms and so seek shelter deep within flowers,by sampling host flowers (in sections)on multiple days with different weather *** traps were used to intercept thrips in flight,thus providing a measure of flight behavior across different *** initial sampling found adult thrips primarily at the petal apex of anthesis-stage flowers where pollen is distributed. We subsequently found that rainfall,atmospheric pressure change,temperature,humidity and wind had no effect on flight behavior of E schultzei,or on their positions within *** findings suggest rainfall is not a serious hazard for *** thrips can survive raindrop collisions during flight,as impacts with water droplets are not expected to break the surface tension.

关键词： barometric pressure Frankliniella schultzei Malvaviscus arboreus rainfall shelter thrips

Mitochondrial therapeutics and mitochondrial transfer for neurodegenerative diseases and aging

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Neural Regeneration Research 2025年第3期20卷 794-796页

作者： Neville Ng michelle Newbery Nicole Miles Lezanne Ooi Molecular Horizons and School of Chemistry and Molecular Bioscience University of WollongongWollongongNSWAustralia

Mitochondrial dysfunction and neurodegeneration:Progressive neurodegenerative diseases affect a significant proportion of the population;in a single year,there are as many as 276 million disabilities and 9 million dea... 详细信息

关键词： degenerative diseases Mitochondrial

Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

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Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.Smith Liwen Zhou Cameron L.Ghergherehchi michelle Mikesh Cathy Z.Yang Haley O.Tucker JuliAnne Allgood Jared S.Bushman George D.Bittner Department of Molecular Biosciences University of Texas at AustinAustinTXUSA Department of Neuroscience University of Texas at AustinAustinTXUSA Division of Pharmaceutical Sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred Sprague–Dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited Wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration

Sixth-Order Compact Finite Difference Method for 2D Helmholtz Equations with Singular Sources and Reduced Pollution Effect

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Communications in Computational Physics 2023年第8期34卷 672-712页

作者： Qiwei Feng Bin Han michelle michelle Department of Mathematical and Statistical Sciences University of AlbertaEdmontonAlbertaCanada T6G 2G1 Department of Mathematics Purdue UniversityWest LafayetteINUSA 47907

Due to its highly oscillating solution,the Helmholtz equation is numerically challenging to *** obtain a reasonable solution,a mesh size that is much smaller than the reciprocal of the wavenumber is typically required(known as the pollution effect).High-order schemes are desirable,because they are better in mitigating the pollution *** this paper,we present a high-order compact finite difference method for 2D Helmholtz equations with singular sources,which can also handle any possible combinations of boundary conditions(Dirichlet,Neumann,and impedance)on a rectangular *** method is sixth-order consistent for a constant wavenumber,and fifth-order consistent for a piecewise constant *** reduce the pollution effect,we propose a new pollution minimization strategy that is based on the average truncation error of plane *** numerical experiments demonstrate the superiority of our proposed finite difference scheme with reduced pollution effect to several state-of-the-art finite difference schemes,particularly in the critical pre-asymptotic region where kh is near 1 with k being the wavenumber and h the mesh size.

关键词： Helmholtz equation finite difference pollution effect interface pollution minimization mixed boundary conditions corner treatment.

Assessing cypermethrin-contaminated soil with three different earthworm test methods

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Journal of Environmental Sciences 2008年第11期20卷 1381-1385页

作者： Wong Hang Gi michelle Laboratory for Conservation and Utilization of Bio-Resource and School of Life Science Yunnan UniversityKunming 650091China

A series of tests (lethal,sublethal,and behavioral) on earthworms were conducted as an eco-assessment of *** this study,the toxicity of cypermethrin-contaminating soil on adult and juvenile earthworms was *** the acute and chronic tests,an avoidance response test was carried *** was shown that the all-round toxicity from cypermethrin was weak on adult *** with adult earthworms,the toxicity of juvenile earthworms from cypermethrin especially chronic toxicity increased...

关键词： earthworms pesticide cypermethrin survival fecundity avoidance response environment disrupting chemicals

Multigrid Methods for Elliptic Optimal Control Problems with Pointwise State Constraints

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Numerical Mathematics(Theory,Methods and Applications) 2012年第1期5卷 99-109页

作者： michelle Vallejos Institute of Mathematics University of the PhilippinesDilimanQuezon CityPhilippines

An elliptic optimal control problem with constraints on the state variable is *** Lavrentiev-type regularization is used to treat the constraints on the state *** solve the problem numerically,the multigrid for optimization(MGOPT)technique and the collective smoothing multigrid(CSMG)are *** results are reported to illustrate and compare the efficiency of both multigrid strategies.

关键词： Elliptic optimal control problems Lavrentiev regularization multigrid methods pointwise state constraints

Auctions to reveal consumers’willingness to pay for low-carbon hydrogen projects:combining lessons from renewables and natural-gas industries

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Clean Energy 2024年第4期8卷 103-110页

作者： Miguel Vazquez michelle Hallack SDA School of Management Bocconi UniversityVia Roberto Sarfatti1020136 MilanMIItaly Florence School of Regulation EUIVia Giovanni Boccaccio12150133 FirenzeFIItaly

Low-carbon hydrogen is expected to play a key role in realizing net-zero and sustainable development ***,there is a gap between the cost of producing low-carbon hydrogen and its potential users’willingness to pay for such *** implement support for the development of the industry,we propose using low-carbon hydrogen long-term agreements allocated through auction *** objectives are 2-fold:(i)matching supply and demand volumes considering the time horizon and geographical delivery point specification and(ii)allocating the *** perspective article innovates by proposing a reference price indexed to liquid to natural-gas prices,which is the main product that low-carbon hydrogen aims to *** premium and the production cost are defined through a double-sided *** aims to minimize the public policy funds required to incentivize the low-carbon hydrogen market while facilitating long-term agreements and mitigating price risks that may hinder investment.

关键词： hydrogen auctions Renewable Eenergy Systems support mechanisms natural gas

Semi-solid materials for controlled release drug formulation： current status and future prospects

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Frontiers of Chemical Science and Engineering 2014年第2期8卷 225-232页

作者： michelle TRAN Chun WANG Department of Biomedical Engineering University of Minnesota 7-105 Hasselmo Hall 312 Church Street S.E. Minneapolis MN 55455 USA

Semi-solid materials represent an important category of inactive ingredients （excipients） of pharmaceutical products. Here we review several common semisolid polymers currently used in the controlled release formulations of many drugs. These polymers are selected based on their importance and broad scope of application in FDA-approved drug products and include several polysaccharides （cellulose, starch, chitosan, alginate） and carbomers, a group of mucoadhesive synthetic polymers. Glyceride-based polymers used in self-emulsifying drug delivery systems （SEDDS） will also be discussed for its importance in formulating poorly water-soluble drugs. Unique features and advantages of each type of semi-solid materials are discussed and examples of their use in oral delivery of drugs are provided. Finally, future prospects of developing new and better semi-solid excipients are discussed with the objective of facilitating clinical translation.

关键词： semi-solids polymer excipient controlledrelease drug delivery

A plant-based diet for the prevention and treatment of type 2 diabetes

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Journal of Geriatric Cardiology 2017年第5期14卷 342-354页

作者： michelle McMacken Sapana Shah Division of General Internal Medicine Department of Medicine New York University School of Medicine New York USA

The prevalence of type 2 diabetes is rising worldwide, especially in older adults. Diet and lifestyle, particularly plant-based diets, are ef-fective tools for type 2 diabetes prevention and management. Plant-based diets are eating patterns that emphasize legumes, whole grains,vegetables, fruits, nuts, and seeds and discourage most or all animal products. Cohort studies strongly support the role of plant-based diets,and food and nutrient components of plant-based diets, in reducing the risk of type 2 diabetes. Evidence from observational and interven-tional studies demonstrates the benefits of plant-based diets in treating type 2 diabetes and reducing key diabetes-related macrovascular andmicrovascular complications. Optimal macronutrient ratios for preventing and treating type 2 diabetes are controversial; the focus should insteadbe on eating patterns and actual foods. However, the evidence does suggest that the type and source of carbohydrate （unrefined versus refined）,fats （monounsaturated and polyunsaturated versus saturated and trans）, and protein （plant versus animal） play a major role in the prevention andmanagement of type 2 diabetes. Multiple potential mechanisms underlie the benefits of a plant-based diet in ameliorating insulin resistance, in-cluding promotion of a healthy body weight, increases in fiber and phytonutrients, food-microbiome interactions, and decreases in saturated fat,advanced glycation endproducts, nitrosamines, and heme iron.

关键词： Diabetes mellitus Insulin resistance Vegan Vegetarian

Metformin treatment of high-fat diet-fed obese male mice restores sperm function and fetal growth,without requiring weight loss

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Asian Journal of Andrology 2020年第6期22卷 560-568页

作者： Nicole O McPherson michelle Lane Robinson Research Institute School of MedicineUniversity of AdelaideAdelaide 5005Australia Freemasons Foundation Centre for Men's Health University of AdelaideAdelaide 5005Australia Repromed Dulwich 5065Australia Monash IVF Group Melbourne 3000Australia.

Male obesity is associated with subfertility and increased disease risk of *** is unknown if effects can be reversed through pharmacological ***-to 6-week-old C57BL6 male mice were fed control diet(n=10,CD)or high-fat diet(n=20,HFD)for 16 *** fed with a HFD were then allocated to continuation of HFD(n=8)or HFD with metformin 28 mg kg1 day-1(n=8)for 6 *** fed with CD continued on a CD(n=9).Males were mated with fertile C57BL6 females for the assessment of pregnancy and fetal *** motility,spermatozoa and testicular morphology,sperm-zona pellucida binding,sperm reactive oxygen species(ROS)(intracellular[DCFDA],superoxide[MSR],and oxidative DNA lesions[8OHdG]),and mitochondrial membrane potential(JC1)were *** treatment of HFD males improved glucose toleranee(+12%,P<0.05)and reduced Homeostatic Model Assessment of Insulin Resistance(HOMA-IR;-36%,P<0.05).This occurred in the absenee of a change in body weight or *** treatment of HFD-fed males restored testicular morphology(+33%,P<0.05),sperm motility(+66%,P<0.05),sperm-zona pellucida binding(+25%,P<0.05),sperm intracellular ROS concentrations(-32%,P<0.05),and oxidative DNA lesions(-45%,P<0.05)to the levels of the CD *** treatment of HFD fathers increased fetal weights and lengths compared with those born to HFD fathers(+8%,P<0.05),with fetal lengths restored to those of fetuses of CD ***-term metformin treatment in men who are obese could be a potential intervention for the treatment of subfertility,without the need for a reduction in body weight/adiposity.

关键词： fertility glucose metabolic syndrome overweight subfertility