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Neoadjuvant treatment for resectable pancreatic cancer: Time for phase Ⅲ testing?

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World Journal of Gastroenterology 2010年第39期16卷 4883-4887页

作者： michele Reni Medical Oncology Unit Department of OncologySan Raffaele Scientific Institute

This paper discusses the rationale for phaseⅢtesting of neoadjuvant therapy in patients affected by resectable pancreatic *** therapeutic management of patients affected by resectable pancreatic cancer is particularly troublesome due to the aggressiveness of the disease and to the limited efficacy and sometimes unfavourable risk-benefit ratio of the available therapeutic *** data on the role of adjuvant chemoradiation have been reported,while adjuvant single-agent chemotherapy significantly improved overall survival(OS)when compared to surgery alone. However,the OS figures for adjuvant chemotherapy remain *** effect,pancreatic cancer exhibits a prominent tendency to recur after a brief median time interval from surgery and extra-pancreatic dissemination represents the predominant pattern of disease *** treatment has a strong rationale in this disease but limited information on the efficacy of this approach is available from single arm trials with low levels of ***,in spite of two decades of investigation there is currently no evidence to support the routine use of pre-surgical therapy in clinical practice. To foster knowledge on the optimal management of this disease,and to produce evidence-based treatment guidelines,there is no alternative to well designed randomized *** chemotherapy is a candidate for testing because it is supported by a more robust rationale than *** chemotherapy regimens with elevated activity in advanced disease warrant *** would suggest the running of an exploratory phaseⅡrandomized trial before embarking on a large phase Ⅲ study.

关键词： Pancreatic cancer Neoadjuvant therapy Phase Ⅲ trial Chemotherapy

Transition Modelling Implications in the CFD Analysis of a Turbine Nozzle Vane Cascade Tested Over a Range of Mach and Reynolds Numbers

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Journal of Thermal Science 2015年第6期24卷 526-534页

作者： michele Marconcini Roberto Pacciani Andrea Arnone University of Florence Department of Industrial Engineering Via Santa Marta

The aerodynamic performance of a gas turbine nozzle vane cascade was investigated over a range of Mach and Reynolds *** work is part of a vast research project aimed at the analysis of fluid dynamics and heat transfer phenomena in cooled *** this paper computed results on the"solid vane"(without cooling devices)are presented and discussed in comparison with experimental *** measurements were provided by the University of Bergamo where the experimental campaign was carried out by means of a subsonic wind *** impact of boundary layer transition is investigated by using a novel laminar kinetic energy transport model and the widely used Langtry-Menterγ-Reθ,t *** comparison between calculations and measurements is presented in terms of blade loading distributions,total pressure loss coefficient contours downstream of the cascade,and velocity/turbulence-intensity profiles within the boundary layer at selected blade surface locations at *** will be shown how transitional calculations compare favorably with experiments.

关键词： Gas turbine CFD validation transition model secondary flows

Scheduling optimization of task allocation in integrated manufacturing system based on task decomposition

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Journal of Systems Engineering and Electronics 2016年第2期27卷 422-433页

作者： Aijun Liu michele Pfund John Fowler Department of Management Engineering School of Economics & Management Xidian University Department of Supply Chain Management W.P. Carey School of Business Arizona State University

How to deal with the collaboration between task decomposition and task scheduling is the key problem of the integrated manufacturing system for complex products. With the development of manufacturing technology, we can probe a new way to solve this problem. Firstly, a new method for task granularity quantitative analysis is put forward, which can precisely evaluate the task granularity of complex product cooperation workflow in the integrated manufacturing system, on the above basis; this method is used to guide the coarse-grained task decomposition and recombine the subtasks with low cohesion coefficient. Then, a multi-objective optimieation model and an algorithm are set up for the scheduling optimization of task scheduling. Finally, the application feasibility of the model and algorithm is ultimately validated through an application case study.

关键词： integrated manufacturing system optimization task decomposition task scheduling

Thermal conductivity of glasses: first-principles theory and applications

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npj Computational Materials 2023年第1期9卷 1253-1274页

作者： michele Simoncelli Francesco Mauri Nicola Marzari Theory of Condensed Matter Group of the Cavendish Laboratory University of CambridgeCambridgeUK Dipartimento di Fisica Universitàdi Roma La SapienzaRomaItaly Theory and Simulation of Materials(THEOS)and National Centre for Computational Design and Discovery of Novel Materials(MARVEL) École Polytechnique Fédérale de LausanneLausanneSwitzerland

Predicting the thermal conductivity of glasses from first principles has hitherto been a very complex *** established Allen-Feldman and Green-Kubo approaches employ approximations with limited validity—the former neglects anharmonicity,the latter misses the quantum Bose-Einstein statistics of vibrations—and require atomistic models that are very challenging for first-principles ***,we present a protocol to determine from first principles the thermal conductivityκ(T)of glasses above the plateau(i.e.,above the temperature-independent region appearing almost without exceptions in theκ(T)of all glasses at cryogenic temperatures).The protocol combines the Wigner formulation of thermal transport with convergence-acceleration techniques,and accounts comprehensively for the effects of structural disorder,anharmonicity,and Bose-Einstein *** validate this approach in vitreous silica,showing that models containing less than 200 atoms can already reproduceκ(T)in the macroscopic *** discuss the effects of anharmonicity and the mechanisms determining the trend ofκ(T)at high temperature,reproducing experiments at temperatures where radiative effects remain negligible.

关键词： glasses conductivity harmonic

Quantifying the contribution of the root system of alpine vegetation in the soil aggregate stability of moraine

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International Soil and Water Conservation Research 2017年第1期5卷 36-42页

作者： Csilla Hudek Silvia Stanchi michele D’Amico michele Freppaz University of Torino DISAFA(Department of AgriculturalForest and Food Sciences)Largo Paolo Braccini2Grugliasco 10095TOItaly Train2Move Fellowship University of TorinoDISAFA(Department of AgriculturalForest and Food Sciences)Largo Paolo Braccini2Grugliasco 10095TOItaly

One fifth of the world's population is living in mountains or in their surrounding *** anthropogenic pressure continues to grow with the increasing number of settlements,especially in areas connected to touristic activities,such as the Italian *** process of soil formation on high mountains is particularly slow and these soils are particularly vulnerable to soil *** alpine regions,extreme meteorological events are increasingly frequent due to climate change,speeding up the process of soil degradation and increasing the number of severe erosion processes,shallow landslides and debris *** cover plays a crucial role in the stabilization of mountain soils thereby reducing the risk of natural hazards effecting downslope *** aggregate stability is one of the main soil properties that can be linked to soil loss *** developed on moraines in recently deglaciated areas typically have low levels of soil aggregation,and a limited or discontinuous vegetation cover making them more susceptible to ***,soil structure can be influenced by the root system of the *** are actively involved in the formation of water-stable soil aggregation,increasing the stability of the soil and its nutrient *** the present study,we aim to quantify the effect of the root system of alpine vegetation on the soil aggregate stability of the forefield of the Lys glacier,in the Aosta Valley(NW-Italy).This proglacial area provides the opportunity to study how the root system of ten pioneer alpine species from different successional stages can contribute to soil development and soil *** quantify the aggregate stability of root permeated soils,a modified wet sieving method was *** root length per soil volume of the different species was also determined and later correlated with the aggregate stability *** results showed that soil aggregate stability was significantly increased by the presence

关键词： Soil aggregate stability Root length density Pioneer alpine species Glacier forefield

Compact n-Manifolds via(n+l)-Colored Graphs:a New Approach

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Algebra Colloquium 2020年第1期27卷 95-120页

作者： Luigi Grasselli michele Mulazzani Dipartimcnto di Scicnze e Metodi dell'Ingegneria Universita di Modena e Reggio Emilia Via Giovanni Amendola2-Pad.Morselli 42122 Reggio EmiliaItaly Dipartimento di Matematica and ARCES Universita di Bologna Piazza di Porta San Donato 540126 BolognaItaly

We introduce a representation via(n+l)-colored graphs of compact n-manifolds with(possibly empty)boundary,which appears to be very convenient for computer aided study and *** construction is a generalization to arbitrary dimension of the one recently given by Cristofori and Mulazzani in dimension three,and it is dual to the one given by Pezzana in the *** this context we establish some results concerning the topology of the represented manifolds:suspensions,fundamental groups,connected sums and moves between graphs representing the same *** results of compact orientable 4-manifolds representable by graphs up to six vertices are obtained,together with some properties of the G-degree of 5-colored graphs relating this approach to tensor models theory.

关键词： compact manifolds colored graphs fundamental groups dipole moves

Sarcopenia, obesity and postoperative outcomes after hepatectomy for hepatocellular carcinoma

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Hepatobiliary Surgery and Nutrition 2020年第2期9卷 198-201页

作者： michele Molinari Department of Surgery University of Pittsburgh Medical CenterPittsburghPAUSA

Over the last few decades,we have learned that the composition of our body is directly related to our *** second and equally important lesson is that when we define a healthy body,we have to go beyond the ratio between the weight and the height of a *** third lesson is that even though a"normal"balance between body fat and muscle is associated with good health and longevity,we still do not know what a"normal body composition"*** bodies can be classified in three main phenotypes based on the work of William Sheldon(1),a constitutional psychologist who worked at Harvard University in the *** three phenotypes are:ectomorphic,mesomorphic and *** we have certain tendency toward one group or the other,the level or physical activity,diet,age,gender or the presence of diseases have a profound impact that can make us migrate from one phenotype to another over time(2).

关键词： obesity diseases migrate

SPH numerical investigation of the characteristics of an oscillating hydraulic jump at an abrupt drop

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Journal of Hydrodynamics 2018年第1期30卷 106-113页

作者： Diana De Padova michele Mossa Stefano Sibilla Department of Civil Environmental Land Building Engineering and ChemistryPolytechnic University of Bari Department of Civil Engineering and Architecture University of Pavia

This paper shows the results of the smooth particle hydrodynamics（SPH） modelling of the hydraulic jump at an abrupt drop,where the transition from supercritical to subcritical flow is characterised by several flow patterns depending upon the inflow and tailwater conditions. SPH simulations are obtained by a pseudo-compressible XSPH scheme with pressure smoothing; turbulent stresses are represented either by an algebraic mixing-length model, or by a two-equation k-ε model. The numerical model is applied to analyse the occurrence of oscillatory flow conditions between two different jump types characterised by quasi-periodic oscillation,and the results are compared with experiments performed at the hydraulics laboratory of Bari Technical University. The purpose of this paper is to obtain a deeper understanding of the physical features of a flow which is in general difficult to be reproduced numerically,owing to its unstable character： in particular, vorticity and turbulent kinetic energy fields, velocity, water depth and pressure spectra downstream of the jump, and velocity and pressure cross-correlations can be computed and analysed.

关键词： Hydraulic jumps smoothed particle hydrodynamics(SPH) models oscillating characteristics

Experimental and Numerical Simulations of Flow and Heat Transfer in Heat Exchanger Elements Using Liquid Crystal Thermography

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Journal of Thermal Science 2004年第2期13卷 133-137页

作者： Jan STASIEK michele CIOFALO Maciej WIERZBOWSKI Heat Technology Dept. Gdansk Univ. of Technology Narutowicza 11/12 80-952 Gdansk PolandUniversity of Palermo Dipartimento Ingeneria Nucleare Viale delle Scienze I-90128 Palermo ItalyHeat Technology Dept. Gdansk Univ. of Technology Narutowicza 11/12 80-952 Gdansk Poland

Experimental and numerical investigation of heat transfer and fluid flow were conducted for classic heat exchanger elements (flat plate with fin-tubes in-line, staggered and with vortex generators) and corrugated-undulated ducts under transitional and weakly turbulent *** dependence of average heat transfer and pressure drop on Reynolds number and geometrical parameters was investigated. Distributions of local heat transfer coefficient were obtained by using liquid crystal thermography and surface-averaged values were computed. Three-dimensional numerical simulations were conducted by a finite-volume method using a low-Reynolds number k-e model under the assumption of fully developed flow. Computed flow fields provided otherwise inaccessible information on the flow patterns and the mechanisms of heat transfer enhancement.

关键词： liquid crystal thermography heat transfer enhancement.