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Beyond peripheral nerve injury:spina gliopathy and maladaptive synaptic plasticity

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Neural Regeneration Research 2016年第9期11卷 1422-1423页

作者： Giovanni Cirillo michele Papa Laboratory of Neuronal Networks Department of Mental and Physical Health and Preventive Medicine Second University of Naples Naples Italy

Who drew the borders between central and peripheral nervous sys tem？ A complex question but a simple answer. Human anatomy and clinical neurology need to differentiate peripheral nerves from central nervous system （CNS）, peripheral or central disorders, respectively. However, there are no anatomical and functional clefts between peripheral axons and central synaps- es. There is a direct continuity from the periphery to the center, from the receptor to the sensory neuron, from the spinal motor neuron to the muscle, just the neuromuscular junction.

关键词： NGF PNI Beyond peripheral nerve injury

Autonomous machine learning for early bot detection in the internet of things

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Digital Communications and Networks 2023年第6期9卷 1301-1309页

作者： Alex Medeiros Araujo Anderson Bergamini de Neira michele Nogueira Department of Informatics Federal University of Parana(UFPR)CuritibaBrazil Department of Computer Science Federal University of Minas Gerais(UFMG)Belo HorizonteBrazil

The high costs incurred due to attacks and the increasing number of different devices in the Internet of Things(IoT)highlight the necessity of the early detection of botnets(i.e.,a network of infected devices)to gain an advantage against ***,early botnet detection is challenging because of continuous malware mutations,the adoption of sophisticated obfuscation techniques,and the massive volume of *** literature addresses botnet detection by modeling the behavior of malware spread,the classification of malicious traffic,and the analysis of traffic *** article details ANTE,a system for ANTicipating botnEt signals based on machine learning *** system adapts itself to different scenarios and detects different types of *** autonomously selects the most appropriate Machine Learning(ML)pipeline for each botnet and improves the classification before an attack effectively *** system evaluation follows trace-driven experiments and compares ANTE results to other relevant results from the literature over four representative datasets:ISOT HTTP Botnet,CTU-13,CICDDoS2019,and *** show an average detection accuracy of 99.06%and an average bot detection precision of 100%.

关键词： Network security Bot early detection Autonomous machine learning Network traffic analysis

Bile acid activated receptors: Integrating immune and metabolic regulation in non-alcoholic fatty liver disease

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Liver Research 2021年第3期5卷 119-141页

作者： michele Biagioli Stefano Fiorucci Department of Medicine and Surgery University of PerugiaPerugiaItaly

Bile acids are a family of atypical steroids generated at the interface of liver-intestinal microbiota acting on a ubiquitously expressed family of membrane and nuclear receptors known as bile acid activated *** two best characterized receptors of this family are the nuclear receptor,farnesoid X re-ceptor(FXR)and the G protein-coupled receptor,G protein-coupled bile acid receptor 1(GPBAR1).FXR and GPBAR1 regulate major aspects of lipid and glucose metabolism,energy balance,autophagy and immunity and have emerged as potential pharmaceutical targets for the treatment of metabolic and inflammatory *** trials in non-alcoholic fatty liver disease(NAFLD),however,have shown that selective FXR agonists cause side effects while their efficacy is *** FXR and GPBAR1 exert additive effects,dual FXR/GPBAR1 ligands have been developed for the treatment of metabolic disorders and are currently advanced to clinical ***,we will review the role of FXR and GPBAR1 agonism in NAFLD and how the two receptors could be exploited to target multiple components of the disease.

关键词： Bile acid Farnesoid X receptor(FXR) G protein-coupled bile acid receptor 1(GPBAR1) Immunity Lipid metabolism Non-alcoholic fatty liver disease(NAFLD) Non-alcoholic steatohepatitis(NASH)

China between Economic Growth and Mass Immigration

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China & World Economy 2013年第2期21卷 56-77页

作者： michele Bruni Department of Economics University of Modena

In order to continue along its path of sustained economic growth, China will need, probably in just a few years, certainly after 2030, an extremely high number of immigrants. This conclusion, which contrasts with a recent World Bank scenario suggesting that the decline in labor supply due to demographic trends can be faced with sustained growth in productivity, is based upon a demand-driven model of migration. Moreover, according to the same model, the decline infertility （and the one ehild policy that has been partially responsible for it） will end up provoking immigration flows above replacement level. The working age population and the total population will continue to increase, and China will remain the most populous country on the planet. The last part of the paper surveys the policies that China could adopt to reduce its structural need for foreign labor.

关键词： China demography international migrations labor market scenarios

Simplified Wave Models Applicability to Shallow Mud Flows Modeled as Power-Law Fluids

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Journal of Mountain Science 2014年第6期11卷 1454-1465页

作者： Cristiana DI CRISTO michele IERVOLINO Andrea VACCA DICeM Università di Cassino e del Lazio Meridionale DICDEA Seconda Università di Napoli

Simplified wave models- such as kinematic,diffusion and quasi-steady- are widely employed as a convenient replacement of the full dynamic one in the analysis of unsteady open-channel flows,and especially for flood *** their use may guarantee a significant reduction of the computational effort,it is mandatory to define the conditions in which they may be confidently *** present paper investigates the applicability conditions of the kinematic,diffusion and quasisteady dynamic shallow wave models for mud flows of power-law *** power-law model describes in an adequate and convenient way fluids that at low shear rates fluids do not posses yield stress,such as clay or kaolin suspensions,which are frequently encountered in Chinese *** the framework of a linear analysis,the propagation characteristics of a periodic perturbation of an initial steady uniform flow predicted by the simplified models are compared with those of the full dynamic *** on this comparison,applicability criteria for the different wave approximations for mud flood of power-law fluids are *** presented results provide guidelines for selecting the appropriate approximation for a given flow problem,and therefore they may represent a useful tool for engineering predictions.

关键词： Power-law fluid Unsteady flows Shallow flows Simplified wave models

Physical and chemical processes promoting dominance of the toxic cyanobacterium Cylindrospermopsis raciborskii

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Chinese Journal of Oceanology and Limnology 2011年第4期29卷 883-891页

作者： michele A. BURFORD Timothy W. DAVIS Australian Rivers Institute Griffith University Nathan Qld. 4111 Australia

The freshwater cyanobacterium, Cylindrospermopsis raciborskii （Woloszyflska） Seenayya and Subba Raju is a common species in lakes and reservoirs globally. In some areas of the world it can produce cytoand hepatotoxins （cylindrospermopsins, saxitoxins）, making blooms of this species a serious health concern for humans. In the last 10 15 years, there has been a considerable body of research conducted on the ecology, physiology and toxin production of this species and this paper reviews these studies with a focus on the cylindrospermopsin （CYN）-producing strains. C. raciborskii has low light requirements, close to neutral buoyancy, and a wide temperature tolerance, giving it the capacity to grow in many lentic waterbodies. It also has a flexible strategy with respect to nitrogen （N） utilisation; being able to switch between utilising fixed and atmospheric N as sources of N fluctuate. Additionally this species has a high phosphate （DIP） affinity and storage capacity. Like many cyanobacteria, it also has the capacity to use dissolved organic phosphorus （DOP）. Changes in nutrient concentrations, light levels and temperature have also been found to affect production of the toxin CYN by this species. However, optimal toxin production does not necessarily occur when growth rates are optimal. Additionally, different strains of C. raciborskii vary in their cell quota of CYN, making it difficult to predict toxin concentrations, based on C. raciborskii cell densities. In summary, the ecological flexibility of this organism means that controlling blooms of C. raciborskii is a difficult undertaking. However, improved understanding of factors promoting the species and toxin production by genetically capable strains will lead to improved predictive models of blooms.

关键词： cyanobacteria freshwater algal toxins nutrients light temperature

ABCDE—agile block chain DApp engineering

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Blockchain(Research and Applications) 2020年第1期1卷 18-35页

作者： Lodovica Marchesi michele Marchesi Roberto Tonelli DMI University of CagliariCagliari09124Italy

Blockchain software development is becoming more and more important for any modern software developer and IT ***,blockchain software production still lacks a disciplined,organized and mature development process,as demonstrated by the many and(in)famous failures and frauds occurred in recent *** this paper we present ABCDE,a complete method addressing blockchain software *** method considers the software integration among the blockchain components—smart contracts,libraries,data structures—and the out-of-chain components,such as web or mobile applications,which all together constitute a complete DApp *** advocate for ABCDE the use of agile practices,because these are suited to develop systems whose requirements are not completely understood since the beginning,or tend to change,as it is the case of most blockchain-based *** is based on Scrum,and is therefore iterative and *** Scrum,we kept the requirement gathering with user stories,the iterative-incremental approach,the key roles,and the *** main difference with Scrum is the separation of development activities in two flows—one for smart contracts and the other for out-of-chain software interacting with the blockchain—each performed iteratively,with integration activities every 2–3 *** makes explicit the activities that must be performed to design,develop,test and integrate smart contracts and out-of-chain software,and documents the smart contracts using formal diagrams to help development,security assessment,and maintenance.A diagram derived from UML class diagram helps to effectively model the data structure of smart contracts,whereas the exchange of messages between the entities of the system is modeled using a modified UML sequence *** proposed method has also specific activities for security assessment and gas optimization,through systematic use of patterns and *** focuses on Ethereum blockchain and its

关键词： Blockchain Smart contracts Blockchain-oriented software engineering UML DApp design

Displacement Trends of Slow-moving Landslides: Classification and Forecasting

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Journal of Mountain Science 2014年第3期11卷 592-606页

作者： CASCINI Leonardo CALVELLO michele GRIMALDI Giuseppe Maria Department of Civil Engineering University of Salerno

A framework is proposed to characterize and forecast the displacement trends of slow-moving landslides, defined as the reactivation stage of phenomena in rocks or fine-grained soils, with movements localized along one or several existing shear surfaces. The framework is developed based on a thorough analysis of the scientific literature and with reference to significant reported case studies for which a consistent dataset of continuous displacement measurements is available. Three distinct trends of movement are defined to characterize the kinematic behavior of the active stages of slow-moving landslides in a velocity-time plot: a linear trend-type I, which is appropriate for stationary phenomena; a convex shaped trend-type II, which is associated with rapid increases in pore water pressure due to rainfall, followed by a slow decrease in the groundwater level with time; and a concave shaped trend-type III, which denotes a non-stationary process related to the presence of new boundary conditions such as those associated with the development of a newly formed local slip surface that connects with the main existing slip surface. Within the proposed framework, a model is developed to forecast future displacements for active stages of trend-type II based on displacement measurements at the beginning of the stage. The proposed model is validated by application to two case studies.

关键词： Slow-moving landslides Displacements forecast Trends of movement

Regular Global Attractors of Type Ⅲ Thermoelastic Extensible Beams

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Chinese Annals of Mathematics,Series B 2010年第5期31卷 619-630页

作者： michele COTI ZELATI Vittorino PATA Ramon QUINTANILLA Mathematics Department Indiana UniversityRawles Hall Dipartimento di Matematica "F. Brioschi" Politecnico di Milano Matemtica Aplicada 2 ETSEIAT-UPC Terrassa

For β∈ R,the authors consider the evolution system in the unknown variables u and ααttu+αxxxxu+αxxtα-(β+αxu L22)αxxu=f,αttα-αxxα-αxxtα-αxxtu=0 describing the dynamics of type III thermoelastic extensible beams,where the dissipation is entirely contributed by the second equation ruling the evolution of the thermal displacement α.Under natural boundary conditions,the existence of the global attractor of optimal regularity for the related dynamical system acting on the phase space of weak energy solutions is established.

关键词： Type III thermoelastic extensible beam Lyapunov functional Global attractor