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Prebiotics in non-dairy products:Technological and physiological functionality,challenges,and perspectives

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Food Bioscience 2022年第2期46卷 122-137页

作者： Tatiana Colombo Pimentel Bianca Beatriz Torres de Assis Caique dos Santos Rocha Vanessa Aparecida Marcolino michele Rosset Marciane Magnani Federal Institute of Paran´a Campus Paranavaí87703-536ParanavaíPRBrazil State University of Maring´a Food Engineering Post-GraduationMaring´aPRBrazil Federal Institute of Paran´a Campus ColomboColomboPRBrazil Department of Food Engineering University of ParaíbaJo˜ao PessoaPBBrazil

Vegan consumers look for fresh,tasty,and nutritious products that use eco/animal-friendly *** are substrates selectively utilized by host microorganisms conferring a health *** study aimed to overview the potentially vegan products added with prebiotics,their health benefits,and the main technological and sensory *** main potentially vegan products added with prebiotics studied were based on water-soluble plant-based extracts(fermented beverages,frozen desserts,cheese analog),fruits(fruit juices,fruit jelly,and ready to eat fruits),and cereals(snack bars,granola bars,bread,and cookies).The main prebiotic compounds used were inulin,fructooligosaccharides,oligofructose,polydextrose,and *** effects of prebiotic on food products’,host health,and technological and sensory properties depended on the prebiotic type and dosage,food matrix,and subject *** positive health effects were related to skin health,gut microbiota improvement,hypocholesterolemic impact,reduction of the risk of metabolic diseases,and improvements in postprandial blood glucose and insulin *** could improve vegan products’technological and sensory properties,such as fermentation time,texture and rheological properties,storage length,sensory acceptance,and probiotic ***,they could increase the concentration and/or bioaccessibility of phenolic compounds and ***,it is of paramount importance the determination of prebiotic *** trends direct to new prebiotic compounds based on microalgae,fruit and cereal by-products,and *** review provides industries and researchers with important information about prebiotics and vegan products.

关键词： Inulin-type fructans Non-dairy products Veganism Prebiotic ingredients

Morphology, flight performance, and water crossing tendencies of Afro-Palearctic raptors during migration

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Current Zoology 2015年第6期61卷 951-958页

作者： Nicolantonio AGOSTINI michele PANUCCIO Cristian PASQUARETTA MEDRAPTORS (Mediterranean Raptor Migration Network) Via Mario Fioretti 18 00152 Rome Italy University of Pavia Department of Earth and Environmental Sciences Via Ferrata 9 27100 Pavia (PV) Italy Universit6 de Strasbourg IPHC 23 rue Becquerel 67087 Strasbourg France CNRS UMR7178 67037 Strasbourg France

Raptors primarily use soaring-gliding flight which exploits thermals and ridge lifts over land to reduce energetic costs. However during migration, these birds often have to cross water surfaces where thermal currents are weak; during these times, birds mainly use flapping (powered) flight which increases energy consumption and mortality risk. As a result, some species have evolved strategies to reduce the amount of time spent over water by taking extensive detours over land. In this paper, we conducted a meta-analysis of water-crossing tendencies in Afro-Palearctic migrating raptors in relation to their morphology, their flight performance, and their phylogenetic relationships. In particular, we considered the aspect ratio (calculated as the wing span squared divided by wing area), the energetic cost of powered flight, and the maximum water crossing length regularly performed by adult birds. Our results suggest that energy consumption during powered flight predominately affects the ability of raptors to fly over water surfaces.

关键词：飞行性能迁移过程形态分析过水能量消耗滑翔飞行进化策略亲缘关系

Hyperthermic intraperitoneal chemotherapy and colorectal cancer:From physiology to surgery

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World Journal of Clinical Cases 2022年第30期10卷 10852-10861页

作者： Giorgio Ammerata Rosalinda Filippo Carmelo Laface Riccardo Memeo Leonardo Solaini Davide Cavaliere Giuseppe Navarra Girolamo Ranieri Giuseppe Currò michele Ammendola Department Digestive Surgery UnitUniversity“Magna Graecia”Medical SchoolCatanzaro 88100Italy Interventional Oncology Unit with Integrated Section of Translational Medical Oncology National Cancer Research Centre“Giovanni Paolo Ⅱ”Bari 70124Italy Hepato-Biliary and Pancreatic Surgical Unit “F.Miulli”HospitalAcquaviva delle FontiBari 70124Italy Department of Medical and Surgical Sciences University of BolognaForlì40126Italy Department of General and Oncologic Surgery Morgagni-Pierantoni HospitalForlì47121Italy Department of Human Pathology of Adult and Evolutive Age Surgical Oncology Division“G.Martino”HospitalUniversity of MessinaMessina 98122Italy

The pursuit of this paper is to collect principal reviews and systematic reviews about hyperthermic intraperitoneal chemotherapy(HIPEC) and cytoreductive surgery(CRS) used in colorectal cancer(CRC).We focus on principal biological aspects of CRC,hyperthermia effects,and surgical *** searched PubMed/MEDLINE for the principal reviews and systematic reviews published from 2010 to 2021 regarding the bimodal treatment(CRS + HIPEC) against local and advanced *** the literature,from several studies,it seems that the efficacy of bimodal treatment with an accurate CRS can extend overall *** these studies,there are not still any straight guidelines more detailed and scheduled about the use of combined treatment in patients with *** if the concept is still not very clear and shared,after a careful evaluation of the published data,and after some technical and pathophysiological descriptions,we concluded that it is possible to improve the overall survival and quality of life and to reduce the tumor relapse in patients affected by locally advanced(pT4) CRC with peritoneal metastases.

关键词： Hyperthermic intraperitoneal chemotherapy Colorectal cancer Peritoneum Cytoreductive surgery

Neurogenesis in the adult peripheral nervous system

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Neural Regeneration Research 2012年第14期7卷 1047-1054页

作者： Krzysztof Czaja michele Fornaro Stefano Geuna Department of Veterinary and Comparative Anatomy Pharmacology and Physiology (VCAPP) College of Veterinary Medicine Washington State University Pullman WA 99163-6520 USA Department of Anatomy Chicago College of Osteopathic Medicine (CCOM) Midwestern University Downers Grove IL 60515 USA Neuroscience Institute of the Cavalieri Ottolenghi Foundation (NICO) & Department of Clinical and Biological Sciences University of Turin Orbassano 10043 Italy

Most researchers believe that neurogenesis in mature mammals is restricted only to the subgranular zone of the dentate gyrus and the subventricular zone of the lateral ventricle in the central nervous system. In the peripheral nervous system, neurogenesis is thought to be active only during prenatal development, with the exception of the olfactory neuroepithelium. However, sensory ganglia in the adult peripheral nervous system have been reported to contain precursor cells that can proliferate in vitro and be induced to differentiate into neurons. The occurrence of insult-induced neurogenesis, which has been reported by several investigators in the brain, is limited to a few recent reports for the peripheral nervous system. These reports suggest that damage to the adult nervous system induces mechanisms similar to those that control the generation of new neurons during prenatal development. Understanding conditions under which neurogenesis can be induced in physiologically non-neurogenic regions in adults is one of the major challenges for developing therapeutic strategies to repair neurological damage. However, the induced neurogenesis in the peripheral nervous system is still largely unexplored. This review presents the history of research on adult neurogenesis in the peripheral nervous system, which dates back more than 100 years and reveals the evidence on the under estimated potential for generation of new neurons in the adult peripheral nervous system.

关键词： adult neurogenesis peripheral nervous system dorsal root ganglia autonomic ganglia stem cells mammals

Adjuvant treatment in biliary tract cancer: To treat or not to treat?

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World Journal of Gastroenterology 2012年第21期18卷 2591-2596页

作者： Stefano Cereda Carmen Belli michele Reni Department of Oncology San Raffaele Scientific Institute20132 Milan Italy

Biliary tract cancer is a rare malignant tumor. There is limited knowledge about biology and natural history of this disease and considerable uncertainty remains regarding its optimal diagnostic and therapeutic man- agement. The role of adjuvant therapy is object of debate and controversy. Although resection is identified as the most effective and the only potentially curative treatment, there is no consensus on the impact of ad- juvant chemotherapy and/or radiotherapy on the high incidence of disease recurrence and on survival. This is mainly due to the rarity of this disease and the consequent difficulty in performing randomized trials. The only two prospectively controlled trials concluded that adjuvant chemotherapy did not improve survival. Most of the retrospective trials, which had limited sample size and included heterogeneous patients population and non-standardized therapies, suggested a marginal benefit of chemoradiotherapy in reducing locoregional recurrence and an uncertain impact on survival. Welldesigned multi-institutional randomized trials are necessary to clarify the role of adjuvant therapy. Two ongoing phase Ⅲ trials may provide relevant information.

关键词：辅助治疗胆道随机试验癌治疗作用恶性肿瘤不确定性手术切除

SYSTEM OF SYSTEMS APPROACH TO POLICY DEVELOPMENT FOR GLOBAL FOOD SECURITY

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Journal of Systems Science and Systems Engineering 2010年第1期19卷 1-21页

作者： Keith W. HIPEL Liping FANG michele HENG Department of Systems Design Engineering University of Waterloo Waterloo Canada Department of Mechanical and Industrial Engineering Ryerson University Toronto Canada

A formal policy development framework, based on a system of systems （SOS） approach, is synthesized to systematically address, in an integrative and adaptive fashion, major global challenges, such as the current food and fjnancial crises, and their interactions with other key natural, societal, and technological systems. A SoS approach seeks to respect the different value systems of multiple participants, to harness complexity through effective integration, and to engage the world of uncertainty and unpredictability with an adaptive response. Faced with the present global challenges, what is needed are strategic and operational methods which lead to ethical policies, enhance integrative and adaptive management practices, and are able to direct conflict resolution in a positive direction. Policy makers need tools to model and analyze complex systems which they are trying to responsibly govern, taking into account values and risks to design and evaluate different policies. A preliminary investigation into the global food system is undertaken to understand the SoS and to provide insights on how to carry out policy development using the proposed framework.

关键词： Complex systems conflict resolution global food system risk management system of systems values

Ambient Affiliation in Comments on YouTube Videos:Communing Around Values About ASMR

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外国语 2021年第1期44卷 21-40页

作者： michele Zappavigna University of New South Wales SydneyAustralia

This paper explores ambient affiliation within the ASMR community on YouT ube,investigating how values are communed around in YouT ube *** community consists of viewers who watch videos designed to elicit an Autonomous Sensory Meridian Response(ASMR),that is,a pleasurable sensory reaction to visual or aural *** paper focuses on the linguistic resources involved in orienting the ambient audience to the values shared,as couplings of ATTITUDE and IDEATION,in the comments *** most comments do not receive any reply,rather than dialogic affiliation,a framework for analysing communing affiliation,based on Zappavigna and Martin’s(2018)approach to Twitter data,is *** systems of meaning are considered:convoking(mustering community around a coupling),finessing(dialogically positioning a coupling),and promoting(emphasising a coupling).The paper develops these systems in terms of *** attitudinal component of the couplings is analysed using the Appraisal framework(Martin and White 2005).The dataset explored is the comments feed of the most viewed video on the Gentle Whispering ASMR YouT ube channel,the most popular ASMR channel at the time of writing.

关键词： ambient affiliation communing affiliation coupling appraisal digital intimacy ASMR YouTube

Environmental complaint insights through text mining based on the driver,pressure,state,impact,and response(DPSIR)framework:Evidence from an Italian environmental agency

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区域可持续发展(英文) 2023年第3期4卷 261-281页

作者： Fabiana MANSERVISI michele BANZI Tomaso TONELLI Paolo VERONESI Susanna RICCI Damiano DISTANTE Stefano FARALLI Giuseppe BORTONE Regional Agency for Prevention Environment and Energy of Emilia-RomagnaVia Po 5Bologna40139Italy Department of Law and Economics University of Rome Unitelma SapienzaPiazza Sassari 4Rome00161Italy Department of Computer Science Sapienza University of RomeViale Regina Elena 295Rome00161Italy

Individuals,local communities,environmental associations,private organizations,and public representatives and bodies may all be aggrieved by environmental problems concerning poor air quality,illegal waste disposal,water contamination,and general *** complaints represent the expressions of dissatisfaction with these *** the timeconsuming of managing a large number of complaints,text mining may be useful for automatically extracting information on stakeholder priorities and *** paper used text mining and semantic network analysis to crawl relevant keywords about environmental complaints from two online complaint submission systems:online claim submission system of Regional Agency for Prevention,Environment and Energy(Arpae)(“Contact Arpae”);and Arpae's internal platform for environmental pollution(“Environmental incident reporting portal”)in the Emilia-Romagna Region,*** evaluated the total of 2477 records and classified this information based on the claim topic(air pollution,water pollution,noise pollution,waste,odor,soil,weather-climate,sea-coast,and electromagnetic radiation)and geographical ***,this paper used natural language processing to extract keywords from the dataset,and classified keywords ranking higher in Term Frequency-Inverse Document Frequency(TF-IDF)based on the driver,pressure,state,impact,and response(DPSIR)*** study provided a systemic approach to understanding the interaction between people and environment in different geographical contexts and builds sustainable and healthy *** results showed that most complaints are from the public and associated with air pollution and ***(particularly foundries and ceramic industries)and farms are identified as the drivers of environmental *** believed that environmental issues mainly affect human ***,the keywords of“odor”,“report”,“request”,“presence”,“municipality”,and“hours”were the most influ

关键词： Environmental complaints Text mining approach Term Frequency-Inverse Document Frequency(TF-IDF) Driver pressure state impact and response(DPSIR)framework Semantic network analysis Regional Agency for Prevention Environment and Energy(Arpae)

Beyond peripheral nerve injury:spina gliopathy and maladaptive synaptic plasticity

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Neural Regeneration Research 2016年第9期11卷 1422-1423页

作者： Giovanni Cirillo michele Papa Laboratory of Neuronal Networks Department of Mental and Physical Health and Preventive Medicine Second University of Naples Naples Italy

Who drew the borders between central and peripheral nervous sys tem？ A complex question but a simple answer. Human anatomy and clinical neurology need to differentiate peripheral nerves from central nervous system （CNS）, peripheral or central disorders, respectively. However, there are no anatomical and functional clefts between peripheral axons and central synaps- es. There is a direct continuity from the periphery to the center, from the receptor to the sensory neuron, from the spinal motor neuron to the muscle, just the neuromuscular junction.

关键词： NGF PNI Beyond peripheral nerve injury