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Rare Presentation of Meningioma as an External Auditory Canal Mass

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International Journal of Otolaryngology and Head & Neck Surgery 2024年第5期13卷 378-383页

作者： Justin Hall Nikitha Jona Crescentia Cho michele gandolfi Department of Otolaryngology Atrium Health Wake Forest Baptist Health Winston Salem NC USA Department of Otolaryngology Wake Forest University School of Medicine Winston Salem NC USA

This is a case of a 60-year-old male with a history of prior left middle fossa meningioma that was partially resected with an operative report noting diffuse attachment to the middle fossa floor. Gamma knife was recommended but he never completed this management. He then presented about eight years later with a mass from his left external auditory canal. It was reported that two years prior another surgeon operated on the left ear for a cholesteatoma. CT temporal bone showed complete opacification of left EAC, mastoid bowl, and remaining mastoid air cells. In addition, there were irregular bony/hyperostotic changes seen within the left sphenoid and temporal bone. There was dural thickening within the middle fossa adjacent to the previously described hyperostotic bony changes. A mastoidectomy and excision of mass revealed extensive adhesive tissue throughout the middle ear, and mastoid up to the tegmen. Pathology of the portions that were resected confirmed Grade 1 meningioma. Stereotactic gamma knife radiation was completed to the area to prevent further growth. This case highlights extracranial meningioma that did not have definitive management for prior middle fossa floor meningioma. It also highlights the need to think of less common pathology in the middle ear and external auditory canal.

关键词： Middle Ear Cranial Base Otology/Neurotology

Selective butyric acid production from CO_(2)and its upgrade to butanol in microbial electrosynthesis cells

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Environmental Science and Ecotechnology 2024年第1期17卷 119-127页

作者： Meritxell Romans-Casas Laura Feliu-Paradeda michele Tedesco Hubertus V.M.Hamelers Lluis Bañeras M.Dolors Balaguer SebastiàPuig Paolo Dessì Institute of the Environment University of Girona.Campus MontiliviCarrer Maria Aurélia Capmany 69E-17003GironaSpain Molecular Microbial Ecology Group Institute of Aquatic EcologyUniversity of GironaMaria Aurelia Capmany 4017003GironaSpain Wetsus European Centre of Excellence for Sustainable Water TechnologyOostergoweg 98911MALeeuwardenthe Netherlands

Microbial electrosynthesis(MES)is a promising carbon utilization technology,but the low-value products(i.e.,acetate or methane)and the high electric power demand hinder its industrial *** this study,electrically efficient MES cells with a low ohmic resistance of 15.7 mU m^(2)were operated galvanostatically in fed-batch mode,alternating periods of high CO_(2)and H2 *** promoted acetic acid and ethanol production,ultimately triggering selective(78%on a carbon basis)butyric acid production via chain *** average production rate of 14.5 g m^(-2)d^(-1)was obtained at an applied current of 1.0 or 1.5 mA cm^(-2),being Megasphaera *** key chain elongating *** a second cell with the catholyte containing the enriched community resulted in butyric acid production at the same rate as the previous cell,but the lag phase was reduced by 82%.Furthermore,interrupting the CO_(2)feeding and setting a constant pH2 of 1.7e1.8 atm in the cathode compartment triggered solventogenic butanol production at a pH below *** efficient cell design resulted in average cell voltages of 2.6e2.8 V and a remarkably low electric energy requirement of 34.6 kWhel kg1 of butyric acid produced,despite coulombic efficiencies being restricted to 45%due to the cross-over of O_(2)and H2 through the *** conclusion,this study revealed the optimal operating conditions to achieve energy-efficient butyric acid production from CO_(2)and suggested a strategy to further upgrade it to valuable butanol.

关键词： Biocathode Bioelectrochemical system Chain elongation Hydrogen partial pressure Megasphaera

Predicted and measured soil retention curve parameters in Lombardy region north of Italy

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International Soil and Water Conservation Research 2016年第3期4卷 207-214页

作者： Fatma Wassar Claudio gandolfi michele Rienzner Enrico Antonio Chiaradia Ettore Bernardoni IBIMET-CNR via Madonna del Piano 1050019 Sesto F.noFIItaly Dipartimento di Scienze Agrarie e Ambientali(DISAA) Universitàdegli Studi di Milano(UNIMI)Via Celoria 220133 MilanoItaly ISSTEG Institut Supérieur des Sciences et Techniques des EauxcitéAmal 46072 GabèsTunisia

Water retention characteristics are fundamental input parameters in any modeling study on water flow and solute *** properties are difficult to measure and for that reason,we usually need to use direct and indirect methods to determine *** extensive comparison between measured and estimated results is needed to determine their applicability for a range of different *** this study attempts to make a contribution specifically in this *** properties were determined in two representative sites located in Landriano field,in Lombardy region,northern *** the laboratory we used the pressure plate apparatus and the tensiometric *** soil water retention was determined including measurements of soil water content with SENTEK probes and matric potential with *** soil waer retention curves(SWRC)were also settled on with some recently developed pedo-transfert functions(PTFs).Field retention curves were compared against those obtained from PTFs estimations and laboratory *** comparison showed that laboratory measurements were the most *** had the highest ranking for the validation indices(RMSE ranging between 2.4%and 7.7%and bias between 0.1%and 6.4%).The second best technique was the PTF Rosetta(Schaap et al.2001).They perform only slightly poorer than the laboratory measurements(RMSE ranging between 2.7%and 10%and bias between 0.3%and 7.7%).The lowest prediction accuracy is observed for the Rawls and Brakensiek(1985)PTF(RMSE ranging between 6.3%and 17%and bias between 5%and 10%)which is in contradiction with previous finding(Calzolari et al.,2001),showing that this function is well representing the retention characteristics of the *** to time and cost investments of laboratory and field measurements,we conclude that the Rosetta PTF developed by Schaap et al.(2001)appears to be the best to predict the soil moisture retention curve from easily available soil properties in the Lombardy area a

关键词： Comparison Laboratory water retention Field measurements Curve measurements Pedo-transfert functions

Rifaximin vs conventional oral therapy for hepatic encephalopathy:A meta-analysis

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World Journal of Gastroenterology 2012年第8期18卷 767-777页

作者： Karim M Eltawil marie Laryea Kevork Peltekian michele Molinari Department of Surgery and Transplantation Queen Elizabeth Ⅱ Health Sciences Center Dalhousie University Department of Medicine Hepatology and Transplantation Queen Elizabeth Ⅱ Health Sciences Center Dalhousie University

AIM: To characterize the efficacy of rifaximin in the management of hepatic encephalopathy (HE) as several randomized controlled studies have shown contradictory results on its effectiveness in comparison to other oral agents. METHODS: We performed a systematic review and random effects meta-analysis of all eligible trials identifi ed through electronic and manual searches. Twelve randomized controlled trials met the inclusion criteria with a total of 565 patients. RESULTS: The clinical effectiveness of rifaximin was equivalent to disaccharides or other oral antibiotics[odds ratio (OR) 0.96; 95% CI: 0.94-4.08] but with a better safety profi le (OR 0.27; 95% CI: 0.12-0.59). At the completion of treatment protocols, patients receiving rifaximin showed lower serum ammonia levels [weighted mean difference (WMD) = -10.65; 95% CI: -23.4-2.1; P = 0.10], better mental status (WMD = -0.24; 95% CI: -0.57-0.08; P = 0.15) and less asterixis (WMD -0.1; 95% CI -0.26-0.07; P = 0.25) without reaching statistical signifi cance. On the other hand, other psychometric outcomes such as electroencephalographic response and grades of portosystemic encephalopathy were superior in patients treated with rifaximin in comparison to the control group (WMD = 0.21, 95% CI: -0.33-0.09, P = 0.0004; and WMD = -2.33, 95% CI: -2.68-1.98, P = 0.00001, respectively). Subgroup and sensitivity analysis did not show any signifi cant difference in the above fi ndings. CONCLUSION: Rifaximin appears to be at least as effective as other conventional oral agents for the treatment of HE with a better safety profi le.

关键词： Hepatic encephalopathy Lactulose Neo-mycin Non-absorbable disaccharides Rifaximin

Fluoride Hydro-geochemistry Studies:A Case Study from Granitic Aquifer System of Maheshwaram,Hyderabad,India

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地学前缘 2009年第S1期16卷 11-12页

作者： Surendra Atal Hélène Pauwels Jean-marie gandolfi Shakeel Ahmed National Geophysical Research Institute(CSIR) BRGM 3 Avenue Claude Guillemin 45060 Orleans IFCGR National Geophysical Research Institute(CSIR)

The impact of population pressure has been observed on several systems,groundwater resource is one among *** and over-exploitation has not only caused the decline of groundwater levels but also causes deterioration in... 详细信息

关键词： fluorine hydro-geochemistry granites hard rock aquifer

A Rare Case of Tarceva Resulting in Tympanic Membrane Necrosis

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International Journal of Otolaryngology and Head & Neck Surgery 2013年第4期2卷 135-137页

作者： michele M. gandolfi Ana H. Kim Department of Otolaryngology New York Eye and Ear Infirmary New York USA

Objective: To report a novel case of Tarceva? treatment for small cell lung carcinoma resulting in tympanic membrane necrosis. Patient: A 49-year-old male with tympanic membrane necrosis and presumed resistant acute otitis externa and chronic inflammation of the left ear. Patient is status post chemotherapy and radiation diagnosed with non-small cell lung cancer in December 2008 with on-going therapy with Tarceva? for residual disease. Intervention: Tympanoplasty of left ear. Results: Improvement of symptoms of irritation and improvement of hearing and speech reception thresholds. All acid fast bacilli, fungal and bacterial cultures of the intra-op specimen were negative. Conclusions: The possibility that long term Tarceva? therapy could have caused the tympanic membrane necrosis and acute otitis media like symptoms is feasible since Tarceva? is an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. Upon activation of EGFRs it undergoes a transition from inactive monomeric form to active homodimer or hertodimer with another member of the ErbB receptor family. This then initiates several signal transduction cascades, leading to DNA synthesis and cell proliferation. Activation of the receptor is important in the innate immune response in human skin. Some of the common side effects include an aceiform skin rash but this is the first reported link between tympanic membrane necrosis and Tarceva?.

关键词： Tympanic Membrane Necrosis Tympanoplasty Tarceva©

Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity

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World Journal of Gastroenterology 2024年第4期30卷 332-345页

作者： Yi-Jie Li Brittney O Baumert Nikos Stratakis Jesse A Goodrich Hao-Tian Wu Jing-Xuan He Yin-Qi Zhao Max T Aung Hong-Xu Wang Sandrah P Eckel Douglas I Walker Damaskini Valvi michele A La Merrill Justin R Ryder Thomas H Inge Todd Jenkins Stephanie Sisley Rohit Kohli Stavra A Xanthakos Andrea A Baccarelli Rob McConnell David V Conti Lida Chatzi Department of Population and Public Health Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90032United States Barcelona Institute of Global Health Barcelona Institute of Global HealthBarcelona 08036Spain Department of Environmental Health Sciences Mailman School of Public HealthColumbia UniversityNew YorkNY 10032United States Gangarosa Department of Environmental Health Rollins School of Public HealthEmory UniversityAtlantaGA 30329United States Department of Environmental Medicine and Public Health Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Environmental Toxicology University of CaliforniaDavisCA 95616United States Department of Surgery Lurie Children’s Hospital of ChicagoChicagoIL 60611United States Northwestern University Feinberg School of Medicine Northwestern UniversityChicagoIL 60611United States Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States Department of Pediatrics University of Cincinnati College of MedicineCincinnatiOH 45229United States Department of Pediatrics Children’s Nutrition Research Center USDA/ARSBaylor College of MedicineHoustonTX 77030United States Department of Gastroenterology Children’s Hospital Los AngelesLos AngelesCA 90027United States Division of Gastroenterology Hepatology and NutritionCincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases in children and *** ranges in severity from isolated hepatic steatosis to nonalcoholic steatohepatitis(NASH),wherein hepatocellular inflammation and/or fibrosis coexist with *** microRNA(miRNA)levels have been suggested to be altered in NAFLD,but the extent to which miRNA are related to NAFLD features remains *** analysis tested the hypothesis that plasma miRNAs are significantly associated with histological features of NAFLD in *** To investigate the relationship between plasma miRNA expression and NAFLD features among adolescents with *** This study included 81 adolescents diagnosed with NAFLD and 54 adolescents without NAFLD from the Teen-Longitudinal Assessment of Bariatric Surgery ***-operative core liver biopsies were collected from participants and used to characterize histological features of *** samples were collected during surgery for miRNA profiling.A total of 843 plasma miRNAs were profiled using the HTG EdgeSeq *** examined associations of plasma miRNAs and NAFLD features using logistic regression after adjusting for age,sex,race,and other key *** Pathways Analysis was used to identify biological functions of miRNAs that were associated with multiple histological features of *** We identified 16 upregulated plasma miRNAs,including miR-193a-5p and miR-193b-5p,and 22 downregulated plasma miRNAs,including miR-1282 and miR-6734-5p,in adolescents with ***,52,16,15,and 9 plasma miRNAs were associated with NASH,fibrosis,ballooning degeneration,and lobular inflammation,***,16 miRNAs were associated with two or more histological features of *** those miRNAs,miR-411-5p was downregulated in NASH,ballooning,and fibrosis,while miR-122-5p,miR-1343-5p,miR-193a-5p,miR-193b-5p,and miR-7845-5p were consistently and posi

关键词： MicroRNA Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Liver fibrosis Lobular inflammation Ballooning degeneration

Audiogram Bone-Conduction Testing Induced Seizure in Patient with Traumatic Brain Injury

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International Journal of Otolaryngology and Head & Neck Surgery 2023年第5期12卷 326-330页

作者： Lauren G. Himes Nelson H. May michele M. gandolfi Department of Otolaryngology Head & Neck Surgery Wake Forest University School of Medicine Winston Salem NC USA

In this case report, we discuss a patient who presented with Tullio’s phenomenon, who also experienced bone-conduction induced seizures on two occasions. Tullio’s phenomenon refers to sound induced vestibular symptoms, including disequilibrium oscillopsia, and vertical nystagmus. We were ultimately able to rule out some of the more common pathologies associated with Tullio’s phenomenon for this patient based on imaging findings. However, given the specific nature of her chronic symptoms, as well as her seizure like activity in clinic, we performed a literature search to investigate other less common pathologies associated with Tullio’s phenomenon. Given her past medical history of mixed psychogenic non-epileptic seizures (PNES), there is likely a somatic component to her presentation. However, given the specific and unexpected nature of these events, we propose that her symptoms may also be related to a unique inner ear pathology. Specifically, we feel that she may have exhibited symptoms of vestibular atelectasis, a relatively new otologic diagnosis characterizing the pathologic collapse of the ampulla and utricle, such that the membranous labyrinth contacts the stapes. In this way, loud sounds or changes in pressure may induce vestibular symptoms. Dizzy patients can be a difficult demographic to diagnose and manage, especially when their presentation is complicated by other functional neurologic disorders. Ultimately, we believe that this case report offers helpful insights into a new disease process associated with Tullio’s phenomenon.

关键词： Seizure Audiogram Traumatic Brain Injury

Quantifying the contribution of the root system of alpine vegetation in the soil aggregate stability of moraine

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International Soil and Water Conservation Research 2017年第1期5卷 36-42页

作者： Csilla Hudek Silvia Stanchi michele D’Amico michele Freppaz University of Torino DISAFA(Department of AgriculturalForest and Food Sciences)Largo Paolo Braccini2Grugliasco 10095TOItaly Train2Move Fellowship University of TorinoDISAFA(Department of AgriculturalForest and Food Sciences)Largo Paolo Braccini2Grugliasco 10095TOItaly

One fifth of the world's population is living in mountains or in their surrounding *** anthropogenic pressure continues to grow with the increasing number of settlements,especially in areas connected to touristic activities,such as the Italian *** process of soil formation on high mountains is particularly slow and these soils are particularly vulnerable to soil *** alpine regions,extreme meteorological events are increasingly frequent due to climate change,speeding up the process of soil degradation and increasing the number of severe erosion processes,shallow landslides and debris *** cover plays a crucial role in the stabilization of mountain soils thereby reducing the risk of natural hazards effecting downslope *** aggregate stability is one of the main soil properties that can be linked to soil loss *** developed on moraines in recently deglaciated areas typically have low levels of soil aggregation,and a limited or discontinuous vegetation cover making them more susceptible to ***,soil structure can be influenced by the root system of the *** are actively involved in the formation of water-stable soil aggregation,increasing the stability of the soil and its nutrient *** the present study,we aim to quantify the effect of the root system of alpine vegetation on the soil aggregate stability of the forefield of the Lys glacier,in the Aosta Valley(NW-Italy).This proglacial area provides the opportunity to study how the root system of ten pioneer alpine species from different successional stages can contribute to soil development and soil *** quantify the aggregate stability of root permeated soils,a modified wet sieving method was *** root length per soil volume of the different species was also determined and later correlated with the aggregate stability *** results showed that soil aggregate stability was significantly increased by the presence

关键词： Soil aggregate stability Root length density Pioneer alpine species Glacier forefield