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close relationship between mediators of inflammation and pancreatic cancer:Our experience

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World Journal of Gastroenterology 2024年第23期30卷 2927-2930页

作者： Francesca Vescio michele Ammendola Giuseppe currò Silvia curcio Department General Surgery UnitUniversity“Magna Graecia”Medical SchoolUniversity Hospital“R.Dulbecco”Catanzaro 88100Italy Science of Health Department Digestive Surgery UnitUniversity“Magna Graecia”Medical SchoolUniversity Hospital“R.Dulbecco”Catanzaro 88100Italy

In this editorial,we focus specifically on the mechanisms by which pancreatic inflammation affects pancreatic *** of the pancreas remains one of the deadliest cancer *** highest incidence and mortality rates of pancreatic cancer are found in developed *** of pancreatic cancer incidence and mortality vary considerably worldwide.A better understanding of the etiology and identification of the risk factors is essential for the primary prevention of this *** tumors are characterized by a complex microenvironment that orchestrates metabolic alterations and supports a milieu of interactions among various cell types within this *** this editorial,we highlight the foundational studies that have driven our understanding of these *** our experimental center,we have carefully studied the mechanisms of that link pancreatic inflammation and pancreatic *** focused on the role of mast cells(Mcs).Mcs contain pro-angiogenic factors,including tryptase,that are associated with increased angiogenesis in various *** this editorial,we address the role of Mcs in angiogenesis in both pancreatic ductal adenocarcinoma tissue and adjacent normal *** assessment includes the density of c-Kit receptor-positive Mcs,the density of tryptase-positive Mcs,the area of tryptasepositive Mcs,and angiogenesis in terms of microvascularization density.

关键词： Mast cells c-Kit receptor Tryptase Angiogenesis Microvascular density Endothelial area Pancreatic tumor tissue Adjacent normal tissue

2014年俄勒冈州一起与娱乐用天然湖泊有关联的诺如病毒暴发

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上海预防医学 2016年第6期28卷 429-431,F0004页

作者： Amy Zlot Maayan Simckes Jennifer Vines Laura Reynolds Amy Sullivan Magdalena Kendall Scott J.Michael McLuckie Dan Kromer Vincent R.Hill Jonathan S.Yoder michele c.hlavsa 宫宵欢陆仁敏 Multnomah county Health Department cDc/cSTE Applied Epidemiology Fellowship Program Oregon Public Health Division Metro Blue Lake Regional Park Fairview Oregon Division of Foodborne Waterborne and Environmental Diseases National Center for Emerging and Zoonotic Infectious Diseases CDC

2014年7月,摩特诺玛郡（Multnomah county）公共卫生人员对一起在俄勒冈州蓝湖地区公园的游客中发生的诺如病毒暴发进行了调查。在报告病例的周末（7月11日周五至7月13日周日）,约1.54万人入园游览。调查确定了65例诺如病毒感染疑似病例... 详细信息

2014年7月,摩特诺玛郡（Multnomah county）公共卫生人员对一起在俄勒冈州蓝湖地区公园的游客中发生的诺如病毒暴发进行了调查。在报告病例的周末（7月11日周五至7月13日周日）,约1.54万人入园游览。调查确定了65例诺如病毒感染疑似病例和5例诺如病毒感染实验室诊断病例（共70例）,未报告住院病例或死亡病例。回顾性队列研究发现。

关键词：诺如病毒俄勒冈州疑似病例天然湖泊卫生人员实验室诊断回顾性队列研究游泳者大肠埃希菌志贺菌

Resampling approaches for the quantitative analysis of spatially distributed cells

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Data Intelligence 2024年第1期6卷 104-119页

作者： Giorgio Bertolazzi michele Tumminello Gaia Morello Beatrice Belmonte claudio Tripodo Department of Economics Business and StatisticsUniversity of PalermoPalermoItaly Tumor Immunology Unit Department of Health SciencesUniversity of PalermoPalermoItaly Histopathology Unit Institute of Molecular Oncology Foundation(IFOM)ETS-The AIRC Institute of Molecular OncologyMilanItaly

Image segmentation is a crucial step in various image analysis pipelines and constitutes one of the cutting-edge areas of digital *** advent of quantitative analysis has enabled the evaluation of millions of individual cells in tissues,allowing for the combined assessment of morphological features,biomarker expression,and spatial *** recorded cells can be described as a point pattern ***,the classical statistical approaches to point pattern processes prove unreliable in this context due to the presence of multiple irregularly-shaped interstitial cell-devoid spaces in the domain,which correspond to anatomical features(***,lipid vacuoles,glandular lumina)or tissue artefacts(*** fractures),and whose coordinates are *** interstitial spaces impede the accurate calculation of the domain area,resulting in biased clustering ***,the mistaken inclusion of empty regions of the domain can directly impact the results of hypothesis *** literature currently lacks any introduced bias correction method to address interstitial cell-devoid *** address this gap,we propose novel resampling methods for testing spatial randomness and evaluating relationships among different cell *** methods obviate the need for domain area estimation and provide non-biased clustering *** created the SpaceR software(https://***/GBertolazzi/SpaceR)to enhance the accessibility of our methodologies.

关键词： Digital pathology spatial cytometry spatial clustering spatial randomness resampling

Machine learning for exploring small polaron configurational space

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npj computational Materials 2022年第1期8卷 1183-1191页

作者： Viktor c.Birschitzky Florian Ellinger Ulrike Diebold michele Reticcioli cesare Franchini University of Vienna Faculty of Physics and Center for Computational Materials ScienceViennaAustria University of Vienna Vienna Doctoral School in PhysicsBoltzmanngasse 51090ViennaAustria Institute of Applied Physics Technische Universität Wien1040ViennaAustria Department of Physics and Astronomy’Augusto Righi’ Alma Mater Studiorum-Universitàdi BolognaBologna40127Italy

Polaron defects are ubiquitous in materials and play an important role in many processes involving carrier mobility,charge transfer and surface *** small polarons’spatial distributions is essential to understand materials properties and ***,the required exploration of the configurational space is computationally demanding when using first principles ***,we propose a machine-learning(ML)accelerated search that determines the ground state polaronic *** ML model is trained on databases of polaron configurations generated by density functional theory(DFT)via molecular dynamics or random *** establish a mapping between configurations and their stability,we designed descriptors modelling the interactions among polarons and charged point *** used the DFT+ML protocol to explore the polaron configurational space for two surface-systems,reduced rutile TiO_(2)(110)and Nb-doped SrTiO_(3)(001).The ML-aided search proposes additional polaronic configurations and can be utilized to determine optimal polaron distributions at any charge concentration.

关键词： configuration polaron charge

Thermodynamics and dielectric response of BaTiO_(3)by data-driven modeling

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npj computational Materials 2022年第1期8卷 1998-2014页

作者： Lorenzo Gigli Max Veit michele Kotiuga Giovanni Pizzi Nicola Marzari michele ceriotti Laboratory of computational Science and Modeling(cOSMO) Institute of MaterialsÉcole Polytechnique Fédérale de LausanneCH-1015LausanneSwitzerland Theory and Simulation of Materials(THEOS)and National centre for computational Design and Discovery of Novel Materials(MARVEL) École Polytechnique Fédérale de LausanneCH-1015LausanneSwitzerland

Modeling ferroelectric materials from first principles is one of the successes of density-functional theory and the driver of much development effort,requiring an accurate description of the electronic processes and the thermodynamic equilibrium that drive the spontaneous symmetry breaking and the emergence of macroscopic *** demonstrate the development and application of an integrated machine learning model that describes on the same footing structural,energetic,and functional properties of barium titanate(BaTiO_(3)),a prototypical *** model uses ab initio calculations as a reference and achieves accurate yet inexpensive predictions of energy and polarization on time and length scales that are not accessible to direct ab initio *** predictions allow us to assess the microscopic mechanism of the ferroelectric *** presence of an order-disorder transition for the Ti off-centered states is the main driver of the ferroelectric transition,even though the coupling between symmetry breaking and cell distortions determines the presence of intermediate,partly-ordered ***,we thoroughly probe the static and dynamical behavior of BaTiO_(3)across its phase diagram without the need to introduce a coarse-grained description of the ferroelectric ***,we apply the polarization model to calculate the dielectric response properties of the material in a full ab initio manner,again reproducing the correct qualitative experimental behavior.

关键词： transition ferroelectric dielectric

comment on:“A review on radiofrequency,microwave and high-intensity focused ultrasound ablations for hepatocellular carcinoma with cirrhosis”

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 640-642页

作者： michele Finotti Maurizio Romano Marco Brizzolari michele Scopelliti Giacomo Zanus 4th Surgery Unit Regional Hospital TrevisoUniversity of PaduaDipartimento di Scienze Chirurgiche Oncologiche e Gastroenterologiche(DISCOG)PaduaItaly Baylor Scott&White Annette c.and Harold c.Simmons Transplant Institute Baylor University MedicalDallasTXUSA

We read with great interest the published article of cheung et al.(1)on Hepatobiliary Surgery and *** authors provided a comprehensive review and critical evaluation of the three main locoregional ablation(LRA)techniques for liver cancer:radiofrequency(RFA),microwave(MWA),and high-intensity focused ultrasound ablations(HIFU).The focus of the paper is on their application to patients affected by hepatocellular carcinoma(Hcc)in the context of end-stage liver disease.

关键词： hepatocellular Surgery al.

A blockchain architecture for industrial applications

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Blockchain(Research and Applications) 2022年第4期3卷 1-13页

作者： Lodovica Marchesi michele Marchesi Roberto Tonelli Maria Ilaria Lunesu Department of Mathematics and computer Science University of CagliariCagliari09124Italy

Blockchain and the programs running on it,called smart contracts,are increasingly applied in all fields where trust and strong certifications are *** work focuses on industrial applications of blockchains and not on cryptocurrencies or *** use frameworks to compare public and permissioned blockchains specifically suited for industrial *** also propose a complete solution based on Ethereum to implement a decentralized application,putting together in an original way,components and patterns already used and *** solution is characterized by a set of validator nodes running the blockchain using Proof-of-Authority or similar efficient consensus algorithms,by the use of an explorer enabling users to check the blockchain state,and the source code of the smart contracts running on *** time to time,the hash digest of the last mined block is written into a public blockchain to guarantee *** right to send transactions is granted by validator nodes to users by endowing them with the Ethers mined ***,the proposed approach has the same transparency and immutability as a public blockchain,largely reducing its drawbacks.

关键词： Permissioned blockchain Industrial application Information system Software application Ethereum

利用强子探针研究奇特原子核的点质子分布半径及强子探针效应

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Science Bulletin 2024年第11期69卷 1647-1652页

作者：张寂潮孙保华 Isao Tanihata Rituparna Kanungo christoph Scheidenberger Satoru Terashima 王枫 Frederic Ameil Joel Atkinson Yassid Ayyad Soumya Bagchi Dolores cortina-Gil Iris Dillmann Alfredo Estradé Alexey Evdokimov Fabio Farinon Hans Geissel Giulia Guastalla Rudolf Janik Satbir Kaur Ronja Knöbel Jan Kurcewicz Yury Litvinov michele Marta Magdalena Mostazo Ivan Mukha chiara Nociforo Hooi Jin Ong Stephane Pietri Andrej Prochazka Branislav Sitar Peter Strmen Maya Takechi Junki Tanaka Jossitt Vargas Helmut Weick John Stuart Winfield School of Physics Beihang UniversityBeijing 100191China Research center for Nuclear Physics(RcNP) Osaka UniversityOsaka 567-0047Japan Astronomy and Physics Department Saint Mary’s UniversityHalifax B3H 3C3Canada TRIUMF Vancouver V6T 4A3Canada GSI Helmholtzzentrum für Schwerionenforschung Darmstadt D-64291Germany Justus-Liebig University Gießn 35392Germany Helmholtz Research Academy Hesse for FAIR(HFHF) GSI Helmholtz Center for Heavy Ion ResearchGießn 35392Germany Universidad de Santiago de compostela Santiago de Compostella E-15706Spain Department of Physics Indian Institute of Technology(Indian School of Mines)Dhanbad 826004India Faculty of Mathematics and Physics Comenius UniversityBratislava 84215Slovakia Department of Physics and Atmospheric Science Dalhousie UniversityHalifax B3H 4R2Canada

We report the charge-changing cross sections(σ_(cc))of 24 p-shell nuclides on both hydrogen and carbon at about 900A MeV,of which^(8,9)Li,^(10–12)Be,^(10,14,15)B,^(14,15,17–22)N and^(16)O on hydrogen and^(8,9)Li on carbon are for the first *** from the data set,we found a new and robust relationship between the scaling factor of the Glauber model calculations and the separation energies of the nuclei of interest on both *** allows us to deduce proton radii(R_p)for the first time from the cross sections on *** identical R_p values are deduced from both target data for the neutron-rich carbon isotopes;however,the R_p from the hydrogen target is systematically smaller in the neutron-rich nitrogen *** calls for further experimental and theoretical investigations.

关键词： Exotic nuclei Nuclear size Reaction cross section Glauber model Radioactive ion beam

Murine studies and expressional analyses of human cardiac pericytes reveal novel trajectories of SARS-coV-2 Spike protein-induced microvascular damage

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3211-3214页

作者： Elisa Avolio Prashant K.Srivastava Jiahui Ji michele carrabba christopher T.W.Tsang Yue Gu Anita c.Thomas Kapil Gupta Imre Berger costanza Emanueli Paolo Madeddu Bristol Medical School Translational Health SciencesUniversity of BristolBristolUK National Heart&Lung Institute Imperial CollegeLondonUK School of Biochemistry University of BristolBristolUK

Dear Editor,The coronavirus disease 2019(cOVID-19)pandemic has caused over 670 million cases and 6.7 million deaths worldwide,many of which are attributed to cardiovascular ***-induced endothelial damage,endothelial b... 详细信息

关键词： damage cardiovascular cardiac