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Molecular features of IGHV3-53-encoded antibodies elicited by SARS-CoV-2

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1040-1042页

作者： Francesca Fagiani michele Catanzaro Cristina Lanni Department of Drug Sciences(Pharmacology Section) University of PaviaV.le Taramelli 1427100 PaviaItaly Scuola Universitaria Superiore IUSS Pavia P.zza Vittoria1527100 PaviaItaly

An elegant paper by Yuan et al.,recently published in Science,provides novel insights into the molecular features of neutralizing antibody responses to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).

关键词： al acute respiratory

Kinetic energy and radial momentum distribution of hydrogen and oxygen atoms of water confined in silica hydrogel in the temperature interval 170-325 K

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Science China(Physics,Mechanics & Astronomy) 2019年第10期62卷 87-90页

作者： Vincenzo De michele Giovanni Romanelli Antonio Cupane Dipartimento di Fisica e Chimica Universita di PalermoPalermo 90128Italy ISIS Facility Rutherford Appleton LaboratoryOxfordshire OX11 0QXUK

Water is an ubiquitous liquid and it is necessary for life;studies on water are therefore of obvious scientific and technological *** view of its peculiar physical properties(the so-called water anomalies,particularly relevant at low temperatures[1]),studies on water structure and dynamics in ample temperature intervals,covering also the supercooling region,have attracted much interest in recent *** particular,studies focused on the supercooled phase are important in order to test theories and hypotheses[2,3],including the liquid-liquid phase transition hypothesis[4-6]and the related fragile-to-strong crossover observed in water confined in silica matrices and in the hydration water of proteins[7,8].In this context,water confined within nanometer-sized porous hydrophilic/hydrophobic matrices has been investigated both to extend the supercooling temperature range accessible to experiment and to mimic the crowding/confined conditions experienced by water molecules in biological systems relevant to biophysics,bio-preservation,and *** view of the above arguments,studies on the short-time dynamics of hydrogen and oxygen atoms of supercooled water(bulk or confined)are of great relevance.

关键词： confined silica matrices

Probiotics against neoplastic transformation of gastric mucosa:Effects on cell proliferation and polyamine metabolism

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World Journal of Gastroenterology 2014年第37期20卷 13258-13272页

作者： Francesco Russo michele Linsalata Antonella Orlando Laboratory of Nutritional Pathophysiology National Institute for Digestive DiseasesI.R.C.C.S. "S.de Bellis"70013 Castellana Grotte (Ba)Italy

Gastric cancer is still the second leading cause of cancer death worldwide, accounting for about 10% of newly diagnosed neoplasms. In the last decades, an emerging role has been attributed to the relations between the intestinal microbiota and the onset of both gastrointestinal and non-gastrointestinal neoplasms. Thus, exogenous microbial administration of peculiar bacterial strains(probiotics) has been suggested as having a profound influence on multiple processes associated with a change in cancer risk. The internationally accepted definition of probiotics is live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. The possible effects on the gastrointestinal tract following probiotic administration have been investigated in vitro and in animal models, as well as in healthy volunteers and in patients suffering from different human gastrointestinal diseases. Although several evidences are available on the use of probiotics against the carcinogen Helicobacter pylori,little is still known about the potential cross-interactions among probiotics, the composition and quality of intestinal flora and the neoplastic transformation of gastric mucosa. In this connection, a significant role in cell proliferation is played by polyamines(putrescine, spermidine, and spermine). These small amines are required in both pre-neoplastic and neoplastic tissue to sustain the cell growth and the evidences here provided suggest that probiotics may act as antineoplastic agents in the stomach by affecting also the polyamine content and functions. This review will summarize data on the most widely recognized effects of probiotics against neoplastic transformation of gastric mucosa and in particular on their ability in modulating cell proliferation, paying attention to the polyamine metabolism.

关键词： Cell proliferation Gastric cancer Microbiota Polyamines Probiotics

Hippocampal plasticity after a vagus nerve injury in the rat

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Neural Regeneration Research 2012年第14期7卷 1055-1063页

作者： Giulia Ronchi Vitaly Ryu michele Fornaro Krzysztof Czaja Department of Clinical and Biological Sciences University of Turin Turin 10043 Italy Neuroscience Institute of the "Cavalieri Ottolenghi" Foundation (NICO) University of Turin Turin 10043 Italy Programs in Neuroscience and Department of Veterinary and Comparative Anatomy Pharmacology and Physiology College of Veterinary Medicine Washington State University Pullman WA 99164 USA Department of Anatomy Midwestern University Downers Grove IL60515 USA

Stimulation of the vagus nerve has been previously reported to promote neural plasticity and neurogenesis in the brain. Several studies also revealed plastic changes in the spinal cord after injuries to somatosensory nerves originating from both the brachial and lumbo-sacral plexuses. However, the neurogenic responses of the brain to the injury of the viscerosensory innervation are not as yet well understood. In the present study, we investigated whether cells in the dentate gyrus of the hippocampus respond to a chemical and physical damage to the vagus nerve in the adult rat. Intraperitoneal capsaicin administration was used to damage non-myelinated vagal afferents while subdiaphragmatic vagotomy was used to damage both the myelinated and non-myelinated vagal afferents. The 5-bromo-2-deoxyuridine （BrdU） incorporation together with cell-specific markers was used to study neural proliferation in subgranular zone, granule cell layer, molecular layer and hilus of the dentate gyrus. Microglia activation was determined by quantifying changes in the intensity of fluorescent staining with a primary antibody against ionizing calcium adapter-binding molecule 1. Results revealed that vagotomy decreased BrdU incorporation in the hilus 15 days after injury compared to the capsaicin group. Capsaicin administration decreased BrdU incorporation in the granular cell layer 60 days after the treatment. Capsaicin decreased the number of doublecortin-expressing cells in the dentate gyrus, whereas vagotomy did not alter the expression of doublecortin in the hippocampus. Both the capsaicin- and the vagotomy-induced damage to the vagus nerve decreased microglia activation in the hippocampus at 15 days after the injury. At 30 days post injury, capsaicin-treated and vagotomized rats revealed significantly more activated microglia. Our findings show that damage to the subdiaphragmatic vagus in adult rats is followed by microglia activation and long-lasting changes in the dentate gyrus, leadi

关键词： vagus injury hippocampus vagotomy capsaicin vagal afferents microglia rat

Anti-inflammatory pathways and alcoholic liver disease: Role of an adiponectin/interleukin-10/heme oxygenase-1 pathway

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World Journal of Gastroenterology 2010年第11期16卷 1330-1336页

作者： Palash Mandal michele T Pritchard Laura E Nagy Department of Pathobiology and Gastroenterology Cleveland ClinicLerner Research Institute/NE-40

The development of alcoholic liver disease (ALD) is a complex process involving both the parenchymal and non-parenchymal cells in the liver. Enhanced inflammation in the liver during ethanol exposure is an important contributor to injury. Kupffer cells, the resident macrophages in liver, are particularly critical to the onset of ethanol-induced liver injury. Chronic ethanol exposure sensitizes Kupffer cells to activation by lipopolysaccharide via Toll-like receptor 4. This sensitization enhances production of inflammatory mediators, such as tumor necrosis factor-α and reactive oxygen species, that contribute to hepatocyte dysfunction, necrosis, apoptosis, and fibrosis. Impaired resolution of the inflammatory process probably also contributes to ALD. The resolution of inflammation is an active, highly coordinated response that can potentially be manipulated via therapeutic interventions to treat chronic inflammatory diseases. Recent studies have identif ied an adiponectin/interleukin-10/heme oxygenase-1 (HO-1) pathway that is profoundly effective in dampening the enhanced activation of innate immune responses in primary cultures of Kupffer cells, as well as in an in vivo mouse model of chronic ethanol feeding. Importantly, induction of HO-1 also reduces ethanol-induced hepatocellular apoptosis in this in vivo model. Based on these data, we hypothesize that the development of therapeutic agents to regulate HO-1 and its downstream targets could be useful in enhancing the resolution of inflammation during ALD and preventing progression of early stages of liver injury.

关键词： Liver disease Alcohol Macrophages Hemeoxygenase-1 Inflammation

Prevalence of musculoskeletal injuries and a proposal for neuromuscular training to prevent lower limb injuries in Brazilian Army soldiers:an observational study

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Military Medical Research 2019年第1期6卷 45-52页

作者： michele Zukauskas de Andrade Gomes Carlos Eduardo Pinfildi Department of Human Movement Science Federal University of Sao Paulo(UNIFESP)Campus Baixada Santista Human Movement Science and Rehabilitation Department of Human Movement ScienceFederal University of Sao Paulo-Physical TherapyCampus Baixada Santista

Background: The activities carried out by soldiers in the army involve great physical demands and require intense trainings to perform combat-specific tasks. Musculoskeletal injury is a potential threat to the health and physical integrity of the soldier. This study aimed to evaluate the prevalence of lower limb musculoskeletal injuries among soldiers and to propose a training protocol to prevent the most frequent ***: This observational(cross-sectional) study recruited a sample of 103 soldiers who required medical attention,from a total 202 new battalion soldiers. The medical records(paper and online) had a form of running text. All data collected were recorded by the registered physicians of the battalion medical post. The records were analyzed by the following variables: medical diagnosis, injury site, mechanism, type of treatment, time loss, existence of previous injury,and recurring ***: A total of 112 musculoskeletal injuries were diagnosed in 71 soldiers, and other types of diseases/injuries were diagnosed in the other soldiers. Joint pain accounted for 55.4% of the diagnoses. The knee was the most affected site, while trauma and overload were the most common mechanisms of injury. Drug treatment was used most frequently, accounting for 58% of the cases. The majority of the sample obtained a temporary leave of absence for1 to 6 days or not at all. Previous injuries and recurrence were not presented as risk factors for injury. With the data received, a protocol for the prevention of injuries to the lower limbs was ***: This study indicated that the most frequent site of injury is the knee, and joint pain is the most common diagnosis. These results may support the necessity to develop a neuromuscular training protocol to prevent lower limb injuries, which we suggest to be applied in future studies.

关键词： Physical therapy Wounds and injuries Primary prevention Lower extremity Proprioception Military personnel

Multiple feature fusion for unimodal emotion recognition

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The Journal of China Universities of Posts and Telecommunications 2019年第2期26卷 17-29页

作者： Yang Lingzhi Ban Xiaojuan michele Mukeshimana Chen Zhe School of Computer and Communication Engineering Beijing Key Laboratory of Knowledge Engineering for Materials ScienceUniversity of Science and Technology BeijingBeijing 10083China Citic Pacific Special Steel Holdings Qingdao Special Iron and Steel Company Limited Faculity of Engineering Sciences University of BurundiBujumbura P.0.Box 1550 BujumburaBurundi Qingdao Hisense Group Company Limited Qingdao 266000China

A new semi-serial fusion method of multiple feature based on learning using privileged information(LUPI) model was put *** exploitation of LUPI paradigm permits the improvement of the learning accuracy and its stability,by additional information and computations using optimization *** execution time is also reduced,by sparsity and dimension of testing *** essence of improvements obtained using multiple features types for the emotion recognition(speech expression recognition),is particularly applicable when there is only one modality but still need to improve the *** results show that the LUPI in unimodal case is effective when the size of the feature is *** comparison to other methods using one type of features or combining them in a concatenated way,this new method outperforms others in recognition accuracy,execution reduction,and stability.

关键词： multiple feature LUPI emotion recognition semi-serial fusion method

Comment on:“A review on radiofrequency,microwave and high-intensity focused ultrasound ablations for hepatocellular carcinoma with cirrhosis”

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 640-642页

作者： michele Finotti Maurizio Romano Marco Brizzolari michele Scopelliti Giacomo Zanus 4th Surgery Unit Regional Hospital TrevisoUniversity of PaduaDipartimento di Scienze Chirurgiche Oncologiche e Gastroenterologiche(DISCOG)PaduaItaly Baylor Scott&White Annette C.and Harold C.Simmons Transplant Institute Baylor University MedicalDallasTXUSA

We read with great interest the published article of Cheung et al.(1)on Hepatobiliary Surgery and *** authors provided a comprehensive review and critical evaluation of the three main locoregional ablation(LRA)techniques for liver cancer:radiofrequency(RFA),microwave(MWA),and high-intensity focused ultrasound ablations(HIFU).The focus of the paper is on their application to patients affected by hepatocellular carcinoma(HCC)in the context of end-stage liver disease.

关键词： hepatocellular Surgery al.

Surgery for hepatocellular carcinoma can provide the same life-expectancy as transplant of that of general population

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Hepatobiliary Surgery and Nutrition 2019年第2期8卷 151-152页

作者： Giorgio Ercolani michele Cucchi Department of Medical and Surgical Sciences DIMECAlma Mater StudiorumUniversity of BolognaBolognaItaly General Surgery MorgagniPierantoni HospitalForlì(FC)Italy

When deciding for the optimal treatment to adopt in patients suffering from hepatocellular carcinoma(HCC),the surgical approach is commonly considered as the most curative option(1,2).The scarcity of donors for liver transplantation(LT)led surgeons to bridge patients until an eventual future transplant(salvage LT),opting in first instance and when feasible for hepatic resection(HR)also for those patients otherwise transplantable(2).In the study published by Pinna and colleagues in Annals of Surgery 2018,it was verified in what measure LT and HR can provide for HCC the same mortality expected in the general population,defining the so called"statistical cure"(3).

关键词： Surgery hepatocellular otherwise