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michela Benaglia&Emanuela Colombo/盒子里的披头士

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摄影之友 2023年第7期 76-85页

作者：健一 michela Benaglia(图) Emanuela Colombo(图) 不详

在西班牙凉菜汤中加入蟋蟀或用蜜蜂蛾制作炸玉米饼的想法可能会让我们大多数人感到局促不安。但面对未来日益严重的食物短缺,昆虫可能很快就会成为厨房的主食。两位来自意大利的摄影师用镜头探讨了昆虫和食品在未来的联系。

关键词：面对未来摄影师西班牙

Patients with hematological malignancies and serological signs of prior resolved hepatitis B

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World Journal of Gastrointestinal Oncology 2012年第3期4卷 37-45页

作者： Massimo Marignani Elia Gigante Paola Begini Alfredo Marzano michela di Fonzo Ilaria Deli Sara Gallina Maria Christina Cox Gianfranco Delle Fave Digestive and Liver Disease Department School of Medicine and Psychology University "Sapienza" Azienda Ospedaliera S. Andrea Via Grottarossa 1035-1039 00189 Rome Italy SCDU of Gastroenterology and Hepatology AO San Giovanni Battista Corso Bramante 88 10125 Torino Italy Haematology Department School of Medicine and Psychology University "Sapienza" Azienda Ospedaliera S. Andrea Via Grottarossa 1035-1039 00189 Rome Italy

Hepatitis B virus (HBV) infection affects a large part of the world population. Within the different virological HBV categories that have been identified, patients with occult HBV infection represent a peculiar group. These individuals harbor a replication competent virus, inhibited in its replicative function. Accordingly, cases of reactivations have been observed in immunosuppressed individuals who lose immunological control over the infection. Patients with hematological malignancies (HM) are treated with intense myeloand immunosuppres-sive chemotherapy regimens which favor HBV reactivation. This event can have severe consequences, such as hepatitis flare, hepatic failure and even death. In addition, it can lead to delays or interruptions of curative treatments, resulting in a decreased disease free and overall survival. In this review, we will examine the event of HBV reactivation in patients with signs of resolved HBV infection undergoing treatment for HM and propose possible management strategies.

关键词： Occult hepatitis B Hematological malignancies Hepatitis B virus Chemotherapy Hepatitis B reactivation

Natural Formulations Addressing Skin Challenges in Baby Care

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Journal of Cosmetics, Dermatological Sciences and Applications 2013年第1期3卷 6-11页

作者： Giada Maramaldi Martino Meneghin Giuseppe Antognazza michela Pollastri Ellegi Biocosmetica Assago Italy. Indena Milano Italy Indena Milano Italy.

Addressing skin challenges in baby care formulations is quite a challenge itself, as the formulation not only needs to be active, but it should also meet specific requirements in terms of ingredients, agreability and rational of the formulation design. Object of this study was the realization of a few different cosmetic formulations blending soundly documented natural active ingredients in systems matching the most common requirements of the baby care products. Additionaly, compatibility evidences of the employed natural actives within the tested systems have also been observed. We are therefore presenting the formulation design of four different formulations for baby care: a baby wash, an immediate rash recovery, an after sun emulsion and a calming and soothing product, each one described for the rational of the actives it contains and provided with a detailed formulation design. Specific attention will be directed to those ingredients for which clinical data supporting the expected skin benefits are available.

关键词： Baby Care Lenitive Soothing Natural Active Ingredients Dermocosmetics

Green Marketing and Renewable Energy： Evidence on Motivations and Behaviour in the Aquacultural Market

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Chinese Business Review 2011年第12期10卷 1111-1130页

作者： Rodolfo Ballestrazzi michela C. Mason Federico Nassivera University of Udine Udine Italy

The purpose of this paper falls within the theoretical framework of green marketing. It investigates the relationships that exist between the motives relating to aquacultural products marketed under the private label of a traditional retailer （Coop）, the attitude towards their purchase, the perception of their quality, their reliability and the willingness to pay for them. Particular importance is given to the green motives, those that lead to a preference for a product made with specific renewable energies such as biogas. The structural equation models （SEM） technique is used to develop propositions representing a theoretical approach to the integration of green marketing, in the context of the process for purchasing Coop brand fish. With regard to distinguishing between the motives, we referred to the approach that sets out three different types of motive： clean, green and ethical. The resulting managerial implications make it possible to assess how much the different types of motive influence the choices of the consumers. Managers will benefit from the results of this paper by understanding better the benefits for consumers of aquacultural products from renewable energy such as biogas. The originality of the paper lies in its focusing on green purchase behaviour in a poorly investigated sector such as that of fish breeding. The paper contributes to an understanding of the factors that influence environmentally responsible purchase behaviour and their exact relationships, that are still unclear in literature. The fact that environmental issues and concerns are constantly changing implies that ongoing research into their influence on consumer behaviour is essential

关键词： green marketing renewable energy aquacultural market biogas SEM

The Use of Spatial Sampling Designs in Business Surveys

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Open Journal of Statistics 2014年第5期4卷 345-354页

作者： Maria michela Dickson Roberto Benedetti Diego Giuliani Giuseppe Espa Department of Economics and Management University of Trento Trento Italy Department of Economics University “G. D’annunzio” Pescara Italy Department of Social Science University “Sapienza” Roma Italy

An innovative use of spatial sampling designs is here presented. Sampling methods which consider spatial locations of statistical units are already used in agricultural and environmental contexts, while they have never been exploited for establishment surveys. However, the rapidly increasing availability of geo- referenced information about business units makes that possible. In business studies, it may indeed be important to take into account the presence of spatial autocorrelation or spatial trends in the variables of interest, in order to have more precise and efficient estimates. The opportunity of using the most innovative spatial sampling designs in business surveys, in order to produce samples that are well spread in space, is here tested by means of Monte Carlo experiments. For all designs, the Horvitz-Thompson estimator of the population total is used both with equal and unequal inclusion probabilities. The efficiency of sampling designs is evaluated in terms of relative RMSE and efficiency gain compared with designs ignoring the spatial information. Furthermore, an evaluation of spatially balancing samples is also conducted.

关键词： Spatial Sampling Design Business Surveys Horvitz-Thompson Estimator Spatial Balance

Difficult case of a trans-septal puncture: Use of a “SafeSept” guidewire

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World Journal of Cardiology 2015年第8期7卷 499-503页

作者： Martina Zucchetti michela Casella Antonio Dello Russo Gaetano Fassini Corrado Carbucicchio Eleonora Russo Vittoria Marino Valentina Catto Claudio Tondo Cardiac Arrhythmia Research Centre Centro Cardiologico Monzino IRCCS 20138 Milan Italy

A 69-year-old man was admitted to our center to undergo catheter ablation of paroxysmal atrial fibrillation refractory to antiarrhythmic drug therapy. This procedure required access to the left atrium through the interatrial septum. During hospitalization, the patient performed routinely pre-procedure transthoracic echocardiography and gadolinium-enhanced cardiac magnetic resonance showing a normal anatomy of both the fossa ovalis and the interatrial septum. Access to the left atrium proved difficult and several unsuccessful attempts to perform the trans-septal puncture were made under both fluoroscopy and intracardiac echocardiography guidance, even with radiofrequency energy delivery. Finally, trans-septal puncture was successfully carried out using a novel nitinol J-shaped "Safe Sept" trans-septal guidewire, designed to cross the interatrial septum through the trans-septal needle thanks to a special sharp tip. Moreover, thanks to its rounded J shape that reduces the risk of atrial perforation, the "Safe Sept" guidewire, when advanced into the left atrium, becomes atraumatic.

关键词： Trans-septal puncture "Safe Sept" guide-wire Atrial fibrillation Interatrial septum Intracardiac echocardiography

Immunoglobulin A vasculitis nephritis:Current understanding of pathogenesis and treatment

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World Journal of Nephrology 2023年第4期12卷 82-92页

作者： michela Amatruda Nicolina Stefania Carucci Roberto Chimenz Giovanni Conti Pediatric Nephrology and Rheumatology Unit AOU G MartinoUniversity of MessinaMessina 98125Italy

The clinical spectrum of immunoglobulin A vasculitis nephritis(IgAVN)ranges from the relatively common transitory microscopic hematuria and/or low-grade proteinuria to nephritic or nephrotic syndrome,rapidly progressive glomerulonephritis,or even renal *** and experimental studies have shown a multifactor pathogenesis:Infection triggers,impaired glycosylation of IgA1,complement activation,Toll-like-receptor activation and B cell *** knowledge can identify IgAVN patients at a greater risk for adverse outcome and increase the evidence for treatment recommendations.

关键词： Immunoglobulin A vasculitis nephritis Immunoglobulin A vasculitis Henoch-Schoenlein purpura Immunoglobulin A nephropathy Vasculitis,glomerulonephritis

Sustained complete response of advanced hepatocellular carcinoma with metronomic capecitabine: a report of three cases

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Cancer Communications 2018年第1期38卷 429-435页

作者： Giovanni Brandi michela Venturi Stefania De Lorenzo Francesca Garuti Giorgio Frega Andrea Palloni Ingrid Garajovà Francesca Abbati Gioconda Saccoccio Rita Golfieri Maria Abbondanza Pantaleo Maria Aurelia Barbera Department of Experimental Diagnostic and Specialty MedicineSt.Orsola-Malpighi HospitalHaematological and Oncological InstituteUniversity of Bologna9 Massarenti street40138 BolognaItaly Department of Medical and Surgical Sciences St.Orsola-Malpighi HospitalUniversity of Bologna40138 BolognaItaly Department of Medicine Bologna Health Authority40139 BolognaItaly Department of Digestive Diseases and Internal Medicine St.Orsola-Malpighi HospitalUniversity of Bologna40138 BolognaItaly

Background:Hepatocellular carcinoma(HCC)is one of the most frequent causes of cancer-related ***,a multitarget angiogenesis inhibitor,is an approved frontline treatment for advanced HCC in Western countries,although a complete response(CR)to treatment is infrequently ***,an oral fluoropyrimidine,has been shown to be effect in both treatment-naïve patients and those previously treated with *** date,how-ever,only one case of sustained CR to metronomic capecitabine has been *** presentation:We describe three cases of advanced HCC treated with metronomic capecitabine where a CR was *** the first case,capecitabine was administered as first line therapy;in the second case,capecitabine was used after intolerance to sorafenib;while in the third case,capecitabine was administered after sorafenib ***:Capecitabine is a potentially important treatment option for patients with advanced HCC and may even represent a cure in certain cases.

关键词： Hepatocellular carcinoma Capecitabine Metronomic capecitabine Complete response Sorafenib

Hydroperoxides and cytokines as biomarkers in detecting atherosclerosis predisposition in cigarette smokers

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Modern Research in Inflammation 2012年第1期1卷 11-17页

作者： Valter Lubrano michela Ballardin Vincenzo Longo Moreno Paolini Roberto Scarpato Department of Human and Environmental Sciences University of Pisa Pisa Italy Department of Pharmacology University of Bologna Bologna Italy Fondazione G. Monasterio CNR-Regione Toscana Pisa Italy Institute of Agricultural Biology and Biotechnology CNR Pisa Italy

Objectives: Smoking increases oxidative modification of LDL, associated with lower HDL plasma levels, systemic inflammatory response and endothelial dysfunction. We tested the hypothesis that the risk status for coronary atherosclerosis disease (CAD) of cigarettes smokers might be identified by means of serum oxidative levels and vascular inflammation determination. Design and Methods: Oxidative stress levels, cytokines, and the metabolic status were investigated on 499 subjects admitted to our institute. The association between biomarkers and smoking habits in the presence/absence of disease and with the number of vessel affected, was studied. Results: Oxidative stress and inflammatory levels (p < 0.001) were strongly induced by smoking habits. Serum values of the subjects categorised as CAD, non CAD and healthy subjects differed significantly (p < 0.001) only for the degree of oxidative stress. Glycaemia was able to affect C-reactive protein serum levels with a positive association (p < 0.05). The analysis of the study population indicated that serum oxidative stress levels significantly increased with increasing number of vessels affected (p < 0.01). When statistical analysis was performed separately in both smoking groups, smokers did not show any particular difference for both oxidative stress and inflammation markers between the two groups of cardiovascular patients (CAD and non CAD) and the control group, while for non smokers, the differences were evident. Conclusion: These findings indicate that the considered biomarkers, especially oxidative stress, can be useful to predict the biological damage caused by cigarette smoking, as well as to identify subjects characterised by a higher risk of cardiovascular event, but cannot evaluate the presence of disease in subjects with smoking habit.

关键词： IL-6 TNFα CRP Hydroperoxides Ossidative Stress CAD